Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 6, 2010, Pages 2245-2254

  Thapa, Pritam ^a   Karki, Radha ^a   Choi, Hoyoung ^a   Choi, Jae Hun ^a   Yun, Minho ^a   Jeong, Byeong Seon ^a   Jung, Mi Ja ^b   Nam, Jung Min ^b   Na, Younghwa ^c   Cho, Won Jea ^d   Kwon, Youngjoo ^b   Lee, Eung Seok ^a  

^a Yeungnam University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Catholic University of Daegu   (South Korea)

^d Chonnam National University   (South Korea)

Author keywords

2 (Thienyl 2 yl) 4 furyl 6 aryl pyridine; 2 (Thienyl 3 yl) 4 furyl 6 aryl pyridine; Cytotoxicity; Topoisomerase I and II inhibition

Indexed keywords

CAMPTOTHECIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ETOPOSIDE; PYRIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; HUMAN; HUMAN CELL; IC 50; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 77649237047     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.065     Document Type: Article

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