Potency of inhibition of human DNA topoisomerase i by flavones assessed through physicochemical parameters

Free Radical Biology and Medicine

Volumn 51, Issue 7, 2011, Pages 1406-1410

  Bensasson, René V ^a   Zoete, Vincent ^b   Jossang, Akino ^a   Bodo, Bernard ^a   Arimondo, Paola B ^a   Land, Edward J ^c,d  

^a MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^b SWISS INSTITUTE OF BIOINFORMATICS   (Switzerland)

^c CHRISTIE HOSPITAL   (United Kingdom)

^d KEELE UNIVERSITY   (United Kingdom)

Author keywords

Anticancer drugs; Energy of the highest occupied molecular orbital; Flavones; Free radicals; Inhibition of eukaryotic topoisomerase I; Redox regulation; Singlet oxygen quenching

Indexed keywords

APIGENIN; CHRYSIN; DNA TOPOISOMERASE; FISETIN; KAEMPFEROL; MORIN; QUERCETIN; REACTIVE OXYGEN METABOLITE; RUTOSIDE;

ARTICLE; BIOLOGICAL ACTIVITY; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; OXIDATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; DNA TOPOISOMERASES, TYPE I; DRUG DESIGN; FLAVONES; HUMANS; KINETICS; MOLECULAR CONFORMATION; NEOPLASMS; OXIDATION-REDUCTION; QUINONES; SINGLET OXYGEN; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; TOPOISOMERASE I INHIBITORS;

EUKARYOTA;

EID: 80052262854     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.06.021     Document Type: Article

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