메뉴 건너뛰기




Volumn 172, Issue 2, 2004, Pages 954-963

IL-12p70-Dependent Th1 Induction by Human B Cells Requires Combined Activation with CD40 Ligand and CpG DNA

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD40 LIGAND; CPG OLIGODEOXYNUCLEOTIDE; IMMUNOGLOBULIN M; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P70; INTERLEUKIN 6; OLIGODEOXYNUCLEOTIDE; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 9144232256     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.172.2.954     Document Type: Article
Times cited : (140)

References (63)
  • 5
    • 0036160406 scopus 로고    scopus 로고
    • Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity
    • Wagner, H. 2002. Interactions between bacterial CpG-DNA and TLR9 bridge innate and adaptive immunity. Curr. Opin. Microbiol. 5:62.
    • (2002) Curr. Opin. Microbiol. , vol.5 , pp. 62
    • Wagner, H.1
  • 6
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung, V., S. Rothenfusser, S. Britsch, A. Krug, B. Jahrsdorfer, T. Giese, S. Endres, and G. Hartmann. 2002. Quantitative expression of Toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 168:4531.
    • (2002) J. Immunol. , vol.168 , pp. 4531
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 9
    • 0033529891 scopus 로고    scopus 로고
    • CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
    • Hartmann, G., G. J. Weiner, and A. M. Krieg. 1999. CpG DNA: a potent signal for growth, activation, and maturation of human dendritic cells. Proc. Natl. Acad. Sci. USA 96:9305.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 9305
    • Hartmann, G.1    Weiner, G.J.2    Krieg, A.M.3
  • 11
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens
    • Kadowaki, N., S. Ho, S. Antonenko, R. W. Malefyt, R. A. Kastelein, F. Bazan, and Y. J. Liu. 2001. Subsets of human dendritic cell precursors express different Toll-like receptors and respond to different microbial antigens. J. Exp. Med. 194:863.
    • (2001) J. Exp. Med. , vol.194 , pp. 863
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3    Malefyt, R.W.4    Kastelein, R.A.5    Bazan, F.6    Liu, Y.J.7
  • 12
    • 0034777579 scopus 로고    scopus 로고
    • Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
    • Krug, A., A. Towarowski, S. Britsch, S. Rothenfusser, V. Hornung, R. Bals, T. Giese, H. Engehnann, S. Endres, A. M. Krieg, and G. Hartmann. 2001. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 31:3026.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3026
    • Krug, A.1    Towarowski, A.2    Britsch, S.3    Rothenfusser, S.4    Hornung, V.5    Bals, R.6    Giese, T.7    Engehnann, H.8    Endres, S.9    Krieg, A.M.10    Hartmann, G.11
  • 15
    • 0038236749 scopus 로고    scopus 로고
    • Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-α induction in plasmacytoid dendritic cells
    • Hartmann, G., J. Battiany, H. Poeck, M. Wagner, M. Kerkmann, N. Lubenow, S. Rothenfusser, and S. Endres. 2003. Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-α induction in plasmacytoid dendritic cells. Eur. J. Immunol. 33:1633.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 1633
    • Hartmann, G.1    Battiany, J.2    Poeck, H.3    Wagner, M.4    Kerkmann, M.5    Lubenow, N.6    Rothenfusser, S.7    Endres, S.8
  • 16
    • 0034650517 scopus 로고    scopus 로고
    • Mechanism and function of a newly identified CpG DNA motif in human primary B cells
    • Hartmann, G., and A. M. Krieg. 2000. Mechanism and function of a newly identified CpG DNA motif in human primary B cells. J. Immunol. 164:944.
    • (2000) J. Immunol. , vol.164 , pp. 944
    • Hartmann, G.1    Krieg, A.M.2
  • 21
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg, A. M. 2002. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 20:709.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 709
    • Krieg, A.M.1
  • 22
    • 0037237628 scopus 로고    scopus 로고
    • Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: Dependency on antigen dose and differential Toll-like receptor ligation
    • Boonstra, A., C. Asselin-Paturel, M. Gilliet, C. Crain, G. Trinchieri, Y. J. Liu, and A. O'Garra. 2003. Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: dependency on antigen dose and differential Toll-like receptor ligation. J. Exp. Med. 197:101.
    • (2003) J. Exp. Med. , vol.197 , pp. 101
    • Boonstra, A.1    Asselin-Paturel, C.2    Gilliet, M.3    Crain, C.4    Trinchieri, G.5    Liu, Y.J.6    O'Garra, A.7
  • 25
    • 0037601712 scopus 로고    scopus 로고
    • CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells
    • Lapointe, R., A. Bellemare-Pelletier, F. Housseau, J. Thibodeau, and P. Hwu, 2003. CD40-stimulated B lymphocytes pulsed with tumor antigens are effective antigen-presenting cells that can generate specific T cells. Cancer Res. 63:2836.
    • (2003) Cancer Res. , vol.63 , pp. 2836
    • Lapointe, R.1    Bellemare-Pelletier, A.2    Housseau, F.3    Thibodeau, J.4    Hwu, P.5
  • 27
    • 0345120862 scopus 로고    scopus 로고
    • Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-γ production in cells from allergic individuals and inhibit IgE synthesis in vitro
    • Bohle, B., B. Jahn-Schmid, D. Maurer, D. Kraft, and C. Ebner. 1999. Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-γ production in cells from allergic individuals and inhibit IgE synthesis in vitro. Eur. J. Immunol. 29:2344.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 2344
    • Bohle, B.1    Jahn-Schmid, B.2    Maurer, D.3    Kraft, D.4    Ebner, C.5
  • 28
    • 0032810718 scopus 로고    scopus 로고
    • DNA activates human immune cells through a CpG sequence-dependent manner
    • Bauer, M., K. Heeg, H. Wagner, and G. B. Lipford. 1999. DNA activates human immune cells through a CpG sequence-dependent manner. Immunology 97:699.
    • (1999) Immunology , vol.97 , pp. 699
    • Bauer, M.1    Heeg, K.2    Wagner, H.3    Lipford, G.B.4
  • 29
    • 0033950421 scopus 로고    scopus 로고
    • CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-γ production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type 1 and interleukin-12
    • Kranzer, K., M. Bauer, G. B. Lipford, K. Heeg, H. Wagner, and R. Lang. 2000. CpG-oligodeoxynucleotides enhance T-cell receptor-triggered interferon-γ production and up-regulation of CD69 via induction of antigen-presenting cell-derived interferon type 1 and interleukin-12. Immunology 99:170.
    • (2000) Immunology , vol.99 , pp. 170
    • Kranzer, K.1    Bauer, M.2    Lipford, G.B.3    Heeg, K.4    Wagner, H.5    Lang, R.6
  • 30
    • 0033027749 scopus 로고    scopus 로고
    • CpG DNA and LPS induce distinct patterns of activation in human monocytes
    • Hartmann, G., and A. M. Krieg. 1999. CpG DNA and LPS induce distinct patterns of activation in human monocytes. Gene Ther. 6:893.
    • (1999) Gene Ther. , vol.6 , pp. 893
    • Hartmann, G.1    Krieg, A.M.2
  • 34
    • 0032476611 scopus 로고    scopus 로고
    • + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells
    • + peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells. J. Exp. Med. 188:1679.
    • (1998) J. Exp. Med. , vol.188 , pp. 1679
    • Klein, U.1    Rajewsky, K.2    Kuppers, R.3
  • 35
    • 0031469361 scopus 로고    scopus 로고
    • CD40-activated human B cells: An alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy
    • Schultze, J. L., S. Michalak, M. J. Seamon, G. Dranoff, K. Jung, J. Daley, J. C. Delgado, J. G. Gribben, and L. M. Nadler. 1997. CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive immunotherapy. J. Clin. Invest. 100:2757.
    • (1997) J. Clin. Invest. , vol.100 , pp. 2757
    • Schultze, J.L.1    Michalak, S.2    Seamon, M.J.3    Dranoff, G.4    Jung, K.5    Daley, J.6    Delgado, J.C.7    Gribben, J.G.8    Nadler, L.M.9
  • 40
    • 0029812593 scopus 로고    scopus 로고
    • Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
    • Cella, M., D. Scheidegger, K. Palmer-Lehmann, P. Lane, A. Lanzavecchia, and G. Alber. 1996. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J. Exp. Med. 184:747.
    • (1996) J. Exp. Med. , vol.184 , pp. 747
    • Cella, M.1    Scheidegger, D.2    Palmer-Lehmann, K.3    Lane, P.4    Lanzavecchia, A.5    Alber, G.6
  • 41
    • 0033697454 scopus 로고    scopus 로고
    • CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal
    • Schulz. O., A. D. Edwards, M. Schito. J. Aliberti, S. Manickasingham, A. Sher, and C. Reis e Sousa. 2000. CD40 triggering of heterodimeric IL-12 p70 production by dendritic cells in vivo requires a microbial priming signal. Immunity 13:453.
    • (2000) Immunity , vol.13 , pp. 453
    • Schulz, O.1    Edwards, A.D.2    Schito, M.3    Aliberti, J.4    Manickasingham, S.5    Sher, A.6    Reis E Sousa, C.7
  • 42
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • Gallucci, S., M. Lolkema, and P. Matzinger. 1999. Natural adjuvants: endogenous activators of dendritic cells. Nat. Med. 5:1249.
    • (1999) Nat. Med. , vol.5 , pp. 1249
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 43
    • 0033521688 scopus 로고    scopus 로고
    • Human non-germinal center B cell interleukin (IL)-12 production is primarily regulated by T cell signals CD40 ligand, interferon-γ, and IL-10: Role of B cells in the maintenance of T cell responses
    • Schultze, J. L., S. Michalak, J. Lowne, A. Wong, M. H. Gilleece, J. G. Gribben, and L. M. Nadler. 1999. Human non-germinal center B cell interleukin (IL)-12 production is primarily regulated by T cell signals CD40 ligand. interferon-γ, and IL-10: role of B cells in the maintenance of T cell responses. J. Exp. Med. 189:1.
    • (1999) J. Exp. Med. , vol.189 , pp. 1
    • Schultze, J.L.1    Michalak, S.2    Lowne, J.3    Wong, A.4    Gilleece, M.H.5    Gribben, J.G.6    Nadler, L.M.7
  • 44
    • 0037100526 scopus 로고    scopus 로고
    • B cells capturing antigen conjugated with CpG oligodeoxynucleotides induce Th1 cells by elaborating IL-12
    • Shirota, H., K. Sano, N. Hirasawa, T. Terui, K. Ohuchi, T. Hattori, and G. Tamura. 2002. B cells capturing antigen conjugated with CpG oligodeoxynucleotides induce Th1 cells by elaborating IL-12. J. Immunol. 169:787.
    • (2002) J. Immunol. , vol.169 , pp. 787
    • Shirota, H.1    Sano, K.2    Hirasawa, N.3    Terui, T.4    Ohuchi, K.5    Hattori, T.6    Tamura, G.7
  • 45
    • 0031252579 scopus 로고    scopus 로고
    • Partial activation of naive CD4 T cells and tolerance induction in response to peptide presented by resting B cells
    • Croft, M., S. B. Joseph, and K. T. Miner. 1997. Partial activation of naive CD4 T cells and tolerance induction in response to peptide presented by resting B cells. J. Immunol. 159:3257.
    • (1997) J. Immunol. , vol.159 , pp. 3257
    • Croft, M.1    Joseph, S.B.2    Miner, K.T.3
  • 46
    • 0034650434 scopus 로고    scopus 로고
    • Resting B lymphocytes as APC for naive T lymphocytes: Dependence on CD40 ligand/CD40
    • Evans, D. E., M. W. Munks, J. M. Purkerson, and D. C. Parker, 2000. Resting B lymphocytes as APC for naive T lymphocytes: dependence on CD40 ligand/ CD40. J. Immunol. 164:688.
    • (2000) J. Immunol. , vol.164 , pp. 688
    • Evans, D.E.1    Munks, M.W.2    Purkerson, J.M.3    Parker, D.C.4
  • 49
    • 0033563084 scopus 로고    scopus 로고
    • + T cell priming in vivo
    • + T cell priming in vivo. J. Immunol. 162:5695.
    • (1999) J. Immunol. , vol.162 , pp. 5695
    • Constant, S.L.1
  • 52
    • 43949169661 scopus 로고
    • Do B cells drive the diversification of immune responses?
    • Mamula, M. J., and C. A. Janeway. Jr. 1993. Do B cells drive the diversification of immune responses? Immunol. Today 14:151.
    • (1993) Immunol. Today , vol.14 , pp. 151
    • Mamula Jr., M.J.1    Janeway, C.A.2
  • 55
    • 0029813549 scopus 로고    scopus 로고
    • Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c
    • Gulbranson-Judge, A., and I. MacLennan. 1996. Sequential antigen-specific growth of T cells in the T zones and follicles in response to pigeon cytochrome c. Eur. J. Immunol. 26:1830.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 1830
    • Gulbranson-Judge, A.1    MacLennan, I.2
  • 56
    • 0025951891 scopus 로고
    • Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens
    • Liu, Y. J., J. Zhang, P. J. Lane, E. Y. Chan, and I. C. MacLennan. 1991. Sites of specific B cell activation in primary and secondary responses to T cell-dependent and T cell-independent antigens. Eur. J. Immunol. 21:2951.
    • (1991) Eur. J. Immunol. , vol.21 , pp. 2951
    • Liu, Y.J.1    Zhang, J.2    Lane, P.J.3    Chan, E.Y.4    MacLennan, I.C.5
  • 58
    • 0037450740 scopus 로고    scopus 로고
    • Prevention of arthritis by interleukin 10-producing B cells
    • Mauri, C., D. Gray, N. Mushtaq, and M. Londei. 2003. Prevention of arthritis by interleukin 10-producing B cells. J. Exp. Med. 197:489.
    • (2003) J. Exp. Med. , vol.197 , pp. 489
    • Mauri, C.1    Gray, D.2    Mushtaq, N.3    Londei, M.4
  • 60
    • 0036721610 scopus 로고    scopus 로고
    • Distinct response of human B cell subpopulations in recognition of an innate immune signal. CpG DNA
    • Jung, J., A. K. Yi, X. Zhang, J. Choe, L. Li, and Y. S. Choi. 2002. Distinct response of human B cell subpopulations in recognition of an innate immune signal. CpG DNA. J. Immunol. 169:2368.
    • (2002) J. Immunol. , vol.169 , pp. 2368
    • Jung, J.1    Yi, A.K.2    Zhang, X.3    Choe, J.4    Li, L.5    Choi, Y.S.6
  • 63
    • 0038639600 scopus 로고    scopus 로고
    • CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells
    • Liu, N., N. Ohnishi, L. Ni, S. Akira, and K. B. Bacon. 2003. CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells. Nat. Immunol. 4:687.
    • (2003) Nat. Immunol. , vol.4 , pp. 687
    • Liu, N.1    Ohnishi, N.2    Ni, L.3    Akira, S.4    Bacon, K.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.