Targeting inducible T-cell Co-stimulator in autoimmune diseases - New evidence supporting its critical function in the maintenance of secondary lymphoid tissue architecture

European Musculoskeletal Review

Volumn 6, Issue 4, 2011, Pages 248-252

  Carlesso, Gianluca ^a   Taylor, Devon ^a   Herbst, Ronald ^a  

^a MEDIMMUNE   (United States)

Author keywords

Anti inducible T cell Co stimulator monoclonal antibody; B cell lymphoma 6; B7 related protein 1; CXC chemokine receptor 5; Germinal centre; Lupus nephritis; Programmed death 1; Sanroque mice; Sj gren's syndrome; Systemic lupus erythematosus; T follicular helper cells

Indexed keywords

AMG 557; AUTOANTIBODY; BELIMUMAB; CHEMOKINE RECEPTOR CXCR5; CXCL13 CHEMOKINE; IMMUNOMODULATING AGENT; INDUCIBLE T CELL COSTIMULATOR; INDUCIBLE T CELL COSTIMULATOR LIGAND; INTERLEUKIN 12; INTERLEUKIN 21; MEDI 570; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNE DISEASE; B LYMPHOCYTE DIFFERENTIATION; CELL INTERACTION; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; EVIDENCE BASED MEDICINE; HELPER CELL; HUMAN; IMMUNOPATHOGENESIS; LYMPHOID TISSUE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; SYSTEMIC LUPUS ERYTHEMATOSUS; T FOLLICULAR HELPER CELL; T LYMPHOCYTE ACTIVATION; TISSUE STRUCTURE;

EID: 84866773396     PISSN: 17545072     EISSN: 17545080     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. Kim CH, Rott LS, Clark-Lewis I, et al., Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells, J Exp Med, 2001;193:1373-81.
2. Nurieva RI, Chung Y, Hwang D, et al., Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages, Immunity, 2008;29:138-49.
3. Schaerli P, Willimann K, Lang AB, et al., CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function, J Exp Med, 2000;192:1553-62.
4. King C, Tangye SG, Mackay CR, T follicular helper (TFH) cells in normal and dysregulated immune responses, Annu Rev Immunol, 2008;26:741-66
5. Vogelzang A, McGuire HM, Yu D, et al., A fundamental role for interleukin-21 in the generation of T follicular helper cells, Immunity, 2008;29:127-37.
6. Yoshinaga SK, Whoriskey JS, Khare SD, et al., T-cell co-stimulation through B7RP-1 and ICOS, Nature, 1999;402:827-32.
7. Hutloff A, Dittrich AM, Beier KC, et al., ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28, Nature, 1999;397:263-6.
8. Bauquet AT, Jin H, Paterson AM, et al., The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells, Nat Immunol, 2009;10:167-75.
9. Wassink L, Vieira PL, Smits HH, et al., ICOS expression by activated human Th cells is enhanced by IL-12 and IL-23: increased ICOS expression enhances the effector function of both Th1 and Th2 cells, J Immunol, 2004;173:1779-86.
10. Chtanova T, Tangye SG, Newton R, et al., T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells, J Immunol, 2004;173:68-78.
11. Vinuesa CG, Cook MC, Angelucci C, et al., A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity, Nature, 2005;435:452-8.
12. Yu D, Tan AH, Hu X, et al., Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA, Nature, 2007;450:299-303.
13. Glasmacher E, Hoefig KP, Vogel KU, et al., Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression, Nat Immunol, 2010;11:725-33.
14. Simpson N, Gatenby PA, Wilson A, et al., Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus, Arthritis Rheum, 2010;62:234-44.
15. Watanabe M, Takagi Y, Kotani M, et al., Down-regulation of ICOS ligand by interaction with ICOS functions as a regulatory mechanism for immune responses, J Immunol, 2008;180:5222-34.
16. Aicher A, Hayden-Ledbetter M, Brady WA, et al., Characterization of human inducible costimulator ligand expression and function, J Immunol, 2000;164:4689-96.
17. Schmitt N, Morita R, Bourdery L, et al., Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12, Immunity, 2009;31:158-69.
18. Ma CS, Suryani S, Avery DT, et al., Early commitment of naive human CD4(+) T cells to the T follicular helper (T(FH)) cell lineage is induced by IL-12, Immunol Cell Biol, 2009;87:590-600.
19. Crotty S, Follicular helper CD4 T cells (TFH), Annu Rev Immunol, 2011;29:621-63
20. Choi YS, Kageyama R, Eto D, et al., ICOS Receptor Instructs T Follicular Helper Cell versus Effector Cell Differentiation via Induction of the Transcriptional Repressor Bcl6, Immunity, 2011;34:932-46.
21. Cyster JG, Ansel KM, Reif K, et al., Follicular stromal cells and lymphocyte homing to follicles, Immunol Rev, 2000;176:181-93.
22. Lee SK, Rigby RJ, Zotos D, et al., B cell priming for extrafollicular antibody responses requires Bcl-6 expression by T cells, J Exp Med, 2011;208:1377-88.
23. Jacobson BA, Panka DJ, Nguyen KA, et al., Anatomy of autoantibody production: dominant localization of antibody-producing cells to T cell zones in Fas-deficient mice, Immunity, 1995;3:509-19.
24. William J, Euler C, Christensen S, Shlomchik MJ, Evolution of autoantibody responses via somatic hypermutation outside of germinal centers, Science, 2002;297:2066-70
25. Odegard JM, Marks BR, DiPlacido LD, et al., ICOS-dependent extrafollicular helper T cells elicit IgG production via IL-21 in systemic autoimmunity, J Exp Med, 2008;205:2873-86.
26. Poholek AC, Hansen K, Hernandez SG, et al., In vivo regulation of Bcl6 and T follicular helper cell development, J Immunol, 2010;185:313-26.
27. Rasheed AU, Rahn HP, Sallusto F, et al., Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression, Eur J Immunol, 2006;36:1892-1903.
28. Barone F, Bombardieri M, Rosado MM, et al., CXCL13, CCL21, and CXCL12 expression in salivary glands of patients with Sjogren's syndrome and MALT lymphoma: association with reactive and malignant areas of lymphoid organization, J Immunol, 2008;180:5130-40.
29. Ezzat M, El-Gammasy T, Shaheen K, Shokr E, Elevated production of serum B-cell-attracting chemokine-1 (BCA-1/CXCL13) is correlated with childhood-onset lupus disease activity, severity, and renal involvement, Lupus, 2011;20:845-54
30. Wong CK, Wong PT, Tam LS, et al., Elevated production of B cell chemokine CXCL13 is correlated with systemic lupus erythematosus disease activity, J Clin Immunol, 2010;30:45-52.
31. Lee HT, Shiao YM, Wu TH, et al., Serum BLC/CXCL13 concentrations and renal expression of CXCL13/CXCR5 in patients with systemic lupus erythematosus and lupus nephritis, J Rheumatol, 2010;37:45-52.
32. Manzo A, Vitolo B, Humby F, et al., Mature antigenexperienced T helper cells synthesize and secrete the B cell chemoattractant CXCL13 in the inflammatory environment of the rheumatoid joint, Arthritis Rheum, 2008;58:3377-87.
33. McAdam AJ, Greenwald RJ, Levin MA, et al., ICOS is critical for CD40-mediated antibody class switching, Nature, 2001;409:102-5.
34. Tafuri A, Shahinian A, Bladt F, et al., ICOS is essential for effective T-helper-cell responses, Nature, 2001;409:105-9.
35. Yong PF, Salzer U, Grimbacher B, The role of costimulation in antibody deficiencies: ICOS and common variable immunodeficiency, Immunol Rev, 2009;229:101-13
36. Kawamoto M, Harigai M, Hara M, et al., Expression and function of inducible co-stimulator in patients with systemic lupus erythematosus: possible involvement in excessive interferon-gamma and anti-double-stranded DNA antibody production, Arthritis Res Ther, 2006;8:R62.
37. Hu YL, Metz DP, Chung J, et al., B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells, J Immunol, 2009;182:1421-8.
38. Rottman JB, Smith T, Tonra JR, et al., The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE, Nat Immunol, 2001;2:605-11.
39. Tajima N, Tezuka K, Tanaka M, et al., Critical role of activation-inducible lymphocyte immunomediatory molecule/inducible costimulator in the effector function of human T cells: a comparative in vitro study of effects of its blockade and CD28 blockade in human beings and monkeys, Hum Immunol, 2008;69:399-408.
40. Carlesso G, et al., manuscript in preparation.
41. Dorner T, Kaufmann J, Wegener WA, et al., Initial clinical trial of epratuzumab (humanized anti-CD22 antibody) for immunotherapy of systemic lupus erythematosus, Arthritis Res Ther, 2006;8:R74.
42. Wallace D, Kalunian K, Petri M, et al., Epratuzumab demonstrates clinically meaningful improvements in patients with moderate to severe systemic lupus erythematosus (SLE): results from EMBLEM, a phase IIb study, Ann Rheum Dis, 2010;69(Suppl. 3):558.
43. Navarra SV, Guzman RM, Gallacher AE, et al., Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial, Lancet, 2011;377:721-31.
44. Sanz I, Yasothan U, Kirkpatrick P, Belimumab, Nat Rev Drug Discov, 2011;10:335-6
45. Amgen A, Randomized, Double-blind, Placebo-controlled, Ascending, Multiple Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 557 in Subjects With Systemic Lupus Erythematosus. Available at: http://clinicaltrials.gov/ct2/show/NCT00774943 (accessed 24 October 2011).
46. MedImmune, A Phase 1, Double-Blind, Randomized, Single Ascending Dose Study of the Safety and Tolerability of MEDI-570 in Systemic Lupus Erythematosus. Available at: http://clinicaltrials.gov/ct2/show/NCT01127321 (accessed 24 October 2011).
47. Liu SM, Xavier R, Good KL, et al., Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes, J Allergy Clin Immunol, 2006;118:496-503.