Azatoxin is a mechanistic hybrid of the topoisomerase II-targeted anticancer drugs etoposide and ellipticine

Biochemistry

Volumn 36, Issue 42, 1997, Pages 13095-13101

  Cline, Susan D ^a   Macdonald, Timothy L ^b   Osheroff, Neil ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; AZATOXIN; DNA TOPOISOMERASE (ATP HYDROLYSING); ELLIPTICINE; ETOPOSIDE; UNCLASSIFIED DRUG;

ARTICLE; DNA CLEAVAGE; DROSOPHILA; DRUG DESIGN; DRUG DNA BINDING; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; SOLID TUMOR;

AMINO ACID SUBSTITUTION; ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; DNA; DNA TOPOISOMERASES, TYPE II; DROSOPHILA; DRUG DESIGN; ELLIPTICINES; ENZYME INHIBITORS; ETOPOSIDE; HUMANS; INDOLES; INTERCALATING AGENTS; KINETICS; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; THYMUS GLAND;

EID: 0030713374     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971770z     Document Type: Article

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