7-Azaindenoisoquinolines as topoisomerase i inhibitors and potential anticancer agents

Journal of Medicinal Chemistry

Volumn 54, Issue 17, 2011, Pages 6106-6116

  Kiselev, Evgeny ^a   Deguire, Sean ^a   Morrell, Andrew ^a   Agama, Keli ^b   Dexheimer, Thomas S ^b   Pommier, Yves ^b   Cushman, Mark ^a  

^a PURDUE UNIVERSITY   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,6 DIHYDRO 2,3 DIMETHOXY 6 METHYL 8,9 METHYLENEDIOXY 5,11 DIOXO 11H INDENO[1,2 C]ISOQUINOLINE; 7 AZAINDENOISOQUINOLINE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN DERIVATIVE; DNA TOPOISOMERASE INHIBITOR; ISOQUINOLINE DERIVATIVE; LMP 400; LMP 776; NSC 724998; NSC 725776; NSC 743400; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CYTOTOXICITY; DNA BINDING; DNA CLEAVAGE; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; INTERCALATION COMPLEX;

ANTINEOPLASTIC AGENTS; AZA COMPOUNDS; DNA CLEAVAGE; DNA TOPOISOMERASES, TYPE I; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEOPLASMS; QUINOLINES; STRUCTURE-ACTIVITY RELATIONSHIP; TOPOISOMERASE I INHIBITORS; TUMOR CELLS, CULTURED;

EID: 80052374753     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200719v     Document Type: Article

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