MAVS ubiquitination by the E3 ligase TRIM25 and degradation by the proteasome is involved in type I interferon production after activation of the antiviral RIG-I-like receptors

BMC Biology

Volumn 10, Issue , 2012, Pages

  Castanier, Céline ^a,b   Zemirli, Naima ^a,b   Portier, Alain ^a,b   Garcin, Dominique ^c   Bidère, Nicolas ^a,b   Vazquez, Aimé ^a,b   Arnoult, Damien ^a,b  

^a HÔPITAL PAUL BROUSSE   (France)

^b UNIVERSITÉ PARIS SACLAY   (France)

^c UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

MAVS; RIG I like receptors; TRIM25; Ubiquitination

Indexed keywords

DEAD BOX PROTEIN; I KAPPA B KINASE; IKBKG PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; PROTEASOME; PROTEIN SERINE THREONINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TBK1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRIM25 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE; VISA PROTEIN, HUMAN;

ARTICLE; CELL STRAIN HEK293; HELA CELL; HUMAN; IMMUNOLOGY; METABOLISM; PHOSPHORYLATION; RESPIROVIRUS INFECTION; SENDAI VIRUS; SIGNAL TRANSDUCTION; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; DEAD-BOX RNA HELICASES; HEK293 CELLS; HELA CELLS; HUMANS; I-KAPPA B KINASE; INTERFERON REGULATORY FACTOR-3; INTERFERON TYPE I; NF-KAPPA B; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN-SERINE-THREONINE KINASES; RESPIROVIRUS INFECTIONS; SENDAI VIRUS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84861330800     PISSN: None     EISSN: 17417007     Source Type: Journal    
DOI: 10.1186/1741-7007-10-44     Document Type: Article

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