Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 12, 2007, Pages 4237-4246

  Nacro, Kassoum ^a   Peace, Denise ^b   Friedrich, Thomas D ^b  

^a Charles)   (United States)

^b ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Camptothecin; Growth inhibition; Luotonin A; Topoisomerase

Indexed keywords

16 AMINOLUOTONIN A; 16 AZALUOTONIN A; 16 CHLOROLUOTONIN A; 16 METHOXYLUOTONIN A; 17,18 DIMETHOXYLUOTONIN A; CAMPTOTHECIN; DNA TOPOISOMERASE; LUOTONIN A DERIVATIVE; NATURAL PRODUCT; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CARCINOMA; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOTOXICITY; DRUG INTOXICATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; ENZYME INHIBITORS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; PYRROLES; QUINONES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 34247620722     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.03.067     Document Type: Article

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