메뉴 건너뛰기




Volumn 85, Issue 9, 2008, Pages 1332-1338

Differential impact of CD154 costimulation blockade on alloreactive effector and regulatory T cells in murine renal transplant recipients

Author keywords

CD154 costimulation; Kidney transplantation; Treg

Indexed keywords

CD40 LIGAND MONOCLONAL ANTIBODY; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; GRANZYME B;

EID: 43449093152     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31816c4f2b     Document Type: Article
Times cited : (29)

References (47)
  • 1
    • 0026528181 scopus 로고
    • Molecular and biological characterization of a murine ligand for CD40
    • Armitage RJ, Fanslow WC, Strockbine L, et al. Molecular and biological characterization of a murine ligand for CD40. Nature 1992; 357: 80.
    • (1992) Nature , vol.357 , pp. 80
    • Armitage, R.J.1    Fanslow, W.C.2    Strockbine, L.3
  • 2
    • 0031944607 scopus 로고    scopus 로고
    • CD40 and CD154 in cell-mediated immunity
    • Grewal IS, Flavell RA. CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 1998; 16: 111.
    • (1998) Annu Rev Immunol , vol.16 , pp. 111
    • Grewal, I.S.1    Flavell, R.A.2
  • 3
    • 0026476032 scopus 로고
    • CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation
    • Noelle RJ, Ledbetter JA, Aruffo A. CD40 and its ligand, an essential ligand-receptor pair for thymus-dependent B-cell activation. Immunol Today 1992; 13: 431.
    • (1992) Immunol Today , vol.13 , pp. 431
    • Noelle, R.J.1    Ledbetter, J.A.2    Aruffo, A.3
  • 4
    • 0035145720 scopus 로고    scopus 로고
    • Prolonged islet graft survival in NOD mice by blockade of the CD40-CD154 pathway of T-cell costimulation
    • Molano RD, Berney T, Li H, et al. Prolonged islet graft survival in NOD mice by blockade of the CD40-CD154 pathway of T-cell costimulation. Diabetes 2001; 50: 270.
    • (2001) Diabetes , vol.50 , pp. 270
    • Molano, R.D.1    Berney, T.2    Li, H.3
  • 5
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434.
    • (1996) Nature , vol.381 , pp. 434
    • Larsen, C.P.1    Elwood, E.T.2    Alexander, D.Z.3
  • 6
    • 0030046808 scopus 로고    scopus 로고
    • CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway
    • Larsen CP, Alexander DZ, Hollenbaugh D, et al. CD40-gp39 interactions play a critical role during allograft rejection. Suppression of allograft rejection by blockade of the CD40-gp39 pathway. Transplantation 1996; 61: 4.
    • (1996) Transplantation , vol.61 , pp. 4
    • Larsen, C.P.1    Alexander, D.Z.2    Hollenbaugh, D.3
  • 7
    • 0032996025 scopus 로고    scopus 로고
    • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
    • Kirk AD, Burkly LC, Batty DS, et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999; 5: 686.
    • (1999) Nat Med , vol.5 , pp. 686
    • Kirk, A.D.1    Burkly, L.C.2    Batty, D.S.3
  • 8
    • 0030474264 scopus 로고    scopus 로고
    • Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
    • Hancock WW, Sayegh MH, Zheng XG, et al. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci USA 1996; 93: 13967.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13967
    • Hancock, W.W.1    Sayegh, M.H.2    Zheng, X.G.3
  • 9
    • 0033917737 scopus 로고    scopus 로고
    • The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo
    • Kishimoto K, Dong VM, Issazadeh S, et al. The role of CD154-CD40 versus CD28-B7 costimulatory pathways in regulating allogeneic Th1 and Th2 responses in vivo. J Clin Invest 2000; 106: 63.
    • (2000) J Clin Invest , vol.106 , pp. 63
    • Kishimoto, K.1    Dong, V.M.2    Issazadeh, S.3
  • 10
    • 0033379266 scopus 로고    scopus 로고
    • Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection
    • Trambley J, Bingaman AW, Lin A, et al. Asialo GM1(+) CD8(+) T cells play a critical role in costimulation blockade-resistant allograft rejection. J Clin Invest 1999; 104: 1715.
    • (1999) J Clin Invest , vol.104 , pp. 1715
    • Trambley, J.1    Bingaman, A.W.2    Lin, A.3
  • 11
    • 0034662277 scopus 로고    scopus 로고
    • CD40-CD40 ligand-independent activation of CD8+T cells can trigger allograft rejection
    • Jones ND, Van Maurik A, Hara M, et al. CD40-CD40 ligand-independent activation of CD8+T cells can trigger allograft rejection. J Immunol 2000; 165: 1111.
    • (2000) J Immunol , vol.165 , pp. 1111
    • Jones, N.D.1    Van Maurik, A.2    Hara, M.3
  • 12
    • 0035872724 scopus 로고    scopus 로고
    • CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway
    • Guo Z, Meng L, Kim O, et al. CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway. Transplantation 2001; 71: 1351.
    • (2001) Transplantation , vol.71 , pp. 1351
    • Guo, Z.1    Meng, L.2    Kim, O.3
  • 13
    • 0035284893 scopus 로고    scopus 로고
    • Immunobiology of allograft rejection in the absence of IFN-gamma: CD8+ effector cells develop independently of CD4+cells and CD40-CD40 ligand interactions
    • Bishop DK, Chan Wood S, Eichwald EJ, et al. Immunobiology of allograft rejection in the absence of IFN-gamma: CD8+ effector cells develop independently of CD4+cells and CD40-CD40 ligand interactions. J Immunol 2001; 166: 3248.
    • (2001) J Immunol , vol.166 , pp. 3248
    • Bishop, D.K.1    Chan Wood, S.2    Eichwald, E.J.3
  • 14
    • 0034720744 scopus 로고    scopus 로고
    • CD8+ T cells contribute to the development of transplant arteriosclerosis despite CD154 blockade
    • Ensminger SM, Witzke O, Spriewald BM, et al. CD8+ T cells contribute to the development of transplant arteriosclerosis despite CD154 blockade. Transplantation 2000; 69: 2609.
    • (2000) Transplantation , vol.69 , pp. 2609
    • Ensminger, S.M.1    Witzke, O.2    Spriewald, B.M.3
  • 15
    • 0142105503 scopus 로고    scopus 로고
    • Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade
    • Monk NJ, Hargreaves RE, Marsh JE, et al. Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade. Nat Med 2003; 9: 1275.
    • (2003) Nat Med , vol.9 , pp. 1275
    • Monk, N.J.1    Hargreaves, R.E.2    Marsh, J.E.3
  • 16
    • 0033980596 scopus 로고    scopus 로고
    • Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner
    • Iwakoshi NN, Mordes JP, Markees TG, et al. Treatment of allograft recipients with donor-specific transfusion and anti-CD154 antibody leads to deletion of alloreactive CD8+ T cells and prolonged graft survival in a CTLA4-dependent manner. J Immunol 2000; 164: 512.
    • (2000) J Immunol , vol.164 , pp. 512
    • Iwakoshi, N.N.1    Mordes, J.P.2    Markees, T.G.3
  • 17
    • 0036556150 scopus 로고    scopus 로고
    • The immunobiology of inductive anti-CD40L therapy in transplantation: Allograft acceptance is not dependent upon the deletion of graft-reactive T cells
    • Nathan MJ, Yin D, Eichwald EJ, et al. The immunobiology of inductive anti-CD40L therapy in transplantation: Allograft acceptance is not dependent upon the deletion of graft-reactive T cells. Am J Transplant 2002; 2: 323.
    • (2002) Am J Transplant , vol.2 , pp. 323
    • Nathan, M.J.1    Yin, D.2    Eichwald, E.J.3
  • 18
    • 0036839226 scopus 로고    scopus 로고
    • CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways
    • Nicolls MR, Coulombe M, Beilke J, et al. CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways. J Immunol 2002; 169: 4831.
    • (2002) J Immunol , vol.169 , pp. 4831
    • Nicolls, M.R.1    Coulombe, M.2    Beilke, J.3
  • 19
    • 3042800728 scopus 로고    scopus 로고
    • Donor-specific transplantation tolerance: The paradoxical behavior of CD4+CD25+T cells
    • Graca L, Le Moine A, Lin CY, et al. Donor-specific transplantation tolerance: The paradoxical behavior of CD4+CD25+T cells. Proc Natl Acad Sci U S A 2004; 101: 10122.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 10122
    • Graca, L.1    Le Moine, A.2    Lin, C.Y.3
  • 20
    • 0004880266 scopus 로고    scopus 로고
    • CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment
    • Zheng XX, Markees TG, Hancock WW, et al. CTLA4 signals are required to optimally induce allograft tolerance with combined donor-specific transfusion and anti-CD154 monoclonal antibody treatment. J Immunol 1999; 162: 4983.
    • (1999) J Immunol , vol.162 , pp. 4983
    • Zheng, X.X.1    Markees, T.G.2    Hancock, W.W.3
  • 21
    • 23244459502 scopus 로고    scopus 로고
    • Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: The interplay of clonal anergy and immune regulation
    • Quezada SA, Bennett K, Blazar BR, et al. Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: The interplay of clonal anergy and immune regulation. J Immunol 2005; 175: 771.
    • (2005) J Immunol , vol.175 , pp. 771
    • Quezada, S.A.1    Bennett, K.2    Blazar, B.R.3
  • 22
    • 33646472267 scopus 로고    scopus 로고
    • CD4+ T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent
    • Zhai Y, Meng L, Gao F, et al. CD4+ T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent. J Immunol 2006; 176: 5988.
    • (2006) J Immunol , vol.176 , pp. 5988
    • Zhai, Y.1    Meng, L.2    Gao, F.3
  • 23
    • 0035806276 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade
    • Taylor PA, Noelle RJ, Blazar BR. CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med 2001; 193: 1311.
    • (2001) J Exp Med , vol.193 , pp. 1311
    • Taylor, P.A.1    Noelle, R.J.2    Blazar, B.R.3
  • 24
    • 33748490733 scopus 로고    scopus 로고
    • TLR engagement prevents transplantation tolerance
    • Chen L, Wang T, Zhou P, et al. TLR engagement prevents transplantation tolerance. Am J Transplant 2006; 6: 2282.
    • (2006) Am J Transplant , vol.6 , pp. 2282
    • Chen, L.1    Wang, T.2    Zhou, P.3
  • 25
    • 17144393320 scopus 로고    scopus 로고
    • Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor
    • Lee I, Wang L, Wells AD, et al. Recruitment of Foxp3+ T regulatory cells mediating allograft tolerance depends on the CCR4 chemokine receptor. J Exp Med 2005; 201: 1037.
    • (2005) J Exp Med , vol.201 , pp. 1037
    • Lee, I.1    Wang, L.2    Wells, A.D.3
  • 26
    • 0032881028 scopus 로고    scopus 로고
    • Modified technique for kidney transplantation in mice
    • Han WR, Murray-Segal LJ, Mottram PL. Modified technique for kidney transplantation in mice. Microsurgery 1999; 19: 272.
    • (1999) Microsurgery , vol.19 , pp. 272
    • Han, W.R.1    Murray-Segal, L.J.2    Mottram, P.L.3
  • 27
    • 0036681543 scopus 로고    scopus 로고
    • The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation
    • Zhai Y, Shen XD, Gao F, et al. The CD154-CD40 T cell costimulation pathway is required for host sensitization of CD8(+) T cells by skin grafts via direct antigen presentation. J Immunol 2002; 169: 1270.
    • (2002) J Immunol , vol.169 , pp. 1270
    • Zhai, Y.1    Shen, X.D.2    Gao, F.3
  • 28
    • 0035903307 scopus 로고    scopus 로고
    • Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells
    • Iellem A, Mariani M, Lang R, et al. Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells. J Exp Med 2001; 194: 847.
    • (2001) J Exp Med , vol.194 , pp. 847
    • Iellem, A.1    Mariani, M.2    Lang, R.3
  • 29
    • 33750816452 scopus 로고    scopus 로고
    • CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes
    • Soler D, Chapman TR, Poisson LR, et al. CCR8 expression identifies CD4 memory T cells enriched for FOXP3+ regulatory and Th2 effector lymphocytes. J Immunol 2006; 177: 6940.
    • (2006) J Immunol , vol.177 , pp. 6940
    • Soler, D.1    Chapman, T.R.2    Poisson, L.R.3
  • 30
    • 0034694024 scopus 로고    scopus 로고
    • Requirement of the chemokine receptor CXCR3 for acute allograft rejection
    • Hancock WW, Lu B, Gao W, et al. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med 2000; 192: 1515.
    • (2000) J Exp Med , vol.192 , pp. 1515
    • Hancock, W.W.1    Lu, B.2    Gao, W.3
  • 31
    • 0038341894 scopus 로고    scopus 로고
    • Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation
    • Xie JH, Nomura N, Lu M, et al. Antibody-mediated blockade of the CXCR3 chemokine receptor results in diminished recruitment of T helper 1 cells into sites of inflammation. J Leukoc Biol 2003; 73: 771.
    • (2003) J Leukoc Biol , vol.73 , pp. 771
    • Xie, J.H.1    Nomura, N.2    Lu, M.3
  • 32
    • 0032519405 scopus 로고    scopus 로고
    • The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
    • Qin S, Rottman JB, Myers P, et al. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest 1998; 101: 746.
    • (1998) J Clin Invest , vol.101 , pp. 746
    • Qin, S.1    Rottman, J.B.2    Myers, P.3
  • 33
    • 0018091349 scopus 로고
    • Kidney transplants in mice. An analysis of the immune status of mice bearing long-term, H-2 incompatible transplants
    • Russell PS, Chase CM, Colvin RB, et al. Kidney transplants in mice. An analysis of the immune status of mice bearing long-term, H-2 incompatible transplants. J Exp Med 1978; 147: 1449.
    • (1978) J Exp Med , vol.147 , pp. 1449
    • Russell, P.S.1    Chase, C.M.2    Colvin, R.B.3
  • 34
    • 0035501023 scopus 로고    scopus 로고
    • Murine renal allografts: Spontaneous acceptance is associated with regulated T cell-mediated immunity
    • Bickerstaff AA, Wang JJ, Pelletier RP, et al. Murine renal allografts: Spontaneous acceptance is associated with regulated T cell-mediated immunity. J Immunol 2001; 167: 4821.
    • (2001) J Immunol , vol.167 , pp. 4821
    • Bickerstaff, A.A.1    Wang, J.J.2    Pelletier, R.P.3
  • 35
    • 1942471974 scopus 로고    scopus 로고
    • In vivo-mobilized kidney dendritic cells are functionally immature, subvert alloreactive T-cell responses, and prolong organ allograft survival
    • Coates PT, Duncan FJ, Colvin BL, et al. In vivo-mobilized kidney dendritic cells are functionally immature, subvert alloreactive T-cell responses, and prolong organ allograft survival. Transplantation 2004; 77: 1080.
    • (2004) Transplantation , vol.77 , pp. 1080
    • Coates, P.T.1    Duncan, F.J.2    Colvin, B.L.3
  • 36
    • 2542450949 scopus 로고    scopus 로고
    • Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: Evidence for anergy and deletion but not regulatory cells
    • Kurtz J, Shaffer J, Lie A, et al. Mechanisms of early peripheral CD4 T-cell tolerance induction by anti-CD154 monoclonal antibody and allogeneic bone marrow transplantation: Evidence for anergy and deletion but not regulatory cells. Blood 2004; 103: 4336.
    • (2004) Blood , vol.103 , pp. 4336
    • Kurtz, J.1    Shaffer, J.2    Lie, A.3
  • 37
    • 2442425262 scopus 로고    scopus 로고
    • Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants
    • Cobbold SP, Castejon R, Adams E, et al. Induction of foxP3+ regulatory T cells in the periphery of T cell receptor transgenic mice tolerized to transplants. J Immunol 2004; 172: 6003.
    • (2004) J Immunol , vol.172 , pp. 6003
    • Cobbold, S.P.1    Castejon, R.2    Adams, E.3
  • 38
    • 0034327171 scopus 로고    scopus 로고
    • Cutting edge: Anti-CD154 therapeutic antibodies induce infectious transplantation tolerance
    • Graca L, Honey K, Adams E, et al. Cutting edge: anti-CD154 therapeutic antibodies induce infectious transplantation tolerance. J Immunol 2000; 165: 4783.
    • (2000) J Immunol , vol.165 , pp. 4783
    • Graca, L.1    Honey, K.2    Adams, E.3
  • 39
    • 27144524938 scopus 로고    scopus 로고
    • Migration matters: Regulatory T-cell compartmentalization determines suppressive activity in vivo
    • Siegmund K, Feuerer M, Siewert C, et al. Migration matters: Regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood 2005; 106: 3097.
    • (2005) Blood , vol.106 , pp. 3097
    • Siegmund, K.1    Feuerer, M.2    Siewert, C.3
  • 40
    • 0142166426 scopus 로고    scopus 로고
    • Chemokines: Agents for the immunotherapy of cancer?
    • Homey B, Muller A, Zlotnik A. Chemokines: Agents for the immunotherapy of cancer? Nat Rev Immunol 2002; 2: 175.
    • (2002) Nat Rev Immunol , vol.2 , pp. 175
    • Homey, B.1    Muller, A.2    Zlotnik, A.3
  • 41
    • 27144512697 scopus 로고    scopus 로고
    • Chemokines provide the sustained inflammatory bridge between innate and acquired immunity
    • Coelho AL, Hogaboam CM, Kunkel SL. Chemokines provide the sustained inflammatory bridge between innate and acquired immunity. Cytokine Growth Factor Rev 2005; 16: 553.
    • (2005) Cytokine Growth Factor Rev , vol.16 , pp. 553
    • Coelho, A.L.1    Hogaboam, C.M.2    Kunkel, S.L.3
  • 42
    • 0035896749 scopus 로고    scopus 로고
    • Donor-derived IP-10 initiates development of acute allograft rejection
    • Hancock WW, Gao W, Csizmadia V, et al. Donor-derived IP-10 initiates development of acute allograft rejection. J Exp Med 2001; 193: 975.
    • (2001) J Exp Med , vol.193 , pp. 975
    • Hancock, W.W.1    Gao, W.2    Csizmadia, V.3
  • 43
    • 10744223643 scopus 로고    scopus 로고
    • Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection
    • Belperio JA, Keane MP, Burdick MD, et al. Role of CXCL9/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection. J Immunol 2003; 171: 4844.
    • (2003) J Immunol , vol.171 , pp. 4844
    • Belperio, J.A.1    Keane, M.P.2    Burdick, M.D.3
  • 44
    • 0036790497 scopus 로고    scopus 로고
    • The role of MIG/CXCL9 in cardiac allograft vasculopathy
    • Yun JJ, Fischbein MP, Whiting D, et al. The role of MIG/CXCL9 in cardiac allograft vasculopathy. Am J Pathol 2002; 161: 1307.
    • (2002) Am J Pathol , vol.161 , pp. 1307
    • Yun, J.J.1    Fischbein, M.P.2    Whiting, D.3
  • 45
    • 0035884817 scopus 로고    scopus 로고
    • Monokine induced by IFN-gamma is a dominant factor directing T cells into murine cardiac allografts during acute rejection
    • Miura M, Morita K, Kobayashi H, et al. Monokine induced by IFN-gamma is a dominant factor directing T cells into murine cardiac allografts during acute rejection. J Immunol 2001; 167: 3494.
    • (2001) J Immunol , vol.167 , pp. 3494
    • Miura, M.1    Morita, K.2    Kobayashi, H.3
  • 46
    • 1542377437 scopus 로고    scopus 로고
    • IP-10-induced recruitment of CXCR3 host T cells is required for small bowel allograft rejection
    • Zhang Z, Kaptanoglu L, Tang Y, et al. IP-10-induced recruitment of CXCR3 host T cells is required for small bowel allograft rejection. Gastroenterology 2004; 126: 809.
    • (2004) Gastroenterology , vol.126 , pp. 809
    • Zhang, Z.1    Kaptanoglu, L.2    Tang, Y.3
  • 47
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med 2004; 10: 942.
    • (2004) Nat Med , vol.10 , pp. 942
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.