Rituximab in the treatment of autoimmune haematological disorders

British Journal of Haematology

Volumn 141, Issue 2, 2008, Pages 149-169

  Garvey, Bernadette ^a  

^a ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Acquired haemophilia; Autoimmune haemolytic anaemia; Cold agglutinin disease; Idiopathic thrombocytopenic purpura; Rituximab; Thrombotic thrombocytopenic purpura

Indexed keywords

AZATHIOPRINE; CD20 ANTIBODY; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DANAZOL; IMMUNOGLOBULIN; PREDNISONE; RHESUS D ANTIBODY; RITUXIMAB; STEROID; VINCRISTINE;

ANAPHYLAXIS; AUTOIMMUNE DISEASE; AUTOIMMUNE HEMOLYTIC ANEMIA; B LYMPHOCYTE; CHICKENPOX; DATA ANALYSIS; DRUG EFFICACY; DRUG FATALITY; DRUG TOLERABILITY; DRUG WITHDRAWAL; HEALTH CARE COST; HEMATOLOGIC DISEASE; HEMOPHILIA; HUMAN; HYPOTENSION; IDIOPATHIC THROMBOCYTOPENIC PURPURA; INFECTION; MONOTHERAPY; PRIORITY JOURNAL; REVIEW; SERUM SICKNESS; SINGLE DRUG DOSE; THROMBOCYTOSIS; THROMBOTIC THROMBOCYTOPENIC PURPURA; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; ANEMIA, HEMOLYTIC, AUTOIMMUNE; ANTIBODIES, MONOCLONAL; ANTIGENS, CD20; AUTOIMMUNE DISEASES; HEMATOLOGIC DISEASES; HEMOPHILIA A; HUMANS; MIDDLE AGED; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; PURPURA, THROMBOTIC THROMBOCYTOPENIC;

EID: 40949154401     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.07054.x     Document Type: Review

References (152)

1. Abdallah, A., Coghlan, D.W., Duncan, E.M., Chunilal, S.D. Lloyd, J.V. (2005) Rituximab-induced long-term remission in patients with refractory acquired hemophilia. Journal of Thrombosis and Haemostasis, 3, 2589 2590.
2. Aggarwal, A., Grewal, R., Green, R.J., Boggio, L., Green, D., Weksler, B.B., Wiestner, A. Schechter, G.P. (2005) Rituximab for autoimmune haemophilia: a proposed treatment algorithm. Haemophilia, 11, 13 19.
3. Ahmad, A., Aggarwal, A., Sharma, D., Dave, H.P., Kinsella, V., Rick, M.E. Schechter, G.P. (2004) Rituximab for treatment of refractory/relapsing thrombotic thrombocytopenic purpura (TTP). American Journal of Hematology, 77, 171 176.
4. Aksoy, S., Harputluoglu, H., Kilickap, S., Dede, D.S., Dizdar, O., Altundag, K. Barista, I. (2007) Rituximab-related viral infections in lymphoma patients. Leukemia and Lymphoma, 48, 1307 1312.
5. Alvarado, Y., Yao, X., Jumper, C., Hardwicke, F., D'Cunha, N. Cobos, E. (2007) Acquired hemophilia: a case report of 2 patients with acquired factor VIII inhibitor treated with rituximab plus a short course of steroid and review of the literature. Clinical and Applied Thrombosis/Hemostasis, 13, 443 448.
6. Arnold, D.M., Dentali, F., Crowther, M., Meyer, R., Cook, R., Sigouin, C., Fraser, G., Lim, W. Kelton, J. (2007) Systemic review: efficacy and safety of rituximab for adults with idiopathic thrombocytopenic purpura. Annals of Internal Medicine, 146, 25 33.
7. Aronis, S., Platokouki, H., Avgeri, M., Pergantou, H. Keramidas, D. (2004) Retrospective evaluation of long-term efficacy and safety of splenectomy in chronic idiopathic thrombocytopenic purpura in children. Acta Paediatrica, 93, 638 642.
8. Benetatos, L., Vassou, A. Bourantas, K.L. (2006) Effectiveness of rituximab as prophylaxis in thrombotic thrombocytopenic purpura. Clinical and Laboratory Haematology, 28, 288 289.
9. Bennett, C.M., Rogers, Z.R., Kinnamon, D.D., Bussel, J.B., Mahoney, D.H., Abshire, T.C., Sawaf, H., Moore, T.B., Loh, M.L., Glader, B.E., McCarthy, M.C., Mueller, B.U., Olson, T.A., Lorenzana, A.N., Mentzer, W.C., Buchanan, G.R., Feldman, H.A. Neufeld, E.J. (2006) Prospective phase 1/2 study of rituximab in childhood and adolescent chronic immune thrombocytopenic purpura. Blood, 107, 2639 2642.
10. Berentsen, S., Ulvestad, E., Gjertsen, B.T., Hjorth-Hansen, H., Langholm, R., Knutsen, H., Ghanima, W., Shammas, F.V. Tjønnfjord, G.E. (2004) Rituximab for primary chronic cold agglutinin disease: a prospective study of 37 courses of therapy in 27 patients. Blood, 103, 2925 2928.
11. Berentsen, S., Ulvestad, E., Langholm, R., Beiske, K., Hjorth-Hansen, H., Ghanima, W., Sørbø, J.H. Tjønnfjord, G.E. (2006) Primary chronic cold agglutinin disease: a population based clinical study of 86 patients. Haematologica, 91, 460 466.
12. Berezné, A., Stieltjes, N., Le-Guern, V., Teixeira, L., Billy, C., Roussel-Robert, V., Flaujac, C., Horellou, M.H., Guillevin, L. Mouthon, L. (2006) Rituximab alone or in association with corticosteroids in the treatment of acquired factor VIII inhibitors: report of two cases. Transfusion Medicine, 16, 209 212.
13. Bisharat, N., Omari, H., Lavi, I. Raz, R. (2001) Risk of infection and death among post-splenectomy patients. Journal of Infection, 43, 182 186.
14. Blanchette, V.S. Price, V. (2003) Childhood chronic immune thrombocytopenic purpura: unresolved issues. Journal of Pediatric Hematology/Oncology, 25 (Suppl. 1 S28 S33.
15. Boctor, F.N. Smith, J.A. (2006) Timing of plasma exchange and rituximab for the treatment of thrombotic thrombocytopenic purpura. American Journal of Clinical Pathology, 126, 965.
16. Boggio, L.N. Green, D. (2001) Acquired hemophilia. Reviews in Clinical and Experimental Hematology, 5, 389 404.
17. Bolton-Maggs, P.H. (2000) Idiopathic thrombocytopenic purpura. Archives of Disease in Childhood, 83, 220 222.
18. Boumpas, D.T., Chrousos, G.P., Wilder, R.L., Cupps, T.R. Balow, J.E. (1993) Glucocorticoid therapy for immune-mediated diseases: basic and clinical correlates. Annals of Internal Medicine, 119, 1198 1208.
19. Braendstrup, P., Bjerrum, O.W., Nielsen, O.J., Jensen, B.A., Clausen, N.T., Hansen, P.B., Andersen, I., Schmidt, K., Andersen, T.M., Peterslund, N.A., Birgens, H.S., Plesner, T., Pedersen, B.B. Hasselbalch, H.C. (2005) Rituximab chimeric anti-CD20 monoclonal antibody treatment for adult refractory idiopathic thrombocytopenic purpura. American Journal of Hematology, 78, 275 280.
20. Brunskill, S.J., Tusold, A., Benjamin, S., Stanworth, S.J. Murphy, M.F. (2007) A systematic review of randomized controlled trials for plasma exchange in the treatment of thrombotic thrombocytopenic purpura. Transfusion Medicine (Oxford, England), 17, 17 35.
21. Carter, R.H. (2004) B cells in health and disease. Mayo Clinic Proceedings, 81, 377 384.
22. Chemnitz, J., Draube, A., Scheid, C., Staib, P., Schulz, A., Diehl, V. Söhngen, D. (2002) Successful treatment of severe thrombotic thrombocytopenic purpura with the monoclonal antibody rituximab. American Journal of Hematology, 71, 105 108.
23. Chow, K.V., Carroll, R., Branley, P., Nicholls, K., Becker, G. Hogan, C. (2007) Anti-CD20 antibody in thrombotic thrombocytopenic purpura refractory to plasma exchange. Internal Medicine Journal, 37, 329 332.
24. Cines, D.B. Blanchette, V.S. (2002) Immune thrombocytopenic purpura. New England Journal of Medicine, 346, 995 1008.
25. Cines, D.B. Bussel, J.B. (2005) How I treat idiopathic thrombocytopenic purpura (ITP). Blood, 106, 2244 2251.
26. Clatworthy, M.R. Jayne, D.R. (2006) Acquired hemophilia in association with ANCA-associated vasculitis: response to rituximab. American Journal of Kidney Diseases, 47, 680 682.
27. Cohen, S.B. (2005) B-cell depletion for rheumatic diseases: where are we? MedGenMed: Mediscape General Medicine, 7, 72.
28. Cohen, S.B., Emery, P., Greenwald, M.W., Dougados, M., Furie, R.A., Genovese, M.C., Keystone, E.C., Loveless, J.E., Burmester, G.R., Cravets, M.W., Hessey, E.W., Shaw, T., Totoritis, M.C. the REFLEX Trial Group (2006) Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis and Rheumatism, 54, 2793 2806.
29. Collins, P., Baglin, T., Brown, S., Dolan, G., Hanley, J., Keeling, D., Liesner, R., Makris, M., Hay, C. on Behalf of UKHCDO9 (2005) UKHCDO Acquired Haemophilia Study: a complete national cohort. Blood, 106, 98a (Abstract 322).
30. Coopamah, M., Garvey, M.B., Freedman, J. Semple, J.W. (2003) Cellular immune mechanisms in autoimmune thrombocytopenic purpura: an update. Transfusion Medicine Reviews, 17, 69 80.
31. Cooper, N., Stasi, R., Cunningham-Rundles, S., Feuerstein, M.A., Leonard, J.P., Amadori, S. Bussel, J.B. (2004) The efficacy and safety of B-cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura. British Journal of Haematology, 125, 232 239.
32. Cooper, N., Evangelista, M.L., Amadori, S. Stasi, R. (2007) Should rituximab be used before or after splenectomy in patients with immune thrombocytopenic purpura? Current Opinion in Hematology, 14, 642 646.
33. Cvetkovic, R.S. Perry, C.M. (2006) Rituximab: a review of its use in non-Hodgkin's lymphoma and chronic lymphocytic leukaemia. Drugs, 66, 791 820.
34. D'Arena, G., Laurenti, L., Capalbo, S., D'Arco, A.M., De Filippi, R., Marcacci, G., Di Renzo, N., Storti, S., Califano, C., Vigliotti, M.L., Tarnani, M., Ferrara, F. Pinto, A. (2006) Rituximab therapy for chronic lymphocytic leukemia-associated autoimmune hemolytic anemia. American Journal of Hematology, 81, 598 602.
35. D'Arena, G., Califano, C., Annunziata, M., Tartarone, A., Capalbo, S., Villani, O., Amendola, G., Pietrantuono, G., Ferrara, F., Pinto, A., Musto, P., D'Arco, A.M. Cascavilla, N. (2007) Rituximab for warm-type idiopathic autoimmune hemolytic anemia: a retrospective study of 11 adult patients. European Journal of Haematology, 79, 53 58.
36. Darabi, K. Berg, A.H. (2006) Rituximab can be combined with daily plasma exchange to achieve effective B-cell depletion and clinical improvement in acute autoimmune TTP. American Journal of Clinical Pathology, 125, 592 597.
37. Delgado, J., Jimenez-Yuste, V., Hernandez-Navarro, F. Villar, A. (2003) Acquired haemophilia: review and meta-analysis focused on therapy and prognostic factors. British Journal of Haematology, 121, 21 35.
38. Edwards, J.C., Szczepanski, L., Szechinski, J., Filipowicz-Sosnowska, A., Emery, P., Close, D.R., Stevens, R.M. Shaw, T. (2004) Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis. New England Journal of Medicine, 350, 2572 2581.
39. El-Najjar, I., Rule, S.A.J. Nokes, T.J.C. (2006) A fixed, low dose of anti-CD20 antibody (Rituximab) is an effective treatment for patients with chronic immune thrombocytopenia. British Journal of Haematology, 133 (Suppl. 1 79 (Abstract 196).
40. Emery, P., Fleischmann, R., Filipowicz-Sosnowska, A., Schechtman, J., Szczepanski, L., Kavanaugh, A., Racewicz, A.J., van Vollenhoven, R.F., Li, N.F., Agarwal, S., Hessey, E.W., Shaw, T.M. for the DANCER Study Group (2006) The efficacy and safety of rituximab in patients with active rheumatoid arthritis despite methotrexate treatment: results of a phase IIB randomized, double-blind, placebo-controlled, dose-ranging trial. Arthritis & Rheumatism, 54, 1390 1400.
41. Fabbri, A., Gozzetti, A., Lazzi, S., Lenoci, M., D'Amuri, A., Leoncini, L. Lauria, F. (2006) Activity of rituximab monotherapy in refractory splenic marginal zone lymphoma complicated with autoimmune hemolytic anemia. Clinical Lymphoma & Myeloma, 6, 496 499.
42. Fakhouri, F., Vernant, J.P., Veyradier, A., Wolf, M., Kaplanski, G., Binaut, R., Rieger, M., Scheiflinger, F., Poullin, P., Deroure, B., Delarue, R., Lesavre, P., Vanhille, P., Hermine, O., Remuzzi, G. Grünfeld, J.P. (2005) Efficiency of curative and prophylactic treatment with rituximab in ADAMTS13-deficient thrombotic thrombocytopenic purpura: a study of 11 cases. Blood, 106, 1932 1937.
43. Field, J.J., Fenske, T.S. Blinder, M.A. (2007) Rituximab for the treatment of patients with very high-titre acquired factor VIII inhibitors refractory to conventional chemotherapy. Haemophilia, 13, 46 50.
44. Fischer, K.G., Deschler, B. Lübbert, M. (2003) Acquired high-titer factor VIII inhibitor: fatal bleeding despite multimodal treatment including rituximab preceded by multiple plasmaphereses. Blood, 101, 3753 3754.
45. Frederiksen, H. Schmidt, K. (1999) The incidence of idiopathic thrombocytopenic purpura in adults increases with age. Blood, 94, 909 913.
46. Freim Wahl, S.G., Folvik, M.R. Torp, S.H. (2007) Progressive multifocal leukoencephalopathy in a lymphoma patient with complete remission after treatment with cytostatics and rituximab: case report and review of the literature. Clinical Neuropathology, 26, 68 73.
47. Galbusera, M., Bresin, E., Noris, M., Gastoldi, S., Belotti, D., Capoferri, C., Daina, E., Perseghin, P., Scheiflinger, F., Fakhouri, F., Grünfeld, J.P., Pogliani, E. Remuzzi, G. (2005) Rituximab prevents recurrence of thrombotic thrombocytopenic purpura: a case report. Blood, 106, 925 928.
48. Garcia-Chavez, J., Majluf-Cruz, A., Montiel-Cervantes, L., Esparza, M.G. Vela-Ojeda, J. (2007) Rituximab therapy for chonic and refractory immune thrombocytopenic purpura: a long-term follow-up analysis. Annals of Hematology, 86, 871 877.
49. Gehrs, B.C. Friedberg, R.C. (2002) Autoimmune hemolytic anemia. American Journal of Hematology, 69, 258 271.
50. George, J.N. (2000) How I treat patients with thrombotic thrombocytopenic purpura-hemolytic uremic syndrome. Blood, 96, 1223 1229.
51. George, J.N., el-Harake, M.A. Raskob, G.E. (1994) Chronic idiopathic thrombocytopenic purpura. New England Journal of Medicine, 331, 1207 1211.
52. George, J.N., Sadler, J.E. Lämmle, B. (2002) Platelets: thrombotic thrombocytopenic purpura. Hematology/the Education Program of the American Society of Hematology, 315 334.
53. Gertz, M.A. (2006) Cold agglutinin disease. Haematologica, 91, 439 441.
54. Giagounidis, A.A., Anhuf, J., Schneider, P., Germing, U., Sohngen, D., Quabeck, K. Aul, C. (2002) Treatment of relapsed idiopathic thrombocytopenic purpura with the anti-CD20 monoclonal antibody rituximab: a pilot study. European Journal of Haematology, 69, 95 100.
55. Gianfaldoni, G., Antonioli, E., Mannelli, F., Vannucchi, A.M. Bosi, A. (2005) Chronic relapsing thrombotic thrombocytopenic purpura successfully treated with rituximab: case report. Journal of Chemotherapy (Florence, Italy), 7, 449 451.
56. Giulino, L.B., Bussel, J.B. Neufeld, E.J. (2007) Treatment with rituximab in benign and malignant hematologic disorders in children. Journal of Pediatrics, 150, 338 344.
57. Godeau, B., Fain, O., Porcher, R., Lefrere, F., Fenaux, P., Cheze, S., Vekhoff, A., Chauveheid, M.-P., Stirnemann, J., Galicier, L., Bourgeois, E., Haiat, S., Varet, B., Leporrier, M., Papo, T., Michel, M. Bierling, P. (2006) Rituximab is an alternative to splenectomy in adults with chronic immune thrombocytopenic purpura: results of a multicenter prospective Phase 2 study. ASH Annual Meeting Abstracts. Blood, 108, 145a (Abstract 478).
58. Goldberg, S.L., Pecora, A.L., Alter, R.S., Kroll, M.S., Rowley, S.D., Waintraub, S.E., Imrit, K. Preti, R.A. (2002) Unusual viral infections (progressive multifocal leukoencephalopathy and cytomegalovirus disease) after high-dose chemotherapy with autologous blood stem cell rescue and peritransplantation rituximab. Blood, 99, 1486 1488.
59. Green, D. Lechner, K. (1981) A survey of 215 non-hemophilic patients with inhibitors to Factor VIII. Thrombosis and Haemostasis, 45, 200 203.
60. Gupta, N., Kavuru, S., Patel, D., Janson, D., Driscoll, N., Ahmed, S. Rai, K.R. (2002) Rituximab-based chemotherapy for steroid-refractory autoimmune hemolytic anemia of chronic lymphocytic leukemia. Leukemia, 16, 2092 2095.
61. Gutterman, L.A., Kloster, B. Tsai, H.M. (2002) Rituximab therapy for refractory thrombotic thrombocytopenic purpura. Blood Cells, Molecules & Diseases, 28, 385 391.
62. Hainsworth, J.D., Litchy, S., Shaffer, D.W., Lackey, V.L., Grimaldi, M. Greco, F.A. (2005) Maximizing therapeutic benefit of rituximab: maintenance therapy versus re-treatment at progression in patients with indolent non-Hodgkin's lymphoma - a randomized Phase II trial of the Minnie Pearl Cancer Research Network. Journal of Clinical Oncology, 23, 1088 1095.
63. Hay, C.R., Brown, S., Collins, P.W., Keeling, D.M. Liesner, R. (2006) The diagnosis and management of factor VIII and IX inhibitors: a guideline from the United Kingdom Haemophilia Centre Doctors Organisation. British Journal of Haematology, 133, 591 605.
64. Heidel, F., Lipka, D.B., von Auer, C., Huber, C., Scharrer, I. Hess, G. (2007) Addition of rituximab to standard therapy improves response rate and progression-free survival in relapsed or refractory thrombotic thrombocytopenic purpura and autoimmune haemolytic anaemia. Thrombosis and Haemostasis, 97, 228 233.
65. Herbei, L. Venugopal, P. (2006) Recurrent thrombotic thrombocytopenic purpura treated repeatedly and successfully with the monoclonal antibody rituximab. Clinical Advances in Hematology & Oncology, 4, 215 217.
66. Herman, C., Boggio, L. Green, D. (2005) Factor VIII inhibitor associated with peginterferon. Haemophilia, 11, 408 410.
67. Holme, P.A., Brosstad, F. Tjønnfjord, G.E. (2005) Acquired haemophilia: management of bleeds and immune therapy to eradicate autoantibodies. Haemophilia, 11, 510 515.
68. Hull, M.J. Eichbaum, Q.G. (2006) Efficacy of rituximab and concurrent plasma exchange in the treatment of thrombotic thrombocytopenic purpura. Clinical Advances in Hematology & Oncology, 4, 210 214.
69. Joshi, A.V., Stephens, J.M., Munro, V., Mathew, P. Botteman, M.F. (2006) Pharmacoeconomic analysis of recombinant factor VIIa versus APCC in the treatment of minor-to-moderate bleeds in hemophilia patients with inhibitors. Current Medical Research and Opinion, 22, 23 31.
70. Jy, W., Gagliano-DeCesare, T., Kett, D.H., Horstman, L.L., Jimenez, J.J., Ruiz-Dayao, Z., Santos, E.S. Ahn, Y.S. (2003) Life-threatening bleeding from refractory acquired FVIII inhibitor successfully treated with rituximab. Acta Haematologica, 109, 206 208.
71. Kain, S., Copeland, T.S. Leahy, M.F. (2002) Treatment of refractory autoimmune (acquired) haemophilia with anti-CD20 (rituximab). British Journal of Haematology, 119, 578.
72. Kameda, T., Dobashi, H., Kittaka, K., Susaki, K., Yamaoka, G., Arai, K., Tokuda, M. Ishida, T. (2007) Two cases of refractory thrombotic thrombocytopenic purpura associated with collagen vascular disease were significantly improved by rituximab treatment. Clinical Rheumatology, 26, 2159 2162.
73. Kang, C.M., Lee, J.G., Kim, K.S., Choi, J.S., Lee, W.J., Kim, B.R., Ko, Y.W., Han, J.S. Min, Y.H. (2007) Long-term follow-up of laparoscopic splenectomy in patients with immune thrombocytopenic purpura. Journal of Korean Medical Science, 22, 420 424.
74. Kappers-Klunne, M.C., Wijermans, P., Fijnheer, R., Croockewit, A.J., van der Holt, B., de Wolf, J.T., Löwenberg, B. Brand, A. (2005) Splenectomy for the treatment of thrombotic thrombocytopenic purpura. British Journal of Haematology, 130, 768 776.
75. Kimby, E. (2005) Tolerability and safety of rituximab (MabThera). Cancer Treatment Reviews, 31, 456 473.
76. King, K.E. Ness, P.M. (2005) Treatment of autoimmune hemolytic anemia. Seminars in Hematology, 42, 131 136.
77. Kosugi, S., Matsumoto, M., Ohtani, Y., Take, H., Ishizashi, H., Fujimura, Y. Kuyama, J. (2005) Rituximab provided long-term remission in a patient with refractory relapsing thrombotic thrombocytopenic purpura. International Journal of Hematology, 81, 433 436.
78. Koulova, L., Alexandrescu, D., Dutcher, J.P., O'Boyle, K.P., Eapen, S. Wiernik, P.H. (2005) Rituximab for the treatment of refractory idiopathic thrombocytopenic purpura (ITP) and thrombotic thrombocytopenic purpura (TTP): report of three cases. American Journal of Hematology, 78, 49 54.
79. Kranick, S.M., Mowry, E.M. Rosenfeld, M.R. (2007) Progressive multifocal leukoencephalopathy after rituximab in a case of non-Hodgkin lymphoma. Neurology, 69, 704 706.
80. Kumar, S., Diehn, F.E., Gertz, M.A. Tefferi, A. (2002) Splenectomy for immune thrombocytopenic purpura: long-term results and treatment of postsplenectomy relapses. Annals of Hematology, 81, 312 319.
81. Lämmle, B., Kremer Hovinga, J.A. Alberio, L. (2005) Thrombotic thrombocytopenic purpura. Journal of Thrombosis and Haemostasis, 3, 1663 1675.
82. Lemieux, B., Bouafia, F., Thieblemont, C., Hequet, O., Arnaud, P., Tartas, S., Traulle, C., Salles, G. Coiffier, B. (2004) Second treatment with rituximab in B-cell non-Hodgkin's lymphoma: efficacy and toxicity on 41 patients treated at CHU-Lyon Sud. Hematology Journal, 5, 467 471.
83. Looney, R.J. (2002) Treating human autoimmune disease by depleting B cells. Annals of Rheumatic Diseases, 61, 863 866.
84. Lottenberg, R., Kentro, T.B. Kitchens, C.S. (1987) Acquired hemophilia. A natural history study of 16 patients with factor VIII inhibitors receiving little or no therapy. Archives of Internal Medicine, 147, 1077 1081.
85. Ma, A.D. Carrizosa, D. (2006) Acquired factor VIII inhibitors: pathophysiology and treatment. Hematology/the Education Program of the American Society of Hematology, 432 437.
86. Maillard, H., Launay, D., Hachulla, E., Goudemand, J., Lambert, M., Morell-Dubois, S., Queyrel, V. Hatron, P.Y. (2006) Rituximab in postpartum-related acquired hemophilia. American Journal of Medicine, 119, 86 88.
87. Marietta, M., Pozzi, S., Luppi, M., Bertesi, M., Cappi, C., Morselli, M. Torelli, G. (2003) Acquired haemophilia in HIV negative, HHV-8 positive multicentric Castleman's disease: a case report. European Journal of Haematology, 70, 181 182.
88. Martin, F. Chan, A.C. (2004) Pathogenic roles of B cells in human autoimmunity; insights from the clinic. Immunity, 20, 517 527.
89. Martin, M.G., Whitlatch, N.L., Shah, B. Arepally, G.M. (2007) Thrombotic thrombocytopenic purpura induced by trimethoprim-sulfamethoxazole in a Jehovah's Witness. American Journal of Hematology, 82, 679 881.
90. Matzdorff, A. Arnold, G. (2007) Treatment of chronic immune thrombocytopenic purpura: the patients' perspective. European Journal of Haematology, 78, 381 388.
91. Millward, P.M., Bandarenko, N., Chang, P.P., Stagg, K.F., Afenyi-Annan, A., Hay, S.N. Brecher, M.E. (2005) Cardiogenic shock complicates successful treatment of refractory thrombotic thrombocytopenia purpura with rituximab. Transfusion, 45, 1481 1486.
92. Moake, J.L. (2002) Thrombotic microangiopathies. New England Journal of Medicine, 22, 589 600.
93. Nakhoul, I.N., Kozuch, P. Varma, M. (2006) Management of adult idiopathic thrombocytopenic purpura. Clinical Advances in Hematology & Oncology, 4, 136 144.
94. Narat, S., Gandla, J., Hoffbrand, A.V., Hughes, R.G. Mehta, A.B. (2005) Rituximab in the treatment of refractory autoimmune cytopenias in adults. Haematologica, 90, 1273 1274.
95. Neylon, A.J., Saunders, P.W., Howard, M.R., Proctor, S.J. Taylor, P.R. (2003) Clinically significant newly presenting autoimmune thrombocytopenic purpura in adults: a prospective study of a population-based cohort of 245 patients. British Journal of Haematology, 122, 966 974.
96. Niewold, T.B., Alpert, D., Scanzello, C.R. Paget, S.A. (2006) Rituximab treatment of thrombotic thrombocytopenic purpura in the setting of connective tissue disease. Journal of Rheumatology, 33, 1194 1196.
97. O'Brien, S.H., Ritchey, A.K. Smith, K.J. (2007) A cost-utility analysis of treatment for acute childhood idiopathic thrombocytopenic purpura (ITP). Pediatric Blood and Cancer, 48, 173 180.
98. van Oers, M.H., Klasa, R., Marcus, R.E., Wolf, M., Kimby, E., Gascoyne, R.D., Jack, A., Van't Veer, M., Vranovsky, A., Holte, H., van Glabbeke, M., Teodorovic, I., Rozewicz, C. Hagenbeek, A. (2006) Rituximab maintenance improves clinical outcome of relapsed/resistant follicular non-Hodgkin's lymphoma, both in patients with and without rituximab during induction: results of a prospective randomized phase 3 intergroup trial. Blood, 108, 3295 3301.
99. Oliveira, B., Arkfeld, D.G., Weitz, I.C., Shinada, S. Ehresmann, G. (2007) Successful rituximab therapy of acquired factor VIII inhibitor in a patient with rheumatoid arthritis. Journal of Clinical Rheumatology, 13, 89 91.
100. Onitilo, A.A., Skorupa, A., Lal, A., Ronish, E., Mercier, R.J., Islam, R. Lazarchick, J. (2006) Rituximab in the treatment of acquired factor VIII inhibitors. Thrombosis & Haemostasis, 96, 84 87.
101. Outschoorn, U.M. Ferber, A. (2006) Outcomes in the treatment of thrombotic thrombocytopenic purpura with splenectomy: a retrospective cohort study. American Journal of Hematology, 81, 895 900.
102. Ozdogu, H., Boga, C., Kizilkilic, E., Yeral, M., Kozanoglu, I. Karatas, M. (2007) A dramatic response to rituximab in a patient with resistant thrombotic thrombocytopenic purpura (TTP) who developed acute stroke. Journal of Thrombosis and Thrombolysis, 23, 147 150.
103. Parodi, E., Nobili, B., Perrotta, S., Rosaria Matarese, S.M., Russo, G., Licciardello, M., Zecca, M., Locatelli, F., Cesaro, S., Bisogno, G., Giordano, P., De Mattia, D. Ramenghia, U. (2006) Rituximab (anti-CD20 monoclonal antibody) in children with chronic refractory symptomatic immune thrombocytopenic purpura: efficacy and safety of treatment. International Journal of Hematology, 84, 48 53.
104. Patino, W. Sarode, R. (2007) Successful repeat therapy with rituximab for relapsed thrombotic thrombocytopenic purpura. Journal of Clinical Apheresis, 22, 17 20.
105. Penalver, F.J., Jimenez-Yuste, V., Almagro, M., Alvarez-Larran, A., Rodriguez, L., Casado, M., Gallur, L., Giraldo, P., Hernández, R., Menor, D., Rodríguez, M.J., Caballero, D., González, R., Mayans, J., Millán, I., Cabrera, J.R. for the Multi-institutional Retrospective Spanish Study Group on the Use of Rituximab in Refractory ITP (2006) Rituximab in the management of chronic immune thrombocytopenic purpura: an effective and safe therapeutic alternative in refractory patients. Annals of Hematology, 85, 400 406.
106. Pérez-Calvo, J.I., Ruiz-Ruiz, F., Amores, B. Torralba, M.A. (2005) Long-term cost-efficacy of rituximab in immune thrombocytopenic purpura. QJM: Monthly Journal of the Association of Physicians, 98, 839 840.
107. Petz, L.D. (2001) Treatment of autoimmune hemolytic anemias. Current Opinion in Hematology, 8, 411 416.
108. Pulik, M., Genet, P., Lionnet, F. Touahri, T. (2002) Treatment of primary chronic cold agglutinin disease with rituximab: maintenance therapy may improve the results. British Journal of Haematology, 117, 998 999.
109. Quartier, P., Brethon, B., Philippet, P., Landman-Parker, J., Le Deist, F. Fischer, A. (2001) Treatment of childhood autoimmune haemolytic anaemia with rituximab. Lancet, 358, 1511 1513.
110. Rao, A., Kelly, M., Musselman, M., Ramadas, J., Wilson, D., Grossman, W. Shenoy, S. (2007) Safety, efficacy, and immune reconstitution after rituximab therapy in pediatric patients with chronic or refractory hematologic autoimmune cytopenias. Pediatric Blood & Cancer, [Epub ahead of print] doi:.
111. Rastetter, W., Molina, A. White, C.A. (2004) Rituximab: expanding role in therapy for lymphomas and autoimmune diseases. Annual Review of Medicine, 55, 477 503.
112. Reddy, P.S., Deauna-Limayo, D., Cook, J.D., Ganguly, S.S., Blecke, C., Bodensteiner, D.C., Skikne, B.S. Sahud, M.A. (2005) Rituximab in the treatment of relapsed thrombotic thrombocytopenic purpura. Annals of Hematology, 84, 232 235.
113. Reff, M.E., Carner, K., Chambers, K.S., Chinn, P.C., Leonard, J.E., Raab, R., Newman, R.A., Hanna, N. Anderson, D.R. (1994) Depletion of B cells in vivo by a chimeric mouse human monoclonal antibody to CD20. Blood, 83, 435 445.
114. Rizvi, M.A., Vesely, S.K., George, J.N., Chandler, L., Duvall, D., Smith, J.W. Gilcher, R.O. (2000) Complications of plasma exchange in 71 consecutive patients treated for clinically suspected thrombotic thrombocytopenic purpura-hemolytic-uremic syndrome. Transfusion, 40, 896 901.
115. Rose, N.R. Mackay, I.R. (1998) Autoimmune Diseases, 3rd edn Academic Press Inc., San Diego, CA.
116. Sadler, J.E., Moake, J.L., Miyata, T. George, J.N. (2004) Recent advances in thrombotic thrombocytopenic purpura. Hematology/the Education Program of the American Society of Hematology, 407 423.
117. Saleh, M.N., Gutheil, J., Moore, M., Bunch, P.W., Butler, J., Kunkel, L., Grillo-López, A.J. LoBuglio, A.F. (2000) A pilot study of the anti-CD20 monoclonal antibody rituximab in patients with refractory immune thrombocytopenia. Seminars in Oncology, 27 (Suppl. 12 99 103.
118. Sallah, S. Aledort, L. (2005) Treatment of patients with acquired inhibitors. Journal of Thrombosis and Haemostasis, 3, 595 597.
119. Sallah, S., Husain, A., Wan, J.Y. Nguyen, N.P. (2004) Rituximab in patients with refractory thrombotic thrombocytopenic purpura. Journal of Thrombosis and Haemostasis, 2, 834 836.
120. Santoro, C., Rago, A., Biondo, F., de Propris, M.S., de Vellis, A., Guarini, A., Pignoloni, P. Mazzucconi, M.G. (2007) Efficacy of rituximab treatment in postpartum acquired haemophilia A. Haemophilia, 14, 147 149.
121. Scheinberg, M., Hamerschlak, N., Kutner, J.M., Ribeiro, A.A., Ferreira, E., Goldenberg, J., Kiss, M.H. Chahade, W.H. (2006) Rituximab in refractory autoimmune diseases: Brazilian experience with 29 patients (2002-2004). Clinical and Experimental Rheumatology, 24, 65 69.
122. Schleinitz, N., Ebbo, M., Mazodier, K., Poullin, P., Bernit, E., Veit, V., Veyradier, A., Fakhouri, F., Kaplanski, G. Harle, J.R. (2007) Rituximab as preventive therapy of a clinical relapse in TTP with ADAMTS13 inhibitor. American Journal of Hematology, 82, 417 418.
123. Schöllkopf, C., Kjeldsen, L., Bjerrum, O.W., Mourits-Andersen, H.T., Nielsen, J.L., Christensen, B.E., Jensen, B.A., Pedersen, B.B., Taaning, E.B., Klausen, T.W. Birgens, H. (2006) Rituximab in chronic cold agglutinin disease: a prospective study of 20 patients. Leukemia & Lymphoma, 47, 253 260.
124. Schweizer, C., Reu, F.J., Ho, A.D. Hensel, M. (2007) Low rate of long-lasting remissions after successful treatment of immune thrombocytopenic purpura with rituximab. Annals of Hematology, 86, 711 717.
125. Scully, M., Cohen, H., Cavenagh, J., Benjamin, S., Starke, R., Killick, S., Mackie, I. Machin, S.J. (2007) Remission in acute refractory and relapsing thrombotic thrombocytopenic purpura following rituximab is associated with a reduction in IgG antibodies to ADAMTS-13. British Journal of Haematology, 136, 451 461.
126. Semple, J.W. (2007) Rituximab disciplines T cells, spares platelets. Blood, 110, 2784 2785.
127. Semple, J.W. Freedman, J. (2005) Autoimmune pathogenesis and autoimmune hemolytic anemia. Seminars in Hematology, 42, 122 130.
128. Shanafelt, T.D., Madueme, H.L., Wolf, R.C. Tefferi, A. (2003) Rituximab for immune cytopenia in adults: idiopathic thrombocytopenic purpura, autoimmune hemolytic anemia, and Evans syndrome. Mayo Clinic Proceedings, 78, 1340 1346.
129. Silverman, G.J. Weisman, S. (2003) Rituximab therapy and autoimmune disorders: prospects for anti-B cell therapy. Arthritis and Rheumatism, 48, 1484 1492.
130. Sokol, R.J., Booker, D.J. Stamps, R. (1992) The pathology of autoimmune haemolytic anaemia. Journal of Clinical Pathology, 45, 1047 1052.
131. Stasi, R., Pagano, A., Stipa, E. Amadori, S. (2001) Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura. Blood, 98, 952 957.
132. Stasi, R., Stipa, E., Forte, V., Meo, P. Amadori, S. (2002) Variable patterns of response to rituximab treatment in adults with chronic idiopathic thrombocytopenic purpura. Blood, 99, 3872 3873.
133. Stasi, R., Brunetti, M., Stipa, E. Amadori, S. (2004) Selective B-cell depletion with rituximab for the treatment of patients with acquired hemophilia. Blood, 103, 4424 4428.
134. Stasi, R., Del Poeta, G., Stipa, E., Evangelista, M.L., Trawinska, M.M., Cooper, N. Amadori, S. (2007) Response to B-cell depleting therapy with rituximab reverts the abnormalities of T cell subsets in patients with idiopathic thrombocytopenic purpura. Blood, 110, 2924 2930.
135. Stein, G.Y., Zeidman, A., Fradin, Z., Varon, M., Cohen, A. Mittelman, M. (2004) Treatment of resistant thrombotic thrombocytopenic purpura with rituximab and cyclophosphamide. International Journal of Hematology, 80, 94 96.
136. Steurer, M., Clausen, J., Gotwald, T., Gunsilius, E., Stockhammer, G., Gastl, G. Nachbaur, D. (2003) Progressive multifocal leukoencephalopathy after allogeneic stem cell transplantation and posttransplantation rituximab. Transplantation, 76, 435 436.
137. Sutor, A.H., Harms, A. Kaufmehl, K. (2001) Acute immune thrombocytopenia (ITP) in childhood: retrospective and prospective survey in Germany. Seminars in Thrombosis and Hemostasis, 27, 253 267.
138. Taube, T., Schmid, H., Reinhard, H., von Stackelberg, A. Overberg, U.S. (2005) Effect of a single dose of rituximab in chronic immune thrombocytopenic purpura in childhood. Haematologica, 90, 281 283.
139. Taylor, R.P. Lindorfer, M.A. (2007) Drug insight: the mechanism of action of rituximab in autoimmune disease - the immune complex decoy hypothesis. Nature Clinical Practice. Rheumatology, 3, 86 95.
140. Trapè, G., Fianchi, L., Lai, M., Laurenti, L., Piscitelli, R., Leone, G. Pagano, L. (2003) Rituximab chimeric anti-CD20 monoclonal antibody treatment for refractory hemolytic anemia in patients with lymphoproliferative disorders. Haematologica, 88, 223 225.
141. Tsai, H.M. (2003) Advances in the pathogenesis, diagnosis, and treatment of thrombotic thrombocytopenic purpura. Journal of the American Society of Nephrology, 14, 1072 1081.
142. Veyradier, A. Meyer, D. (2005) Thrombotic thrombocytopenic purpura and its diagnosis. Journal of Thrombosis and Haemostasis, 3, 2420 2427.
143. Wang, J., Wiley, J.M., Luddy, R., Greenberg, J., Feuerstein, M.A. Bussel, J.B. (2005) Chronic immune thrombocytopenic purpura in children: assessment of rituximab treatment. Journal of Pediatrics, 146, 217 221.
144. Wang, T., Xu, M., Ji, L. Yang, R. (2006) Splenectomy for chronic idiopathic thrombocytopenic purpura in children: a single center study in China. Acta Haematologia, 115, 39 45.
145. Wiestner, A., Cho, H.J., Asch, A.S., Michelis, M.A., Zeller, J.A., Peerschke, E.I., Weksler, B.B. Schechter, G.P. (2002) Rituximab in the treatment of acquired factor VIII inhibitors. Blood, 100, 3426 3428.
146. Yomtovian, R., Niklinski, W., Silver, B., Sarode, R. Tsai, H.M. (2004) Rituximab for chronic recurring thrombotic thrombocytopenic purpura: a case report and review of the literature. British Journal of Haematology, 124, 787 795.
147. Zaja, F., Vianelli, N., Sperotto, A., De Vita, S., Iacona, I., Zaccaria, A., Masolini, P., Tomadini, V., Tani, M., Molinari, A.L., Baccarani, M. Fanin, R. (2003a) B-cell compartment as the selective target for the treatment of
148. Zaja, F., Vianelli, N., Sperotto, A., Patriarca, F., Tani, M., Marin, L., Tiribelli, M., Candoni, A., Baccarani, M. Fanin, R. (2003b) Anti-CD20 therapy for chronic lymphocytic leukemia-associated autoimmune diseases. Leukemia & Lymphoma, 44, 1951 1955.
149. Zaja, F., Vianelli, N., Battista, M., Sperotto, A., Patriarca, F., Tomadini, V., Filì, C., Tani, M., Baccarani, M. Fanin, R. (2006) Earlier administration of rituximab allows higher rate of long-lasting response in adult patients with autoimmune thrombocytopenia. Experimental Hematology, 34, 571 572.
150. Zecca, M., Nobili, B., Ramenghi, U., Perrotta, S., Amendola, G., Rosito, P., Jankovic, M., Pierani, P., De Stefano, P., Bonora, M.R. Locatelli, F. (2003) Rituximab for the treatment of refractory autoimmune hemolytic anemia in children. Blood, 101, 3857 3861.
151. Zeller, B., Rajantie, J., Hedlund-Treutiger, I., Tedgard, U., Wesenberg, F., Jonsson, O.G. Henter, J.I. (2005) Childhood idiopathic thrombocytopenic purpura in the Nordic countries: epidemiology and predictors of chronic disease. Acta Paediatrica, 94, 178 184.
152. Zheng, X., Pallera, A.M., Goodnough, L.T., Sadler, J.E. Blinder, M.A. (2003) Remission of chronic thrombotic thrombocytopenic purpura after treatment with cyclophosphamide and rituximab. Annals of Internal Medicine, 138, 105 108.