Synthesis and biological evaluation of tetracyclic fluoroquinolones as antibacterial and anticancer agents

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 16, 2010, Pages 5873-5884

  Al Trawneh, Salah A ^a   Zahra, Jalal A ^a   Kamal, Marwan R ^a   El Abadelah, Mustafa M ^a   Zani, Franca ^b   Incerti, Matteo ^b   Cavazzoni, Andrea ^b   Alfieri, Roberta R ^b   Petronini, Pier G ^b   Vicini, Paola ^b  

^a UNIVERSITY OF JORDAN   (Jordan)

^b UNIVERSITY OF PARMA   (Italy)

Author keywords

4 Oxo 1,4 dihydropyrido 2,3 a carbazoles; 4 Oxothieno 2 ,3 :4,5 pyrrolo 3,2 h quinoline; 6 Fluoroquinolones; Antibacterial activity; Anticancer activity

Indexed keywords

1 CYCLOPROPYL 6 FLUORO 4 OXO 4,10 DIHYDRO 1H THIENO[2',3':4,5]PYRROLO[3,2 H]QUINOLINE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 9 METHOXY 4 OXO 4,11 DIHYDRO 1H PYRIDO[2,3 A]CARBAZOLE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 9 METHOXY 8,10 DIMETHYL 4 OXO 4,11 DIHYDRO 1H PYRIDO[2,3 A]CARBAZOLE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6 FLUORO 9 METHYL 4 OXO 4,11 DIHYDRO 1H PYRIDO[2,3 A]CARBAZOLE 3 CARBOXYLIC ACID; 1 CYCLOPROPYL 6,9 DIFLUORO 4 OXO 4,11 DIHYDRO 1H PYRIDO[2,3 A]CARBAZOLE 3 CARBOXYLIC ACID; 1 CYCLORPOPYL 6 FLUORO 4 OXO 4,11 DIHYDRO 1H PYRIDO[2,3 A]CARBAZOLE 3 CARBOXYLIC ACID; 6 FLUORO 4 OXOPYRIDO[2,3 A]CARBAZOLE 3 CARBOXYLIC ACID; 6 FLUORO 4 OXOTHIENO[2',3':4,5]PYRROLO[3,2 H]QUINOLINE; 7 CHLORO 6 FLUORO 8 NITRO 4 OXOQUINOLINE 3 CARBOXYLATE; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; CARBOXYLIC ACID DERIVATIVE; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE IV; ELLIPTICINE; ETHYL 1 CYCLOPROPYL 6 FLUORO 4 OXO 4,10 DIHYDRO 1H THIENO[2',3':4,5]PYRROLO[3,2 H]QUINOLINE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 6 FLUORO 4 OXO 4,11 DIHYDRO 1H PYRIDO[2,3 A]CARBAZOLE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 6 FLUORO 7 (4 FLUOROPHENYL) 8 NITRO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 6 FLUORO 7 (4 METHOXY 3,5 DIMETHYLPHENYL) 8 NITRO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 6 FLUORO 7 (4 METHOXYPHENYL) 8 NITRO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 6 FLUORO 7 (4 METHYLPHENYL) 8 NITRO 4 OXO 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 6 FLUORO 8 NITRO 4 OXO 7 (THIEN 2 YL) 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 6 FLUORO 8 NITRO 4 OXO 7 PHENYL 1,4 DIHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 6 FLUORO 9 METHOXY 4 OXO 4,11 DIHYDRO 1H PYRIDO[2,3 A]CARBAZOLE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 6 FLUORO 9 METHOXY 8,10 DIMETHYL 4 OXO 4,11 DIHYDRO 1H PYRIDO[2,3 A]CARBAZOLE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 6 FLUORO 9 METHYL 4 OXO 4,11 DIHYDRO 1H PYRIDO[2,3 A]CARBAZOLE 3 CARBOXYLATE; ETHYL 1 CYCLOPROPYL 6,9 DIFLUORO 4 OXO 4,11 DIHYDRO 1H PYRIDO[2,3 A]CARBAZOLE 3 CARBOXYLATE; LEVOFLOXACIN; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ACINETOBACTER BAUMANNII; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY TEST; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESCHERICHIA COLI; EVALUATION; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; LUNG NON SMALL CELL CANCER; MICROWAVE RADIATION; MINIMUM INHIBITORY CONCENTRATION; PSEUDOMONAS AERUGINOSA; SKIN FIBROBLAST; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; STILLE REACTION;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARCINOMA, NON-SMALL-CELL LUNG; CELL DEATH; CELL LINE; CELL LINE, TUMOR; DNA GYRASE; DNA TOPOISOMERASE IV; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FEMALE; FLUOROQUINOLONES; HUMANS; MICROBIAL SENSITIVITY TESTS;

STAPHYLOCOCCUS;

EID: 77955473628     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.098     Document Type: Article

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