Positive selection and lineage commitment during peripheral B-lymphocyte development

Immunological Reviews

Volumn 197, Issue , 2004, Pages 206-218

  Pillai, Shiv ^a   Cariappa, Annaiah ^a   Moran, Stewart T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN RECEPTOR;

B LYMPHOCYTE; CELL MATURATION; CELL POPULATION; HUMAN; MOLECULAR MODEL; NONHUMAN; OVARY FOLLICLE CELL; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; SPLEEN CELL;

ANIMALS; B-LYMPHOCYTE SUBSETS; CELL LINEAGE; HUMANS; LYMPHOID TISSUE; MICE; NF-KAPPA B; NF-KAPPA B P50 SUBUNIT; RECEPTOR, NOTCH2; RECEPTORS, ANTIGEN, B-CELL; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; SPLEEN;

EID: 0942279505     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0105-2896.2003.097.x     Document Type: Review

References (93)

1. Lam K-P, Kuhn R, Rajewsky K. In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid death. Cell 1997;90: 1073-1083.
2. Neuberger MS. Antigen receptor signaling gives lymphocytes a long life. Cell 1997; 90:971-973.
3. Pillai S. The chosen few? Positive selection and the generation of naive B lymphocytes. Immunity 1999;10:493-502
4. Polic B, Kunkel D, Scheffold A, Rajewsky K. How αβ T cells deal with induced TCR-α ablation. Proc Natl Acad Sci USA 2001; 98:8744-8749.
5. Pillai S. Immunoglobulin transport in B cell development. Int Rev Cytol 1991;130:1-36.
6. Aoki Y, Isselbacher KJ, Pillai S. Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells. Proc Natl Acad Sci USA 1994;91:10606-10609.
7. Aoki Y, Isselbacher KJ, Cherayil BJ, Pillai S. Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells. Proc Natl Acad Sci USA 1994;91:4204-4208.
8. Ohnishi K, Melchers F. The nonimmunoglobulin portion of λ5 mediates cell-autonomous pre-B cell receptor signaling. Nat Immunol 2003;4:849-856.
9. Fehling HJ, Krotkova A, Saint-Ruf C, von Boehmer H. Crucial role of the pre-T-cell receptor α gene in development of αβ but not γδ T cells. Nature 1995;375:795-798.
10. Shaffer AL, Schlissel MS. A truncated heavy chain protein relieves the requirement for surrogate light chains in early B cell development. J Immunol 1997;159: 1265-1275.
11. Bannish G, Fuentes-Panana EM, Cambier JC, Pear WS, Monroe JG. Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis. J Exp Med 2001;194:1583-1596.
12. von Boehmer H, et al. Thymic selection revisited: how essential is it? Immunol Rev 2003;191:62-78.
13. Cariappa A, Pillai S. Antigen-dependent B-cell development. Curr Opin Immunol 2002;14:241-249.
14. Zerrahn J, Held W, Raulet DH. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 1997;88:627-636.
15. Hao Z, Rajewsky K. Homeostasis of peripheral B cells in the absence of B cell influx from the bone marrow. J Exp Med 2001;194:1151-1164.
16. Martin F, Kearney JF. B-cell subsets and the mature preimmune repertoire. Marginal zone and B1 B cells as part of a 'natural immune memory'. Immunol Rev 2000;175:70-79.
17. high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells. J Immunol 1999;162:7198-7207.
18. Hayakawa K, Hardy RR. Development and function of B1 cells. Curr Opin Immunol 2000;12:346-353.
19. Tsukada S, et al. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 1993; 72:279-290.
20. Vetrie D, et al. The gene involved in X-linked agammaglobulinemia is a member of the src family of protein tyrosine kinases. Nature 1993;361:226-233.
21. Thomas JD, Sideras P, Smith CI, Vorechovsky I, Chapman V, Paul WE. Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science 1993;261:355-358.
22. Saouaf SJ, et al. Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement. Proc Natl Acad Sci USA 1994;91:9524-9528.
23. de Weers M, et al. B-cell antigen receptor stimulation activates the human Bruton's tyrosine kinase, which is deficient in X-linked agammaglobulinemia. J Biol Chem 1994; 269:23857-23860.
24. Khan WN, et al. Defective B cell development and function in Btk deficient mice. Immunity 1995;3:283-299.
25. Kerner JD, et al. Impaired expansion of mouse B cell progenitors lacking Btk. Immunity 1995;3:301-312.
26. Hendriks RW, deBruijn MFTR, Maas A, Dingjan GM, Karis A, Grosveld F. Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B stage. EMBO J 1996;15:4862-4872.
27. Weiss A, Littman D. Signal transduction by lymphocyte antigen receptors. Cell 1994; 76:263-274.
28. DeFranco AL. The complexity of signaling pathways activated by the BCR. Curr Opin Immunol 1997;9:296-308.
29. Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T. BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation. Immunity 2000;13:817-827.
30. O'Rourke LM, et al. CD19 as a membrane-anchored adaptor protein of B lymphocytes: costimulation of lipid and protein kinases by recruitment of Vav. Immunity 1998;8: 635-645.
31. Janssen E, Zhu M, Zhang W, Koonpaew S, Zhang W. LAB: a new membrane-associated adaptor molecule in B cell activation. Nat Immunol 2003;4:117-123.
32. Lewis CM, Broussard C, Czar MJ, Schwartzberg PL. Tec kinases: modulators of lymphocyte signaling and development. Curr Opin Immunol 2001;13:317-325.
33. Scharenberg AM, Kinet J-P. PtdIns-3,4,5-P3: a regulatory nexus between tyrosine kinases and sustained calcium signals. Cell 1998;94:5-9.
34. Pillai S, Moran ST. Tec kinase pathways in lymphocyte development and transformation. Biochim Biophys Acta 2002;1602:162-167.
35. Takata M, Kurosaki T. A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-γ2. J Exp Med 1996;184:31-40.
36. Xu S, Tan JE, Wong EP, Manickam A, Ponniah S, Lam KP. B cell development and activation defects resulting in xid-like immunodeficiency in BLNK/SLP-65-deficient mice. Int Immunol 2000;12:397-404.
37. + thymocytes, and B cell maturation. J Exp Med 1996;183: 1707-1718.
38. Pappu R, et al. Requirement for B cell linker protein (BLNK) in B cell development. Science 1999;286:1949-1954.
39. Jumaa H, Wollscheid B, Mitterer M, Wienands J, Reth M, Nielsen PJ. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity 1999;11: 547-554.
40. Yamazaki T, Takeda K, Gotoh K, Takeshima H, Akira S, Kurosaki T. Essential immunoregulatory role for BCAP in B cell development and function. J Exp Med 2002;195:535-545.
41. Wang D, et al. Phospholipase Cγ2 is essential in the functions of B cell and several Fc receptors. Immunity 2000;13:25-35.
42. Cariappa A, Kim TJ, Pillai S. Accelerated emigration of B lymphocytes in the Xid mouse. J Immunol 1999;162:4417-4423.
43. Leitges M, et al. Immunodeficiency in protein kinase cβ-deficient mice. Science 1996; 273:788-791.
44. Cariappa A, et al. The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21. Immunity 2001;14:603-615.
45. Wang JH, et al. Aiolos regulates B cell activation and maturation to effector state. Immunity 1998;9:543-554.
46. Samardzic T, Marinkovic D, Danzer CP, Gerlach J, Nitschke L, Wirth T. Reduction of marginal zone B cells in CD22-deficient mice. Eur J Immunol 2002;32:561-567.
47. Loder F, et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor derived signals. J Exp Med 1999; 190:75-89.
48. Saito T, et al. Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity 2003;18:675-685.
49. Cyster JG, Goodnow CC. Protein tyrosine phosphatase 1C negatively regulates antigen receptor signaling in B lymphocytes and determines thresholds for negative selection. Immunity 1995;2:13-24.
50. Martin F, Kearney JF. Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk. Immunity 2000;12:39-49.
51. Lam KP, Rajewsky K. B cell antigen receptor specificity and surface density together determine B1 versus B2 cell development. J Exp Med 1999;190:471-477.
52. Amano H, et al. The Yaa mutation promoting murine lupus causes defective development of marginal zone B cells. J Immunol 2003;170:2293-2301.
53. Tanigaki K, et al. Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells. Nat Immunol 2002;3:443-450.
54. Cariappa A, Liou HC, Horwitz BH, Pillai S. Nuclear factor K B is required for the development of marginal zone B lymphocytes. J Exp Med 2000;192: 1175-1182.
55. Guinamard R, Okigaki M, Schlessinger J, Ravetch JV. Absence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral response. Nat Immunol 2000;1:31-36.
56. Girkontaite I, et al. Lsc is required for marginal zone B cells, regulation of lymphocyte motility and immune responses. Nat Immunol 2001;2:855-862.
57. Fukui Y, et al. Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration. Nature 2001;412:826-831.
58. Lu TT, Cyster JG. Integrin-mediated long-term B cell retention in the splenic marginal zone. Science 2002;297:409-412.
59. Samardzic T, Marinkovic D, Nielsen PJ, Nitschke L, Wirth T. BOB. 1/OBF.1 deficiency affects marginal-zone B-cell compartment. Mol Cell Biol 2002;22:8320-8331.
60. Witt CM, Won WJ, Hurez V, Klug CA. Notch2 haploinsufficiency results in diminished B1 B cells and a severe reduction in marginal zone B cells. J Immunol 2003;171:2783-2788.
61. Kuroda K, et al. Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway. Immunity 2003;18:301-312.
62. Karlsson MC, Guinamard R, Bolland S, Sankala M, Steinman RM, Ravetch JV. Macrophages control the retention and trafficking of B lymphocytes in the splenic marginal zone. J Exp Med 2003;198: 333-340.
63. Petro JB, Rahman SM, Ballard DW, Khan WN. Bruton's tyrosine kinase is required for activation of 1KB kinase and nuclear factor KB in response to B cell receptor engagement. J Exp Med 2000;191:1745-1754.
64. Bajpai UD, Zhang K, Teutsch M, Sen R, Wortis HH. Bruton's tyrosine kinase links the B cell receptor to nuclear factor κB activation. J Exp Med 2000;191:1735-1744.
65. Petto JB, Khan WN. Phospholipase C-γ 2 couples Bruton's tyrosine kinase to the NF-κB signaling pathway in B lymphocytes. J Biol Chem 2001;276:1715-1719.
66. Yamazaki T, Kurosaki T. Contribution of BCAP to maintenance of mature B cells through c-Rel. Nat Immunol 2003;4: 780-786.
67. Tomayko MM, Cancro MP. Long-lived B cells are distinguished by elevated expression of A1. J Immunol 1998;160:107-111.
68. Chen C, Edelstein LC, Gelinas C. The Rel/NF-κK B family directly activates expression of the apoptosis inhibitor Bel-XL. Mol Cell Biol 2000;20:2687-2695.
69. Caamano JH, Rizzo CA, Durham SK, Barton DS, Raventos-Suarez C, Bravo R. NF-κB2 (p100/p52) is required for normal splenic microarchitecture and B cell mediated immune responses. J Exp Med 1998;187:185-196.
70. Franzoso G, et al. Mice deficient in NF-κB/ p52 present with defects in humoral responses, germinal center rections, and splenic microarchitecture. J Exp Med 1998; 187:147-159.
71. Senftleben U, et al. Activation by IKKα of a second, evolutionary conserved, NFκKB signaling pathway. Science 2001;293: 1495-1499.
72. Kayagaki N, et al. Baff/BLyS receptor 3 binds the B cell survival factor BAFF ligand through a discrete surface loop and promotes processing of NF-KB2. Immunity 2002;17:515-524.
73. Claudio E, Brown K, Park S, Wang H, Siebenlist U. BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells. Nat Immunol 2002;3: 958-965.
74. Dejardin E, et al. The lymphotoxin-b receptor induces different patterns of gene expression via two NF-κB pathways. Immunity 2002;17:525-535.
75. Schiemann B, et al. An essential role for BAFF in the normal development of B cells through a BCMA-independent pathway. Science 2001;293:2111-2114.
76. Hsu BL, Harless SM, Lindsley RC, Hilbert DM, Cancro MP. Cutting edge. BLyS enables survival of transitional and mature B cells through distinct mediators. J Immunol 2002;168:5993-5996.
77. Smith SH, Cancro MP. Cutting edge: B cell receptor signals regulate BLyS receptor levels in mature B cells and their immediate progenitors. J Immunol 2003;170: 5280-5283.
78. Hayakawa K, et al. Positive selection of natural autoreactive B cells. Science 1999;285:113-116.
79. Alugupalli KR, Gerstein RM, Chen J, Szomolanyi-Tsuda E, Woodland RT, Leong JM. The resolution of relapsing fever borreliosis requires IgM and is concurrent with expansion of B1 B lymphocytes. J Immunol 2003;170:3819-3827.
80. Tiegs SL, Russell DM, Nemazee D. Receptor editing in self-reactive bone-marrow B cells. J Exp Med 1993;177:1009-1020.
81. Bikah G, Carey J, Ciallella JR, Tarakhovsky A, Bondada S. CD5-mediated negative regulation of antigen receptor growth signals in B-1 B cells. Science 1996;274:1906-1909.
82. Karras JG, Wang Z, Huo L, Howard RG, Frank DA, Rothstein TL. STAT3 is constitutively activated in normal, self-renewing B1 cells, but only inducibly expressed in conventional B1 lymphocytes. J Exp Med 1997;185:1035-1042.
83. Morris DL, Rothstein TL. Abnormal transcription factor induction through the surface immunoglobulin M receptor of B1 lymphocytes. J Exp Med 1993;177:857-861.
84. Carvalho TL, Mota-Santos T, Cumano A, Demengeot J, Vieira P. Arrested B lymphopoiesis and persistence of activated B cells in adult interleukin 7(-/-) mice. J Exp Med 2001;194:1141-1150.
85. Wortis H, Teutsch M, Higer M, Zheng J, Parker DC. B-cell activation by crosslinking of surface IgM or ligation of CD40 involves alternative signal pathways and results in different B cell phenotypes. Proc Natl Acad Sci USA 1995;92:3348-3352.
86. Wortis HH, Berland R. Cutting edge commentary: origins of B1 cells. J Immunol 2001;166:2163-2166.
87. Su TT, et al. PKC-b controls 1κB kinase lipid raft recruitment and activation in response to BCR signaling. Nat Immunol 2002;3:780-786.
88. Pomerantz JL, Denny EM, Baltimore D. CARD11 mediates factor-specific activation of NF-κB by the T cell receptor complex. EMBO J 2002;21:5184-5194.
89. Ruland J, et al. Bcl10 is a positive regulator of antigen receptor-induced activation of NF-κB and neural tube closure. Cell 2001;104:33-42.
90. Liquan X, et al. Defective development and function of Bcl10-deficient follicular, marginal zone and B1 B cells. Nat Immunol 2003;4:857-865.
91. Chen L, Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S. Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase. J Biol Chem 2001;276:21737-21744.
92. Moran ST, Haider K, Ow Y, Milton P, Chen L, Pillai S. Protein kinase C-associated kinase can activate NF-κB in both a kinase-dependent and a kinase-independent manner. J Biol Chem 2003;278:21526-21533.
93. Cariappa A, et al. A catalytically inactive form of protein kinase C-associated kinase/ receptor interacting protein 4, a protein kinase Cβ-associated kinase that mediates NF-κB activation, interferes with early B cell development. J Immunol 2003:171: 1875-1880.