Antigen-unspecific B cells and lymphoid dendritic cells both show extensive surface expression of processed antigen-major histocompatibility complex class II complexes after soluble protein exposure in vivo or in vitro

Journal of Experimental Medicine

Volumn 186, Issue 5, 1997, Pages 673-682

  Zhong, Guangming ^a,c   Reis E Sousa, Caetano ^a   Germain, Ronald N ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF MANITOBA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; LYSOZYME; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROTEIN; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ARTICLE; B LYMPHOCYTE; DENDRITIC CELL; IMMUNOLOGICAL TOLERANCE; LIGAND BINDING; LYMPHOID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGEN PRESENTATION; B-LYMPHOCYTES; DENDRITIC CELLS; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOHISTOCHEMISTRY; LIGANDS; LYMPH NODES; MICE; MICE, INBRED CBA; MICE, INBRED STRAINS; MURAMIDASE; RECEPTORS, ANTIGEN, T-CELL; SERUM ALBUMIN, BOVINE; SOLUBILITY; SPLEEN;

EID: 1842377506     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.5.673     Document Type: Article

References (43)

1. Germain, R.N. 1994. MHC-dependent antigen processing and peptide presentation: providing ligands for T lymphocyte activation. Cell. 76:287-299.
2. MacLennan, I.C. 1994. Germinal centers. Annu. Rev. Immunol. 12:117-139.
3. Mondino, A., A. Khoruts, and M.K. Jenkins. 1996. The anatomy of T-cell activation and tolerance. Proc. Natl. Acad. Sci. USA. 93:2245-2252.
4. Eynon, E.E., and D.C. Parker. 1992. Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens. J. Exp. Med. 175:131-138.
5. Fuchs, E.J., and P. Matzinger. 1992. B cells turn off virgin but not memory T cells. Science (Wash. DC). 258:1156-1159.
6. Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991-1045.
7. Crowley, M., K. Inaba, and R.M. Steinman. 1990. Dendritic cells are the principal cells in mouse spleen bearing immunogenic fragments of foreign proteins. J. Exp. Med. 172:383-386.
8. Liu, L.M., and G.G. MacPherson. 1991. Lymph-borne (veiled) dendritic cells can acquire and present intestinally administered antigens. Immunology. 73:281-286.
9. Liu, L.M., and G.G. MacPherson. 1993. Antigen acquisition by dendritic cells: intestinal dendritic cells acquire antigen administered orally and can prime naive T cells in vivo. J. Exp. Med. 177:1299-1307.
10. + T cells to protein antigens in vivo. J. Immunol. 155:3734-3741.
11. Guéry, J.C., F. Ria, and L. Adorini. 1996. Dendritic cells but not B cells present antigenic complexes to class II-restricted T cells after administration of protein in adjuvant. J. Exp. Med. 183:751-757.
12. Guéry, J.C., F. Ria, F. Galbiati, S. Smiroldo, and L. Adorini. 1997. The mode of protein antigen administration determines preferential presentation of peptide-class II complexes by lymph node dendritic or B cells. Int. Immunol. 9:9-15.
13. Porgador, A., J.W. Yewdell, Y. Deng, J.R. Bennink, and R.N. Germain. 1997. Intracellular localization, surface quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity. 6:715-726.
14. Weigle, W.O. 1980. Analysis of autoimmunity through experimental models of thyroiditis and allergic encephalomyelitis. Adv. Immunol. 30:159-273.
15. De Wit, D., M. Van Mechelen, M. Ryelandt, A.C. Figueiredo, D. Abramowicz, M. Goldman, H. Bazin, J. Urbain, and O. Leo. 1992. The injection of deaggregated gamma globulins in adult mice induces antigen-specific unresponsiveness of T helper type 1 but not type 2 lymphocytes. J. Exp. Med. 175: 9-14.
16. Burstein, H.J., C.M. Shea, and A.K. Abbas. 1992. Aqueous antigens induce in vivo tolerance selectively in IL-2-and IFN-gamma-producing (Th1) cells. J. Immunol. 148:3687-3691.
17. + cell subsets. J. Exp. Med. 178: 1637-1644.
18. + T cell population to the T helper 2 cell pathway. J. Immunol. 157:3260-3269.
19. + T cell selection in mice lacking invariant chain expression. J. Exp. Med. 177:1699-1712.
20. Bikoff, E.K., R.N. Germain, and E.J. Robertson. 1995. Allelic differences affecting invariant chain dependency of MHC class II subunit assembly. Immunity. 2:301-310.
21. Swiggard, W., R.M. Nonacs, M.D. Witmer-Pack, and R.M. Steinman. 1991. Enrichment of dendritic cells by plastic adherence and EA rosetting. In Current Protocols in Immunology, Volume 1. J.E. Coligan, A.M. Kruisbeek, D.H. Margulies, E.M. Shevach, and W. Strober, editors. John Wiley & Sons, Inc., New York. 3.7.1-3.7.11.
22. Metlay, J.P., M.D. Witmer-Pack, R. Agger, M.T. Crowley, D. Lawless, and R.M. Steinman. 1990. The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies. J. Exp. Med. 171: 1753-1771.
23. Nussenzweig, M.C., R.M. Steinman, M.D. Witmer, and B. Gutchinov. 1982. A monoclonal antibody specific for mouse dendritic cells. Proc. Natl. Acad. Sci. USA. 79:161-165.
24. Kraal, G., M. Breel, M. Janse, and G. Bruin. 1986. Langerhans' cells, veiled cells, and interdigitating cells in the mouse recognized by a monoclonal antibody. J. Exp. Med. 163:981-997.
25. Allen, P.M., D.J. Strydom, and E.R. Unanue. 1984. Processing of lysozyme by macrophages: identification of the determinant recognized by two T-cell hybridomas. Proc. Natl. Acad. Sci. USA. 81:2489-2493.
26. Reis e Sousa, C., and R.N. Germain. 1995. Major histocompatibility complex class I presentation of peptides derived from soluble exogenous antigen by a subset of cells engaged in phagocytosis. J. Exp. Med. 182:841-851.
27. Nelson, C.A., R.W. Roof, D.W. McCourt, and E.R. Unanue. 1992. Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak. Proc. Natl. Acad. Sci. USA. 89:7380-7383.
28. Lanzavecchia, A. 1990. Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Annu. Rev. Immunol. 8:773-793.
29. McHeyzer-Williams, M.G., and M.M. Davis. 1995. Antigen-specific development of primary and memory T cells in vivo. Science (Wash. DC). 268:106-111.
30. Luther, S.A., A. Gulbranson-Judge, H. Acha-Orbea, and I.C. MacLennan. 1997. Viral superantigen drives extrafollicular and follicular B cell differentiation leading to virus-specific antibody production. J. Exp. Med. 185:551-562.
31. Kearney, E.R., K.A. Pape, D.Y. Loh, and M.K. Jenkins. 1994. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity. 1:327-339.
32. Shokat, K.M., and C.C. Goodnow. 1995. Antigen-induced B-cell death and elimination during germinal-centre immune responses. Nature (Lond.). 375:334-338.
33. van den Eertwegh, A.J.M., W.J.A. Boersma, and E. Claassen. 1992. Immunological functions and in vivo cell-cell interactions of T cells in the spleen. Crit. Rev. Immunol. 11:337-380.
34. Inaba, K., J.P. Metlay, M.T. Crowley, and R.M. Steinman. 1990. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ. J. Exp. Med. 172:631-640.
35. Mitchison, N.A. 1964. Induction of immunological paralysis in two zones of dosage. Proc. R. Soc. Lond. B. Biol. Sci. 161: 275-292.
36. Umlauf, S.W., B. Beverly, S.M. Kang, K. Brorson, A.C. Tran, and R.H. Schwartz. 1993. Molecular regulation of the IL-2 gene: rheostatic control of the immune system. Immunol. Rev. 133:177-197.
37. Gilbert, K.M., and W.O. Weigle. 1994. Tolerogenicity of resting and activated B cells. J. Exp. Med. 179:249-258.
38. Cassell, D.J., and R.H. Schwartz. 1994. A quantitative analysis of antigen-presenting cell function: activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation. J. Exp. Med. 180:1829-1840.
39. Steinman, R.M. 1991. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9:271-296.
40. Austyn, J.M. 1996. New insights into the mobilization and phagocytic activity of dendritic cells. J. Exp. Med. 183:1287-1292.
41. Reis e Sousa, C., P.D. Stahl, and J.M. Austyn. 1993. Phagocytosis of antigens by Langerhans cells in vitro. J. Exp. Med. 178:509-519.
42. Romani, N., S. Koide, M. Crowley, P.M. Witmer, A.M. Livingstone, C.G. Fathman, K. Inaba, and R.M. Steinman. 1989. Presentation of exogenous protein antigens by dendritic cells to T cell clones. Intact protein is presented best by immature, epidermal Langerhans cells. J. Exp. Med. 169: 1169-1178.
43. Sallusto, F., and A. Lanzavecchia. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 179:1109-1118.