-
1
-
-
0345359924
-
A positive-feedback-based bistable 'memory module' that governs a cell fate decision
-
W. Xiong, and J.E. Ferrell Jr. A positive-feedback-based bistable 'memory module' that governs a cell fate decision Nature 426 2003 460 465
-
(2003)
Nature
, vol.426
, pp. 460-465
-
-
Xiong, W.1
Ferrell Jr., J.E.2
-
2
-
-
0037047611
-
MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network
-
U.S. Bhalla, P.T. Ram, and R. Iyengar MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network Science 297 2002 1018 1023
-
(2002)
Science
, vol.297
, pp. 1018-1023
-
-
Bhalla, U.S.1
Ram, P.T.2
Iyengar, R.3
-
3
-
-
0037376655
-
Sniffers, buzzers, toggles and blinkers: Dynamics of regulatory and signaling pathways in the cell
-
J.J. Tyson, K.C. Chen, and B. Novak Sniffers, buzzers, toggles and blinkers: dynamics of regulatory and signaling pathways in the cell Curr Opin Cell Biol 15 2003 221 231
-
(2003)
Curr Opin Cell Biol
, vol.15
, pp. 221-231
-
-
Tyson, J.J.1
Chen, K.C.2
Novak, B.3
-
4
-
-
0037453510
-
Assembly of cell regulatory systems through protein interaction domains
-
T. Pawson, and P. Nash Assembly of cell regulatory systems through protein interaction domains Science 300 2003 445 452
-
(2003)
Science
, vol.300
, pp. 445-452
-
-
Pawson, T.1
Nash, P.2
-
5
-
-
0037039328
-
Signaling complexes: Junctions on the intracellular information super highway
-
F.D. Smith, and J.D. Scott Signaling complexes: junctions on the intracellular information super highway Curr Biol 12 2002 R32 R40
-
(2002)
Curr Biol
, vol.12
-
-
Smith, F.D.1
Scott, J.D.2
-
6
-
-
73649152457
-
Allosteric proteins and cellular control systems
-
J. Monod, J.P. Changeux, and F. Jacob Allosteric proteins and cellular control systems J Mol Biol 6 1963 306 329
-
(1963)
J Mol Biol
, vol.6
, pp. 306-329
-
-
Monod, J.1
Changeux, J.P.2
Jacob, F.3
-
7
-
-
0018168011
-
Hemoglobin structure and respiratory transport
-
M.F. Perutz Hemoglobin structure and respiratory transport Sci Am 239 1978 92 125
-
(1978)
Sci Am
, vol.239
, pp. 92-125
-
-
Perutz, M.F.1
-
8
-
-
0027732538
-
Proteins regulating Ras and its relatives
-
M.S. Boguski, and F. McCormick Proteins regulating Ras and its relatives Nature 366 1993 643 654
-
(1993)
Nature
, vol.366
, pp. 643-654
-
-
Boguski, M.S.1
McCormick, F.2
-
9
-
-
0037954572
-
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
-
R.M. Biondi, and A.R. Nebreda Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions Biochem J 372 2003 1 13
-
(2003)
Biochem J
, vol.372
, pp. 1-13
-
-
Biondi, R.M.1
Nebreda, A.R.2
-
10
-
-
0031452274
-
Structures of Src-family tyrosine kinases
-
F. Sicheri, and J. Kuriyan Structures of Src-family tyrosine kinases Curr Opin Struct Biol 7 1997 777 785
-
(1997)
Curr Opin Struct Biol
, vol.7
, pp. 777-785
-
-
Sicheri, F.1
Kuriyan, J.2
-
11
-
-
0037013143
-
The conformational plasticity of protein kinases
-
M. Huse, and J. Kuriyan The conformational plasticity of protein kinases Cell 109 2002 275 282
-
(2002)
Cell
, vol.109
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
12
-
-
0036468436
-
The modular logic of signaling proteins: Building allosteric switches from simple binding domains
-
W.A. Lim The modular logic of signaling proteins: building allosteric switches from simple binding domains Curr Opin Struct Biol 12 2002 61 68
-
(2002)
Curr Opin Struct Biol
, vol.12
, pp. 61-68
-
-
Lim, W.A.1
-
13
-
-
0036441510
-
Autoinhibitory domains: Modular effectors of cellular regulation
-
M.A. Pufall, and B.J. Graves Autoinhibitory domains: modular effectors of cellular regulation Annu Rev Cell Dev Biol 18 2002 421 462
-
(2002)
Annu Rev Cell Dev Biol
, vol.18
, pp. 421-462
-
-
Pufall, M.A.1
Graves, B.J.2
-
14
-
-
0031197185
-
Protein kinase inhibition: Natural and synthetic variations on a theme
-
S.S. Taylor, and E. Radzio-Andzelm Protein kinase inhibition: natural and synthetic variations on a theme Curr Opin Chem Biol 1 1997 219 226
-
(1997)
Curr Opin Chem Biol
, vol.1
, pp. 219-226
-
-
Taylor, S.S.1
Radzio-Andzelm, E.2
-
15
-
-
0033604499
-
Active site-directed protein regulation
-
B. Kobe, and B.E. Kemp Active site-directed protein regulation Nature 402 1999 373 376
-
(1999)
Nature
, vol.402
, pp. 373-376
-
-
Kobe, B.1
Kemp, B.E.2
-
18
-
-
0344626926
-
Structural basis for the autoinhibition of c-Abl tyrosine kinase
-
••] describe the mechanism of autoinhibition of the kinase c-Abl. Like the Src family kinases, intramolecular SH2 and SH3 domain interactions participate in autoinhibition. In addition, an N-terminal myristoyl group docks against the kinase domain to form a third autoinhibitory interaction. Thus, inputs that disrupt any of these three autoinhibitory interactions may serve as activating stimuli.
-
(2003)
Cell
, vol.112
, pp. 859-871
-
-
Nagar, B.1
Hantschel, O.2
Young, M.A.3
Scheffzek, K.4
Veach, D.5
Bornmann, W.6
Clarkson, B.7
Superti-Furga, G.8
Kuriyan, J.9
-
19
-
-
0033574722
-
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
-
R. Rohatgi, L. Ma, H. Miki, M. Lopez, T. Kirchhausen, T. Takenawa, and M.W. Kirschner The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly Cell 97 1999 221 231
-
(1999)
Cell
, vol.97
, pp. 221-231
-
-
Rohatgi, R.1
Ma, L.2
Miki, H.3
Lopez, M.4
Kirchhausen, T.5
Takenawa, T.6
Kirschner, M.W.7
-
20
-
-
0034721696
-
Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex
-
K.E. Prehoda, J.A. Scott, R.D. Mullins, and W.A. Lim Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex Science 290 2000 801 806
-
(2000)
Science
, vol.290
, pp. 801-806
-
-
Prehoda, K.E.1
Scott, J.A.2
Mullins, R.D.3
Lim, W.A.4
-
21
-
-
0038392871
-
Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP
-
E. Torres, and M.K. Rosen Contingent phosphorylation/dephosphorylation provides a mechanism of molecular memory in WASP Mol Cell 11 2003 1215 1227 This study, together with [22,23], shows that tyrosine phosphorylation of the autoinhibitory GBD can serve as an activating input for the actin-regulatory protein WASP. Torres et al. examined the relationship between Cdc42 and phosphorylation-dependent activation. Their findings indicate that phosphorylation of Tyr256 is unfavorable unless activated Cdc42 is present. They suggest that transient activation of N-WASP by Cdc42 may allow long-term activation via phosphorylation, a form of memory.
-
(2003)
Mol Cell
, vol.11
, pp. 1215-1227
-
-
Torres, E.1
Rosen, M.K.2
-
22
-
-
0037160142
-
Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein
-
G.O. Cory, R. Garg, R. Cramer, and A.J. Ridley Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein J Biol Chem 277 2002 45115 45121
-
(2002)
J Biol Chem
, vol.277
, pp. 45115-45121
-
-
Cory, G.O.1
Garg, R.2
Cramer, R.3
Ridley, A.J.4
-
23
-
-
0347915637
-
Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation
-
K. Badour, J. Zhang, F. Shi, Y. Leng, M. Collins, and K.A. Siminovitch Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation J Exp Med 199 2004 99 112
-
(2004)
J Exp Med
, vol.199
, pp. 99-112
-
-
Badour, K.1
Zhang, J.2
Shi, F.3
Leng, Y.4
Collins, M.5
Siminovitch, K.A.6
-
24
-
-
0031739144
-
Structural basis for cytokine hormone-receptor recognition and receptor activation
-
A.A. Kossiakoff, and A.M. De Vos Structural basis for cytokine hormone-receptor recognition and receptor activation Adv Protein Chem 52 1998 67 108
-
(1998)
Adv Protein Chem
, vol.52
, pp. 67-108
-
-
Kossiakoff, A.A.1
De Vos, A.M.2
-
25
-
-
10744230127
-
An open-and-shut case? Recent insights into the activation of EGF/ErbB receptors
-
••].
-
(2003)
Mol Cell
, vol.12
, pp. 541-552
-
-
Burgess, A.W.1
Cho, H.S.2
Eigenbrot, C.3
Ferguson, K.M.4
Garrett, T.P.5
Leahy, D.J.6
Lemmon, M.A.7
Sliwkowski, M.X.8
Ward, C.W.9
Yokoyama, S.10
-
26
-
-
18644370411
-
Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha
-
••].
-
(2002)
Cell
, vol.110
, pp. 763-773
-
-
Garrett, T.P.1
McKern, N.M.2
Lou, M.3
Elleman, T.C.4
Adams, T.E.5
Lovrecz, G.O.6
Zhu, H.J.7
Walker, F.8
Frenkel, M.J.9
Hoyne, P.A.10
-
28
-
-
0141757323
-
Reprogramming control of an allosteric signaling switch through modular recombination
-
J.E. Dueber, B.J. Yeh, K. Chak, and W.A. Lim Reprogramming control of an allosteric signaling switch through modular recombination Science 301 2003 1904 1908 Inspired by the modular architecture of many signaling proteins, heterologous protein-protein interaction domains were recombined with the output domain of the actin polymerization switch N-WASP. The resulting synthetic proteins displayed diverse and complex gating behaviors analogous to those observed in natural signaling proteins. These findings support the hypothesis that such a modular framework may facilitate the evolution of novel gates and, therefore, novel signaling networks.
-
(2003)
Science
, vol.301
, pp. 1904-1908
-
-
Dueber, J.E.1
Yeh, B.J.2
Chak, K.3
Lim, W.A.4
-
30
-
-
0042736856
-
Allosteric switching by mutually exclusive folding of protein domains
-
•] describe another approach to generating synthetic proteins with gating behavior. In both of these studies, two distinct protein folds are energetically linked by inserting one within the sequence of the other. This thermodynamic coupling allows ligands of one fold to modulate the activity of the other fold.
-
(2003)
J Mol Biol
, vol.332
, pp. 529-536
-
-
Radley, T.L.1
Markowska, A.I.2
Bettinger, B.T.3
Ha, J.H.4
Loh, S.N.5
-
31
-
-
0028938721
-
Catalytic specificity of protein-tyrosine kinases is critical for selective signalling
-
Z. Songyang, K.L. Carraway III, M.J. Eck, S.C. Harrison, R.A. Feldman, M. Mohammadi, J. Schlessinger, S.R. Hubbard, D.P. Smith, and C. Eng Catalytic specificity of protein-tyrosine kinases is critical for selective signalling Nature 373 1995 536 539
-
(1995)
Nature
, vol.373
, pp. 536-539
-
-
Songyang, Z.1
Carraway III, K.L.2
Eck, M.J.3
Harrison, S.C.4
Feldman, R.A.5
Mohammadi, M.6
Schlessinger, J.7
Hubbard, S.R.8
Smith, D.P.9
Eng, C.10
-
32
-
-
0037444809
-
Docking sites on mitogen-activated protein kinase (MAPK) kinases. MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity
-
A.J. Bardwell, M. Abdollahi, and L. Bardwell Docking sites on mitogen-activated protein kinase (MAPK) kinases. MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity Biochem J 370 2003 1077 1085
-
(2003)
Biochem J
, vol.370
, pp. 1077-1085
-
-
Bardwell, A.J.1
Abdollahi, M.2
Bardwell, L.3
-
33
-
-
0038002916
-
Determinants of substrate recognition in nonreceptor tyrosine kinases
-
W.T. Miller Determinants of substrate recognition in nonreceptor tyrosine kinases Acc Chem Res 36 2003 393 400
-
(2003)
Acc Chem Res
, vol.36
, pp. 393-400
-
-
Miller, W.T.1
-
34
-
-
0344393408
-
Regulation of MAP kinase signaling modules by scaffold proteins in mammals
-
D.K. Morrison, and R.J. Davis Regulation of MAP kinase signaling modules by scaffold proteins in mammals Annu Rev Cell Dev Biol 19 2003 91 118
-
(2003)
Annu Rev Cell Dev Biol
, vol.19
, pp. 91-118
-
-
Morrison, D.K.1
Davis, R.J.2
-
35
-
-
0035195491
-
The Ste5p scaffold
-
E.A. Elion The Ste5p scaffold J Cell Sci 114 2001 3967 3978
-
(2001)
J Cell Sci
, vol.114
, pp. 3967-3978
-
-
Elion, E.A.1
-
36
-
-
0037436155
-
Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms
-
S.H. Park, A. Zarrinpar, and W.A. Lim Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms Science 299 2003 1061 1064 In this study, alternative scaffolding interactions were used to rewire MAPK signaling in yeast. Interaction-defective scaffolds could be rescued by re-recruiting components via heterologous protein-protein interactions. Moreover, chimeric scaffolds that recruit a novel set of kinases could redirect signaling, resulting in cells that display a novel, non-physiological input/output signaling response. This paper and the following one [37] highlight the importance of co-recruitment in determining signaling specificity.
-
(2003)
Science
, vol.299
, pp. 1061-1064
-
-
Park, S.H.1
Zarrinpar, A.2
Lim, W.A.3
-
37
-
-
0035960710
-
Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins
-
K. Harris, R.E. Lamson, B. Nelson, T.R. Hughes, M.J. Marton, C.J. Roberts, C. Boone, and P.M. Pryciak Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins Curr Biol 11 2001 1815 1824
-
(2001)
Curr Biol
, vol.11
, pp. 1815-1824
-
-
Harris, K.1
Lamson, R.E.2
Nelson, B.3
Hughes, T.R.4
Marton, M.J.5
Roberts, C.J.6
Boone, C.7
Pryciak, P.M.8
-
39
-
-
0038719729
-
The Yersinia virulence factor YopM forms a novel protein complex with two cellular kinases
-
C. McDonald, P.O. Vacratsis, J.B. Bliska, and J.E. Dixon The Yersinia virulence factor YopM forms a novel protein complex with two cellular kinases J Biol Chem 278 2003 18514 18523
-
(2003)
J Biol Chem
, vol.278
, pp. 18514-18523
-
-
McDonald, C.1
Vacratsis, P.O.2
Bliska, J.B.3
Dixon, J.E.4
-
40
-
-
0036239642
-
Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo
-
•].
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3035-3045
-
-
Nguyen, A.1
Burack, W.R.2
Stock, J.L.3
Kortum, R.4
Chaika, O.V.5
Afkarian, M.6
Muller, W.J.7
Murphy, K.M.8
Morrison, D.K.9
Lewis, R.E.10
-
42
-
-
1642471746
-
Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP
-
•] exemplify new findings indicating that natural scaffold proteins utilize higher order mechanisms of regulation in addition to simple tethering of pathway components. The interactions of the Ras pathway scaffold KSR (kinase suppressor of Ras) are highly regulated. First, signaling activity induces KSR membrane recruitment and interaction with ERK (via displacement of a 14-3-3 protein). Second, signaling activity also relieves repression by the newly identified negative regulator IMP (impedes mitogenic signal propagation), which sequesters KSR in an inactive state. These multiple layers of scaffold regulation are likely to result in a precise, finely tuned Ras pathway response.
-
(2004)
Nature
, vol.427
, pp. 256-260
-
-
Matheny, S.A.1
Chen, C.2
Kortum, R.L.3
Razidlo, G.L.4
Lewis, R.E.5
White, M.A.6
-
43
-
-
0034688173
-
A synthetic oscillatory network of transcriptional regulators
-
M.B. Elowitz, and S. Leibler A synthetic oscillatory network of transcriptional regulators Nature 403 2000 335 338
-
(2000)
Nature
, vol.403
, pp. 335-338
-
-
Elowitz, M.B.1
Leibler, S.2
-
44
-
-
2942614884
-
Programmable cells: Interfacing natural and engineered gene networks
-
H. Kobayashi, M. Kaern, M. Araki, K. Chung, T.S. Gardner, C.R. Cantor, and J.J. Collins Programmable cells: interfacing natural and engineered gene networks Proc Natl Acad Sci USA 101 2004 8414 8419
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8414-8419
-
-
Kobayashi, H.1
Kaern, M.2
Araki, M.3
Chung, K.4
Gardner, T.S.5
Cantor, C.R.6
Collins, J.J.7
-
45
-
-
0032548830
-
Crystal structure of the tyrosine phosphatase SHP-2
-
P. Hof, S. Pluskey, S. Dhe-Paganon, M.J. Eck, and S.E. Shoelson Crystal structure of the tyrosine phosphatase SHP-2 Cell 92 1998 441 450
-
(1998)
Cell
, vol.92
, pp. 441-450
-
-
Hof, P.1
Pluskey, S.2
Dhe-Paganon, S.3
Eck, M.J.4
Shoelson, S.E.5
-
46
-
-
0034604338
-
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
-
M. Lei, W. Lu, W. Meng, M.C. Parrini, M.J. Eck, B.J. Mayer, and S.C. Harrison Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch Cell 102 2000 387 397
-
(2000)
Cell
, vol.102
, pp. 387-397
-
-
Lei, M.1
Lu, W.2
Meng, W.3
Parrini, M.C.4
Eck, M.J.5
Mayer, B.J.6
Harrison, S.C.7
-
47
-
-
0030469482
-
Giant protein kinases: Domain interactions and structural basis of autoregulation
-
B. Kobe, J. Heierhorst, S.C. Feil, M.W. Parker, G.M. Benian, K.R. Weiss, and B.E. Kemp Giant protein kinases: domain interactions and structural basis of autoregulation EMBO J 15 1996 6810 6821
-
(1996)
EMBO J
, vol.15
, pp. 6810-6821
-
-
Kobe, B.1
Heierhorst, J.2
Feil, S.C.3
Parker, M.W.4
Benian, G.M.5
Weiss, K.R.6
Kemp, B.E.7
-
48
-
-
0037722978
-
Molecular basis of phosphorylation-induced activation of the NADPH oxidase
-
Y. Groemping, K. Lapouge, S.J. Smerdon, and K. Rittinger Molecular basis of phosphorylation-induced activation of the NADPH oxidase Cell 113 2003 343 355
-
(2003)
Cell
, vol.113
, pp. 343-355
-
-
Groemping, Y.1
Lapouge, K.2
Smerdon, S.J.3
Rittinger, K.4
-
49
-
-
0034269240
-
Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation
-
B. Aghazadeh, W.E. Lowry, X.Y. Huang, and M.K. Rosen Structural basis for relief of autoinhibition of the Dbl homology domain of proto-oncogene Vav by tyrosine phosphorylation Cell 102 2000 625 633
-
(2000)
Cell
, vol.102
, pp. 625-633
-
-
Aghazadeh, B.1
Lowry, W.E.2
Huang, X.Y.3
Rosen, M.K.4
-
50
-
-
0037133203
-
Functional studies on the role of the C-terminal domain of mammalian polo-like kinase
-
Y.J. Jang, C.Y. Lin, S. Ma, and R.L. Erikson Functional studies on the role of the C-terminal domain of mammalian polo-like kinase Proc Natl Acad Sci USA 99 2002 1984 1989
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 1984-1989
-
-
Jang, Y.J.1
Lin, C.Y.2
Ma, S.3
Erikson, R.L.4
-
51
-
-
0035138272
-
Autoinhibition mechanism of proto-Dbl
-
F. Bi, B. Debreceni, K. Zhu, B. Salani, A. Eva, and Y. Zheng Autoinhibition mechanism of proto-Dbl Mol Cell Biol 21 2001 1463 1474
-
(2001)
Mol Cell Biol
, vol.21
, pp. 1463-1474
-
-
Bi, F.1
Debreceni, B.2
Zhu, K.3
Salani, B.4
Eva, A.5
Zheng, Y.6
-
52
-
-
0034795425
-
Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP
-
N.K. Hussain, S. Jenna, M. Glogauer, C.C. Quinn, S. Wasiak, M. Guipponi, S.E. Antonarakis, B.K. Kay, T.P. Stossel, and N. Lamarche-Vane Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP Nat Cell Biol 3 2001 927 932
-
(2001)
Nat Cell Biol
, vol.3
, pp. 927-932
-
-
Hussain, N.K.1
Jenna, S.2
Glogauer, M.3
Quinn, C.C.4
Wasiak, S.5
Guipponi, M.6
Antonarakis, S.E.7
Kay, B.K.8
Stossel, T.P.9
Lamarche-Vane, N.10
-
53
-
-
0038032733
-
Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis
-
J.L. Zamanian, and R.B. Kelly Intersectin 1L guanine nucleotide exchange activity is regulated by adjacent src homology 3 domains that are also involved in endocytosis Mol Biol Cell 14 2003 1624 1637
-
(2003)
Mol Biol Cell
, vol.14
, pp. 1624-1637
-
-
Zamanian, J.L.1
Kelly, R.B.2
-
54
-
-
1842472163
-
The nucleotide exchange factor Cdc24p may be regulated by auto-inhibition
-
Y. Shimada, P. Wiget, M.P. Gulli, E. Bi, and M. Peter The nucleotide exchange factor Cdc24p may be regulated by auto-inhibition EMBO J 23 2004 1051 1062
-
(2004)
EMBO J
, vol.23
, pp. 1051-1062
-
-
Shimada, Y.1
Wiget, P.2
Gulli, M.P.3
Bi, E.4
Peter, M.5
-
55
-
-
0027258578
-
A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. the p21rac-GTPase activating protein n-chimaerin
-
S. Ahmed, J. Lee, R. Kozma, A. Best, C. Monfries, and L. Lim A novel functional target for tumor-promoting phorbol esters and lysophosphatidic acid. The p21rac-GTPase activating protein n-chimaerin J Biol Chem 268 1993 10709 10712
-
(1993)
J Biol Chem
, vol.268
, pp. 10709-10712
-
-
Ahmed, S.1
Lee, J.2
Kozma, R.3
Best, A.4
Monfries, C.5
Lim, L.6
-
56
-
-
0037155727
-
P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac
-
H.C. Welch, W.J. Coadwell, C.D. Ellson, G.J. Ferguson, S.R. Andrews, H. Erdjument-Bromage, P. Tempst, P.T. Hawkins, and L.R. Stephens P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac Cell 108 2002 809 821
-
(2002)
Cell
, vol.108
, pp. 809-821
-
-
Welch, H.C.1
Coadwell, W.J.2
Ellson, C.D.3
Ferguson, G.J.4
Andrews, S.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Hawkins, P.T.8
Stephens, L.R.9
-
57
-
-
0033527745
-
The COOH terminus of Rho-kinase negatively regulates rho-kinase activity
-
M. Amano, K. Chihara, N. Nakamura, T. Kaneko, Y. Matsuura, and K. Kaibuchi The COOH terminus of Rho-kinase negatively regulates rho-kinase activity J Biol Chem 274 1999 32418 32424
-
(1999)
J Biol Chem
, vol.274
, pp. 32418-32424
-
-
Amano, M.1
Chihara, K.2
Nakamura, N.3
Kaneko, T.4
Matsuura, Y.5
Kaibuchi, K.6
|