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Volumn 15, Issue SUPPL.1, 2013, Pages

B-cell targeted therapeutics in clinical development

Author keywords

[No Author keywords available]

Indexed keywords

AMG 557; ATACICEPT; AUTOANTIBODY; B CELL ACTIVATING FACTOR; BELIMUMAB; BLISIBIMOD; CD19 ANTIGEN; CD20 ANTIBODY; CD22 ANTIGEN; CDP 7657; EPRATUZUMAB; MEDI 551; MEDI 570; METHOTREXATE; MYCOPHENOLIC ACID; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NN 8828; OCRELIZUMAB; OFATUMUMAB; RITUXIMAB; TABALUMAB; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; UNCLASSIFIED DRUG; VELTUZUMAB;

EID: 84875873134     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3906     Document Type: Review
Times cited : (92)

References (209)
  • 1
  • 2
    • 33344470255 scopus 로고    scopus 로고
    • T-independent type II immune responses generate memory B cells
    • Obukhanych TV, Nussenzweig MC. T-independent type II immune responses generate memory B cells. J Exp Med 2006, 203:305-310.
    • (2006) J Exp Med , vol.203 , pp. 305-310
    • Obukhanych, T.V.1    Nussenzweig, M.C.2
  • 3
    • 0942279505 scopus 로고    scopus 로고
    • Positive selection and lineage commitment during peripheral B-lymphocyte development
    • Pillai S, Cariappa A, Moran ST. Positive selection and lineage commitment during peripheral B-lymphocyte development. Immunol Rev 2004, 197:206-218.
    • (2004) Immunol Rev , vol.197 , pp. 206-218
    • Pillai, S.1    Cariappa, A.2    Moran, S.T.3
  • 4
    • 72449136292 scopus 로고    scopus 로고
    • Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets
    • Anolik JH, Looney RJ, Lund FE, Randall TD, Sanz I. Insights into the heterogeneity of human B cells: diverse functions, roles in autoimmunity, and use as therapeutic targets. Immunol Res 2009, 45:144-158.
    • (2009) Immunol Res , vol.45 , pp. 144-158
    • Anolik, J.H.1    Looney, R.J.2    Lund, F.E.3    Randall, T.D.4    Sanz, I.5
  • 5
    • 0036217975 scopus 로고    scopus 로고
    • Origins and functions of B-1 cells with notes on the role of CD5
    • Berland R, Wortis HH. Origins and functions of B-1 cells with notes on the role of CD5. Annu Rev Immunol 2002, 20:253-300.
    • (2002) Annu Rev Immunol , vol.20 , pp. 253-300
    • Berland, R.1    Wortis, H.H.2
  • 7
    • 0024147110 scopus 로고
    • Normal, autoimmune, and malignant CD5+ B cells: the Ly-1 B lineage?
    • Hayakawa K, Hardy RR. Normal, autoimmune, and malignant CD5+ B cells: the Ly-1 B lineage?. Annu Rev Immunol 1988, 6:197-218.
    • (1988) Annu Rev Immunol , vol.6 , pp. 197-218
    • Hayakawa, K.1    Hardy, R.R.2
  • 9
    • 0023127468 scopus 로고
    • Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset
    • Casali P, Burastero SE, Nakamura M, Inghirami G, Notkins AL. Human lymphocytes making rheumatoid factor and antibody to ssDNA belong to Leu-1+ B-cell subset. Science 1987, 236:77-81.
    • (1987) Science , vol.236 , pp. 77-81
    • Casali, P.1    Burastero, S.E.2    Nakamura, M.3    Inghirami, G.4    Notkins, A.L.5
  • 10
    • 78650600361 scopus 로고    scopus 로고
    • The double life of a B-1 cell: self-reactivity selects for protective effector functions
    • Baumgarth N. The double life of a B-1 cell: self-reactivity selects for protective effector functions. Nat Rev Immunol 2011, 11:34-46.
    • (2011) Nat Rev Immunol , vol.11 , pp. 34-46
    • Baumgarth, N.1
  • 11
    • 0021956416 scopus 로고
    • Antigen-specific interaction between T and B cells
    • Lanzavecchia A. Antigen-specific interaction between T and B cells. Nature 1985, 314:537-539.
    • (1985) Nature , vol.314 , pp. 537-539
    • Lanzavecchia, A.1
  • 12
    • 33646036416 scopus 로고    scopus 로고
    • B cells as antigen presenting cells
    • Rodriguez-Pinto D. B cells as antigen presenting cells. Cell Immunol 2005, 238:67-75.
    • (2005) Cell Immunol , vol.238 , pp. 67-75
    • Rodriguez-Pinto, D.1
  • 13
    • 42349090206 scopus 로고    scopus 로고
    • The role of B lymphocytes as antigen-presenting cells
    • Chen X, Jensen PE. The role of B lymphocytes as antigen-presenting cells. Arch Immunol Ther Exp (Warsz) 2008, 56:77-83.
    • (2008) Arch Immunol Ther Exp (Warsz) , vol.56 , pp. 77-83
    • Chen, X.1    Jensen, P.E.2
  • 14
    • 0028958669 scopus 로고
    • The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity
    • Fearon DT, Carter RH. The CD19/CR2/TAPA-1 complex of B lymphocytes: linking natural to acquired immunity. Annu Rev Immunol 1995, 13:127-149.
    • (1995) Annu Rev Immunol , vol.13 , pp. 127-149
    • Fearon, D.T.1    Carter, R.H.2
  • 16
    • 1842377506 scopus 로고    scopus 로고
    • Antigen-unspecific B cells and lymphoid dendritic cells both show extensive surface expression of processed antigen-major histocompatibility complex class II complexes after soluble protein exposure in vivo or in vitro
    • Zhong G, Reis e Sousa C, Germain RN. Antigen-unspecific B cells and lymphoid dendritic cells both show extensive surface expression of processed antigen-major histocompatibility complex class II complexes after soluble protein exposure in vivo or in vitro. J Exp Med 1997, 186:673-682.
    • (1997) J Exp Med , vol.186 , pp. 673-682
    • Zhong, G.1    Reis e Sousa, C.2    Germain, R.N.3
  • 17
    • 0028113922 scopus 로고
    • A quantitative analysis of antigen-presenting cell function: activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation
    • Cassell DJ, Schwartz RH. A quantitative analysis of antigen-presenting cell function: activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation. J Exp Med 1994, 180:1829-1840.
    • (1994) J Exp Med , vol.180 , pp. 1829-1840
    • Cassell, D.J.1    Schwartz, R.H.2
  • 19
    • 0028261578 scopus 로고
    • In vivo activation of naive T cells by antigen-presenting B cells
    • Morris SC, Lees A, Finkelman FD. In vivo activation of naive T cells by antigen-presenting B cells. J Immunol 1994, 152:3777-3785.
    • (1994) J Immunol , vol.152 , pp. 3777-3785
    • Morris, S.C.1    Lees, A.2    Finkelman, F.D.3
  • 21
    • 14844347864 scopus 로고    scopus 로고
    • Antigenspecific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis
    • O'Neill SK, Shlomchik MJ, Glant TT, Cao Y, Doodes PD, Finnegan A. Antigenspecific B cells are required as APCs and autoantibody-producing cells for induction of severe autoimmune arthritis. J Immunol 2005, 174:3781-3788.
    • (2005) J Immunol , vol.174 , pp. 3781-3788
    • O'Neill, S.K.1    Shlomchik, M.J.2    Glant, T.T.3    Cao, Y.4    Doodes, P.D.5    Finnegan, A.6
  • 23
    • 45449099469 scopus 로고    scopus 로고
    • Cytokine-producing B lymphocytes-key regulators of immunity
    • Lund FE. Cytokine-producing B lymphocytes-key regulators of immunity. Curr Opin Immunol 2008, 20:332-338.
    • (2008) Curr Opin Immunol , vol.20 , pp. 332-338
    • Lund, F.E.1
  • 24
    • 0030741166 scopus 로고    scopus 로고
    • Production of cytokines by human B cells in health and disease
    • Pistoia V. Production of cytokines by human B cells in health and disease. Immunol Today 1997, 18:343-350.
    • (1997) Immunol Today , vol.18 , pp. 343-350
    • Pistoia, V.1
  • 26
    • 2942737209 scopus 로고    scopus 로고
    • Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer's patches
    • Tumanov AV, Kuprash DV, Mach JA, Nedospasov SA, Chervonsky AV. Lymphotoxin and TNF produced by B cells are dispensable for maintenance of the follicle-associated epithelium but are required for development of lymphoid follicles in the Peyer's patches. J Immunol 2004, 173:86-91.
    • (2004) J Immunol , vol.173 , pp. 86-91
    • Tumanov, A.V.1    Kuprash, D.V.2    Mach, J.A.3    Nedospasov, S.A.4    Chervonsky, A.V.5
  • 33
    • 0030666959 scopus 로고    scopus 로고
    • Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice
    • Mizoguchi A, Mizoguchi E, Smith RN, Preffer FI, Bhan AK. Suppressive role of B cells in chronic colitis of T cell receptor alpha mutant mice. J Exp Med 1997, 186:1749-1756.
    • (1997) J Exp Med , vol.186 , pp. 1749-1756
    • Mizoguchi, A.1    Mizoguchi, E.2    Smith, R.N.3    Preffer, F.I.4    Bhan, A.K.5
  • 34
    • 0037450740 scopus 로고    scopus 로고
    • Prevention of arthritis by interleukin 10-producing B cells
    • Mauri C, Gray D, Mushtaq N, Londei M. Prevention of arthritis by interleukin 10-producing B cells. J Exp Med 2003, 197:489-501.
    • (2003) J Exp Med , vol.197 , pp. 489-501
    • Mauri, C.1    Gray, D.2    Mushtaq, N.3    Londei, M.4
  • 35
    • 0035879105 scopus 로고    scopus 로고
    • Lipopolysaccharideactivated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice
    • Tian J, Zekzer D, Hanssen L, Lu Y, Olcott A, Kaufman DL. Lipopolysaccharideactivated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice. J Immunol 2001, 167:1081-1089.
    • (2001) J Immunol , vol.167 , pp. 1081-1089
    • Tian, J.1    Zekzer, D.2    Hanssen, L.3    Lu, Y.4    Olcott, A.5    Kaufman, D.L.6
  • 36
    • 34248230257 scopus 로고    scopus 로고
    • Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis
    • Duddy M, Niino M, Adatia F, Hebert S, Freedman M, Atkins H, Kim HJ, Bar-Or A. Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J Immunol 2007, 178:6092-6099.
    • (2007) J Immunol , vol.178 , pp. 6092-6099
    • Duddy, M.1    Niino, M.2    Adatia, F.3    Hebert, S.4    Freedman, M.5    Atkins, H.6    Kim, H.J.7    Bar-Or, A.8
  • 37
    • 37549036732 scopus 로고    scopus 로고
    • Fcγ receptors as regulators of immune responses
    • Nimmerjahn F, Ravetch JV. Fcγ receptors as regulators of immune responses. Nat Rev Immunol 2008, 8:34-47.
    • (2008) Nat Rev Immunol , vol.8 , pp. 34-47
    • Nimmerjahn, F.1    Ravetch, J.V.2
  • 38
    • 34548221347 scopus 로고    scopus 로고
    • Mechanisms of killing by anti- CD20 monoclonal antibodies
    • Glennie MJ, French RR, Cragg MS, Taylor RP. Mechanisms of killing by anti- CD20 monoclonal antibodies. Mol Immunol 2007, 44:3823-3837.
    • (2007) Mol Immunol , vol.44 , pp. 3823-3837
    • Glennie, M.J.1    French, R.R.2    Cragg, M.S.3    Taylor, R.P.4
  • 39
    • 0036464719 scopus 로고    scopus 로고
    • Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene
    • Cartron G, Dacheux L, Salles G, Solal-Celigny P, Bardos P, Colombat P, Watier H. Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcγRIIIa gene. Blood 2002, 99:754-758.
    • (2002) Blood , vol.99 , pp. 754-758
    • Cartron, G.1    Dacheux, L.2    Salles, G.3    Solal-Celigny, P.4    Bardos, P.5    Colombat, P.6    Watier, H.7
  • 40
    • 0642373290 scopus 로고    scopus 로고
    • Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
    • Weng WK, Levy R. Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol 2003, 21:3940-3947.
    • (2003) J Clin Oncol , vol.21 , pp. 3940-3947
    • Weng, W.K.1    Levy, R.2
  • 41
    • 0037289807 scopus 로고    scopus 로고
    • The relationship of FcγRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus
    • Anolik JH, Campbell D, Felgar RE, Young F, Sanz I, Rosenblatt J, Looney RJ. The relationship of FcγRIIIa genotype to degree of B cell depletion by rituximab in the treatment of systemic lupus erythematosus. Arthritis Rheum 2003, 48:455-459.
    • (2003) Arthritis Rheum , vol.48 , pp. 455-459
    • Anolik, J.H.1    Campbell, D.2    Felgar, R.E.3    Young, F.4    Sanz, I.5    Rosenblatt, J.6    Looney, R.J.7
  • 42
    • 35748949531 scopus 로고    scopus 로고
    • Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective
    • Desjarlais JR, Lazar GA, Zhukovsky EA, Chu SY. Optimizing engagement of the immune system by anti-tumor antibodies: an engineer's perspective. Drug Discov Today 2007, 12:898-910.
    • (2007) Drug Discov Today , vol.12 , pp. 898-910
    • Desjarlais, J.R.1    Lazar, G.A.2    Zhukovsky, E.A.3    Chu, S.Y.4
  • 43
    • 0037178791 scopus 로고    scopus 로고
    • Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human FcγRIII and antibody-dependent cellular toxicity
    • Shields RL, Lai J, Keck R, O'Connell LY, Hong K, Meng YG, Weikert SH, Presta LG. Lack of fucose on human IgG1 N-linked oligosaccharide improves binding to human FcγRIII and antibody-dependent cellular toxicity. J Biol Chem 2002, 277:26733-26740.
    • (2002) J Biol Chem , vol.277 , pp. 26733-26740
    • Shields, R.L.1    Lai, J.2    Keck, R.3    O'Connell, L.Y.4    Hong, K.5    Meng, Y.G.6    Weikert, S.H.7    Presta, L.G.8
  • 45
    • 34548770705 scopus 로고    scopus 로고
    • Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating Fcgamma receptors
    • Stavenhagen JB, Gorlatov S, Tuaillon N, Rankin CT, Li H, Burke S, Huang L, Vijh S, Johnson S, Bonvini E, Koenig S. Fc optimization of therapeutic antibodies enhances their ability to kill tumor cells in vitro and controls tumor expansion in vivo via low-affinity activating Fcgamma receptors. Cancer Res 2007, 67:8882-8890.
    • (2007) Cancer Res , vol.67 , pp. 8882-8890
    • Stavenhagen, J.B.1    Gorlatov, S.2    Tuaillon, N.3    Rankin, C.T.4    Li, H.5    Burke, S.6    Huang, L.7    Vijh, S.8    Johnson, S.9    Bonvini, E.10    Koenig, S.11
  • 47
    • 34247215987 scopus 로고    scopus 로고
    • Enhanced binding affinity for FcγRIIIa of fucose-negative antibody is sufficient to induce maximal antibody-dependent cellular cytotoxicity
    • Masuda K, Kubota T, Kaneko E, Iida S, Wakitani M, Kobayashi-Natsume Y, Kubota A, Shitara K, Nakamura K. Enhanced binding affinity for FcγRIIIa of fucose-negative antibody is sufficient to induce maximal antibody-dependent cellular cytotoxicity. Mol Immunol 2007, 44:3122-3131.
    • (2007) Mol Immunol , vol.44 , pp. 3122-3131
    • Masuda, K.1    Kubota, T.2    Kaneko, E.3    Iida, S.4    Wakitani, M.5    Kobayashi-Natsume, Y.6    Kubota, A.7    Shitara, K.8    Nakamura, K.9
  • 48
    • 52949138251 scopus 로고    scopus 로고
    • The role of complement in the mechanism of action of rituximab for B-cell lymphoma: implications for therapy
    • Zhou X, Hu W, Qin X. The role of complement in the mechanism of action of rituximab for B-cell lymphoma: implications for therapy. Oncologist 2008, 13:954-966.
    • (2008) Oncologist , vol.13 , pp. 954-966
    • Zhou, X.1    Hu, W.2    Qin, X.3
  • 50
    • 39749182212 scopus 로고    scopus 로고
    • A decade of rituximab: improving survival outcomes in non-Hodgkin's lymphoma
    • Molina A. A decade of rituximab: improving survival outcomes in non-Hodgkin's lymphoma. Annu Rev Med 2008, 59:237-250.
    • (2008) Annu Rev Med , vol.59 , pp. 237-250
    • Molina, A.1
  • 53
    • 24044439146 scopus 로고    scopus 로고
    • B cell depletion in autoimmune rheumatic diseases
    • Pitashny M, Shoenfeld Y. B cell depletion in autoimmune rheumatic diseases. Autoimmun Rev 2005, 4:436-441.
    • (2005) Autoimmun Rev , vol.4 , pp. 436-441
    • Pitashny, M.1    Shoenfeld, Y.2
  • 54
    • 38149098399 scopus 로고    scopus 로고
    • B cell-directed therapies for autoimmune disease and correlates of disease response and relapse
    • quiz 22-23
    • Levesque MC, St Clair EW. B cell-directed therapies for autoimmune disease and correlates of disease response and relapse. J Allergy Clin Immunol 2008, 121:13-21. quiz 22-23.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 13-21
    • Levesque, M.C.1    St Clair, E.W.2
  • 55
    • 32444447885 scopus 로고    scopus 로고
    • Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis
    • Leandro MJ, Cambridge G, Ehrenstein MR, Edwards JC. Reconstitution of peripheral blood B cells after depletion with rituximab in patients with rheumatoid arthritis. Arthritis Rheum 2006, 54:613-620.
    • (2006) Arthritis Rheum , vol.54 , pp. 613-620
    • Leandro, M.J.1    Cambridge, G.2    Ehrenstein, M.R.3    Edwards, J.C.4
  • 57
    • 79953712616 scopus 로고    scopus 로고
    • B cell reconstitution and T helper cell balance after rituximab treatment of active primary Sjogren's syndrome: a double-blind, placebo-controlled study
    • Abdulahad WH, Meijer JM, Kroese FG, Meiners PM, Vissink A, Spijkervet FK, Kallenberg CG, Bootsma H. B cell reconstitution and T helper cell balance after rituximab treatment of active primary Sjogren's syndrome: a double-blind, placebo-controlled study. Arthritis Rheum 2011, 63:1116-1123.
    • (2011) Arthritis Rheum , vol.63 , pp. 1116-1123
    • Abdulahad, W.H.1    Meijer, J.M.2    Kroese, F.G.3    Meiners, P.M.4    Vissink, A.5    Spijkervet, F.K.6    Kallenberg, C.G.7    Bootsma, H.8
  • 58
    • 79953314262 scopus 로고    scopus 로고
    • Phenotypic changes of lymphocytes in patients with systemic lupus erythematosus who are in longterm remission after B cell depletion therapy with rituximab
    • Iwata S, Saito K, Tokunaga M, Yamaoka K, Nawata M, Yukawa S, Hanami K, Fukuyo S, Miyagawa I, Kubo S, Tanaka Y. Phenotypic changes of lymphocytes in patients with systemic lupus erythematosus who are in longterm remission after B cell depletion therapy with rituximab. J Rheumatol 2011, 38:633-641.
    • (2011) J Rheumatol , vol.38 , pp. 633-641
    • Iwata, S.1    Saito, K.2    Tokunaga, M.3    Yamaoka, K.4    Nawata, M.5    Yukawa, S.6    Hanami, K.7    Fukuyo, S.8    Miyagawa, I.9    Kubo, S.10    Tanaka, Y.11
  • 59
    • 33746942234 scopus 로고    scopus 로고
    • Regeneration of B cell subsets after transient B cell depletion using anti-CD20 antibodies in rheumatoid arthritis
    • Roll P, Palanichamy A, Kneitz C, Dorner T, Tony HP. Regeneration of B cell subsets after transient B cell depletion using anti-CD20 antibodies in rheumatoid arthritis. Arthritis Rheum 2006, 54:2377-2386.
    • (2006) Arthritis Rheum , vol.54 , pp. 2377-2386
    • Roll, P.1    Palanichamy, A.2    Kneitz, C.3    Dorner, T.4    Tony, H.P.5
  • 66
    • 70350539709 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy following rituximab treatment in a patient with rheumatoid arthritis
    • Fleischmann RM. Progressive multifocal leukoencephalopathy following rituximab treatment in a patient with rheumatoid arthritis. Arthritis Rheum 2009, 60:3225-3228.
    • (2009) Arthritis Rheum , vol.60 , pp. 3225-3228
    • Fleischmann, R.M.1
  • 68
    • 84865315420 scopus 로고    scopus 로고
    • Progressive multifocal leukoencephalopathy associated with immunosuppressive therapy in rheumatic diseases: evolving role of biologic therapies
    • Molloy ES, Calabrese LH. Progressive multifocal leukoencephalopathy associated with immunosuppressive therapy in rheumatic diseases: evolving role of biologic therapies. Arthritis Rheum 2012, 64:3043-3051.
    • (2012) Arthritis Rheum , vol.64 , pp. 3043-3051
    • Molloy, E.S.1    Calabrese, L.H.2
  • 76
    • 28544449032 scopus 로고    scopus 로고
    • B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients
    • Leandro MJ, Cambridge G, Edwards JC, Ehrenstein MR, Isenberg DA. B-cell depletion in the treatment of patients with systemic lupus erythematosus: a longitudinal analysis of 24 patients. Rheumatology (Oxford) 2005, 44:1542-1545.
    • (2005) Rheumatology (Oxford) , vol.44 , pp. 1542-1545
    • Leandro, M.J.1    Cambridge, G.2    Edwards, J.C.3    Ehrenstein, M.R.4    Isenberg, D.A.5
  • 77
    • 33749331884 scopus 로고    scopus 로고
    • Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis: Remission, relapse, and re-treatment
    • Smith KG, Jones RB, Burns SM, Jayne DR. Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis: Remission, relapse, and re-treatment. Arthritis Rheum 2006, 54:2970-2982.
    • (2006) Arthritis Rheum , vol.54 , pp. 2970-2982
    • Smith, K.G.1    Jones, R.B.2    Burns, S.M.3    Jayne, D.R.4
  • 78
  • 80
    • 44349131653 scopus 로고    scopus 로고
    • Longterm clinical and immunological effects of anti-CD20 treatment in patients with refractory systemic lupus erythematosus
    • Lindholm C, Borjesson-Asp K, Zendjanchi K, Sundqvist AC, Tarkowski A, Bokarewa M. Longterm clinical and immunological effects of anti-CD20 treatment in patients with refractory systemic lupus erythematosus. J Rheumatol 2008, 35:826-833.
    • (2008) J Rheumatol , vol.35 , pp. 826-833
    • Lindholm, C.1    Borjesson-Asp, K.2    Zendjanchi, K.3    Sundqvist, A.C.4    Tarkowski, A.5    Bokarewa, M.6
  • 81
    • 79952196706 scopus 로고    scopus 로고
    • Long-term efficacy and safety of rituximab in refractory and relapsing systemic lupus erythematosus
    • Catapano F, Chaudhry AN, Jones RB, Smith KG, Jayne DW. Long-term efficacy and safety of rituximab in refractory and relapsing systemic lupus erythematosus. Nephrol Dial Transplant 2010, 25:3586-3592.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 3586-3592
    • Catapano, F.1    Chaudhry, A.N.2    Jones, R.B.3    Smith, K.G.4    Jayne, D.W.5
  • 83
    • 77954707963 scopus 로고    scopus 로고
    • Clinical improvements in proliferative vs membranous lupus nephritis following B-cell depletion: pooled data from two cohorts
    • Jonsdottir T, Gunnarsson I, Mourao AF, Lu TY, van Vollenhoven RF, Isenberg D. Clinical improvements in proliferative vs membranous lupus nephritis following B-cell depletion: pooled data from two cohorts. Rheumatology (Oxford) 2010, 49:1502-1504.
    • (2010) Rheumatology (Oxford) , vol.49 , pp. 1502-1504
    • Jonsdottir, T.1    Gunnarsson, I.2    Mourao, A.F.3    Lu, T.Y.4    van Vollenhoven, R.F.5    Isenberg, D.6
  • 85
    • 84866095964 scopus 로고    scopus 로고
    • Rituximab versus oral cyclophosphamide for treatment of relapses of proliferative lupus nephritis: a clinical observational study
    • Moroni G, Gallelli B, Sinico RA, Romano G, Sinigaglia L, Messa P. Rituximab versus oral cyclophosphamide for treatment of relapses of proliferative lupus nephritis: a clinical observational study. Ann Rheum Dis 2012, 71:1751-1752.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1751-1752
    • Moroni, G.1    Gallelli, B.2    Sinico, R.A.3    Romano, G.4    Sinigaglia, L.5    Messa, P.6
  • 88
    • 79957617387 scopus 로고    scopus 로고
    • Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER)
    • Merrill J, Buyon J, Furie R, Latinis K, Gordon C, Hsieh HJ, Brunetta P. Assessment of flares in lupus patients enrolled in a phase II/III study of rituximab (EXPLORER). Lupus 2011, 20:709-716.
    • (2011) Lupus , vol.20 , pp. 709-716
    • Merrill, J.1    Buyon, J.2    Furie, R.3    Latinis, K.4    Gordon, C.5    Hsieh, H.J.6    Brunetta, P.7
  • 91
    • 84867914693 scopus 로고    scopus 로고
    • Biomarkers for systemic lupus erythematosus
    • Herbst R, Liu Z, Jallal B, Yao Y. Biomarkers for systemic lupus erythematosus. Int J Rheum Dis 2012, 15:433-444.
    • (2012) Int J Rheum Dis , vol.15 , pp. 433-444
    • Herbst, R.1    Liu, Z.2    Jallal, B.3    Yao, Y.4
  • 92
    • 77956391938 scopus 로고    scopus 로고
    • Significance of B cells and B cell clonality in Sjogren's syndrome
    • Youinou P, Devauchelle-Pensec V, Pers JO. Significance of B cells and B cell clonality in Sjogren's syndrome. Arthritis Rheum 2010, 62:2605-2610.
    • (2010) Arthritis Rheum , vol.62 , pp. 2605-2610
    • Youinou, P.1    Devauchelle-Pensec, V.2    Pers, J.O.3
  • 95
    • 70349305443 scopus 로고    scopus 로고
    • Novel therapies for pemphigus vulgaris: an overview
    • Perez OA, Patton T. Novel therapies for pemphigus vulgaris: an overview. Drugs Aging 2009, 26:833-846.
    • (2009) Drugs Aging , vol.26 , pp. 833-846
    • Perez, O.A.1    Patton, T.2
  • 97
    • 0033557198 scopus 로고    scopus 로고
    • Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris
    • Mahoney MG, Wang Z, Rothenberger K, Koch PJ, Amagai M, Stanley JR. Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris. J Clin Invest 1999, 103:461-468.
    • (1999) J Clin Invest , vol.103 , pp. 461-468
    • Mahoney, M.G.1    Wang, Z.2    Rothenberger, K.3    Koch, P.J.4    Amagai, M.5    Stanley, J.R.6
  • 98
    • 84856909766 scopus 로고    scopus 로고
    • Desmoglein as a target in skin disease and beyond
    • Amagai M, Stanley JR. Desmoglein as a target in skin disease and beyond. J Invest Dermatol 2012, 132(3 Pt 2):776-784.
    • (2012) J Invest Dermatol , vol.132 , Issue.3 PART 2 , pp. 776-784
    • Amagai, M.1    Stanley, J.R.2
  • 101
  • 102
    • 70449669099 scopus 로고    scopus 로고
    • Antiplatelet antibodies in chronic immune thrombocytopenia and their role in platelet destruction and defective platelet production
    • McMillan R. Antiplatelet antibodies in chronic immune thrombocytopenia and their role in platelet destruction and defective platelet production. Hematol Oncol Clin North Am 2009, 23:1163-1175.
    • (2009) Hematol Oncol Clin North Am , vol.23 , pp. 1163-1175
    • McMillan, R.1
  • 103
    • 79958253464 scopus 로고    scopus 로고
    • Immune thrombocytopenia: no longer 'idiopathic'
    • McCrae K. Immune thrombocytopenia: no longer 'idiopathic'. Cleve Clin J Med 2011, 78:358-373.
    • (2011) Cleve Clin J Med , vol.78 , pp. 358-373
    • McCrae, K.1
  • 104
    • 40949154401 scopus 로고    scopus 로고
    • Rituximab in the treatment of autoimmune haematological disorders
    • Garvey B. Rituximab in the treatment of autoimmune haematological disorders. Br J Haematol 2008, 141:149-169.
    • (2008) Br J Haematol , vol.141 , pp. 149-169
    • Garvey, B.1
  • 106
    • 70449629813 scopus 로고    scopus 로고
    • Traditional and new approaches to the management of immune thrombocytopenia: issues of when and who to treat
    • Bussel JB. Traditional and new approaches to the management of immune thrombocytopenia: issues of when and who to treat. Hematol Oncol Clin North Am 2009, 23:1329-1341.
    • (2009) Hematol Oncol Clin North Am , vol.23 , pp. 1329-1341
    • Bussel, J.B.1
  • 107
    • 84863826816 scopus 로고    scopus 로고
    • Rituximab before splenectomy in adults with primary idiopathic thrombocytopenic purpura: a meta-analysis
    • Auger S, Duny Y, Rossi JF, Quittet P. Rituximab before splenectomy in adults with primary idiopathic thrombocytopenic purpura: a meta-analysis. Br J Haematol 2012, 158:386-398.
    • (2012) Br J Haematol , vol.158 , pp. 386-398
    • Auger, S.1    Duny, Y.2    Rossi, J.F.3    Quittet, P.4
  • 109
    • 0037093086 scopus 로고    scopus 로고
    • Variable patterns of response to rituximab treatment in adults with chronic idiopathic thrombocytopenic purpura
    • Stasi R, Stipa E, Forte V, Meo P, Amadori S. Variable patterns of response to rituximab treatment in adults with chronic idiopathic thrombocytopenic purpura. Blood 2002, 99:3872-3873.
    • (2002) Blood , vol.99 , pp. 3872-3873
    • Stasi, R.1    Stipa, E.2    Forte, V.3    Meo, P.4    Amadori, S.5
  • 112
    • 84863229726 scopus 로고    scopus 로고
    • Safety and efficacy of various dosages of ocrelizumab in Japanese patients with rheumatoid arthritis with an inadequate response to methotrexate therapy: a placebo-controlled double-blind parallel-group study
    • JA21963 Study Group
    • Harigai M, Tanaka Y, Maisawa S, JA21963 Study Group Safety and efficacy of various dosages of ocrelizumab in Japanese patients with rheumatoid arthritis with an inadequate response to methotrexate therapy: a placebo-controlled double-blind parallel-group study. J Rheumatol 2012, 39:486-495. JA21963 Study Group.
    • (2012) J Rheumatol , vol.39 , pp. 486-495
    • Harigai, M.1    Tanaka, Y.2    Maisawa, S.3
  • 113
    • 84856388514 scopus 로고    scopus 로고
    • Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial
    • Rigby W, Tony HP, Oelke K, Combe B, Laster A, von Muhlen CA, Fisheleva E, Martin C, Travers H, Dummer W. Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial. Arthritis Rheum 2012, 64:350-359.
    • (2012) Arthritis Rheum , vol.64 , pp. 350-359
    • Rigby, W.1    Tony, H.P.2    Oelke, K.3    Combe, B.4    Laster, A.5    von Muhlen, C.A.6    Fisheleva, E.7    Martin, C.8    Travers, H.9    Dummer, W.10
  • 115
    • 84863012323 scopus 로고    scopus 로고
    • Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial
    • Tak PP, Mease PJ, Genovese MC, Kremer J, Haraoui B, Tanaka Y, Bingham CO, Ashrafzadeh A, Travers H, Safa-Leathers S, Kumar S, Dummer W. Safety and efficacy of ocrelizumab in patients with rheumatoid arthritis and an inadequate response to at least one tumor necrosis factor inhibitor: results of a forty-eight-week randomized, double-blind, placebo-controlled, parallel-group phase III trial. Arthritis Rheum 2012, 64:360-370.
    • (2012) Arthritis Rheum , vol.64 , pp. 360-370
    • Tak, P.P.1    Mease, P.J.2    Genovese, M.C.3    Kremer, J.4    Haraoui, B.5    Tanaka, Y.6    Bingham, C.O.7    Ashrafzadeh, A.8    Travers, H.9    Safa-Leathers, S.10    Kumar, S.11    Dummer, W.12
  • 116
    • 55349135951 scopus 로고    scopus 로고
    • Novel therapeutic strategies for multiple sclerosis--a multifaceted adversary
    • Lopez-Diego RS, Weiner HL. Novel therapeutic strategies for multiple sclerosis--a multifaceted adversary. Nat Rev Drug Discov 2008, 7:909-925.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 909-925
    • Lopez-Diego, R.S.1    Weiner, H.L.2
  • 118
    • 33947509525 scopus 로고    scopus 로고
    • The immunopathology of multiple sclerosis: an overview
    • Lassmann H, Bruck W, Lucchinetti CF. The immunopathology of multiple sclerosis: an overview. Brain Pathol 2007, 17:210-218.
    • (2007) Brain Pathol , vol.17 , pp. 210-218
    • Lassmann, H.1    Bruck, W.2    Lucchinetti, C.F.3
  • 119
    • 84856297433 scopus 로고    scopus 로고
    • Treatment of multiple sclerosis with anti-CD20 antibodies
    • Barun B, Bar-Or A. Treatment of multiple sclerosis with anti-CD20 antibodies. Clin Immunol 2012, 142:31-37.
    • (2012) Clin Immunol , vol.142 , pp. 31-37
    • Barun, B.1    Bar-Or, A.2
  • 120
    • 79955648491 scopus 로고    scopus 로고
    • Development of anti-CD20 therapy for multiple sclerosis
    • Bartok B, Silverman GJ. Development of anti-CD20 therapy for multiple sclerosis. Exp Cell Res 2011, 317:1312-1318.
    • (2011) Exp Cell Res , vol.317 , pp. 1312-1318
    • Bartok, B.1    Silverman, G.J.2
  • 125
    • 67649368710 scopus 로고    scopus 로고
    • Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders
    • Castillo J, Milani C, Mendez-Allwood D. Ofatumumab, a second-generation anti-CD20 monoclonal antibody, for the treatment of lymphoproliferative and autoimmune disorders. Expert Opin Investig Drugs 2009, 18:491-500.
    • (2009) Expert Opin Investig Drugs , vol.18 , pp. 491-500
    • Castillo, J.1    Milani, C.2    Mendez-Allwood, D.3
  • 128
    • 68949129063 scopus 로고    scopus 로고
    • Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): considerably higher levels of CDC are induced by OFA than by RTX
    • Pawluczkowycz AW, Beurskens FJ, Beum PV, Lindorfer MA, van de Winkel JG, Parren PW, Taylor RP. Binding of submaximal C1q promotes complement-dependent cytotoxicity (CDC) of B cells opsonized with anti-CD20 mAbs ofatumumab (OFA) or rituximab (RTX): considerably higher levels of CDC are induced by OFA than by RTX. J Immunol 2009, 183:749-758.
    • (2009) J Immunol , vol.183 , pp. 749-758
    • Pawluczkowycz, A.W.1    Beurskens, F.J.2    Beum, P.V.3    Lindorfer, M.A.4    van de Winkel, J.G.5    Parren, P.W.6    Taylor, R.P.7
  • 129
    • 77955386129 scopus 로고    scopus 로고
    • Ofatumumab, a human anti-CD20 monoclonal antibody, for treatment of rheumatoid arthritis with an inadequate response to one or more disease-modifying antirheumatic drugs: results of a randomized, double-blind, placebo-controlled, phase I/II study
    • Ostergaard M, Baslund B, Rigby W, Rojkovich B, Jorgensen C, Dawes PT, Wiell C, Wallace DJ, Tamer SC, Kastberg H, Petersen J, Sierakowski S. Ofatumumab, a human anti-CD20 monoclonal antibody, for treatment of rheumatoid arthritis with an inadequate response to one or more disease-modifying antirheumatic drugs: results of a randomized, double-blind, placebo-controlled, phase I/II study. Arthritis Rheum 2010, 62:2227-2238.
    • (2010) Arthritis Rheum , vol.62 , pp. 2227-2238
    • Ostergaard, M.1    Baslund, B.2    Rigby, W.3    Rojkovich, B.4    Jorgensen, C.5    Dawes, P.T.6    Wiell, C.7    Wallace, D.J.8    Tamer, S.C.9    Kastberg, H.10    Petersen, J.11    Sierakowski, S.12
  • 130
    • 84860390375 scopus 로고    scopus 로고
    • Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: a randomised, double-blind, placebocontrolled clinical trial
    • Taylor PC, Quattrocchi E, Mallett S, Kurrasch R, Petersen J, Chang DJ. Ofatumumab, a fully human anti-CD20 monoclonal antibody, in biological-naive, rheumatoid arthritis patients with an inadequate response to methotrexate: a randomised, double-blind, placebocontrolled clinical trial. Ann Rheum Dis 2011, 70:2119-2125.
    • (2011) Ann Rheum Dis , vol.70 , pp. 2119-2125
    • Taylor, P.C.1    Quattrocchi, E.2    Mallett, S.3    Kurrasch, R.4    Petersen, J.5    Chang, D.J.6
  • 132
    • 70349973753 scopus 로고    scopus 로고
    • CD19: a promising B cell target for rheumatoid arthritis
    • Tedder TF. CD19: a promising B cell target for rheumatoid arthritis. Nat Rev Rheumatol 2009, 5:572-577.
    • (2009) Nat Rev Rheumatol , vol.5 , pp. 572-577
    • Tedder, T.F.1
  • 133
    • 0029094609 scopus 로고
    • Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule
    • Engel P, Zhou LJ, Ord DC, Sato S, Koller B, Tedder TF. Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity 1995, 3:39-50.
    • (1995) Immunity , vol.3 , pp. 39-50
    • Engel, P.1    Zhou, L.J.2    Ord, D.C.3    Sato, S.4    Koller, B.5    Tedder, T.F.6
  • 134
    • 0029558617 scopus 로고
    • The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation
    • Sato S, Steeber DA, Tedder TF. The CD19 signal transduction molecule is a response regulator of B-lymphocyte differentiation. Proc Natl Acad Sci USA 1995, 92:11558-11562.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 11558-11562
    • Sato, S.1    Steeber, D.A.2    Tedder, T.F.3
  • 135
    • 27244432745 scopus 로고    scopus 로고
    • Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease
    • Yazawa N, Hamaguchi Y, Poe JC, Tedder TF. Immunotherapy using unconjugated CD19 monoclonal antibodies in animal models for B lymphocyte malignancies and autoimmune disease. Proc Natl Acad Sci USA 2005, 102:15178-15183.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 15178-15183
    • Yazawa, N.1    Hamaguchi, Y.2    Poe, J.C.3    Tedder, T.F.4
  • 136
    • 26644450721 scopus 로고    scopus 로고
    • CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction
    • Tedder TF, Poe JC, Haas KM. CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. Adv Immunol 2005, 88:1-50.
    • (2005) Adv Immunol , vol.88 , pp. 1-50
    • Tedder, T.F.1    Poe, J.C.2    Haas, K.M.3
  • 137
    • 38849203194 scopus 로고    scopus 로고
    • CD22: an inhibitory enigma
    • Walker JA, Smith KG. CD22: an inhibitory enigma. Immunology 2008, 123:314-325.
    • (2008) Immunology , vol.123 , pp. 314-325
    • Walker, J.A.1    Smith, K.G.2
  • 139
    • 69149100376 scopus 로고    scopus 로고
    • CD22 expression on blastic plasmacytoid dendritic cell neoplasms and reactivity of anti- CD22 antibodies to peripheral blood dendritic cells
    • Reineks EZ, Osei ES, Rosenberg A, Auletta J, Meyerson HJ. CD22 expression on blastic plasmacytoid dendritic cell neoplasms and reactivity of anti- CD22 antibodies to peripheral blood dendritic cells. Cytometry B Clin Cytom 2009, 76:237-248.
    • (2009) Cytometry B Clin Cytom , vol.76 , pp. 237-248
    • Reineks, E.Z.1    Osei, E.S.2    Rosenberg, A.3    Auletta, J.4    Meyerson, H.J.5
  • 140
    • 80052903903 scopus 로고    scopus 로고
    • Basophils and plasmacytoid dendritic cells are potential sources for error in flow cytometric monitoring of patients receiving anti-CD22 therapies. AKA not all anti-CD22 antibodies are created equal
    • Acon-Laws M, Bayerl MG, Ehman C, Malysz J, Boyer C. Basophils and plasmacytoid dendritic cells are potential sources for error in flow cytometric monitoring of patients receiving anti-CD22 therapies. AKA not all anti-CD22 antibodies are created equal. Am J Hematol 2011, 86:891-892.
    • (2011) Am J Hematol , vol.86 , pp. 891-892
    • Acon-Laws, M.1    Bayerl, M.G.2    Ehman, C.3    Malysz, J.4    Boyer, C.5
  • 141
    • 0029609863 scopus 로고
    • Construction and characterization of a humanized, internalizing, B-cell (CD22)-specific, leukemia/lymphoma antibody, LL2
    • Leung SO, Goldenberg DM, Dion AS, Pellegrini MC, Shevitz J, Shih LB, Hansen HJ. Construction and characterization of a humanized, internalizing, B-cell (CD22)-specific, leukemia/lymphoma antibody, LL2. Mol Immunol 1995, 32:1413-1427.
    • (1995) Mol Immunol , vol.32 , pp. 1413-1427
    • Leung, S.O.1    Goldenberg, D.M.2    Dion, A.S.3    Pellegrini, M.C.4    Shevitz, J.5    Shih, L.B.6    Hansen, H.J.7
  • 142
    • 33748778482 scopus 로고    scopus 로고
    • Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab
    • Carnahan J, Stein R, Qu Z, Hess K, Cesano A, Hansen HJ, Goldenberg DM. Epratuzumab, a CD22-targeting recombinant humanized antibody with a different mode of action from rituximab. Mol Immunol 2007, 44:1331-1341.
    • (2007) Mol Immunol , vol.44 , pp. 1331-1341
    • Carnahan, J.1    Stein, R.2    Qu, Z.3    Hess, K.4    Cesano, A.5    Hansen, H.J.6    Goldenberg, D.M.7
  • 145
    • 53749095799 scopus 로고    scopus 로고
    • Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus
    • Dorner T, Kaufmann J, Wegener WA, Teoh N, Goldenberg DM, Burmester GR. Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus. Arthritis Res Ther 2006, 8:R74.
    • (2006) Arthritis Res Ther , vol.8
    • Dorner, T.1    Kaufmann, J.2    Wegener, W.A.3    Teoh, N.4    Goldenberg, D.M.5    Burmester, G.R.6
  • 146
    • 67651110504 scopus 로고    scopus 로고
    • Randomized controlled trials of epratuzumab (anti-CD22 mAb targeting B-cells) reveal clinically meaningful reductions in corticosteroid (CS) use with favorable safety profile in moderate and severe flaring SLE patients [abstract]
    • Wallace D, Hobbs K, Houssiau F, Strand V, Tak P, Wegener W, Kelley L, Barry A. Randomized controlled trials of epratuzumab (anti-CD22 mAb targeting B-cells) reveal clinically meaningful reductions in corticosteroid (CS) use with favorable safety profile in moderate and severe flaring SLE patients [abstract]. Ann Rheum Dis 2008, 67(Suppl 2):212.
    • (2008) Ann Rheum Dis , vol.67 , Issue.SUPPL. 2 , pp. 212
    • Wallace, D.1    Hobbs, K.2    Houssiau, F.3    Strand, V.4    Tak, P.5    Wegener, W.6    Kelley, L.7    Barry, A.8
  • 147
    • 67651125355 scopus 로고    scopus 로고
    • Randomized controlled trials (RCTs) of epratuzumab (anti-CD22 mAb targeting B-cells) show meaningful improvements in health related-quality of life (HRQOL) in SLE patients (pts) with high disease activity and low baseline (BL) self-report measures [abstract]
    • Strand V, Gordon C, Kalunian K, Coteur G, Barry A, Keininger D, Wegener W, Petri M. Randomized controlled trials (RCTs) of epratuzumab (anti-CD22 mAb targeting B-cells) show meaningful improvements in health related-quality of life (HRQOL) in SLE patients (pts) with high disease activity and low baseline (BL) self-report measures [abstract]. Ann Rheum Dis 2008, 67(Suppl 2):212.
    • (2008) Ann Rheum Dis , vol.67 , Issue.SUPPL. 2 , pp. 212
    • Strand, V.1    Gordon, C.2    Kalunian, K.3    Coteur, G.4    Barry, A.5    Keininger, D.6    Wegener, W.7    Petri, M.8
  • 148
    • 67651084006 scopus 로고    scopus 로고
    • Randomized controlled trials (RCTs) of epratuzumab (anti-CD22 mAb targeting B-cells) reveal clinically meaningful improvements in patients (pts) with moderate/severe SLE flares [abstract]
    • Petri M, Hobbs K, Gordon C, Strand V, Wallace D, Kelley L, Wegener W, Barry A. Randomized controlled trials (RCTs) of epratuzumab (anti-CD22 mAb targeting B-cells) reveal clinically meaningful improvements in patients (pts) with moderate/severe SLE flares [abstract]. Ann Rheum Dis 2008, 67(Suppl 2):53.
    • (2008) Ann Rheum Dis , vol.67 , Issue.SUPPL. 2 , pp. 53
    • Petri, M.1    Hobbs, K.2    Gordon, C.3    Strand, V.4    Wallace, D.5    Kelley, L.6    Wegener, W.7    Barry, A.8
  • 149
    • 78650826030 scopus 로고    scopus 로고
    • Epratuzumab demonstrates clinically meaningful improvements in patients with moderate to severe systemic lupus erythematosus (SLE): results from EMBLEM™, a phase IIb study [abstract]
    • Wallace DJ, Kalunian KC, Petri MA, Strand V, Kilgallen B, Kelley L, Gordon CP. Epratuzumab demonstrates clinically meaningful improvements in patients with moderate to severe systemic lupus erythematosus (SLE): results from EMBLEM™, a phase IIb study [abstract]. Ann Rheum Dis 2010, 69(Suppl 3):559.
    • (2010) Ann Rheum Dis , vol.69 , Issue.SUPPL. 3 , pp. 559
    • Wallace, D.J.1    Kalunian, K.C.2    Petri, M.A.3    Strand, V.4    Kilgallen, B.5    Kelley, L.6    Gordon, C.P.7
  • 150
    • 19344376101 scopus 로고    scopus 로고
    • Identification and characterization of circulating human transitional B cells
    • Sims GP, Ettinger R, Shirota Y, Yarboro CH, Illei GG, Lipsky PE. Identification and characterization of circulating human transitional B cells. Blood 2005, 105:4390-4398.
    • (2005) Blood , vol.105 , pp. 4390-4398
    • Sims, G.P.1    Ettinger, R.2    Shirota, Y.3    Yarboro, C.H.4    Illei, G.G.5    Lipsky, P.E.6
  • 151
  • 152
    • 74849122596 scopus 로고    scopus 로고
    • Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, doubleblind, placebo-controlled, dose-ranging study
    • Jacobi AM, Huang W, Wang T, Freimuth W, Sanz I, Furie R, Mackay M, Aranow C, Diamond B, Davidson A. Effect of long-term belimumab treatment on B cells in systemic lupus erythematosus: extension of a phase II, doubleblind, placebo-controlled, dose-ranging study. Arthritis Rheum 2010, 62:201-210.
    • (2010) Arthritis Rheum , vol.62 , pp. 201-210
    • Jacobi, A.M.1    Huang, W.2    Wang, T.3    Freimuth, W.4    Sanz, I.5    Furie, R.6    Mackay, M.7    Aranow, C.8    Diamond, B.9    Davidson, A.10
  • 154
    • 0032476617 scopus 로고    scopus 로고
    • Identification of functional human splenic memory B cells by expression of CD148 and CD27
    • Tangye SG, Liu YJ, Aversa G, Phillips JH, de Vries JE. Identification of functional human splenic memory B cells by expression of CD148 and CD27. J Exp Med 1998, 188:1691-1703.
    • (1998) J Exp Med , vol.188 , pp. 1691-1703
    • Tangye, S.G.1    Liu, Y.J.2    Aversa, G.3    Phillips, J.H.4    de Vries, J.E.5
  • 155
    • 0035869281 scopus 로고    scopus 로고
    • Interleukin-6 is a growth factor for nonmalignant human plasmablasts
    • Jego G, Bataille R, Pellat-Deceunynck C. Interleukin-6 is a growth factor for nonmalignant human plasmablasts. Blood 2001, 97:1817-1822.
    • (2001) Blood , vol.97 , pp. 1817-1822
    • Jego, G.1    Bataille, R.2    Pellat-Deceunynck, C.3
  • 156
    • 38049110981 scopus 로고    scopus 로고
    • Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration
    • Kuchen S, Robbins R, Sims GP, Sheng C, Phillips TM, Lipsky PE, Ettinger R. Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration. J Immunol 2007, 179:5886-5896.
    • (2007) J Immunol , vol.179 , pp. 5886-5896
    • Kuchen, S.1    Robbins, R.2    Sims, G.P.3    Sheng, C.4    Phillips, T.M.5    Lipsky, P.E.6    Ettinger, R.7
  • 158
    • 38049101408 scopus 로고    scopus 로고
    • Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells
    • Bryant VL, Ma CS, Avery DT, Li Y, Good KL, Corcoran LM, de Waal Malefyt R, Tangye SG. Cytokine-mediated regulation of human B cell differentiation into Ig-secreting cells: predominant role of IL-21 produced by CXCR5+ T follicular helper cells. J Immunol 2007, 179:8180-8190.
    • (2007) J Immunol , vol.179 , pp. 8180-8190
    • Bryant, V.L.1    Ma, C.S.2    Avery, D.T.3    Li, Y.4    Good, K.L.5    Corcoran, L.M.6    de Waal Malefyt, R.7    Tangye, S.G.8
  • 160
    • 47249097068 scopus 로고    scopus 로고
    • The role of IL-21 in regulating B-cell function in health and disease
    • Ettinger R, Kuchen S, Lipsky PE. The role of IL-21 in regulating B-cell function in health and disease. Immunol Rev 2008, 223:60-86.
    • (2008) Immunol Rev , vol.223 , pp. 60-86
    • Ettinger, R.1    Kuchen, S.2    Lipsky, P.E.3
  • 161
    • 73149085517 scopus 로고    scopus 로고
    • IL-21 and IL-10 have redundant roles but differential capacities at different stages of plasma cell generation from human germinal center B cells
    • Yoon SO, Zhang X, Berner P, Choi YS. IL-21 and IL-10 have redundant roles but differential capacities at different stages of plasma cell generation from human germinal center B cells. J Leukoc Biol 2009, 86:1311-1318.
    • (2009) J Leukoc Biol , vol.86 , pp. 1311-1318
    • Yoon, S.O.1    Zhang, X.2    Berner, P.3    Choi, Y.S.4
  • 162
    • 33847342813 scopus 로고    scopus 로고
    • IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells
    • Ettinger R, Sims GP, Robbins R, Withers D, Fischer RT, Grammer AC, Kuchen S, Lipsky PE. IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells. J Immunol 2007, 178:2872-2882.
    • (2007) J Immunol , vol.178 , pp. 2872-2882
    • Ettinger, R.1    Sims, G.P.2    Robbins, R.3    Withers, D.4    Fischer, R.T.5    Grammer, A.C.6    Kuchen, S.7    Lipsky, P.E.8
  • 165
    • 84860778480 scopus 로고    scopus 로고
    • Zacks Investment Research, Zacks Equity Research
    • Zacks Equity Research CHMP Backs Benlysta 2011, Zacks Investment Research, Zacks Equity Research., http://www.zacks.com
    • (2011) CHMP Backs Benlysta
  • 169
    • 84867398973 scopus 로고    scopus 로고
    • Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials
    • on behalf of the BLISS-52 and BLISS-76 Study Groups
    • Manzi S, Sanchez-Guerrero J, Merrill JT, Furie R, Gladman D, Navarra SV, Ginzler EM, D'Cruz DP, Doria A, Cooper S, Zhong ZJ, Hough D, Freimuth W, Petri MA, on behalf of the BLISS-52 and BLISS-76 Study Groups Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across multiple organ domains in patients with systemic lupus erythematosus: combined results from two phase III trials. Ann Rheum Dis 2012, 71:1833-1838. on behalf of the BLISS-52 and BLISS-76 Study Groups.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1833-1838
    • Manzi, S.1    Sanchez-Guerrero, J.2    Merrill, J.T.3    Furie, R.4    Gladman, D.5    Navarra, S.V.6    Ginzler, E.M.7    D'Cruz, D.P.8    Doria, A.9    Cooper, S.10    Zhong, Z.J.11    Hough, D.12    Freimuth, W.13    Petri, M.A.14
  • 170
    • 84860191332 scopus 로고    scopus 로고
    • Belimumab: review of use in systemic lupus erythematosus
    • Boyce EG, Fusco BE. Belimumab: review of use in systemic lupus erythematosus. Clin Ther 2012, 34:1006-1022.
    • (2012) Clin Ther , vol.34 , pp. 1006-1022
    • Boyce, E.G.1    Fusco, B.E.2
  • 171
    • 78649835509 scopus 로고    scopus 로고
    • Targeting BAFF in autoimmunity
    • Davidson A. Targeting BAFF in autoimmunity. Curr Opin Immunol 2010, 22:732-739.
    • (2010) Curr Opin Immunol , vol.22 , pp. 732-739
    • Davidson, A.1
  • 173
    • 37149032474 scopus 로고    scopus 로고
    • Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, doubleblind, placebo-controlled, dose-escalating trial
    • Dall'Era M, Chakravarty E, Wallace D, Genovese M, Weisman M, Kavanaugh A, Kalunian K, Dhar P, Vincent E, Pena-Rossi C, Wofsy D. Reduced B lymphocyte and immunoglobulin levels after atacicept treatment in patients with systemic lupus erythematosus: results of a multicenter, phase Ib, doubleblind, placebo-controlled, dose-escalating trial. Arthritis Rheum 2007, 56:4142-4150.
    • (2007) Arthritis Rheum , vol.56 , pp. 4142-4150
    • Dall'Era, M.1    Chakravarty, E.2    Wallace, D.3    Genovese, M.4    Weisman, M.5    Kavanaugh, A.6    Kalunian, K.7    Dhar, P.8    Vincent, E.9    Pena-Rossi, C.10    Wofsy, D.11
  • 174
    • 65149106325 scopus 로고    scopus 로고
    • An exploratory dose-escalating study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous atacicept in patients with systemic lupus erythematosus
    • Pena-Rossi C, Nasonov E, Stanislav M, Yakusevich V, Ershova O, Lomareva N, Saunders H, Hill J, Nestorov I. An exploratory dose-escalating study investigating the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous atacicept in patients with systemic lupus erythematosus. Lupus 2009, 18:547-555.
    • (2009) Lupus , vol.18 , pp. 547-555
    • Pena-Rossi, C.1    Nasonov, E.2    Stanislav, M.3    Yakusevich, V.4    Ershova, O.5    Lomareva, N.6    Saunders, H.7    Hill, J.8    Nestorov, I.9
  • 175
    • 73949102012 scopus 로고    scopus 로고
    • Pharmacokinetics and immunoglobulin response of subcutaneous and intravenous atacicept in patients with systemic lupus erythematosus
    • Nestorov I, Papasouliotis O, Pena Rossi C, Munafo A. Pharmacokinetics and immunoglobulin response of subcutaneous and intravenous atacicept in patients with systemic lupus erythematosus. J Pharm Sci 2010, 99:524-538.
    • (2010) J Pharm Sci , vol.99 , pp. 524-538
    • Nestorov, I.1    Papasouliotis, O.2    Pena Rossi, C.3    Munafo, A.4
  • 176
    • 79959832697 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: results of a phase II, randomized, placebo-controlled, dose-finding trial
    • Genovese MC, Kinnman N, de La Bourdonnaye G, Pena Rossi C, Tak PP. Atacicept in patients with rheumatoid arthritis and an inadequate response to tumor necrosis factor antagonist therapy: results of a phase II, randomized, placebo-controlled, dose-finding trial. Arthritis Rheum 2011, 63:1793-1803.
    • (2011) Arthritis Rheum , vol.63 , pp. 1793-1803
    • Genovese, M.C.1    Kinnman, N.2    de La Bourdonnaye, G.3    Pena Rossi, C.4    Tak, P.P.5
  • 177
    • 79959856423 scopus 로고    scopus 로고
    • Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial
    • van Vollenhoven RF, Kinnman N, Vincent E, Wax S, Bathon J. Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial. Arthritis Rheum 2011, 63:1782-1792.
    • (2011) Arthritis Rheum , vol.63 , pp. 1782-1792
    • van Vollenhoven, R.F.1    Kinnman, N.2    Vincent, E.3    Wax, S.4    Bathon, J.5
  • 179
    • 42649134105 scopus 로고    scopus 로고
    • Interleukin-21: basic biology and implications for cancer and autoimmunity
    • Spolski R, Leonard WJ. Interleukin-21: basic biology and implications for cancer and autoimmunity. Annu Rev Immunol 2008, 26:57-79.
    • (2008) Annu Rev Immunol , vol.26 , pp. 57-79
    • Spolski, R.1    Leonard, W.J.2
  • 182
    • 77957879962 scopus 로고    scopus 로고
    • Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis
    • Rasmussen TK, Andersen T, Hvid M, Hetland ML, Horslev-Petersen K, Stengaard-Pedersen K, Holm CK, Deleuran B. Increased interleukin 21 (IL-21) and IL-23 are associated with increased disease activity and with radiographic status in patients with early rheumatoid arthritis. J Rheumatol 2010, 37:2014-2020.
    • (2010) J Rheumatol , vol.37 , pp. 2014-2020
    • Rasmussen, T.K.1    Andersen, T.2    Hvid, M.3    Hetland, M.L.4    Horslev-Petersen, K.5    Stengaard-Pedersen, K.6    Holm, C.K.7    Deleuran, B.8
  • 183
    • 84855445128 scopus 로고    scopus 로고
    • Impact of interleukin-21 in the pathogenesis of primary Sjogren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands
    • Kang KY, Kim HO, Kwok SK, Ju JH, Park KS, Sun DI, Jhun JY, Oh HJ, Park SH, Kim HY. Impact of interleukin-21 in the pathogenesis of primary Sjogren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands. Arthritis Res Ther 2011, 13:R179.
    • (2011) Arthritis Res Ther , vol.13
    • Kang, K.Y.1    Kim, H.O.2    Kwok, S.K.3    Ju, J.H.4    Park, K.S.5    Sun, D.I.6    Jhun, J.Y.7    Oh, H.J.8    Park, S.H.9    Kim, H.Y.10
  • 186
    • 84862575218 scopus 로고    scopus 로고
    • Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort
    • Gottenberg JE, Dayer JM, Lukas C, Ducot B, Chiocchia G, Cantagrel A, Saraux A, Roux-Lombard P, Mariette X. Serum IL-6 and IL-21 are associated with markers of B cell activation and structural progression in early rheumatoid arthritis: results from the ESPOIR cohort. Ann Rheum Dis 2012, 71:1243-1248.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1243-1248
    • Gottenberg, J.E.1    Dayer, J.M.2    Lukas, C.3    Ducot, B.4    Chiocchia, G.5    Cantagrel, A.6    Saraux, A.7    Roux-Lombard, P.8    Mariette, X.9
  • 188
    • 79961177838 scopus 로고    scopus 로고
    • Autoimmune therapies targeting costimulation and emerging trends in multivalent therapeutics
    • Chittasupho C, Siahaan TJ, Vines CM, Berkland C. Autoimmune therapies targeting costimulation and emerging trends in multivalent therapeutics. Ther Deliv 2011, 2:873-889.
    • (2011) Ther Deliv , vol.2 , pp. 873-889
    • Chittasupho, C.1    Siahaan, T.J.2    Vines, C.M.3    Berkland, C.4
  • 190
    • 0035869525 scopus 로고    scopus 로고
    • Cutting edge: critical role of inducible costimulator in germinal center reactions
    • Dong C, Temann UA, Flavell RA. Cutting edge: critical role of inducible costimulator in germinal center reactions. J Immunol 2001, 166:3659-3662.
    • (2001) J Immunol , vol.166 , pp. 3659-3662
    • Dong, C.1    Temann, U.A.2    Flavell, R.A.3
  • 191
    • 84875862838 scopus 로고    scopus 로고
    • Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges
    • New York, NY: Landes Bioscience and Springer Science+Business Media, Grewal I
    • Law C, Grewal I. Therapeutic interventions targeting CD40L (CD154) and CD40: the opportunities and challenges. Therapeutic Targets of the TNF Superfamily (Advances in Experimental Medicine and Biology Volume 647) 2009, 8:36. New York, NY: Landes Bioscience and Springer Science+Business Media, Grewal I.
    • (2009) Therapeutic Targets of the TNF Superfamily (Advances in Experimental Medicine and Biology Volume 647) , vol.8 , pp. 36
    • Law, C.1    Grewal, I.2
  • 194
    • 84855174025 scopus 로고    scopus 로고
    • CD154: an immunoinflammatory mediator in systemic lupus erythematosus and rheumatoid arthritis
    • Alaaeddine N, Hassan GS, Yacoub D, Mourad W. CD154: an immunoinflammatory mediator in systemic lupus erythematosus and rheumatoid arthritis. Clin Dev Immunol 2012, 2012:490148.
    • (2012) Clin Dev Immunol , vol.2012 , pp. 490148
    • Alaaeddine, N.1    Hassan, G.S.2    Yacoub, D.3    Mourad, W.4
  • 195
    • 84875839723 scopus 로고    scopus 로고
    • A flow cytometric receptor occupancy assay demonstrates dose-dependent blockade of B7RP-1 by AMG 557 on circulating B cells from SLE subjects [abstract]
    • Sullivan BA, Green CL, Zhang M, Abbott C, Belouski S, Thomas G, Gorski K. A flow cytometric receptor occupancy assay demonstrates dose-dependent blockade of B7RP-1 by AMG 557 on circulating B cells from SLE subjects [abstract]. Arthritis Rheum 2010, 62(Suppl 10):1141.
    • (2010) Arthritis Rheum , vol.62 , Issue.SUPPL. 10 , pp. 1141
    • Sullivan, B.A.1    Green, C.L.2    Zhang, M.3    Abbott, C.4    Belouski, S.5    Thomas, G.6    Gorski, K.7
  • 196
    • 63149093151 scopus 로고    scopus 로고
    • B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells
    • Hu YL, Metz DP, Chung J, Siu G, Zhang M. B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells. J Immunol 2009, 182:1421-1428.
    • (2009) J Immunol , vol.182 , pp. 1421-1428
    • Hu, Y.L.1    Metz, D.P.2    Chung, J.3    Siu, G.4    Zhang, M.5
  • 198
    • 84866773396 scopus 로고    scopus 로고
    • Targeting inducible T-cell co-stimulator in autoimmune diseases - new evidence supporting its critical function in the maintenance of secondary lymphoid tissue architecture
    • Carlesso G, Taylor D, Herbst R. Targeting inducible T-cell co-stimulator in autoimmune diseases - new evidence supporting its critical function in the maintenance of secondary lymphoid tissue architecture. Eur Musculoskeletal Rev 2011, 6:248-252.
    • (2011) Eur Musculoskeletal Rev , vol.6 , pp. 248-252
    • Carlesso, G.1    Taylor, D.2    Herbst, R.3
  • 200
    • 80052095265 scopus 로고    scopus 로고
    • CDP7657, a monovalent Fab PEG anti-CD40L antibody, inhibits immune responses in both HuSCID mice and non-human primates. [abstract]
    • Wakefield I, Peters C, Burkly L, Garber E, Ferrant J, Taylor F, Su L. CDP7657, a monovalent Fab PEG anti-CD40L antibody, inhibits immune responses in both HuSCID mice and non-human primates. [abstract]. Arthritis Rheum 2010, 62(Suppl 10):1245.
    • (2010) Arthritis Rheum , vol.62 , Issue.SUPPL. 10 , pp. 1245
    • Wakefield, I.1    Peters, C.2    Burkly, L.3    Garber, E.4    Ferrant, J.5    Taylor, F.6    Su, L.7
  • 201
    • 77953182426 scopus 로고    scopus 로고
    • B cells as therapeutic targets in SLE
    • Sanz I, Lee FE. B cells as therapeutic targets in SLE. Nat Rev Rheumatol 2010, 6:326-337.
    • (2010) Nat Rev Rheumatol , vol.6 , pp. 326-337
    • Sanz, I.1    Lee, F.E.2
  • 202
    • 77949501905 scopus 로고    scopus 로고
    • Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis
    • Huang H, Benoist C, Mathis D. Rituximab specifically depletes short-lived autoreactive plasma cells in a mouse model of inflammatory arthritis. Proc Natl Acad Sci USA 2010, 107:4658-4663.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 4658-4663
    • Huang, H.1    Benoist, C.2    Mathis, D.3
  • 207
    • 33751085414 scopus 로고    scopus 로고
    • Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients
    • Cross AH, Stark JL, Lauber J, Ramsbottom MJ, Lyons JA. Rituximab reduces B cells and T cells in cerebrospinal fluid of multiple sclerosis patients. J Neuroimmunol 2006, 180:63-70.
    • (2006) J Neuroimmunol , vol.180 , pp. 63-70
    • Cross, A.H.1    Stark, J.L.2    Lauber, J.3    Ramsbottom, M.J.4    Lyons, J.A.5


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