Synthesis and structure-activity relationships of a novel series of pyrimidines as potent inhibitors of TBK1/IKKε kinases

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 23, 2012, Pages 7169-7173

  McIver, Edward G ^a   Bryans, Justin ^a   Birchall, Kristian ^a   Chugh, Jasveen ^a   Drake, Thomas ^a   Lewis, Stephen J ^a   Osborne, Joanne ^a   Smiljanic Hurley, Ela ^a   Tsang, William ^a   Kamal, Ahmad ^a   Levy, Alison ^a   Newman, Michelle ^a   Taylor, Debra ^a   Arthur, J Simon C ^b   Clark, Kristopher ^b   Cohen, Philip ^b  

^a MEDICAL RESEARCH COUNCIL   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

I B kinase epsilon; IKK ; Interferon ; RANTES; TANK binding kinase; TBK1

Indexed keywords

BX320; BX795; I KAPPA B KINASE EPSILON; PHOSPHOTRANSFERASE; PYRIMIDINE DERIVATIVE; TANK BINDING KINASE 1; UNCLASSIFIED DRUG;

ARTICLE; DRUG PENETRATION; DRUG SYNTHESIS; ENZYME INHIBITION; IN VIVO STUDY; INFLAMMATION; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BINDING SITES; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; DRUG DESIGN; HUMANS; I-KAPPA B KINASE; MICE; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 84869093852     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.09.063     Document Type: Article

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