-
1
-
-
20444485767
-
Cellular and genetic mechanisms of self tolerance and autoimmunity
-
Goodnow CC, Sprent J, de St Groth BF, Vinuesa CG. Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 2005;435:590-597.
-
(2005)
Nature
, vol.435
, pp. 590-597
-
-
Goodnow, C.C.1
Sprent, J.2
de St Groth, B.F.3
Vinuesa, C.G.4
-
2
-
-
33845341462
-
Genetics of autoimmune diseases - disorders of immune homeostasis
-
Gregersen PK, Behrens TW. Genetics of autoimmune diseases - disorders of immune homeostasis. Nat Rev Genet 2006;7:917-928.
-
(2006)
Nat Rev Genet
, vol.7
, pp. 917-928
-
-
Gregersen, P.K.1
Behrens, T.W.2
-
3
-
-
77951776390
-
Genetics, pathogenesis and clinical interventions in type 1 diabetes
-
Bluestone JA, Herold K, Eisenbarth G. Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 2010;464:1293-1300.
-
(2010)
Nature
, vol.464
, pp. 1293-1300
-
-
Bluestone, J.A.1
Herold, K.2
Eisenbarth, G.3
-
4
-
-
0027378612
-
Following a diabetogenic T cell from genesis through pathogenesis
-
Katz JD, Wang B, Haskins K, Benoist C, Mathis D. Following a diabetogenic T cell from genesis through pathogenesis. Cell 1993;74:1089-1100.
-
(1993)
Cell
, vol.74
, pp. 1089-1100
-
-
Katz, J.D.1
Wang, B.2
Haskins, K.3
Benoist, C.4
Mathis, D.5
-
5
-
-
0034176744
-
Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions
-
Graser RT, et al. Identification of a CD8 T cell that can independently mediate autoimmune diabetes development in the complete absence of CD4 T cell helper functions. J Immunol 2000;164:3913-3918.
-
(2000)
J Immunol
, vol.164
, pp. 3913-3918
-
-
Graser, R.T.1
-
6
-
-
0030588572
-
+ T cells expressing identical endogenous TCR-α chains
-
+ T cells expressing identical endogenous TCR-α chains. J Immunol 1996;157:4726-4735.
-
(1996)
J Immunol
, vol.157
, pp. 4726-4735
-
-
Verdaguer, J.1
-
7
-
-
17644361955
-
The NOD mouse: a model of immune dysregulation
-
Anderson MS, Bluestone JA. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 2005;23:447-485.
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 447-485
-
-
Anderson, M.S.1
Bluestone, J.A.2
-
8
-
-
0035380479
-
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes
-
Lee KH, Wucherpfennig KW, Wiley DC. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat Immunol 2001;2:501-507.
-
(2001)
Nat Immunol
, vol.2
, pp. 501-507
-
-
Lee, K.H.1
Wucherpfennig, K.W.2
Wiley, D.C.3
-
9
-
-
27144475336
-
Type 1 diabetes genes and pathways shared by humans and NOD mice
-
Wicker LS, et al. Type 1 diabetes genes and pathways shared by humans and NOD mice. J Autoimmun 2005;25(Suppl):29-33.
-
(2005)
J Autoimmun
, vol.25
, Issue.SUPPL.
, pp. 29-33
-
-
Wicker, L.S.1
-
10
-
-
23844525846
-
A comprehensive review of interventions in the NOD mouse and implications for translation
-
Shoda LK, et al. A comprehensive review of interventions in the NOD mouse and implications for translation. Immunity 2005;23:115-126.
-
(2005)
Immunity
, vol.23
, pp. 115-126
-
-
Shoda, L.K.1
-
11
-
-
0033669375
-
Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice
-
Serreze DV, Post CM, Chapman HD, Johnson EA, Lu B, Rothman PB. Interferon-gamma receptor signaling is dispensable in the development of autoimmune type 1 diabetes in NOD mice. Diabetes 2000;49:2007-2011.
-
(2000)
Diabetes
, vol.49
, pp. 2007-2011
-
-
Serreze, D.V.1
Post, C.M.2
Chapman, H.D.3
Johnson, E.A.4
Lu, B.5
Rothman, P.B.6
-
12
-
-
0029948898
-
Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice
-
Hultgren B, Huang X, Dybdal N, Stewart TA. Genetic absence of γ-interferon delays but does not prevent diabetes in NOD mice. Diabetes 1996;45:812-817.
-
(1996)
Diabetes
, vol.45
, pp. 812-817
-
-
Hultgren, B.1
Huang, X.2
Dybdal, N.3
Stewart, T.A.4
-
13
-
-
68949102074
-
T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function
-
Esensten JH, Lee MR, Glimcher LH, Bluestone JA. T-bet-deficient NOD mice are protected from diabetes due to defects in both T cell and innate immune system function. J Immunol 2009;183:75-82.
-
(2009)
J Immunol
, vol.183
, pp. 75-82
-
-
Esensten, J.H.1
Lee, M.R.2
Glimcher, L.H.3
Bluestone, J.A.4
-
14
-
-
77955417412
-
Adjuvant treatment suppresses IL-17 production by T cell-independent myeloid sources in nonobese diabetic mice
-
Gao X, et al. Adjuvant treatment suppresses IL-17 production by T cell-independent myeloid sources in nonobese diabetic mice. Mol Immunol 2010;47:2397-2404.
-
(2010)
Mol Immunol
, vol.47
, pp. 2397-2404
-
-
Gao, X.1
-
15
-
-
66649113381
-
Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice
-
Emamaullee JA, et al. Inhibition of Th17 cells regulates autoimmune diabetes in NOD mice. Diabetes 2009;58:1302-1311.
-
(2009)
Diabetes
, vol.58
, pp. 1302-1311
-
-
Emamaullee, J.A.1
-
16
-
-
38749111445
-
Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production
-
Jain R, et al. Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production. J Exp Med 2008;205:207-218.
-
(2008)
J Exp Med
, vol.205
, pp. 207-218
-
-
Jain, R.1
-
17
-
-
78149485627
-
NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity
-
Tse HM, et al. NADPH oxidase deficiency regulates Th lineage commitment and modulates autoimmunity. J Immunol 2010;185:5247-5258.
-
(2010)
J Immunol
, vol.185
, pp. 5247-5258
-
-
Tse, H.M.1
-
18
-
-
77954518232
-
Th17 polarized cells from nonobese diabetic mice following mycobacterial adjuvant immunotherapy delay type 1 diabetes
-
Nikoopour E, et al. Th17 polarized cells from nonobese diabetic mice following mycobacterial adjuvant immunotherapy delay type 1 diabetes. J Immunol 2010;184:4779-4788.
-
(2010)
J Immunol
, vol.184
, pp. 4779-4788
-
-
Nikoopour, E.1
-
19
-
-
67650650890
-
Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice
-
Bending D, et al. Highly purified Th17 cells from BDC2.5NOD mice convert into Th1-like cells in NOD/SCID recipient mice. J Clin Invest 2009;119:565-572.
-
(2009)
J Clin Invest
, vol.119
, pp. 565-572
-
-
Bending, D.1
-
20
-
-
60549086638
-
Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells
-
Martin-Orozco N, Chung Y, Chang SH, Wang YH, Dong C. Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells. Eur J Immunol 2009;39:216-224.
-
(2009)
Eur J Immunol
, vol.39
, pp. 216-224
-
-
Martin-Orozco, N.1
Chung, Y.2
Chang, S.H.3
Wang, Y.H.4
Dong, C.5
-
22
-
-
47249124078
-
Human regulatory T cells: role in autoimmune disease and therapeutic opportunities
-
Brusko TM, Putnam AL, Bluestone JA. Human regulatory T cells: role in autoimmune disease and therapeutic opportunities. Immunol Rev 2008;223:371-390.
-
(2008)
Immunol Rev
, vol.223
, pp. 371-390
-
-
Brusko, T.M.1
Putnam, A.L.2
Bluestone, J.A.3
-
23
-
-
65649129352
-
Control of type 1 diabetes by CD4+Foxp3+ regulatory T cells: lessons from mouse models and implications for human disease
-
Sgouroudis E, Piccirillo CA. Control of type 1 diabetes by CD4+Foxp3+ regulatory T cells: lessons from mouse models and implications for human disease. Diabetes Metab Res Rev 2009;25:208-218.
-
(2009)
Diabetes Metab Res Rev
, vol.25
, pp. 208-218
-
-
Sgouroudis, E.1
Piccirillo, C.A.2
-
24
-
-
0029978038
-
Checkpoints in the progression of autoimmune disease: lessons from diabetes models
-
André I, Gonzalez A, Wang B, Katz J, Benoist C, Mathis D. Checkpoints in the progression of autoimmune disease: lessons from diabetes models. Proc Natl Acad Sci USA 1996;93:2260-2263.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 2260-2263
-
-
André, I.1
Gonzalez, A.2
Wang, B.3
Katz, J.4
Benoist, C.5
Mathis, D.6
-
25
-
-
85047694553
-
Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity
-
Stratmann T, et al. Susceptible MHC alleles, not background genes, select an autoimmune T cell reactivity. J Clin Invest 2003;112:902-914.
-
(2003)
J Clin Invest
, vol.112
, pp. 902-914
-
-
Stratmann, T.1
-
26
-
-
0028276510
-
Early environmental events as a cause of IDDM. Evidence and implications
-
Leslie RD, Elliott RB. Early environmental events as a cause of IDDM. Evidence and implications. Diabetes 1994;43:843-850.
-
(1994)
Diabetes
, vol.43
, pp. 843-850
-
-
Leslie, R.D.1
Elliott, R.B.2
-
27
-
-
74049161267
-
Influence of microbial environment on autoimmunity
-
Chervonsky AV. Influence of microbial environment on autoimmunity. Nat Immunol 2010;11:28-35.
-
(2010)
Nat Immunol
, vol.11
, pp. 28-35
-
-
Chervonsky, A.V.1
-
28
-
-
0024417450
-
Hay fever, hygiene, and household size
-
Strachan DP. Hay fever, hygiene, and household size. BMJ 1989;299:1259-1260.
-
(1989)
BMJ
, vol.299
, pp. 1259-1260
-
-
Strachan, D.P.1
-
29
-
-
0035495857
-
The germless theory of allergic disease: revisiting the hygiene hypothesis
-
Wills-Karp M, Santeliz J, Karp CL. The germless theory of allergic disease: revisiting the hygiene hypothesis. Nat Rev Immunol 2001;1:69-75.
-
(2001)
Nat Rev Immunol
, vol.1
, pp. 69-75
-
-
Wills-Karp, M.1
Santeliz, J.2
Karp, C.L.3
-
30
-
-
56749184864
-
Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated
-
Villasenor J, Besse W, Benoist C, Mathis D. Ectopic expression of peripheral-tissue antigens in the thymic epithelium: probabilistic, monoallelic, misinitiated. Proc Natl Acad Sci USA 2008;105:15854-15859.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 15854-15859
-
-
Villasenor, J.1
Besse, W.2
Benoist, C.3
Mathis, D.4
-
32
-
-
72849129001
-
Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes
-
MacFarlane AJ, Strom A, Scott FW. Epigenetics: deciphering how environmental factors may modify autoimmune type 1 diabetes. Mamm Genome 2009;20:624-632.
-
(2009)
Mamm Genome
, vol.20
, pp. 624-632
-
-
MacFarlane, A.J.1
Strom, A.2
Scott, F.W.3
-
33
-
-
63249089823
-
Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice
-
Jimenez-Chillaron JC, et al. Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice. Diabetes 2009;58:460-468.
-
(2009)
Diabetes
, vol.58
, pp. 460-468
-
-
Jimenez-Chillaron, J.C.1
-
34
-
-
79954632388
-
Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes
-
Lee SM, et al. Prevention and treatment of diabetes with resveratrol in a non-obese mouse model of type 1 diabetes. Diabetologia 2011;54:1136-1146.
-
(2011)
Diabetologia
, vol.54
, pp. 1136-1146
-
-
Lee, S.M.1
-
35
-
-
79957949655
-
The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet beta cells in vivo and in vitro
-
Lewis EC, et al. The oral histone deacetylase inhibitor ITF2357 reduces cytokines and protects islet beta cells in vivo and in vitro. Mol Med 2011;17:369-377.
-
(2011)
Mol Med
, vol.17
, pp. 369-377
-
-
Lewis, E.C.1
-
36
-
-
79952748287
-
Unravelling the effects of the environment and host genotype on the gut microbiome
-
Spor A, Koren O, Ley R. Unravelling the effects of the environment and host genotype on the gut microbiome. Nat Rev Microbiol 2011;9:279-290.
-
(2011)
Nat Rev Microbiol
, vol.9
, pp. 279-290
-
-
Spor, A.1
Koren, O.2
Ley, R.3
-
37
-
-
15544369658
-
Host-bacterial mutualism in the human intestine
-
Backhed F, Ley RE, Sonnenburg JL, Peterson DA, Gordon JI. Host-bacterial mutualism in the human intestine. Science 2005;307:1915-1920.
-
(2005)
Science
, vol.307
, pp. 1915-1920
-
-
Backhed, F.1
Ley, R.E.2
Sonnenburg, J.L.3
Peterson, D.A.4
Gordon, J.I.5
-
38
-
-
32944466887
-
Ecological and evolutionary forces shaping microbial diversity in the human intestine
-
Ley RE, Peterson DA, Gordon JI. Ecological and evolutionary forces shaping microbial diversity in the human intestine. Cell 2006;124:837-848.
-
(2006)
Cell
, vol.124
, pp. 837-848
-
-
Ley, R.E.1
Peterson, D.A.2
Gordon, J.I.3
-
39
-
-
46249085739
-
Evolution of mammals and their gut microbes
-
Ley RE, et al. Evolution of mammals and their gut microbes. Science 2008;320:1647-1651.
-
(2008)
Science
, vol.320
, pp. 1647-1651
-
-
Ley, R.E.1
-
40
-
-
52049092682
-
Worlds within worlds: evolution of the vertebrate gut microbiota
-
Ley RE, Lozupone CA, Hamady M, Knight R, Gordon JI. Worlds within worlds: evolution of the vertebrate gut microbiota. Nat Rev Microbiol 2008;6:776-788.
-
(2008)
Nat Rev Microbiol
, vol.6
, pp. 776-788
-
-
Ley, R.E.1
Lozupone, C.A.2
Hamady, M.3
Knight, R.4
Gordon, J.I.5
-
41
-
-
58749112734
-
A core gut microbiome in obese and lean twins
-
Turnbaugh PJ, et al. A core gut microbiome in obese and lean twins. Nature 2009;457:480-484.
-
(2009)
Nature
, vol.457
, pp. 480-484
-
-
Turnbaugh, P.J.1
-
42
-
-
78449296237
-
Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors
-
Benson AK, et al. Individuality in gut microbiota composition is a complex polygenic trait shaped by multiple environmental and host genetic factors. Proc Natl Acad Sci USA 2010;107:18933-18938.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 18933-18938
-
-
Benson, A.K.1
-
43
-
-
77950847866
-
Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota
-
Hehemann JH, Correc G, Barbeyron T, Helbert W, Czjzek M, Michel G. Transfer of carbohydrate-active enzymes from marine bacteria to Japanese gut microbiota. Nature 2010;464:908-912.
-
(2010)
Nature
, vol.464
, pp. 908-912
-
-
Hehemann, J.H.1
Correc, G.2
Barbeyron, T.3
Helbert, W.4
Czjzek, M.5
Michel, G.6
-
44
-
-
33845874101
-
An obesity-associated gut microbiome with increased capacity for energy harvest
-
Turnbaugh PJ, Ley RE, Mahowald MA, Magrini V, Mardis ER, Gordon JI. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 2006;444:1027-1031.
-
(2006)
Nature
, vol.444
, pp. 1027-1031
-
-
Turnbaugh, P.J.1
Ley, R.E.2
Mahowald, M.A.3
Magrini, V.4
Mardis, E.R.5
Gordon, J.I.6
-
45
-
-
77950250064
-
Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
-
Vijay-Kumar M, et al. Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 2010;328:228-231.
-
(2010)
Science
, vol.328
, pp. 228-231
-
-
Vijay-Kumar, M.1
-
46
-
-
34848889673
-
Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system
-
Garrett WS, et al. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell 2007;131:33-45.
-
(2007)
Cell
, vol.131
, pp. 33-45
-
-
Garrett, W.S.1
-
47
-
-
78650647326
-
Has the microbiota played a critical role in the evolution of the adaptive immune system?
-
Lee YK, Mazmanian SK. Has the microbiota played a critical role in the evolution of the adaptive immune system? Science 2010;330:1768-1773.
-
(2010)
Science
, vol.330
, pp. 1768-1773
-
-
Lee, Y.K.1
Mazmanian, S.K.2
-
48
-
-
53349173070
-
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine
-
Ivanov II, et al. Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe 2008;4:337-349.
-
(2008)
Cell Host Microbe
, vol.4
, pp. 337-349
-
-
Ivanov, I.I.1
-
49
-
-
53649100675
-
ATP drives lamina propria T(H)17 cell differentiation
-
Atarashi K, et al. ATP drives lamina propria T(H)17 cell differentiation. Nature 2008;455:808-812.
-
(2008)
Nature
, vol.455
, pp. 808-812
-
-
Atarashi, K.1
-
50
-
-
70350343544
-
Induction of intestinal Th17 cells by segmented filamentous bacteria
-
Ivanov II, et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009;139:485-498.
-
(2009)
Cell
, vol.139
, pp. 485-498
-
-
Ivanov, I.I.1
-
51
-
-
70349742524
-
The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses
-
Gaboriau-Routhiau V, et al. The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses. Immunity 2009;31:677-689.
-
(2009)
Immunity
, vol.31
, pp. 677-689
-
-
Gaboriau-Routhiau, V.1
-
52
-
-
0026877204
-
Intestinal, segmented, filamentous bacteria
-
Klaasen HL, Koopman JP, Poelma FG, Beynen AC. Intestinal, segmented, filamentous bacteria. FEMS Microbiol Rev 1992;8:165-180.
-
(1992)
FEMS Microbiol Rev
, vol.8
, pp. 165-180
-
-
Klaasen, H.L.1
Koopman, J.P.2
Poelma, F.G.3
Beynen, A.C.4
-
53
-
-
80051994193
-
The lifestyle of the segmented filamentous bacterium: a non-culturable gut-associated immunostimulating microbe inferred by whole-genome sequencing
-
Kuwahara T, et al. The lifestyle of the segmented filamentous bacterium: a non-culturable gut-associated immunostimulating microbe inferred by whole-genome sequencing. DNA Res 2011;18:291-303.
-
(2011)
DNA Res
, vol.18
, pp. 291-303
-
-
Kuwahara, T.1
-
54
-
-
80053045987
-
Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of th17 cell differentiation
-
Prakash T, et al. Complete genome sequences of rat and mouse segmented filamentous bacteria, a potent inducer of th17 cell differentiation. Cell Host Microbe 2011;10:273-284.
-
(2011)
Cell Host Microbe
, vol.10
, pp. 273-284
-
-
Prakash, T.1
-
55
-
-
80053025965
-
The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment
-
Sczesnak A, et al. The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment. Cell Host Microbe 2011;10:260-272.
-
(2011)
Cell Host Microbe
, vol.10
, pp. 260-272
-
-
Sczesnak, A.1
-
56
-
-
85027947787
-
Induction of colonic regulatory T cells by indigenous Clostridium species
-
Atarashi K, et al. Induction of colonic regulatory T cells by indigenous Clostridium species. Science 2011;331:337-341.
-
(2011)
Science
, vol.331
, pp. 337-341
-
-
Atarashi, K.1
-
57
-
-
80054020840
-
Peripheral education of the immune system by colonic commensal microbiota
-
Lathrop SK, et al. Peripheral education of the immune system by colonic commensal microbiota. Nature 2011;478:250-254.
-
(2011)
Nature
, vol.478
, pp. 250-254
-
-
Lathrop, S.K.1
-
58
-
-
22144490199
-
An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
-
Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell 2005;122:107-118.
-
(2005)
Cell
, vol.122
, pp. 107-118
-
-
Mazmanian, S.K.1
Liu, C.H.2
Tzianabos, A.O.3
Kasper, D.L.4
-
59
-
-
44449106055
-
A microbial symbiosis factor prevents intestinal inflammatory disease
-
Mazmanian SK, Round JL, Kasper DL. A microbial symbiosis factor prevents intestinal inflammatory disease. Nature 2008;453:620-625.
-
(2008)
Nature
, vol.453
, pp. 620-625
-
-
Mazmanian, S.K.1
Round, J.L.2
Kasper, D.L.3
-
60
-
-
77954738601
-
Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
-
Round JL, Mazmanian SK. Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci USA 2010;107:12204-12209.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 12204-12209
-
-
Round, J.L.1
Mazmanian, S.K.2
-
61
-
-
79956311926
-
The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
-
Round JL, et al. The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 2011;332:974-977.
-
(2011)
Science
, vol.332
, pp. 974-977
-
-
Round, J.L.1
-
62
-
-
34547685588
-
Importance of microbial colonization of the gut in early life to the development of immunity
-
Kelly D, King T, Aminov R. Importance of microbial colonization of the gut in early life to the development of immunity. Mutat Res 2007;622:58-69.
-
(2007)
Mutat Res
, vol.622
, pp. 58-69
-
-
Kelly, D.1
King, T.2
Aminov, R.3
-
63
-
-
38149048556
-
Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
-
Abdollahi-Roodsaz S, et al. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J Clin Invest 2008;118:205-216.
-
(2008)
J Clin Invest
, vol.118
, pp. 205-216
-
-
Abdollahi-Roodsaz, S.1
-
64
-
-
77953913586
-
Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells
-
Wu HJ, et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity 2010;32:815-827.
-
(2010)
Immunity
, vol.32
, pp. 815-827
-
-
Wu, H.J.1
-
65
-
-
79952748674
-
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
-
Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci USA 2011;108(Suppl):4615-4622.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, Issue.SUPPL.
, pp. 4615-4622
-
-
Lee, Y.K.1
Menezes, J.S.2
Umesaki, Y.3
Mazmanian, S.K.4
-
67
-
-
0027415058
-
Influence of the bacterial flora on collagen-induced arthritis in susceptible and resistant strains of rats
-
Breban MA, Moreau MC, Fournier C, Ducluzeau R, Kahn MF. Influence of the bacterial flora on collagen-induced arthritis in susceptible and resistant strains of rats. Clin Exp Rheumatol 1993;11:61-64.
-
(1993)
Clin Exp Rheumatol
, vol.11
, pp. 61-64
-
-
Breban, M.A.1
Moreau, M.C.2
Fournier, C.3
Ducluzeau, R.4
Kahn, M.F.5
-
68
-
-
79960983258
-
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice
-
Kriegel MA, Sefik E, Hill JA, Wu HJ, Benoist C, Mathis D. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proc Natl Acad Sci USA 2011;108:11548-11553.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 11548-11553
-
-
Kriegel, M.A.1
Sefik, E.2
Hill, J.A.3
Wu, H.J.4
Benoist, C.5
Mathis, D.6
-
69
-
-
79952142398
-
The incidence of type-1 diabetes in NOD mice is modulated by restricted flora not germ-free conditions
-
King C, Sarvetnick N. The incidence of type-1 diabetes in NOD mice is modulated by restricted flora not germ-free conditions. PLoS ONE 2011;6:e17049.
-
(2011)
PLoS ONE
, vol.6
-
-
King, C.1
Sarvetnick, N.2
-
71
-
-
0345414139
-
Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice
-
Sakaguchi N, et al. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature 2003;426:454-460.
-
(2003)
Nature
, vol.426
, pp. 454-460
-
-
Sakaguchi, N.1
-
72
-
-
20244373339
-
A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice
-
Yoshitomi H, et al. A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med 2005;201:949-960.
-
(2005)
J Exp Med
, vol.201
, pp. 949-960
-
-
Yoshitomi, H.1
-
73
-
-
77953497686
-
Complement drives Th17 cell differentiation and triggers autoimmune arthritis
-
Hashimoto M, et al. Complement drives Th17 cell differentiation and triggers autoimmune arthritis. J Exp Med 2010;207:1135-1143.
-
(2010)
J Exp Med
, vol.207
, pp. 1135-1143
-
-
Hashimoto, M.1
-
74
-
-
0001982584
-
Diabetogenic Effects of Lymphocyte Transfusion on the NOD or NOD Nude Mouse
-
Rygaard J, Brunner N, Groem N, Spang-Thomsen M eds. New York: S. Karger Publishers Inc
-
Suzuki T, et al. Diabetogenic Effects of Lymphocyte Transfusion on the NOD or NOD Nude Mouse. In: Rygaard J, Brunner N, Groem N, Spang-Thomsen M eds. Immune-deficient Animals in Biomedical Research. New York: S. Karger Publishers Inc, 1987:112-116.
-
(1987)
Immune-deficient Animals in Biomedical Research
, pp. 112-116
-
-
Suzuki, T.1
-
75
-
-
54549122338
-
Innate immunity and intestinal microbiota in the development of Type 1 diabetes
-
Wen L, et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature 2008;455:1109-1113.
-
(2008)
Nature
, vol.455
, pp. 1109-1113
-
-
Wen, L.1
-
76
-
-
80052517464
-
Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (NOD) mice
-
Alam C, et al. Effects of a germ-free environment on gut immune regulation and diabetes progression in non-obese diabetic (NOD) mice. Diabetologia 2011;54:1398-406.
-
(2011)
Diabetologia
, vol.54
, pp. 1398-1406
-
-
Alam, C.1
-
77
-
-
77949272755
-
Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice
-
Lee AS, Gibson DL, Zhang Y, Sham HP, Vallance BA, Dutz JP. Gut barrier disruption by an enteric bacterial pathogen accelerates insulitis in NOD mice. Diabetologia 2010;53:741-748.
-
(2010)
Diabetologia
, vol.53
, pp. 741-748
-
-
Lee, A.S.1
Gibson, D.L.2
Zhang, Y.3
Sham, H.P.4
Vallance, B.A.5
Dutz, J.P.6
-
78
-
-
14544277099
-
Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats
-
Watts T, et al. Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci USA 2005;102:2916-2921.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 2916-2921
-
-
Watts, T.1
-
79
-
-
58149388025
-
The impact of circulating dendritic cells on the development and differentiation of thymocytes
-
Proietto AI, van DS, Wu L. The impact of circulating dendritic cells on the development and differentiation of thymocytes. Immunol Cell Biol 2009;87:39-45.
-
(2009)
Immunol Cell Biol
, vol.87
, pp. 39-45
-
-
Proietto, A.I.1
van, D.S.2
Wu, L.3
-
80
-
-
11144353743
-
Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type I diabetic patients
-
Secondulfo M, et al. Ultrastructural mucosal alterations and increased intestinal permeability in non-celiac, type I diabetic patients. Dig Liver Dis 2004;36:35-45.
-
(2004)
Dig Liver Dis
, vol.36
, pp. 35-45
-
-
Secondulfo, M.1
-
81
-
-
33745311630
-
Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives
-
Sapone A, et al. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives. Diabetes 2006;55:1443-1449.
-
(2006)
Diabetes
, vol.55
, pp. 1443-1449
-
-
Sapone, A.1
-
82
-
-
33750906233
-
Increased intestinal permeability precedes clinical onset of type 1 diabetes
-
Bosi E, et al. Increased intestinal permeability precedes clinical onset of type 1 diabetes. Diabetologia 2006;49:2824-2827.
-
(2006)
Diabetologia
, vol.49
, pp. 2824-2827
-
-
Bosi, E.1
-
83
-
-
67249096227
-
Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms
-
Visser J, Rozing J, Sapone A, Lammers K, Fasano A. Tight junctions, intestinal permeability, and autoimmunity: celiac disease and type 1 diabetes paradigms. Ann NY Acad Sci 2009;1165:195-205.
-
(2009)
Ann NY Acad Sci
, vol.1165
, pp. 195-205
-
-
Visser, J.1
Rozing, J.2
Sapone, A.3
Lammers, K.4
Fasano, A.5
-
84
-
-
29144508394
-
Endocrine self and gut non-self intersect in the pancreatic lymph nodes
-
Turley SJ, Lee JW, Dutton-Swain N, Mathis D, Benoist C. Endocrine self and gut non-self intersect in the pancreatic lymph nodes. Proc Natl Acad Sci USA 2005;102:17729-17733.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17729-17733
-
-
Turley, S.J.1
Lee, J.W.2
Dutton-Swain, N.3
Mathis, D.4
Benoist, C.5
-
85
-
-
66449108669
-
Cd1d-dependent regulation of bacterial colonization in the intestine of mice
-
Nieuwenhuis EE, et al. Cd1d-dependent regulation of bacterial colonization in the intestine of mice. J Clin Invest 2009;119:1241-1250.
-
(2009)
J Clin Invest
, vol.119
, pp. 1241-1250
-
-
Nieuwenhuis, E.E.1
-
86
-
-
78650616947
-
Toward defining the autoimmune microbiome for type 1 diabetes
-
Giongo A, et al. Toward defining the autoimmune microbiome for type 1 diabetes. ISME J 2011;5:82-91.
-
(2011)
ISME J
, vol.5
, pp. 82-91
-
-
Giongo, A.1
-
87
-
-
79551686425
-
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
-
Spence JR, et al. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 2011;470:105-109.
-
(2011)
Nature
, vol.470
, pp. 105-109
-
-
Spence, J.R.1
|