Synthesis and biological evaluation of tetracyclic thienopyridones as antibacterial and antitumor agents

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 8, 2011, Pages 2541-2548

  Al Trawneh, Salah A ^a   El Abadelah, Mustafa M ^a,c   Zahra, Jalal A ^a   Al Taweel, Samir A ^b   Zani, Franca ^c   Incerti, Matteo ^c   Cavazzoni, Andrea ^c   Vicini, Paola ^c  

^a UNIVERSITY OF JORDAN   (Jordan)

^b MUTAH UNIVERSITY   (Jordan)

^c UNIVERSITY OF PARMA   (Italy)

Author keywords

4 Oxopyrido 3 ,2 :4,5 thieno 3,2 b indole 3 carboxylic acids; 4 Oxothieno 2,3 b pyridines; Antibacterial activity; Anticancer activity

Indexed keywords

1 CYCLOPROPYL 4 OXO 1,5 DIHYDRO 4H PYRIDO[3',2':4,5]THIENO[3,2 B]INDOLE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6,8 DIMETHYL 7 METHOXY 4 OXO 1,5 DIHYDRO 4H PYRIDO[3',2':4,5]THIENO[3,2 B]INDOLE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 7 FLUORO 4 OXO 1,5 DIHYDRO 4H PYRIDO[3',2':4,5]THIENO[3,2 B]INDOLE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 7 METHOXY 4 OXO 1,5 DIHYDRO 4H PYRIDO[3',2':4,5]THIENO[3,2 B]INDOLE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 7 METHYL 4 OXO 1,5 DIHYDRO 4H PYRIDO[3',2':4,5]THIENO[3,2 B]INDOLE 3 CARBOXYLIC ACID; 4 OXOPYRIDO[3',2':4,5]THIENO[3,2 B]INDOLE 3 CARBOXYLIC ACID; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; ELLIPTICINE; ETHYL 1 CYCLOPROPYL 4 OXO 1,5 DIHYDRO 4H PYRIDO[3',2':4,5]THIENO[3,2 B]INDOLE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 6,8 DIMETHYL 7 METHOXY 4 OXO 1,5 DIHYDRO 4H PYRIDO[3',2':4,5]THIENO[3,2 B]INDOLE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 7 FLUORO 4 OXO 1,5 DIHYDRO 4H PYRIDO[3',2':4,5]THIENO[3,2 B]INDOLE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 7 METHOXY 4 OXO 1,5 DIHYDRO 4H PYRIDO[3',2':4,5]THIENO[3,2 B]INDOLE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 7 METHYL 4 OXO 1,5 DIHYDRO 4H PYRIDO[3',2':4,5]THIENO[3,2 B]INDOLE 3 CARBOXYLATE; ETHYL 2 ARYL 7 CYCLOPROPYL 3 NITRO 4 OXO 4,7 DIHYDROTHIENO[2,3 B]PYRIDINE 5 CARBOXYLATE; ETHYL 2 CHLORO 7 CYCLOPROPYL 3 NITRO 4 OXO 4,7 DIHYDROTHIENO[2,3 B]PYRIDINE 5 CARBOXYLATE; ETHYL 7 CYCLOPROPYL 2 (4 FLUOROPHENYL) 3 NITRO 4 OXO 4,7 DIHYDROTHIENO[2,3 B]PYRIDINE 5 CARBOXYLATE; ETHYL 7 CYCLOPROPYL 2 (4 METHOXY 3,5 DIMETHYLPHENYL) 3 NITRO 4 OXO 4,7 DIHYDROTHIENO[2,3 B]PYRIDINE 5 CARBOXYLATE; ETHYL 7 CYCLOPROPYL 2 (4 METHOXYPHENYL) 3 NITRO 4 OXO 4,7 DIHYDROTHIENO[2,3 B]PYRIDINE 5 CARBOXYLATE; ETHYL 7 CYCLOPROPYL 2 (4 METHYLPHENYL) 3 NITRO 4 OXO 4,7 DIHYDROTHIENO[2,3 B]PYRIDINE 5 CARBOXYLATE; ETHYL 7 CYCLOPROPYL 3 NITRO 4 OXO 2 PHENYL 4,7 DIHYDROTHIENO[2,3 B]PYRIDINE 5 CARBOXYLATE; GEMIFLOXACIN; LEVOFLOXACIN; MICONAZOLE; MOXIFLOXACIN; TETRACYCLIC THIENOPYRIDONE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; ARYLATION; BACILLUS MEGATERIUM; BACILLUS SUBTILIS; CANCER CELL; CELL STRAIN; CELL STRAIN A549; CELL STRAIN MCF 7; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HAEMOPHILUS INFLUENZAE; HUMAN; HUMAN CELL; IC 50; LUNG NON SMALL CELL CANCER; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; DNA GYRASE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; THIENOPYRIDINES;

BACILLI (CLASS); BACILLUS MEGATERIUM; BACILLUS SUBTILIS; HAEMOPHILUS INFLUENZAE; NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS;

EID: 79954426396     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.018     Document Type: Article

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