2-Thienyl-4-furyl-6-aryl pyridine derivatives: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 1, 2010, Pages 377-386

  Thapa, Pritam ^a   Karki, Radha ^a   Thapa, Uttam ^a   Jahng, Yurngdong ^a   Jung, Mi Ja ^b   Nam, Jung Min ^b   Na, Younghwa ^c   Kwon, Youngjoo ^b   Lee, Eung Seok ^a  

^a Yeungnam University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Catholic University of Daegu   (South Korea)

Author keywords

2 (5 Chlorothiophen 2 yl) 4 (furan 3 yl); 2 Thienyl 4 furyl 6 aryl pyridine; Cytotoxicity; Topoisomerase I and II

Indexed keywords

2 (2 CHLOROPHENYL) 4 (FURAN 2 YL) 6 (3 METHYLTHIOPHEN 2 YL)PYRIDINE; 2 (2 CHLOROPHENYL) 6 (5 CHLOROTHIOPHEN 2 YL) 4 (FURAN 3 YL)PYRIDINE; 2 (3 CHLOROPHENYL) 6 (5 CHLOROTHIOPHEN 2 YL) 4 (FURAN 3 YL)PYRIDINE; 2 (4 CHLOROPHENYL) 4 (FURAN 2 YL) 6 (3 METHYLTHIOPHEN 2 YL)PYRIDINE; 2 (4 CHLOROPHENYL) 4 (FURAN 3 YL) 6 (3 METHYLTHIOPHEN 2 YL)PYRIDINE; 2 (4 CHLOROPHENYL) 6 (5 CHLOROTHIOPHEN 2 YL) 4 (FURAN 2 YL)PYRIDINE; 2 (4 CHLOROPHENYL) 6 (5 CHLOROTHIOPHEN 2 YL) 4 (FURAN 3 YL)PYRIDINE; 2 (5 CHLOROTHIOPHEN 2 YL) 4 (FURAN 3 YL) 6 (5 METHYLFURAN 2 YL)PYRIDINE; 2 (5 CHLOROTHIOPHEN 2 YL) 4 (FURAN 3 YL) 6 3 TOLYLPYRIDINE; 2 (5 CHLOROTHIOPHEN 2 YL) 4 (FURAN 3 YL) 6 4 TOLYLPYRIDINE; 2 (5 CHLOROTHIOPHEN 2 YL) 6 (FURAN 2 YL) 4 (FURAN 3 YL)PYRIDINE; 2 (FURAN 2 YL) 4 (FURAN 3 YL) 6 (3 METHYLTHIOPHEN 2 YL)PYRIDINE; 2 THIENYL 4 FURYL 6 ARYL PYRIDINE DERIVATIVE; 4 (5 CHLOROFURAN 2 YL) 2 (3 CHLOROPHENYL) 6 (5 CHLOROTHIOPHEN 2 YL)PYRIDINE; 4 (5 CHLOROFURAN 2 YL) 2 (4 CHLOROPHENYL) 6 (3 METHYLTHIOPHEN 2 YL)PYRIDINE; 4 (5 CHLOROFURAN 2 YL) 2 (4 CHLOROPHENYL) 6 (5 CHLOROTHIOPHEN 2 YL)PYRIDINE; 4 (5 CHLOROFURAN 2 YL) 2 (5 CHLOROTHIOPHEN 2 YL) 6 (FURAN 2 YL) PYRIDINE; 4 (5 CHLOROFURAN 2 YL) 2 (5 CHLOROTHIOPHEN 2 YL) 6 2 TOLYLPYRIDINE; 4 (5 CHLOROFURAN 2 YL) 2 (FURAN 2 YL) 6 (3 METHYLTHIOPHEN 2 YL)PYRIDINE; 4 (5 CHLOROFURAN 2 YL) 6 (3 METHYLTHIOPHEN 2 YL) 2,3' BIPYRIDINE; 6 (5 CHLOROTHIOPHEN 2 YL) 4 (FURAN 3 YL) 2, 2' BIPYRIDINE; 6 (5 CHLOROTHIOPHEN 2 YL) 4 (FURAN 3 YL) 2,3' BIPYRIDINE; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ETOPOSIDE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL STRAIN K 562; CELL STRAIN MCF 7; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HELA CELL; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; NEOPLASMS; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 72049095310     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.10.049     Document Type: Article

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