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Volumn 23, Issue 6, 2009, Pages 1163-1175

Antiplatelet Antibodies in Chronic Immune Thrombocytopenia and Their Role in Platelet Destruction and Defective Platelet Production

Author keywords

Autoantibody; Autoimmune; Immune thrombocytopenia; Thrombocytopenia

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; EPITOPE; FIBRINOGEN RECEPTOR; GROWTH FACTOR; THROMBIN RECEPTOR; THROMBOCYTE ANTIBODY; THROMBOPOIETIN;

EID: 70449669099     PISSN: 08898588     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hoc.2009.08.008     Document Type: Review
Times cited : (62)

References (59)
  • 1
    • 8944225498 scopus 로고    scopus 로고
    • Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology
    • George J.N., Woolf S.H., Raskob G.E., et al. Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology. Blood 88 (1996) 3-40
    • (1996) Blood , vol.88 , pp. 3-40
    • George, J.N.1    Woolf, S.H.2    Raskob, G.E.3
  • 2
    • 84958689732 scopus 로고
    • Immunologic mechanisms in idiopathic and neonatal thrombocytopenic purpura
    • Harrington W.J., Sprague C.C., Minnich V., et al. Immunologic mechanisms in idiopathic and neonatal thrombocytopenic purpura. Ann Intern Med 38 (1953) 433-469
    • (1953) Ann Intern Med , vol.38 , pp. 433-469
    • Harrington, W.J.1    Sprague, C.C.2    Minnich, V.3
  • 3
    • 0013855839 scopus 로고
    • Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic purpura: physiologic, serologic, and isotopic studies
    • Shulman N.R., Marder V.J., and Weinrach R.S. Similarities between known antiplatelet antibodies and the factor responsible for thrombocytopenia in idiopathic purpura: physiologic, serologic, and isotopic studies. Ann NY Acad Sci 124 (1965) 499-542
    • (1965) Ann NY Acad Sci , vol.124 , pp. 499-542
    • Shulman, N.R.1    Marder, V.J.2    Weinrach, R.S.3
  • 4
    • 0019922299 scopus 로고
    • A prospective study of the usefulness of the measurement of platelet-associated IgG for the diagnosis of idiopathic thrombocytopenic purpura
    • Kelton J.G., Powers P.J., and Carter C.J. A prospective study of the usefulness of the measurement of platelet-associated IgG for the diagnosis of idiopathic thrombocytopenic purpura. Blood 60 (1982) 1050-1053
    • (1982) Blood , vol.60 , pp. 1050-1053
    • Kelton, J.G.1    Powers, P.J.2    Carter, C.J.3
  • 5
    • 0018973908 scopus 로고
    • The clinical significance of platelet-associated IgG: a study on 298 patients with various disorders
    • Mueller-Eckhardt C., Kayser W., Mersch-Baumert K., et al. The clinical significance of platelet-associated IgG: a study on 298 patients with various disorders. Br J Haematol 46 (1980) 123-131
    • (1980) Br J Haematol , vol.46 , pp. 123-131
    • Mueller-Eckhardt, C.1    Kayser, W.2    Mersch-Baumert, K.3
  • 6
    • 0020060104 scopus 로고
    • Specificity of autoantibodies in autoimmune thrombocytopenia
    • van Leeuwen E.F., van der Ven J.T.H., Engelfriet C.P., et al. Specificity of autoantibodies in autoimmune thrombocytopenia. Blood 59 (1982) 23-26
    • (1982) Blood , vol.59 , pp. 23-26
    • van Leeuwen, E.F.1    van der Ven, J.T.H.2    Engelfriet, C.P.3
  • 7
    • 0023635835 scopus 로고
    • Platelet-associated and plasma anti-glycoprotein autoantibodies in chronic ITP
    • McMillan R., Tani P., Millard F., et al. Platelet-associated and plasma anti-glycoprotein autoantibodies in chronic ITP. Blood 70 (1987) 1040-1045
    • (1987) Blood , vol.70 , pp. 1040-1045
    • McMillan, R.1    Tani, P.2    Millard, F.3
  • 8
    • 0023607547 scopus 로고
    • Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet-reactive antibodies
    • Kiefel V., Santoso S., Weisheit M., et al. Monoclonal antibody-specific immobilization of platelet antigens (MAIPA): a new tool for the identification of platelet-reactive antibodies. Blood 70 (1987) 1722-1726
    • (1987) Blood , vol.70 , pp. 1722-1726
    • Kiefel, V.1    Santoso, S.2    Weisheit, M.3
  • 9
    • 0029902152 scopus 로고    scopus 로고
    • Prospective evaluation of the clinical usefulness of an antigen-specific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias
    • Brighton T.A., Evans S., Castaldi P.A., et al. Prospective evaluation of the clinical usefulness of an antigen-specific assay (MAIPA) in idiopathic thrombocytopenic purpura and other immune thrombocytopenias. Blood 88 (1996) 194-201
    • (1996) Blood , vol.88 , pp. 194-201
    • Brighton, T.A.1    Evans, S.2    Castaldi, P.A.3
  • 10
    • 0033059567 scopus 로고    scopus 로고
    • A prospective study of protein-specific assays used to investigate idiopathic thrombocytopenic purpura
    • Warner M.N., Moore J.C., Warkentin T.E., et al. A prospective study of protein-specific assays used to investigate idiopathic thrombocytopenic purpura. Br J Haematol 104 (1999) 442-447
    • (1999) Br J Haematol , vol.104 , pp. 442-447
    • Warner, M.N.1    Moore, J.C.2    Warkentin, T.E.3
  • 11
    • 0344179126 scopus 로고    scopus 로고
    • Prospective evaluation of the immunobead assay for the diagnosis of adult chronic immune thrombocytopenic purpura (ITP)
    • McMillan R., Wang L., and Tani P. Prospective evaluation of the immunobead assay for the diagnosis of adult chronic immune thrombocytopenic purpura (ITP). J Thromb Haemost 1 (2003) 485-491
    • (2003) J Thromb Haemost , vol.1 , pp. 485-491
    • McMillan, R.1    Wang, L.2    Tani, P.3
  • 12
    • 0027247408 scopus 로고
    • The effect of therapy on platelet-associated autoantibody in chronic immune thrombocytopenic purpura
    • Fujisawa K., Tani P., Piro L., et al. The effect of therapy on platelet-associated autoantibody in chronic immune thrombocytopenic purpura. Blood 81 (1993) 2872-2877
    • (1993) Blood , vol.81 , pp. 2872-2877
    • Fujisawa, K.1    Tani, P.2    Piro, L.3
  • 13
    • 0141684568 scopus 로고    scopus 로고
    • T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura
    • Olsson B., Andersson P., Jernas M., et al. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nat Med 9 (2003) 1123-1124
    • (2003) Nat Med , vol.9 , pp. 1123-1124
    • Olsson, B.1    Andersson, P.2    Jernas, M.3
  • 14
    • 2942586618 scopus 로고    scopus 로고
    • Platelet-associated autoantibodies as detected by a solid-phase modified antigen capture ELISA test (MACE) are a useful prognostic factor in idiopathic thrombocytopenic purpura
    • Fabris F., Scandellari R., Ruzzon E., et al. Platelet-associated autoantibodies as detected by a solid-phase modified antigen capture ELISA test (MACE) are a useful prognostic factor in idiopathic thrombocytopenic purpura. Blood 103 (2004) 4562-4564
    • (2004) Blood , vol.103 , pp. 4562-4564
    • Fabris, F.1    Scandellari, R.2    Ruzzon, E.3
  • 15
    • 0021074932 scopus 로고
    • A monoclonal antiplatelet antibody with decreased reactivity for autoimmune thrombocytopenic platelets
    • Varon D., and Karpatkin S. A monoclonal antiplatelet antibody with decreased reactivity for autoimmune thrombocytopenic platelets. Proc Natl Acad Sci U S A 80 (1983) 6992-6995
    • (1983) Proc Natl Acad Sci U S A , vol.80 , pp. 6992-6995
    • Varon, D.1    Karpatkin, S.2
  • 16
    • 0028887066 scopus 로고
    • Glycoprotein IIb/IIIa autoantigenic repertoire in chronic idiopathic thrombcytopenic purpura
    • Hou M., Stockelberg D., Kutti J., et al. Glycoprotein IIb/IIIa autoantigenic repertoire in chronic idiopathic thrombcytopenic purpura. Br J Haematol 91 (1995) 971-975
    • (1995) Br J Haematol , vol.91 , pp. 971-975
    • Hou, M.1    Stockelberg, D.2    Kutti, J.3
  • 17
    • 0031813649 scopus 로고    scopus 로고
    • Recombinant human natural autoantibodies against GPIIb/IIIa inhibit binding of autoantibodies from patients with AITP
    • Escher R., Muller D., Vogel M., et al. Recombinant human natural autoantibodies against GPIIb/IIIa inhibit binding of autoantibodies from patients with AITP. Br J Haematol 102 (1998) 820-828
    • (1998) Br J Haematol , vol.102 , pp. 820-828
    • Escher, R.1    Muller, D.2    Vogel, M.3
  • 18
    • 0001902706 scopus 로고
    • Human monoclonal antibodies in the characterization of platelet antigens
    • Kunicki T., and George J.N. (Eds), Lippincott, Philadelphia
    • Nugent D.J. Human monoclonal antibodies in the characterization of platelet antigens. In: Kunicki T., and George J.N. (Eds). Platelet immunobiology: molecular and clinical aspects (1989), Lippincott, Philadelphia 273-290
    • (1989) Platelet immunobiology: molecular and clinical aspects , pp. 273-290
    • Nugent, D.J.1
  • 19
    • 0028884246 scopus 로고
    • Extracellular epitopes of platelet glycoprotein Iba reactive with serum antibodies from patients with chronic idiopathic thrombocytopenic purpura
    • He R., Reid D.M., Jones C.E., et al. Extracellular epitopes of platelet glycoprotein Iba reactive with serum antibodies from patients with chronic idiopathic thrombocytopenic purpura. Blood 86 (1995) 3789-3796
    • (1995) Blood , vol.86 , pp. 3789-3796
    • He, R.1    Reid, D.M.2    Jones, C.E.3
  • 20
    • 0035012460 scopus 로고    scopus 로고
    • Clonal restriction of platelet-associated anti-GPIIb/IIIa autoantibodies in patients with chronic ITP
    • McMillan R., Lopez-Dee J., and Bowditch R. Clonal restriction of platelet-associated anti-GPIIb/IIIa autoantibodies in patients with chronic ITP. Thromb Haemost 85 (2001) 821-823
    • (2001) Thromb Haemost , vol.85 , pp. 821-823
    • McMillan, R.1    Lopez-Dee, J.2    Bowditch, R.3
  • 21
    • 0037103361 scopus 로고    scopus 로고
    • Genetic analysis of autoantibodies in idiopathic thrombocytopenic purpura reveals evidence of clonal expansion and somatic mutation
    • Roark J.H., Bussel J.B., Cines D.B., et al. Genetic analysis of autoantibodies in idiopathic thrombocytopenic purpura reveals evidence of clonal expansion and somatic mutation. Blood 100 (2002) 1388-1398
    • (2002) Blood , vol.100 , pp. 1388-1398
    • Roark, J.H.1    Bussel, J.B.2    Cines, D.B.3
  • 22
    • 0027403205 scopus 로고
    • Platelet-associated antibody to glycoprotein IIb/IIIa from chronic immune thrombocytopenic purpura patients often binds to divalent cation-dependent antigens
    • Fujisawa K., and McMillan R. Platelet-associated antibody to glycoprotein IIb/IIIa from chronic immune thrombocytopenic purpura patients often binds to divalent cation-dependent antigens. Blood 81 (1993) 1284-1289
    • (1993) Blood , vol.81 , pp. 1284-1289
    • Fujisawa, K.1    McMillan, R.2
  • 23
    • 0029876681 scopus 로고    scopus 로고
    • Platelet-associated anti-glycoprotein (GP) IIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura mainly recognize cation-dependent conformations: comparison with the epitopes of serum autoantibodies
    • Kosugi S., Tomiyama Y., Shiraga M., et al. Platelet-associated anti-glycoprotein (GP) IIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura mainly recognize cation-dependent conformations: comparison with the epitopes of serum autoantibodies. Thromb Haemost 75 (1996) 339-345
    • (1996) Thromb Haemost , vol.75 , pp. 339-345
    • Kosugi, S.1    Tomiyama, Y.2    Shiraga, M.3
  • 24
    • 0029021986 scopus 로고
    • Reactivity of autoantibodies from chronic ITP patients with recombinant glycoprotein IIIa peptides
    • Bowditch R.D., Tani P., and McMillan R. Reactivity of autoantibodies from chronic ITP patients with recombinant glycoprotein IIIa peptides. Br J Haematol 91 (1995) 178-184
    • (1995) Br J Haematol , vol.91 , pp. 178-184
    • Bowditch, R.D.1    Tani, P.2    McMillan, R.3
  • 25
    • 0035312980 scopus 로고    scopus 로고
    • Autoantibodies to aIIbb3 in patients with chronic immune thrombocytopenic purpura bind primarily to epitopes on aIIb
    • McMillan R., Lopez-Dee J., and Loftus J.C. Autoantibodies to aIIbb3 in patients with chronic immune thrombocytopenic purpura bind primarily to epitopes on aIIb. Blood 97 (2001) 2171-2172
    • (2001) Blood , vol.97 , pp. 2171-2172
    • McMillan, R.1    Lopez-Dee, J.2    Loftus, J.C.3
  • 26
    • 0023280872 scopus 로고
    • Platelet glycoprotein IIb as a target antigen in two patients with chronic immune thrombocytopenic purpura
    • Tomiyama Y., Kurata Y., Mizutani H., et al. Platelet glycoprotein IIb as a target antigen in two patients with chronic immune thrombocytopenic purpura. Br J Haematol 66 (1987) 535-538
    • (1987) Br J Haematol , vol.66 , pp. 535-538
    • Tomiyama, Y.1    Kurata, Y.2    Mizutani, H.3
  • 27
    • 0035982902 scopus 로고    scopus 로고
    • Many aIIbb3 autoepitopes are localized to aIIb between amino acids L1 and Q459
    • McMillan R., Wang L., Lopez-Dee J., et al. Many aIIbb3 autoepitopes are localized to aIIb between amino acids L1 and Q459. Br J Haematol 118 (2002) 1132-1136
    • (2002) Br J Haematol , vol.118 , pp. 1132-1136
    • McMillan, R.1    Wang, L.2    Lopez-Dee, J.3
  • 28
    • 0035885952 scopus 로고    scopus 로고
    • Platelet-associated anti-GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of GPIIb
    • Kosugi S., Tomiyama Y., Honda S., et al. Platelet-associated anti-GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of GPIIb. Blood 98 (2001) 1819-1827
    • (2001) Blood , vol.98 , pp. 1819-1827
    • Kosugi, S.1    Tomiyama, Y.2    Honda, S.3
  • 29
    • 0342957177 scopus 로고
    • Formation of specific antibodies and g-globulin in vitro: a study of the synthetic ability of various tissues from rabbits immunized by different methods
    • Askonas B.A., and Humphrey J.H. Formation of specific antibodies and g-globulin in vitro: a study of the synthetic ability of various tissues from rabbits immunized by different methods. Biochem J 68 (1958) 252-261
    • (1958) Biochem J , vol.68 , pp. 252-261
    • Askonas, B.A.1    Humphrey, J.H.2
  • 30
    • 0015529253 scopus 로고
    • Immunoglobulin synthesis in vitro by splenic tissue in idiopathic thrombocytopenic purpura
    • McMillan R., Longmire R.L., Yelenosky R., et al. Immunoglobulin synthesis in vitro by splenic tissue in idiopathic thrombocytopenic purpura. N Engl J Med 286 (1972) 681-684
    • (1972) N Engl J Med , vol.286 , pp. 681-684
    • McMillan, R.1    Longmire, R.L.2    Yelenosky, R.3
  • 31
    • 0015385113 scopus 로고
    • Detection of splenic anti-platelet antibody synthesis in idiopathic autoimmune thrombocytopenic purpura (ATP)
    • Karpatkin S., Strick N., and Siskind G.W. Detection of splenic anti-platelet antibody synthesis in idiopathic autoimmune thrombocytopenic purpura (ATP). Br J Haematol 23 (1972) 167-176
    • (1972) Br J Haematol , vol.23 , pp. 167-176
    • Karpatkin, S.1    Strick, N.2    Siskind, G.W.3
  • 32
    • 0016395808 scopus 로고
    • Quantitation of platelet-binding IgG produced in vitro by spleens from patients with idiopathic thrombocytopenic purpura
    • McMillan R., Longmire R.L., Yelenosky R., et al. Quantitation of platelet-binding IgG produced in vitro by spleens from patients with idiopathic thrombocytopenic purpura. N Engl J Med 291 (1974) 812-817
    • (1974) N Engl J Med , vol.291 , pp. 812-817
    • McMillan, R.1    Longmire, R.L.2    Yelenosky, R.3
  • 33
    • 0018146633 scopus 로고
    • Antibody against megakaryocytes in idiopathic thrombocytopenic purpura
    • McMillan R., Luiken G.A., Levy R., et al. Antibody against megakaryocytes in idiopathic thrombocytopenic purpura. JAMA 239 (1978) 2460-2462
    • (1978) JAMA , vol.239 , pp. 2460-2462
    • McMillan, R.1    Luiken, G.A.2    Levy, R.3
  • 34
    • 0013564811 scopus 로고
    • Antiplatelet antibody production by the spleen and bone marrow in immune thrombocytopenic purpura
    • Battisto J.R., and Streinlein J.W. (Eds), North Holland Biomedical Press, Amsterdam
    • McMillan R., Yelenosky R.J., and Longmire R.L. Antiplatelet antibody production by the spleen and bone marrow in immune thrombocytopenic purpura. In: Battisto J.R., and Streinlein J.W. (Eds). Immunoaspects of the spleen (1976), North Holland Biomedical Press, Amsterdam 227-237
    • (1976) Immunoaspects of the spleen , pp. 227-237
    • McMillan, R.1    Yelenosky, R.J.2    Longmire, R.L.3
  • 35
    • 0014822892 scopus 로고
    • Thrombokinetics in idiopathic thrombocytopenic purpura
    • Harker L.A. Thrombokinetics in idiopathic thrombocytopenic purpura. Br J Haematol 19 (1970) 95-104
    • (1970) Br J Haematol , vol.19 , pp. 95-104
    • Harker, L.A.1
  • 36
    • 0016229715 scopus 로고
    • Platelet survival and platelet production in idiopathic thrombocytopenic purpura (ITP)
    • Branehog I., Kutti J., and Weinfeld A. Platelet survival and platelet production in idiopathic thrombocytopenic purpura (ITP). Br J Haematol 27 (1974) 127-143
    • (1974) Br J Haematol , vol.27 , pp. 127-143
    • Branehog, I.1    Kutti, J.2    Weinfeld, A.3
  • 37
    • 0021918452 scopus 로고
    • Platelet kinetics in patients with idiopathic thrombocytopenic purpura and moderate thrombocytopenia
    • Stoll D., Cines D.B., Aster R.H., et al. Platelet kinetics in patients with idiopathic thrombocytopenic purpura and moderate thrombocytopenia. Blood 65 (1985) 584-588
    • (1985) Blood , vol.65 , pp. 584-588
    • Stoll, D.1    Cines, D.B.2    Aster, R.H.3
  • 38
    • 0022623857 scopus 로고
    • Platelet turnover and kinetics in immune thrombocytopenic purpura: results with autologous 111-In-labeled and homologous 51- Cr-labeled platelets differ
    • Heyns A.P., Badenhorst P.N., Lotter M.G., et al. Platelet turnover and kinetics in immune thrombocytopenic purpura: results with autologous 111-In-labeled and homologous 51- Cr-labeled platelets differ. Blood 67 (1986) 86-92
    • (1986) Blood , vol.67 , pp. 86-92
    • Heyns, A.P.1    Badenhorst, P.N.2    Lotter, M.G.3
  • 39
    • 0023218341 scopus 로고
    • Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura: evidence for both impaired platelet production and increased platelet clearance
    • Ballem P.J., Segal G.M., Stratton J.R., et al. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura: evidence for both impaired platelet production and increased platelet clearance. J Clin Invest 80 (1987) 33-40
    • (1987) J Clin Invest , vol.80 , pp. 33-40
    • Ballem, P.J.1    Segal, G.M.2    Stratton, J.R.3
  • 40
    • 0016383010 scopus 로고
    • Phagocytosis of antibody-coated platelets by human granulocytes
    • Handin R.I., and Stossel T.P. Phagocytosis of antibody-coated platelets by human granulocytes. N Engl J Med 290 (1974) 989-993
    • (1974) N Engl J Med , vol.290 , pp. 989-993
    • Handin, R.I.1    Stossel, T.P.2
  • 41
    • 0017672529 scopus 로고
    • Red-cell and platelet fragmentation in idiopathic autoimmune thrombocytopenic purpura
    • Zucker-Franklin D., and Karpatkin S. Red-cell and platelet fragmentation in idiopathic autoimmune thrombocytopenic purpura. N Engl J Med 297 (1977) 517-523
    • (1977) N Engl J Med , vol.297 , pp. 517-523
    • Zucker-Franklin, D.1    Karpatkin, S.2
  • 42
    • 0016405697 scopus 로고
    • In vitro platelet phagocytosis by ITP splenic leukocytes in idiopathic thrombocytopenic purpura
    • McMillan R., Longmire R.L., Tavassoli M., et al. In vitro platelet phagocytosis by ITP splenic leukocytes in idiopathic thrombocytopenic purpura. N Engl J Med 290 (1974) 249-251
    • (1974) N Engl J Med , vol.290 , pp. 249-251
    • McMillan, R.1    Longmire, R.L.2    Tavassoli, M.3
  • 43
    • 0020575793 scopus 로고
    • In vitro platelet phagocytosis in idiopathic thrombocytopenic purpura
    • Tsubakio T., Kurata Y., Kanayama Y., et al. In vitro platelet phagocytosis in idiopathic thrombocytopenic purpura. Acta Haematol 70 (1983) 250-256
    • (1983) Acta Haematol , vol.70 , pp. 250-256
    • Tsubakio, T.1    Kurata, Y.2    Kanayama, Y.3
  • 44
    • 0013831385 scopus 로고
    • The role of the reticuloendothelial system in the pathogenesis of idiopathic thrombocytopenic purpura
    • Shulman N.R., Weinrach R.S., Libre E.P., et al. The role of the reticuloendothelial system in the pathogenesis of idiopathic thrombocytopenic purpura. Trans Assoc Am Physicians 78 (1965) 374-390
    • (1965) Trans Assoc Am Physicians , vol.78 , pp. 374-390
    • Shulman, N.R.1    Weinrach, R.S.2    Libre, E.P.3
  • 45
    • 0022644378 scopus 로고
    • Treatment of refractory immune thrombocytopenic purpura with anti-Fcg-receptor antibody
    • Clarkson S.B., Bussel J.B., Kimberly R.P., et al. Treatment of refractory immune thrombocytopenic purpura with anti-Fcg-receptor antibody. N Engl J Med 314 (1986) 1236-1239
    • (1986) N Engl J Med , vol.314 , pp. 1236-1239
    • Clarkson, S.B.1    Bussel, J.B.2    Kimberly, R.P.3
  • 46
    • 0030472803 scopus 로고    scopus 로고
    • A non-thrombocytopenic bleeding disorder due to an IgG4-kappa anti-GPIIb/III a autoantibody
    • McMillan R., Bowditch R., Tani P., et al. A non-thrombocytopenic bleeding disorder due to an IgG4-kappa anti-GPIIb/III a autoantibody. Br J Haematol 95 (1996) 747-749
    • (1996) Br J Haematol , vol.95 , pp. 747-749
    • McMillan, R.1    Bowditch, R.2    Tani, P.3
  • 47
    • 0017717784 scopus 로고
    • Platelet-bound complement (C3) in immune thrombocytopenia
    • Hauch T.W., and Rosse W.F. Platelet-bound complement (C3) in immune thrombocytopenia. Blood 50 (1977) 1129-1136
    • (1977) Blood , vol.50 , pp. 1129-1136
    • Hauch, T.W.1    Rosse, W.F.2
  • 48
    • 0021823291 scopus 로고
    • Platelet-associated complement in chronic ITP
    • Kurata Y., Curd J.G., Tamerius J.D., et al. Platelet-associated complement in chronic ITP. Br J Haematol 60 (1985) 723-733
    • (1985) Br J Haematol , vol.60 , pp. 723-733
    • Kurata, Y.1    Curd, J.G.2    Tamerius, J.D.3
  • 49
    • 0019502659 scopus 로고
    • Fixation of the third component of complement (C3) to platelets in vitro by antiplatelet antibody for patients with ITP
    • McMillan R., and Martin M. Fixation of the third component of complement (C3) to platelets in vitro by antiplatelet antibody for patients with ITP. Br J Haematol 47 (1981) 251-256
    • (1981) Br J Haematol , vol.47 , pp. 251-256
    • McMillan, R.1    Martin, M.2
  • 50
    • 0008781796 scopus 로고
    • The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism
    • Dameshek W., and Miller E.B. The megakaryocytes in idiopathic thrombocytopenic purpura, a form of hypersplenism. Blood 1 (1946) 27-52
    • (1946) Blood , vol.1 , pp. 27-52
    • Dameshek, W.1    Miller, E.B.2
  • 51
    • 0010487152 scopus 로고
    • Studies on platelets. X. Morphologic characteristics of megakaryocytes by phase contrast microscopy in normals and in patients with idiopathic thrombocytopenic purpura
    • Pisciotta A.V., Stefanini M., and Dameshek W. Studies on platelets. X. Morphologic characteristics of megakaryocytes by phase contrast microscopy in normals and in patients with idiopathic thrombocytopenic purpura. Blood 8 (1953) 703-723
    • (1953) Blood , vol.8 , pp. 703-723
    • Pisciotta, A.V.1    Stefanini, M.2    Dameshek, W.3
  • 52
    • 0842276665 scopus 로고
    • A study of the bone marrow from thirty-six patients with idiopathic hemorrhagic (thrombopenic) purpura
    • Diggs L.W., and Hewlett J.S. A study of the bone marrow from thirty-six patients with idiopathic hemorrhagic (thrombopenic) purpura. Blood 3 (1948) 1090-1104
    • (1948) Blood , vol.3 , pp. 1090-1104
    • Diggs, L.W.1    Hewlett, J.S.2
  • 53
    • 0022637280 scopus 로고
    • Incomplete antigenic cross-reactivity between platelets and megakaryocytes: relevance to ITP
    • Stahl C.P., Zucker-Franklin D., and McDonald T.P. Incomplete antigenic cross-reactivity between platelets and megakaryocytes: relevance to ITP. Blood 67 (1986) 421-428
    • (1986) Blood , vol.67 , pp. 421-428
    • Stahl, C.P.1    Zucker-Franklin, D.2    McDonald, T.P.3
  • 54
    • 0942287736 scopus 로고    scopus 로고
    • Ultrastructural study shows morphological features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura
    • Houwerzijl E.J., Blom N.R., van der Want J.J.L., et al. Ultrastructural study shows morphological features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura. Blood 103 (2004) 500-506
    • (2004) Blood , vol.103 , pp. 500-506
    • Houwerzijl, E.J.1    Blom, N.R.2    van der Want, J.J.L.3
  • 55
    • 0020031045 scopus 로고
    • Kinetics and sites of destruction of 111-Indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study
    • Heyns A.P., Lotter M.G., Badenhorst P.N., et al. Kinetics and sites of destruction of 111-Indium-oxine-labeled platelets in idiopathic thrombocytopenic purpura: a quantitative study. Am J Hematol 12 (1982) 167-177
    • (1982) Am J Hematol , vol.12 , pp. 167-177
    • Heyns, A.P.1    Lotter, M.G.2    Badenhorst, P.N.3
  • 56
    • 0842328846 scopus 로고    scopus 로고
    • Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult chronic ITP patients
    • McMillan R., Wang L., Tomer A., et al. Suppression of in vitro megakaryocyte production by antiplatelet autoantibodies from adult chronic ITP patients. Blood 103 (2004) 1364-1369
    • (2004) Blood , vol.103 , pp. 1364-1369
    • McMillan, R.1    Wang, L.2    Tomer, A.3
  • 57
    • 0043245959 scopus 로고    scopus 로고
    • Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro
    • Chang M., Nakagawa P.A., Williams S.A., et al. Immune thrombocytopenic purpura (ITP) plasma and purified ITP monoclonal autoantibodies inhibit megakaryocytopoiesis in vitro. Blood 102 (2003) 887-895
    • (2003) Blood , vol.102 , pp. 887-895
    • Chang, M.1    Nakagawa, P.A.2    Williams, S.A.3
  • 58
    • 63849111465 scopus 로고    scopus 로고
    • Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP
    • Bussel J.B., Kuter D.J., Pullarkat V., et al. Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP. Lancet 113 (2009) 2161-2171
    • (2009) Lancet , vol.113 , pp. 2161-2171
    • Bussel, J.B.1    Kuter, D.J.2    Pullarkat, V.3
  • 59
    • 60249099882 scopus 로고    scopus 로고
    • Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomized, double-blind, placebo-controlled trial
    • Bussel J.B., Provan D., Shamsi T., et al. Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomized, double-blind, placebo-controlled trial. Lancet 373 (2009) 641-648
    • (2009) Lancet , vol.373 , pp. 641-648
    • Bussel, J.B.1    Provan, D.2    Shamsi, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.