-
1
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol 1995, 155:1151-1164.
-
(1995)
J Immunol
, vol.155
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
Itoh, M.4
Toda, M.5
-
2
-
-
0036345337
-
Origin of regulatory T cells with known specificity for antigen
-
[Epub 2002 Jul 2001]
-
Apostolou I., Sarukhan A., Klein L., von Boehmer H. Origin of regulatory T cells with known specificity for antigen. Nat Immunol 2002, 3:756-763. [Epub 2002 Jul 2001].
-
(2002)
Nat Immunol
, vol.3
, pp. 756-763
-
-
Apostolou, I.1
Sarukhan, A.2
Klein, L.3
von Boehmer, H.4
-
3
-
-
0037120053
-
Interleukin 2 signaling is required for CD4(+) regulatory T cell function
-
Furtado G.C., Curotto de Lafaille M.A., Kutchukhidze N., Lafaille J.J. Interleukin 2 signaling is required for CD4(+) regulatory T cell function. J Exp Med 2002, 196:851-857.
-
(2002)
J Exp Med
, vol.196
, pp. 851-857
-
-
Furtado, G.C.1
Curotto de Lafaille, M.A.2
Kutchukhidze, N.3
Lafaille, J.J.4
-
4
-
-
0037385330
-
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
-
Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003, 4:330-336.
-
(2003)
Nat Immunol
, vol.4
, pp. 330-336
-
-
Fontenot, J.D.1
Gavin, M.A.2
Rudensky, A.Y.3
-
5
-
-
0347785480
-
Control of regulatory T cell development by the transcription factor Foxp3
-
Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
-
(2003)
Science
, vol.299
, pp. 1057-1061
-
-
Hori, S.1
Nomura, T.2
Sakaguchi, S.3
-
6
-
-
0037385314
-
An essential role for Scurfin in CD4+CD25+ T regulatory cells
-
Khattri R., Cox T., Yasayko S.A., Ramsdell F. An essential role for Scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003, 4:337-342.
-
(2003)
Nat Immunol
, vol.4
, pp. 337-342
-
-
Khattri, R.1
Cox, T.2
Yasayko, S.A.3
Ramsdell, F.4
-
7
-
-
0348223787
-
Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
-
Chen W., Jin W., Hardegen N., et al. Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003, 198:1875-1886.
-
(2003)
J Exp Med
, vol.198
, pp. 1875-1886
-
-
Chen, W.1
Jin, W.2
Hardegen, N.3
-
8
-
-
2142645808
-
Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7
-
Fantini M.C., Becker C., Monteleone G., Pallone F., Galle P.R., Neurath M.F. Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7. J Immunol 2004, 172:5149-5153.
-
(2004)
J Immunol
, vol.172
, pp. 5149-5153
-
-
Fantini, M.C.1
Becker, C.2
Monteleone, G.3
Pallone, F.4
Galle, P.R.5
Neurath, M.F.6
-
9
-
-
4744356110
-
TGF-beta induces Foxp3+ T-regulatory cells from CD4+CD25- precursors
-
Fu S., Zhang N., Yopp A.C., et al. TGF-beta induces Foxp3+ T-regulatory cells from CD4+CD25- precursors. Am J Transplant 2004, 4:1614-1627.
-
(2004)
Am J Transplant
, vol.4
, pp. 1614-1627
-
-
Fu, S.1
Zhang, N.2
Yopp, A.C.3
-
10
-
-
33947644716
-
Cutting edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells
-
Davidson T.S., DiPaolo R.J., Andersson J., Shevach E.M. Cutting edge: IL-2 is essential for TGF-beta-mediated induction of Foxp3+ T regulatory cells. J Immunol 2007, 178:4022-4026.
-
(2007)
J Immunol
, vol.178
, pp. 4022-4026
-
-
Davidson, T.S.1
DiPaolo, R.J.2
Andersson, J.3
Shevach, E.M.4
-
11
-
-
33644835247
-
TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells
-
Zheng S.G., Wang J.H., Stohl W., Kim K.S., Gray J.D., Horwitz D.A. TGF-beta requires CTLA-4 early after T cell activation to induce FoxP3 and generate adaptive CD4+CD25+ regulatory cells. J Immunol 2006, 176:3321-3329.
-
(2006)
J Immunol
, vol.176
, pp. 3321-3329
-
-
Zheng, S.G.1
Wang, J.H.2
Stohl, W.3
Kim, K.S.4
Gray, J.D.5
Horwitz, D.A.6
-
12
-
-
17144400393
-
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells
-
Marie J.C., Letterio J.J., Gavin M., Rudensky A.Y. TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J Exp Med 2005, 201:1061-1067.
-
(2005)
J Exp Med
, vol.201
, pp. 1061-1067
-
-
Marie, J.C.1
Letterio, J.J.2
Gavin, M.3
Rudensky, A.Y.4
-
13
-
-
0034678908
-
Transcriptional control by the TGF-beta/Smad signaling system
-
Massague J., Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J 2000, 19:1745-1754.
-
(2000)
EMBO J
, vol.19
, pp. 1745-1754
-
-
Massague, J.1
Wotton, D.2
-
14
-
-
38349095578
-
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer
-
Tone Y., Furuuchi K., Kojima Y., Tykocinski M.L., Greene M.I., Tone M. Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat Immunol 2008, 9:194-202.
-
(2008)
Nat Immunol
, vol.9
, pp. 194-202
-
-
Tone, Y.1
Furuuchi, K.2
Kojima, Y.3
Tykocinski, M.L.4
Greene, M.I.5
Tone, M.6
-
15
-
-
0034596993
-
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta
-
Feng X.H., Lin X., Derynck R. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J 2000, 19:5178-5193.
-
(2000)
EMBO J
, vol.19
, pp. 5178-5193
-
-
Feng, X.H.1
Lin, X.2
Derynck, R.3
-
16
-
-
0032572723
-
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription
-
Zhang Y., Feng X.H., Derynck R. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-beta-induced transcription. Nature 1998, 394:909-913.
-
(1998)
Nature
, vol.394
, pp. 909-913
-
-
Zhang, Y.1
Feng, X.H.2
Derynck, R.3
-
17
-
-
33644844341
-
Molecular mechanisms underlying FOXP3 induction in human T cells
-
Mantel P.Y., Ouaked N., Ruckert B., et al. Molecular mechanisms underlying FOXP3 induction in human T cells. J Immunol 2006, 176:3593-3602.
-
(2006)
J Immunol
, vol.176
, pp. 3593-3602
-
-
Mantel, P.Y.1
Ouaked, N.2
Ruckert, B.3
-
18
-
-
4544357207
-
TGFbeta regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo
-
Schramm C., Huber S., Protschka M., et al. TGFbeta regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo. Int Immunol 2004, 16:1241-1249.
-
(2004)
Int Immunol
, vol.16
, pp. 1241-1249
-
-
Schramm, C.1
Huber, S.2
Protschka, M.3
-
19
-
-
0033485401
-
Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells
-
McDonald P.P., Fadok V.A., Bratton D., Henson P.M. Transcriptional and translational regulation of inflammatory mediator production by endogenous TGF-beta in macrophages that have ingested apoptotic cells. J Immunol 1999, 163:6164-6172.
-
(1999)
J Immunol
, vol.163
, pp. 6164-6172
-
-
McDonald, P.P.1
Fadok, V.A.2
Bratton, D.3
Henson, P.M.4
-
20
-
-
33947615039
-
Cutting edge: immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-beta-dependent manner
-
Gandhi R., Anderson D.E., Weiner H.L. Cutting edge: immature human dendritic cells express latency-associated peptide and inhibit T cell activation in a TGF-beta-dependent manner. J Immunol 2007, 178:4017-4021.
-
(2007)
J Immunol
, vol.178
, pp. 4017-4021
-
-
Gandhi, R.1
Anderson, D.E.2
Weiner, H.L.3
-
21
-
-
77954096689
-
IL-6: regulator of Treg/Th17 balance
-
Kimura A., Kishimoto T. IL-6: regulator of Treg/Th17 balance. Eur J Immunol 2010, 40:1830-1835.
-
(2010)
Eur J Immunol
, vol.40
, pp. 1830-1835
-
-
Kimura, A.1
Kishimoto, T.2
-
22
-
-
79251543298
-
The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells
-
Fujimoto M., Nakano M., Terabe F., et al. The influence of excessive IL-6 production in vivo on the development and function of Foxp3+ regulatory T cells. J Immunol 2011, 186:32-40.
-
(2011)
J Immunol
, vol.186
, pp. 32-40
-
-
Fujimoto, M.1
Nakano, M.2
Terabe, F.3
-
23
-
-
34447511609
-
IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state
-
Nishihara M., Ogura H., Ueda N., et al. IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state. Int Immunol 2007, 19:695-702.
-
(2007)
Int Immunol
, vol.19
, pp. 695-702
-
-
Nishihara, M.1
Ogura, H.2
Ueda, N.3
-
24
-
-
34547232503
-
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
-
Korn T., Bettelli E., Gao W., et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 2007, 448:484-487.
-
(2007)
Nature
, vol.448
, pp. 484-487
-
-
Korn, T.1
Bettelli, E.2
Gao, W.3
-
25
-
-
47249166438
-
Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6
-
Zheng S.G., Wang J., Horwitz D.A. Cutting edge: Foxp3+CD4+CD25+ regulatory T cells induced by IL-2 and TGF-beta are resistant to Th17 conversion by IL-6. J Immunol 2008, 180:7112-7116.
-
(2008)
J Immunol
, vol.180
, pp. 7112-7116
-
-
Zheng, S.G.1
Wang, J.2
Horwitz, D.A.3
-
26
-
-
0037436119
-
Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
-
Pasare C., Medzhitov R. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003, 299:1033-1036.
-
(2003)
Science
, vol.299
, pp. 1033-1036
-
-
Pasare, C.1
Medzhitov, R.2
-
27
-
-
42649115767
-
TH17 cells in development: an updated view of their molecular identity and genetic programming
-
Dong C. TH17 cells in development: an updated view of their molecular identity and genetic programming. Nat Rev Immunol 2008, 8:337-348.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 337-348
-
-
Dong, C.1
-
28
-
-
69049107358
-
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo
-
Zhou X., Bailey-Bucktrout S.L., Jeker L.T., et al. Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol 2009, 10:1000-1007.
-
(2009)
Nat Immunol
, vol.10
, pp. 1000-1007
-
-
Zhou, X.1
Bailey-Bucktrout, S.L.2
Jeker, L.T.3
-
29
-
-
32244442562
-
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
-
Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006, 24:179-189.
-
(2006)
Immunity
, vol.24
, pp. 179-189
-
-
Veldhoen, M.1
Hocking, R.J.2
Atkins, C.J.3
Locksley, R.M.4
Stockinger, B.5
-
30
-
-
33845948381
-
IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+ T cell regulatory functions
-
Wan S., Xia C., Morel L. IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+ T cell regulatory functions. J Immunol 2007, 178:271-279.
-
(2007)
J Immunol
, vol.178
, pp. 271-279
-
-
Wan, S.1
Xia, C.2
Morel, L.3
-
31
-
-
33646577466
-
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
-
Bettelli E., Carrier Y., Gao W., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006, 441:235-238.
-
(2006)
Nature
, vol.441
, pp. 235-238
-
-
Bettelli, E.1
Carrier, Y.2
Gao, W.3
-
32
-
-
34848876937
-
Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells
-
Dominitzki S., Fantini M.C., Neufert C., et al. Cutting edge: trans-signaling via the soluble IL-6R abrogates the induction of FoxP3 in naive CD4+CD25 T cells. J Immunol 2007, 179:2041-2045.
-
(2007)
J Immunol
, vol.179
, pp. 2041-2045
-
-
Dominitzki, S.1
Fantini, M.C.2
Neufert, C.3
-
33
-
-
52949138267
-
TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3
-
Samanta A., Li B., Song X., et al. TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc Natl Acad Sci U S A 2008, 105:14023-14027.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 14023-14027
-
-
Samanta, A.1
Li, B.2
Song, X.3
-
34
-
-
66649115650
-
Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t
-
Ayyoub M., Deknuydt F., Raimbaud I., et al. Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the T(H)17 lineage-specific transcription factor RORgamma t. Proc Natl Acad Sci U S A 2009, 106:8635-8640.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 8635-8640
-
-
Ayyoub, M.1
Deknuydt, F.2
Raimbaud, I.3
-
35
-
-
55149094300
-
Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
-
Koenen H.J., Smeets R.L., Vink P.M., van Rijssen E., Boots A.M., Joosten I. Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells. Blood 2008, 112:2340-2352.
-
(2008)
Blood
, vol.112
, pp. 2340-2352
-
-
Koenen, H.J.1
Smeets, R.L.2
Vink, P.M.3
van Rijssen, E.4
Boots, A.M.5
Joosten, I.6
-
36
-
-
63849183918
-
Identification of IL-17-producing FOXP3+ regulatory T cells in humans
-
Voo K.S., Wang Y.H., Santori F.R., et al. Identification of IL-17-producing FOXP3+ regulatory T cells in humans. Proc Natl Acad Sci U S A 2009, 106:4793-4798.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 4793-4798
-
-
Voo, K.S.1
Wang, Y.H.2
Santori, F.R.3
-
37
-
-
72449188166
-
Regulatory T cell counter-regulation by innate immunity is a barrier to transplantation tolerance
-
Kim J.I., Lee M.K., Moore D.J., et al. Regulatory T cell counter-regulation by innate immunity is a barrier to transplantation tolerance. Am J Transplant 2009, 9:1-9.
-
(2009)
Am J Transplant
, vol.9
, pp. 1-9
-
-
Kim, J.I.1
Lee, M.K.2
Moore, D.J.3
-
38
-
-
59849093427
-
Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation
-
Chauhan S.K., Saban D.R., Lee H.K., Dana R. Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation. J Immunol 2009, 182:148-153.
-
(2009)
J Immunol
, vol.182
, pp. 148-153
-
-
Chauhan, S.K.1
Saban, D.R.2
Lee, H.K.3
Dana, R.4
-
39
-
-
33847125247
-
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
-
Wan Y.Y., Flavell R.A. Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007, 445:766-770.
-
(2007)
Nature
, vol.445
, pp. 766-770
-
-
Wan, Y.Y.1
Flavell, R.A.2
-
40
-
-
34247271308
-
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
-
Williams L.M., Rudensky A.Y. Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol 2007, 8:277-284.
-
(2007)
Nat Immunol
, vol.8
, pp. 277-284
-
-
Williams, L.M.1
Rudensky, A.Y.2
-
41
-
-
65649131286
-
IL-6 and TNF-alpha synergistically inhibit allograft acceptance
-
Shen H., Goldstein D.R. IL-6 and TNF-alpha synergistically inhibit allograft acceptance. J Am Soc Nephrol 2009, 20:1032-1040.
-
(2009)
J Am Soc Nephrol
, vol.20
, pp. 1032-1040
-
-
Shen, H.1
Goldstein, D.R.2
-
42
-
-
0032213273
-
Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice
-
Takeda K., Kaisho T., Yoshida N., Takeda J., Kishimoto T., Akira S. Stat3 activation is responsible for IL-6-dependent T cell proliferation through preventing apoptosis: generation and characterization of T cell-specific Stat3-deficient mice. J Immunol 1998, 161:4652-4660.
-
(1998)
J Immunol
, vol.161
, pp. 4652-4660
-
-
Takeda, K.1
Kaisho, T.2
Yoshida, N.3
Takeda, J.4
Kishimoto, T.5
Akira, S.6
-
43
-
-
6344279933
-
Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells
-
Stephens G.L., McHugh R.S., Whitters M.J., et al. Engagement of glucocorticoid-induced TNFR family-related receptor on effector T cells by its ligand mediates resistance to suppression by CD4+CD25+ T cells. J Immunol 2004, 173:5008-5020.
-
(2004)
J Immunol
, vol.173
, pp. 5008-5020
-
-
Stephens, G.L.1
McHugh, R.S.2
Whitters, M.J.3
-
44
-
-
0345598872
-
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells
-
Tone M., Tone Y., Adams E., et al. Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc Natl Acad Sci U S A 2003, 100:15059-15064.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15059-15064
-
-
Tone, M.1
Tone, Y.2
Adams, E.3
-
45
-
-
24644515759
-
In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology
-
Suvas S., Kim B., Sarangi P.P., Tone M., Waldmann H., Rouse B.T. In vivo kinetics of GITR and GITR ligand expression and their functional significance in regulating viral immunopathology. J Virol 2005, 79:11935-11942.
-
(2005)
J Virol
, vol.79
, pp. 11935-11942
-
-
Suvas, S.1
Kim, B.2
Sarangi, P.P.3
Tone, M.4
Waldmann, H.5
Rouse, B.T.6
-
46
-
-
0036195161
-
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor
-
McHugh R.S., Whitters M.J., Piccirillo C.A., et al. CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity 2002, 16:311-323.
-
(2002)
Immunity
, vol.16
, pp. 311-323
-
-
McHugh, R.S.1
Whitters, M.J.2
Piccirillo, C.A.3
-
47
-
-
0036170938
-
Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance
-
Shimizu J., Yamazaki S., Takahashi T., Ishida Y., Sakaguchi S. Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance. Nat Immunol 2002, 3:135-142.
-
(2002)
Nat Immunol
, vol.3
, pp. 135-142
-
-
Shimizu, J.1
Yamazaki, S.2
Takahashi, T.3
Ishida, Y.4
Sakaguchi, S.5
-
48
-
-
0030962132
-
A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis
-
Nocentini G., Giunchi L., Ronchetti S., et al. A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis. Proc Natl Acad Sci U S A 1997, 94:6216-6221.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 6216-6221
-
-
Nocentini, G.1
Giunchi, L.2
Ronchetti, S.3
-
49
-
-
2942532501
-
Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells
-
Kanamaru F., Youngnak P., Hashiguchi M., et al. Costimulation via glucocorticoid-induced TNF receptor in both conventional and CD25+ regulatory CD4+ T cells. J Immunol 2004, 172:7306-7314.
-
(2004)
J Immunol
, vol.172
, pp. 7306-7314
-
-
Kanamaru, F.1
Youngnak, P.2
Hashiguchi, M.3
-
50
-
-
1842424807
-
Cutting edge: ligation of the glucocorticoid-induced TNF receptor enhances autoreactive CD4+ T cell activation and experimental autoimmune encephalomyelitis
-
Kohm A.P., Williams J.S., Miller S.D. Cutting edge: ligation of the glucocorticoid-induced TNF receptor enhances autoreactive CD4+ T cell activation and experimental autoimmune encephalomyelitis. J Immunol 2004, 172:4686-4690.
-
(2004)
J Immunol
, vol.172
, pp. 4686-4690
-
-
Kohm, A.P.1
Williams, J.S.2
Miller, S.D.3
-
51
-
-
33947667952
-
GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function
-
Bushell A., Wood K. GITR ligation blocks allograft protection by induced CD25+CD4+ regulatory T cells without enhancing effector T-cell function. Am J Transplant 2007, 7:759-768.
-
(2007)
Am J Transplant
, vol.7
, pp. 759-768
-
-
Bushell, A.1
Wood, K.2
-
52
-
-
77951742201
-
Blockade of GITR-GITRL interaction maintains regulatory T cell function to prolong allograft survival
-
[in press]
-
Kim J., Sonawane S., Lee M.K., et al. Blockade of GITR-GITRL interaction maintains regulatory T cell function to prolong allograft survival. Eur J Immunol 2010, [in press].
-
(2010)
Eur J Immunol
-
-
Kim, J.1
Sonawane, S.2
Lee, M.K.3
-
53
-
-
73849110532
-
GITR blockade facilitates Treg mediated allograft survival
-
Sonawane S.B., Kim J.I., Lee M.K., et al. GITR blockade facilitates Treg mediated allograft survival. Transplantation 2009, 88:1169-1177.
-
(2009)
Transplantation
, vol.88
, pp. 1169-1177
-
-
Sonawane, S.B.1
Kim, J.I.2
Lee, M.K.3
-
54
-
-
0033602151
-
Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR
-
Gurney A.L., Marsters S.A., Huang R.M., et al. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr Biol 1999, 9:215-218.
-
(1999)
Curr Biol
, vol.9
, pp. 215-218
-
-
Gurney, A.L.1
Marsters, S.A.2
Huang, R.M.3
-
55
-
-
34249725559
-
Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy
-
Grohmann U., Volpi C., Fallarino F., et al. Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. Nat Med 2007, 13:579-586.
-
(2007)
Nat Med
, vol.13
, pp. 579-586
-
-
Grohmann, U.1
Volpi, C.2
Fallarino, F.3
-
56
-
-
49649085838
-
Mechanisms underlying blockade of allograft acceptance by TLR ligands
-
Porrett P.M., Yuan X., LaRosa D.F., et al. Mechanisms underlying blockade of allograft acceptance by TLR ligands. J Immunol 2008, 181:1692-1699.
-
(2008)
J Immunol
, vol.181
, pp. 1692-1699
-
-
Porrett, P.M.1
Yuan, X.2
LaRosa, D.F.3
-
57
-
-
8444245925
-
Toll-dependent control mechanisms of CD4 T cell activation
-
Pasare C., Medzhitov R. Toll-dependent control mechanisms of CD4 T cell activation. Immunity 2004, 21:733-741.
-
(2004)
Immunity
, vol.21
, pp. 733-741
-
-
Pasare, C.1
Medzhitov, R.2
-
58
-
-
27844541797
-
Control of B-cell responses by Toll-like receptors
-
Pasare C., Medzhitov R. Control of B-cell responses by Toll-like receptors. Nature 2005, 438:364-368.
-
(2005)
Nature
, vol.438
, pp. 364-368
-
-
Pasare, C.1
Medzhitov, R.2
-
59
-
-
31144479123
-
TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts
-
Thornley T.B., Brehm M.A., Markees T.G., et al. TLR agonists abrogate costimulation blockade-induced prolongation of skin allografts. J Immunol 2006, 176:1561-1570.
-
(2006)
J Immunol
, vol.176
, pp. 1561-1570
-
-
Thornley, T.B.1
Brehm, M.A.2
Markees, T.G.3
-
60
-
-
0037974914
-
Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection
-
Goldstein D.R., Tesar B.M., Akira S., Lakkis F.G. Critical role of the Toll-like receptor signal adaptor protein MyD88 in acute allograft rejection. J Clin Invest 2003, 111:1571-1578.
-
(2003)
J Clin Invest
, vol.111
, pp. 1571-1578
-
-
Goldstein, D.R.1
Tesar, B.M.2
Akira, S.3
Lakkis, F.G.4
-
61
-
-
38449109678
-
Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance
-
Thornley T.B., Phillips N.E., Beaudette-Zlatanova B.C., et al. Type 1 IFN mediates cross-talk between innate and adaptive immunity that abrogates transplantation tolerance. J Immunol 2007, 179:6620-6629.
-
(2007)
J Immunol
, vol.179
, pp. 6620-6629
-
-
Thornley, T.B.1
Phillips, N.E.2
Beaudette-Zlatanova, B.C.3
-
62
-
-
33646472267
-
CD4+ T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent
-
Zhai Y., Meng L., Gao F., Wang Y., Busuttil R.W., Kupiec-Weglinski J.W. CD4+ T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent. J Immunol 2006, 176:5988-5994.
-
(2006)
J Immunol
, vol.176
, pp. 5988-5994
-
-
Zhai, Y.1
Meng, L.2
Gao, F.3
Wang, Y.4
Busuttil, R.W.5
Kupiec-Weglinski, J.W.6
-
63
-
-
33749515463
-
Absence of innate MyD88 signaling promotes inducible allograft acceptance
-
Walker W.E., Nasr I.W., Camirand G., Tesar B.M., Booth C.J., Goldstein D.R. Absence of innate MyD88 signaling promotes inducible allograft acceptance. J Immunol 2006, 177:5307-5316.
-
(2006)
J Immunol
, vol.177
, pp. 5307-5316
-
-
Walker, W.E.1
Nasr, I.W.2
Camirand, G.3
Tesar, B.M.4
Booth, C.J.5
Goldstein, D.R.6
-
64
-
-
33748490733
-
TLR engagement prevents transplantation tolerance
-
Chen L., Wang T., Zhou P., et al. TLR engagement prevents transplantation tolerance. Am J Transplant 2006, 6:2282-2291.
-
(2006)
Am J Transplant
, vol.6
, pp. 2282-2291
-
-
Chen, L.1
Wang, T.2
Zhou, P.3
-
65
-
-
70149101645
-
IDO activates regulatory T cells and blocks their conversion into Th17-like T cells
-
Baban B., Chandler P.R., Sharma M.D., et al. IDO activates regulatory T cells and blocks their conversion into Th17-like T cells. J Immunol 2009, 183:2475-2483.
-
(2009)
J Immunol
, vol.183
, pp. 2475-2483
-
-
Baban, B.1
Chandler, P.R.2
Sharma, M.D.3
-
66
-
-
0030474264
-
Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
-
Hancock W.W., Sayegh M.H., Zheng X.G., Peach R., Linsley P.S., Turka L.A. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci U S A 1996, 93:13967-13972.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 13967-13972
-
-
Hancock, W.W.1
Sayegh, M.H.2
Zheng, X.G.3
Peach, R.4
Linsley, P.S.5
Turka, L.A.6
-
67
-
-
0032996025
-
Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
-
Kirk A.D., Burkly L.C., Batty D.S., et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999, 5:686-693.
-
(1999)
Nat Med
, vol.5
, pp. 686-693
-
-
Kirk, A.D.1
Burkly, L.C.2
Batty, D.S.3
-
68
-
-
15844404353
-
Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
-
Larsen C.P., Elwood E.T., Alexander D.Z., et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996, 381:434-438.
-
(1996)
Nature
, vol.381
, pp. 434-438
-
-
Larsen, C.P.1
Elwood, E.T.2
Alexander, D.Z.3
-
69
-
-
0035082145
-
Prolonged survival of allogeneic islet grafts in NOD mice treated with a combination of anti-CD45RB and anti-CD154 antibodies
-
Molano R.D., Berney T., Pileggi A., et al. Prolonged survival of allogeneic islet grafts in NOD mice treated with a combination of anti-CD45RB and anti-CD154 antibodies. Transplant Proc 2001, 33:248-249.
-
(2001)
Transplant Proc
, vol.33
, pp. 248-249
-
-
Molano, R.D.1
Berney, T.2
Pileggi, A.3
-
70
-
-
0242660129
-
CD154 on the surface of CD4+CD25+ regulatory T cells contributes to skin transplant tolerance
-
Jarvinen L.Z., Blazar B.R., Adeyi O.A., Strom T.B., Noelle R.J. CD154 on the surface of CD4+CD25+ regulatory T cells contributes to skin transplant tolerance. Transplantation 2003, 76:1375-1379.
-
(2003)
Transplantation
, vol.76
, pp. 1375-1379
-
-
Jarvinen, L.Z.1
Blazar, B.R.2
Adeyi, O.A.3
Strom, T.B.4
Noelle, R.J.5
-
71
-
-
43449093152
-
Differential impact of CD154 costimulation blockade on alloreactive effector and regulatory T cells in murine renal transplant recipients
-
Meng L., Wu Z., Wang Y., et al. Differential impact of CD154 costimulation blockade on alloreactive effector and regulatory T cells in murine renal transplant recipients. Transplantation 2008, 85:1332-1338.
-
(2008)
Transplantation
, vol.85
, pp. 1332-1338
-
-
Meng, L.1
Wu, Z.2
Wang, Y.3
-
72
-
-
0025819340
-
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers
-
Chan S.H., Perussia B., Gupta J.W., et al. Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers. J Exp Med 1991, 173:869-879.
-
(1991)
J Exp Med
, vol.173
, pp. 869-879
-
-
Chan, S.H.1
Perussia, B.2
Gupta, J.W.3
-
73
-
-
0033970867
-
Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells
-
Fukao T., Matsuda S., Koyasu S. Synergistic effects of IL-4 and IL-18 on IL-12-dependent IFN-gamma production by dendritic cells. J Immunol 2000, 164:64-71.
-
(2000)
J Immunol
, vol.164
, pp. 64-71
-
-
Fukao, T.1
Matsuda, S.2
Koyasu, S.3
-
74
-
-
0037097540
-
Role of IFN-gamma in Th1 differentiation: IFN-gamma regulates IL-18R alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression
-
Smeltz R.B., Chen J., Ehrhardt R., Shevach E.M. Role of IFN-gamma in Th1 differentiation: IFN-gamma regulates IL-18R alpha expression by preventing the negative effects of IL-4 and by inducing/maintaining IL-12 receptor beta 2 expression. J Immunol 2002, 168:6165-6172.
-
(2002)
J Immunol
, vol.168
, pp. 6165-6172
-
-
Smeltz, R.B.1
Chen, J.2
Ehrhardt, R.3
Shevach, E.M.4
-
75
-
-
0034677646
-
A novel transcription factor, T-bet, directs Th1 lineage commitment
-
Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000, 100:655-669.
-
(2000)
Cell
, vol.100
, pp. 655-669
-
-
Szabo, S.J.1
Kim, S.T.2
Costa, G.L.3
Zhang, X.4
Fathman, C.G.5
Glimcher, L.H.6
-
76
-
-
65749103365
-
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
-
Koch M.A., Tucker-Heard G., Perdue N.R., Killebrew J.R., Urdahl K.B., Campbell D.J. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 2009, 10:595-602.
-
(2009)
Nat Immunol
, vol.10
, pp. 595-602
-
-
Koch, M.A.1
Tucker-Heard, G.2
Perdue, N.R.3
Killebrew, J.R.4
Urdahl, K.B.5
Campbell, D.J.6
-
77
-
-
70049098536
-
Regulatory T cells reinforce intestinal homeostasis
-
Barnes M.J., Powrie F. Regulatory T cells reinforce intestinal homeostasis. Immunity 2009, 31:401-411.
-
(2009)
Immunity
, vol.31
, pp. 401-411
-
-
Barnes, M.J.1
Powrie, F.2
-
78
-
-
62649165369
-
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
-
Zheng Y., Chaudhry A., Kas A., et al. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 2009, 458:351-356.
-
(2009)
Nature
, vol.458
, pp. 351-356
-
-
Zheng, Y.1
Chaudhry, A.2
Kas, A.3
|