Topoisomerase as target for antibacterial and anticancer drug discovery

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 28, Issue 3, 2013, Pages 419-435

  Kathiravan, Muthu K ^a   Khilare, Madhavi M ^a   Nikoomanesh, Kiana ^a   Chothe, Aparna S ^b   Jain, Kishor S ^a  

^a SINHGAD COLLEGE OF PHARMACY   (India)

^b AISSMS COLLEGE OF PHARMACY   (India)

Author keywords

Dual targeting; Intercalating; Topoisomerase

Indexed keywords

2 (2 DIMETHYLAMINOETHYL) 9 METHOXY 5 NITROPYRAZOLO[3,4,5 KL]ACRIDINE; 2,3 BIS(3,5 DIOXO 1 PIPERAZINYL)BUTANE; 6 [2 (DIMETHYLAMINO)ETHYLAMINO] 3 HYDROXY 7H INDENO[2,1 C]QUINOLIN 7 ONE; 6 FORMYLAMINO 12,13 DIHYDRO 1,11 DIHYDROXY 5H INDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE 5,7(6H) DIONE 13 GLUCOSIDE; 7 HYDROXY 8 METHOXY 5 METHYL 2,3 METHYLENEDIOXYBENZO[C]PHENANTHRIDINIUM HYDROGEN SULFATE; 9 AMINOCAMPTOTHECIN; ACRIDINE; AMSACRINE; ANTINEOPLASTIC AGENT; AURINTRICARBOXYLIC ACID; CIPROFLOXACIN; CISPLATIN; COSITECAN; DN 80915; DNA TOPOISOMERASE; DOXORUBICIN; EDOTECARIN; EPIPODOPHYLLOTOXIN; EPIRUBICIN; ETOPOSIDE; EXATECAN; HU 331; IRINOTECAN; LOMEFLOXACIN; MERBARONE; NALIDIXIC ACID; NORFLOXACIN; NOVOBIOCIN; OFLOXACIN; SPARFLOXACIN; TENIPOSIDE; TOPOTECAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VOSAROXIN; XR 11576; 2, 4, 6 TRISUBSTITUED PYRIDINE; AMINOCOUMARIN DERIVATIVE; ANTIBIOTIC AGENT; AZATOXIN; BACTERIAL ENZYME; BENZOPHENANTHRIDINE DERIVATIVE; CAMPTOTHECIN; CARBAZOLE DERIVATIVE; DACTINOMYCIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; ELLIPTICINE; EPIPODOPHYLLOTOXIN DERIVATIVE; ETOPOFOS; HETEROCYCLIC COMPOUND; PODOPHYLLOTOXIN DERIVATIVE; PYRIDINE DERIVATIVE; PYRIDONE DERIVATIVE; QUINOLINE DERIVATIVE; RAZOXANE; XANTHONE DERIVATIVE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; BREAST CANCER; CANCER INHIBITION; CHILDHOOD LEUKEMIA; CHROMOSOME CONDENSATION; COLORECTAL CANCER; DNA DAMAGE; DNA HELIX; DNA STRAND; DNA SUPERCOILING; DRUG DEVELOPMENT; DRUG SOLUBILITY; DRUG TARGETING; EUKARYOTE; HEAD AND NECK TUMOR; HUMAN; LEUKEMIA; LUNG CANCER; LUNG SMALL CELL CANCER; LYMPHOMA; NONHUMAN; OVARY CANCER; PRIORITY JOURNAL; REVIEW; STRUCTURE ACTIVITY RELATION; CHROMOSOMAL INSTABILITY; DNA REPLICATION; DNA STRAND BREAKAGE; DRUG ACTIVITY; DRUG STRUCTURE; ESCHERICHIA COLI; GENETIC CODE; PROTEIN FUNCTION; RUTA GRAVEOLENS;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BACTERIAL PROTEINS; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG DISCOVERY; HUMANS; MOLECULAR TARGETED THERAPY; TOPOISOMERASE I INHIBITORS; TOPOISOMERASE II INHIBITORS; TOPOISOMERASE INHIBITORS;

EID: 84875400562     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2012.658785     Document Type: Review

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