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Volumn 4, Issue 3, 2013, Pages 395-413

Application of genomics, proteomics and metabolomics in drug discovery, development and clinic

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; DNA FRAGMENT;

EID: 84874588078     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.13.4     Document Type: Article
Times cited : (57)

References (97)
  • 2
    • 0030031766 scopus 로고    scopus 로고
    • Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
    • Butchdanger E, Zimmermann J, Mett H et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 56, 100-104 (1996).
    • (1996) Cancer Res , vol.56 , pp. 100-104
    • Butchdanger, E.1    Zimmermann, J.2    Mett, H.3
  • 3
    • 14844289540 scopus 로고    scopus 로고
    • Illuminating drug discovery with biological pathways
    • Apic G, Ignjatovic T, Boyer S, Russell RB. Illuminating drug discovery with biological pathways. FEBS Lett. 579, 1872-1877 (2005).
    • (2005) FEBS Lett , vol.579 , pp. 1872-1877
    • Apic, G.1    Ignjatovic, T.2    Boyer, S.3    Russell, R.B.4
  • 4
    • 32044441048 scopus 로고    scopus 로고
    • Using the transcriptome to annotage the genome revisited: Application of massively parallel signature sequencing (MPSS
    • Shah T, de Villiers E, Nene V et al. Using the transcriptome to annotage the genome revisited: application of massively parallel signature sequencing (MPSS). Gene 336, 104-108 (2006).
    • (2006) Gene , vol.336 , pp. 104-108
    • Shah, T.1    De Villiers, E.2    Nene, V.3
  • 5
    • 33750953227 scopus 로고    scopus 로고
    • Whole-genome re-sequencing
    • Bentley DR. Whole-genome re-sequencing. Curr. Opin. Gen. Dev. 16, 545-552 (2006).
    • (2006) Curr. Opin. Gen. Dev , vol.16 , pp. 545-552
    • Bentley, D.R.1
  • 6
    • 0031854986 scopus 로고    scopus 로고
    • Man-made cell-like compartments for molecular evolution
    • Tawfik DS, Griffiths AD. Man-made cell-like compartments for molecular evolution. Nat. Biotechnol. 16, 652-656 (1997).
    • (1997) Nat. Biotechnol , vol.16 , pp. 652-656
    • Tawfik, D.S.1    Griffiths, A.D.2
  • 7
    • 53649088131 scopus 로고    scopus 로고
    • Applications of next-generation sequencing technologies in functional genomics
    • Morozova O, Marra MA. Applications of next-generation sequencing technologies in functional genomics. Genomics 92, 255-264 (2008).
    • (2008) Genomics , vol.92 , pp. 255-264
    • Morozova, O.1    Marra, M.A.2
  • 8
    • 79953753919 scopus 로고    scopus 로고
    • A comprehensive study of multiple mapping and feature selection for correction strategy in the analysis of small RNAs from SOLiD sequencing
    • Guo L, Liang T, Lu Z. A comprehensive study of multiple mapping and feature selection for correction strategy in the analysis of small RNAs from SOLiD sequencing. Biosystems 104, 87-93 (2011).
    • (2011) Biosystems , vol.104 , pp. 87-93
    • Guo, L.1    Liang, T.2    Lu, Z.3
  • 9
    • 79960597679 scopus 로고    scopus 로고
    • An integrated semiconductor device enabling non-optical genome sequencing
    • Rothberg JM, Hinz W, Rearick TM et al. An integrated semiconductor device enabling non-optical genome sequencing. Nature 475, 348-352 (2011).
    • (2011) Nature , vol.475 , pp. 348-352
    • Rothberg, J.M.1    Hinz, W.2    Rearick, T.M.3
  • 10
    • 58149234737 scopus 로고    scopus 로고
    • Real-time DNA sequencing from single polymerase molecules
    • Eid J, Fehr A, Gray J et al. Real-time DNA sequencing from single polymerase molecules. Science 323, 133-138 (2009).
    • (2009) Science , vol.323 , pp. 133-138
    • Eid, J.1    Fehr, A.2    Gray, J.3
  • 11
    • 84867887849 scopus 로고    scopus 로고
    • Emerging real-time technologies in molecular medicine and the evolution of integrated 'pharmacomics' approaches to personalized medicine and drug discovery
    • Milward EA, Daneshi N, Johnstone DM. Emerging real-time technologies in molecular medicine and the evolution of integrated 'pharmacomics' approaches to personalized medicine and drug discovery. Pharmacol. Ther. 136, 295-304 (2012).
    • (2012) Pharmacol. Ther , vol.136 , pp. 295-304
    • Milward, E.A.1    Daneshi, N.2    Johnstone, D.M.3
  • 12
    • 85157182797 scopus 로고    scopus 로고
    • DNA sequencing-spanning the generations
    • 00869-2
    • McGinn S, Gut IG. DNA sequencing-spanning the generations. N. Biotechnol. S1871-S6784(12), 00869-2 (2012).
    • (2012) N. Biotechnol , Issue.12
    • McGinn, S.1    Gut, I.G.2
  • 13
    • 64449088698 scopus 로고    scopus 로고
    • Continuous base identification for single-molecule nanopore DNA sequencing
    • Clarke J, Wu HC, Jayasinghe L, Patel A, Reid S, Bayley H. Continuous base identification for single-molecule nanopore DNA sequencing. Nat. Nanotechnol. 4(4), 265-270 (2009).
    • (2009) Nat. Nanotechnol , vol.4 , Issue.4 , pp. 265-270
    • Clarke, J.1    Wu, H.C.2    Jayasinghe, L.3    Patel, A.4    Reid, S.5    Bayley, H.6
  • 15
    • 37549026870 scopus 로고    scopus 로고
    • Protein nanopores with covalently attached molecular adapters
    • Wu HC, Astier Y, Maglia G, Mikhailova E, Bayley H. Protein nanopores with covalently attached molecular adapters. J. Am. Chem. Soc. 129(51) 16142-16148 (2007).
    • (2007) J. Am. Chem. Soc , vol.129 , Issue.51 , pp. 16142-16148
    • Wu, H.C.1    Astier, Y.2    Maglia, G.3    Mikhailova, E.4    Bayley, H.5
  • 17
    • 0020071534 scopus 로고
    • Cloning and screening of sequences expressed in a mouse colon tumor
    • Augenlicht LH, Kobrin D. Cloning and screening of sequences expressed in a mouse colon tumor. Cancer Res. 42(3), 1088-1093 (1982).
    • (1982) Cancer Res , vol.42 , Issue.3 , pp. 1088-1093
    • Augenlicht, L.H.1    Kobrin, D.2
  • 18
    • 0028806048 scopus 로고
    • Quantitative monitoring of gene expression patterns with a complementary DNA microarray
    • Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 270(5235), 467-470 (1995).
    • (1995) Science , vol.270 , Issue.5235 , pp. 467-470
    • Schena, M.1    Shalon, D.2    Davis, R.W.3    Brown, P.O.4
  • 19
    • 0030699475 scopus 로고    scopus 로고
    • Yeast microarrays for genome wide parallel genetic and gene expression analysis
    • Lashkari DA, DeRisi JL, McCusker JH et al. Yeast microarrays for genome wide parallel genetic and gene expression analysis. Proc. Natl Acad. Sci. USA 94(24), 13057-13062 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , Issue.24 , pp. 13057-13062
    • Lashkari, D.A.1    Derisi, J.L.2    McCusker, J.H.3
  • 21
    • 71749113955 scopus 로고    scopus 로고
    • Detection and subtyping of influenza A virus based on a short oligonucleotide microarray
    • Li X, Qi X, Miao L et al. Detection and subtyping of influenza A virus based on a short oligonucleotide microarray. Diagn. Microbiol. Infect. Dis. 65, 261-270 (2012).
    • (2012) Diagn. Microbiol. Infect. Dis , vol.65 , pp. 261-270
    • Li, X.1    Qi, X.2    Miao, L.3
  • 22
    • 70849112355 scopus 로고    scopus 로고
    • Oligonucleotide-based microarray for detection of plant viruses employing sequence-independent amplification of targets
    • Grover V, Pierce ML, Hoyt P, Zhang F, Melcher U. Oligonucleotide-based microarray for detection of plant viruses employing sequence-independent amplification of targets. J. Virol. Methods. 163, 57-67 (2010).
    • (2010) J. Virol. Methods , vol.163 , pp. 57-67
    • Grover, V.1    Pierce, M.L.2    Hoyt, P.3    Zhang, F.4    Melcher, U.5
  • 23
    • 26244466536 scopus 로고    scopus 로고
    • Validation of a first-generation long-oligonucleotide microarray for transcriptional profiling in the pig
    • Zhao S, Recknor J, Lunney JK et al. Validation of a first-generation long-oligonucleotide microarray for transcriptional profiling in the pig. Genomics 86, 618-625 (2005).
    • (2005) Genomics , vol.86 , pp. 618-625
    • Zhao, S.1    Recknor, J.2    Lunney, J.K.3
  • 24
    • 0037458085 scopus 로고    scopus 로고
    • Microarrays: The use of oligonucleotides and cDNA for the analysis of gene expression
    • Barrett JC, Kawasaki ES. Microarrays: the use of oligonucleotides and cDNA for the analysis of gene expression. Rev. Res. Focus 8(3), 134-141 (2003).
    • (2003) Rev. Res. Focus , vol.8 , Issue.3 , pp. 134-141
    • Barrett, J.C.1    Kawasaki, E.S.2
  • 25
    • 8444236646 scopus 로고    scopus 로고
    • MALDI-TOF MS: A platform technology for genetic discovery
    • van den Boom D, Beaulieu M, Oeth P et al. MALDI-TOF MS: a platform technology for genetic discovery. Int. J. Mass Spectrom. 238, 173-188 (2004).
    • (2004) Int. J. Mass Spectrom , vol.238 , pp. 173-188
    • Van Den Boom, D.1    Beaulieu, M.2    Oeth, P.3
  • 26
    • 7944238046 scopus 로고    scopus 로고
    • Molecular biomarkers in drug development
    • Lewin DA, Weiner MP. Molecular biomarkers in drug development. Drug Discov. Today 9(22), 976-983 (2004).
    • (2004) Drug Discov. Today , vol.9 , Issue.22 , pp. 976-983
    • Lewin, D.A.1    Weiner, M.P.2
  • 27
    • 80051800111 scopus 로고    scopus 로고
    • Summary of the OA biomarkers workshop 2010-genetics and genomics: New targets in OA
    • Meulenbelt I, Kraus VB, Sandell LJ, Loughlin J. Summary of the OA biomarkers workshop 2010-genetics and genomics: new targets in OA. Osteoarthr. Cartil. 19, 1091-1094 (2011).
    • (2011) Osteoarthr. Cartil , vol.19 , pp. 1091-1094
    • Meulenbelt, I.1    Kraus, V.B.2    Sandell, L.J.3    Loughlin, J.4
  • 29
    • 84861227432 scopus 로고    scopus 로고
    • Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain
    • Hernandez DG, Nalls MA, Moore M et al. Integration of GWAS SNPs and tissue specific expression profiling reveal discrete eQTLs for human traits in blood and brain. Neurobiol. Dis. 47, 20-28 (2012).
    • (2012) Neurobiol. Dis , vol.47 , pp. 20-28
    • Hernandez, D.G.1    Nalls, M.A.2    Moore, M.3
  • 30
    • 34248672837 scopus 로고    scopus 로고
    • Toxicogenomics of non-viral drug delivery systems for RNAi: Potential impact on siRNA-mediated gene silencing activity and specificity
    • Akhtar S, Benter I. Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity. Adv. Drug Deliv. Rev. 59, 164-182 (2007).
    • (2007) Adv. Drug Deliv. Rev , vol.59 , pp. 164-182
    • Akhtar, S.1    Benter, I.2
  • 31
    • 33746506568 scopus 로고    scopus 로고
    • Genome-wide profiling of segmental-regulated transcriptomes in human epididymis using oligo microarray
    • Zhang J, Liu Q, Li Y, Hall SH, French FS, Zhang YL. Genome-wide profiling of segmental-regulated transcriptomes in human epididymis using oligo microarray. Mol. Cell. Endocrinol. 250, 169-177 (2006).
    • (2006) Mol. Cell. Endocrinol , vol.250 , pp. 169-177
    • Zhang, J.1    Liu, Q.2    Li, Y.3    Hall, S.H.4    French, F.S.5    Zhang, Y.L.6
  • 32
    • 84861181290 scopus 로고    scopus 로고
    • Identification of a novel set of biomarkers for evaluating phospholipidosis-inducing potential of compounds using rat liver microarray data measured 24 h after single dose administration
    • Yudate HT, Kai T, Aoki M et al. Identification of a novel set of biomarkers for evaluating phospholipidosis-inducing potential of compounds using rat liver microarray data measured 24 h after single dose administration. Toxicology 295, 1-7 (2012).
    • (2012) Toxicology , vol.295 , pp. 1-7
    • Yudate, H.T.1    Kai, T.2    Aoki, M.3
  • 34
    • 84862813807 scopus 로고    scopus 로고
    • Pharmacological mechanisms of clack cohosh in Sprague-Dawley rats
    • Einbond LS, Soffritti M, Esposti DD et al. Pharmacological mechanisms of clack cohosh in Sprague-Dawley rats. Fitoterapia 83, 461-468 (2012).
    • (2012) Fitoterapia , vol.83 , pp. 461-468
    • Einbond, L.S.1    Soffritti, M.2    Esposti, D.D.3
  • 35
    • 85135550906 scopus 로고    scopus 로고
    • Application of ultra-high throughput sequencing and microarray technologies in pharmacogenomics testing
    • (Chapter 7) Dasgupta A (Ed.). Elsevier Science Publishing Co Inc., London, UK
    • Hardiman G. Application of ultra-high throughput sequencing and microarray technologies in pharmacogenomics testing. In: Therapeutic Drug Monitoring: Newer Drugs and Biomarkers (Chapter 7). Dasgupta A (Ed.). Elsevier Science Publishing Co Inc., London, UK, 144-159 (2012).
    • (2012) Therapeutic Drug Monitoring: Newer Drugs and Biomarkers , pp. 144-159
    • Hardiman, G.1
  • 36
    • 84865989623 scopus 로고    scopus 로고
    • A knowledge-driven conditional approach to extract pharmacogenomics specific drug-gene relationships from free text
    • Xu R, Wang Q. A knowledge-driven conditional approach to extract pharmacogenomics specific drug-gene relationships from free text. J. Biomed. Inform. 45(5), 827-834 (2012).
    • (2012) J. Biomed. Inform , vol.45 , Issue.5 , pp. 827-834
    • Xu, R.1    Wang, Q.2
  • 37
    • 84865961913 scopus 로고    scopus 로고
    • Systematic identification of pharmacogenomics information from clinical trials
    • Li J, Lu Z. Systematic identification of pharmacogenomics information from clinical trials. J. Biomed. Inform. 45(5), 870-878 (2012).
    • (2012) J. Biomed. Inform , vol.45 , Issue.5 , pp. 870-878
    • Li, J.1    Lu, Z.2
  • 38
    • 85135551547 scopus 로고    scopus 로고
    • An introduction to personalized medicine
    • (Chapter 6) Dasgupta A (Ed.). Elsevier Science Publishing Co Inc., London, UK
    • Stone A, Bornhorst J. An introduction to personalized medicine. In: Therapeutic Drug Monitoring: Newer Drugs and Biomarkers (Chapter 6). Dasgupta A (Ed.). Elsevier Science Publishing Co Inc., London, UK, 122-142 (2012).
    • (2012) Therapeutic Drug Monitoring: Newer Drugs and Biomarkers , pp. 122-142
    • Stone, A.1    Bornhorst, J.2
  • 39
    • 84869015900 scopus 로고    scopus 로고
    • Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci
    • Sati S, Ghosh S, Jain V, Scaria V, Sengupta S. Genome-wide analysis reveals distinct patterns of epigenetic features in long non-coding RNA loci. Nucleic Acids Res. 40(20), 10018-31 (2012).
    • (2012) Nucleic Acids Res , vol.40 , Issue.20 , pp. 10018-10031
    • Sati, S.1    Ghosh, S.2    Jain, V.3    Scaria, V.4    Sengupta, S.5
  • 40
    • 77957276865 scopus 로고    scopus 로고
    • Introduction into the analysis of high-throughput-sequencing based epigenome data
    • Huss M. Introduction into the analysis of high-throughput-sequencing based epigenome data. Brief. Bioinform. 11(5), 512-523 (2010).
    • (2010) Brief. Bioinform , vol.11 , Issue.5 , pp. 512-523
    • Huss, M.1
  • 41
    • 84455194082 scopus 로고    scopus 로고
    • Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: Comparison with mRNA levels and activities
    • Ohtsuki S, Schaefer O, Kawakami H et al. Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP- glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities. Drug Metab. Dispos. 40(1), 83-92 (2012).
    • (2012) Drug Metab. Dispos , vol.40 , Issue.1 , pp. 83-92
    • Ohtsuki, S.1    Schaefer, O.2    Kawakami, H.3
  • 42
    • 84860294536 scopus 로고    scopus 로고
    • Proteomics in chromatin biology and epigenetics: Elucidation of post-translational modifications of histone proteins by mass spectrometry
    • Sidoli S, Cheng L, Jensen ON. Proteomics in chromatin biology and epigenetics: elucidation of post-translational modifications of histone proteins by mass spectrometry. J. Proteomics 75, 3419-3433 (2012).
    • (2012) J. Proteomics , vol.75 , pp. 3419-3433
    • Sidoli, S.1    Cheng, L.2    Jensen, O.N.3
  • 43
    • 84954358406 scopus 로고    scopus 로고
    • Quantitative proteome-property relationships (QPPRs). Part 1: Finding biomarkers of organic drugs with mean Markov connectivity indices of spiral networks of blood mass spectra
    • Cruz-Monteagudo M, Munteanu CR, Borges F, Cordeiro MN, Uriarte E, Gonzalez-Diaz H. Quantitative proteome-property relationships (QPPRs). Part 1: finding biomarkers of organic drugs with mean Markov connectivity indices of spiral networks of blood mass spectra. Bioorg. Med. Chem. 16, 9684-9693 (2008).
    • (2008) Bioorg. Med. Chem , vol.16 , pp. 9684-9693
    • Cruz-Monteagudo, M.1    Munteanu, C.R.2    Borges, F.3    Cordeiro, M.N.4    Uriarte, E.5    Gonzalez-Diaz, H.6
  • 44
    • 0036684101 scopus 로고    scopus 로고
    • Comparison of three directly coupled HPLC MS/MS strategies for identification of proteins from complex mixtures: Single-dimension LC-MS/MS, 2-phase MudPIT, and 3-phase MudPIT
    • McDonald WH, Ohi R, Miyamoto DT, Mitchison TJ, Yates JR. Comparison of three directly coupled HPLC MS/MS strategies for identification of proteins from complex mixtures: single-dimension LC-MS/MS, 2-phase MudPIT, and 3-phase MudPIT. Int. J. Mass Spectrom. 219, 245-251 (2002).
    • (2002) Int. J. Mass Spectrom , vol.219 , pp. 245-251
    • McDonald, W.H.1    Ohi, R.2    Miyamoto, D.T.3    Mitchison, T.J.4    Yates, J.R.5
  • 47
    • 33845329203 scopus 로고    scopus 로고
    • Functional and quantitative proteomics using SILAC
    • Mann M. Functional and quantitative proteomics using SILAC. Nat. Rev. Mol. Cell Biol. 7(12), 952-958 (2006).
    • (2006) Nat. Rev. Mol. Cell Biol , vol.7 , Issue.12 , pp. 952-958
    • Mann, M.1
  • 48
    • 19944432197 scopus 로고    scopus 로고
    • Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents
    • Ross PL, Huang YN, Marchese JN et al. Multiplexed protein quantitation in Saccharomyces cerevisiae using amine-reactive isobaric tagging reagents. Mol. Cell. Proteomics 3, 1154-1169 (2004).
    • (2004) Mol. Cell. Proteomics , vol.3 , pp. 1154-1169
    • Ross, P.L.1    Huang, Y.N.2    Marchese, J.N.3
  • 49
    • 80052032307 scopus 로고    scopus 로고
    • Activity-based proteomics: Identification of ABHD11 and ESD activities as potential biomarkers for human lung adenomacarconoma
    • Wiedl T, Arni S, Roschitzki B et al. Activity-based proteomics: identification of ABHD11 and ESD activities as potential biomarkers for human lung adenomacarconoma. J. Proteomics 74, 1884-1894 (2011).
    • (2011) J. Proteomics , vol.74 , pp. 1884-1894
    • Wiedl, T.1    Arni, S.2    Roschitzki, B.3
  • 50
    • 84861344535 scopus 로고    scopus 로고
    • Profiling of differentially expressed proteins in stage IV colorectal cancers with good and poor outcomes
    • Kim H, Kang U, Lee H et al. Profiling of differentially expressed proteins in stage IV colorectal cancers with good and poor outcomes. J. Proteomics 75, 2982-2997 (2011).
    • (2011) J. Proteomics , vol.75 , pp. 2982-2997
    • Kim, H.1    Kang, U.2    Lee, H.3
  • 51
    • 84862193068 scopus 로고    scopus 로고
    • Effective correction of experimental errors in quantitative proteomics using stable isotope labeling by amino acids in cell culture (SILAC
    • Park SS, Wu WW, Zhou Y et al. Effective correction of experimental errors in quantitative proteomics using stable isotope labeling by amino acids in cell culture (SILAC). J. Proteomics 75, 3720-3732, (2012).
    • (2012) J. Proteomics , vol.75 , pp. 3720-3732
    • Park, S.S.1    Wu, W.W.2    Zhou, Y.3
  • 52
    • 74049115774 scopus 로고    scopus 로고
    • Mass spectrometry-based label-free quantitative proteomics
    • Zhu W, Smith JW, Huang CM. Mass spectrometry-based label-free quantitative proteomics. J. Biomed. Biotechnol. 2010, 840518 (2010).
    • (2010) J. Biomed. Biotechnol , vol.2010 , pp. 840518
    • Zhu, W.1    Smith, J.W.2    Huang, C.M.3
  • 53
    • 84866992804 scopus 로고    scopus 로고
    • Detection of ubiquitin-proteasome enzymatic activities in cells: Application of activity-based probes to inhibitor development
    • Kramer HB, Nicholson B, Kessler BM, Altun M. Detection of ubiquitin-proteasome enzymatic activities in cells: application of activity-based probes to inhibitor development. Biochim. Biophys. Acta 1823(11), 2029-2037 (2012).
    • (2012) Biochim. Biophys. Acta , vol.1823 , Issue.11 , pp. 2029-2037
    • Kramer, H.B.1    Nicholson, B.2    Kessler, B.M.3    Altun, M.4
  • 56
    • 0035887145 scopus 로고    scopus 로고
    • Profiling of cancer cells using protein microarrays: Discovery of novel radiation-regulated proteins
    • Sreekumar A, Nyati MK, Varambally S et al. Profiling of cancer cells using protein microarrays: discovery of novel radiation-regulated proteins. Cancer Res. 61, 7585-7593 (2001).
    • (2001) Cancer Res , vol.61 , pp. 7585-7593
    • Sreekumar, A.1    Nyati, M.K.2    Varambally, S.3
  • 57
    • 5644229499 scopus 로고    scopus 로고
    • Regulation of gene expression by a metabolic enzyme
    • Hall DA, Zhu H, Zhu X et al. Regulation of gene expression by a metabolic enzyme. Science 306, 482-484 (2004).
    • (2004) Science , vol.306 , pp. 482-484
    • Hall, D.A.1    Zhu, H.2    Zhu, X.3
  • 58
    • 0035860499 scopus 로고    scopus 로고
    • Global analysis of protein activities using proteome chips
    • Zhu H, Bilgin M, Bangham, R et al. Global analysis of protein activities using proteome chips. Science 293, 2101-2105 (2001).
    • (2001) Science , vol.293 , pp. 2101-2105
    • Zhu, H.1    Bilgin, M.2    Bangham, R.3
  • 61
    • 2442575025 scopus 로고    scopus 로고
    • Bio-bar-code-based DNA detection with PCR-like sensitivity
    • Nam J, Stoeva SI, Mirkin CA. Bio-bar-code-based DNA detection with PCR-like sensitivity. J. Am. Chem. Soc. 126, 5932-5933 (2004).
    • (2004) J. Am. Chem. Soc , vol.126 , pp. 5932-5933
    • Nam, J.1    Stoeva, S.I.2    Mirkin, C.A.3
  • 62
    • 3242886171 scopus 로고    scopus 로고
    • Ribosome display: Cell-free protein display technology
    • He M, Taussig MJ. Ribosome display: cell-free protein display technology. Brief. Funct. Genomic. Proteomic. 1(2), 204-212 (2002).
    • (2002) Brief. Funct. Genomic. Proteomic , vol.1 , Issue.2 , pp. 204-212
    • He, M.1    Taussig, M.J.2
  • 63
    • 32944454774 scopus 로고    scopus 로고
    • Ribosomal display for improved biotherapeutic molecules
    • Rothe A, Hosse RJ, Power BE. Ribosomal display for improved biotherapeutic molecules. Expert Opin. Biol. Ther. 6(2), 177-187 (2006).
    • (2006) Expert Opin. Biol. Ther , vol.6 , Issue.2 , pp. 177-187
    • Rothe, A.1    Hosse, R.J.2    Power, B.E.3
  • 65
    • 1542285258 scopus 로고    scopus 로고
    • Application of the split-ubiquitin membrane yeast two-hybrid system to investigate membrane protein interactions
    • Fetchko M, Stagljar I. Application of the split-ubiquitin membrane yeast two-hybrid system to investigate membrane protein interactions. Methods 32, 349-362 (2004).
    • (2004) Methods , vol.32 , pp. 349-362
    • Fetchko, M.1    Stagljar, I.2
  • 66
    • 0031051417 scopus 로고    scopus 로고
    • Mammalian two-hybrid system: A complementary approach to the yeast two-hybrid system
    • Luo Y, Batalao A, Zhou H, Zhu L. Mammalian two-hybrid system: a complementary approach to the yeast two-hybrid system. Biotechniques 22, 350-352 (1997).
    • (1997) Biotechniques , vol.22 , pp. 350-352
    • Luo, Y.1    Batalao, A.2    Zhou, H.3    Zhu, L.4
  • 67
    • 54049090766 scopus 로고    scopus 로고
    • Selected reaction monitoring for quantitative proteomics: A tutorial
    • Lange V, Picotti P, Domon B et al. Selected reaction monitoring for quantitative proteomics: a tutorial. Mol. Syst. Biol. 4(222), 1-14 (2008).
    • (2008) Mol. Syst. Biol , vol.4 , Issue.222 , pp. 1-14
    • Lange, V.1    Picotti, P.2    Domon, B.3
  • 68
    • 33751356224 scopus 로고    scopus 로고
    • Systems biology, metabolic modeling and metabolomics in drug discovery and development
    • Kell DB, Systems biology, metabolic modeling and metabolomics in drug discovery and development. Drug Discov. Today 11(23-24), 1085-1092 (2006).
    • (2006) Drug Discov. Today , vol.11 , Issue.23-24 , pp. 1085-1092
    • Kell, D.B.1
  • 69
    • 84855845466 scopus 로고    scopus 로고
    • Metabolomics and cancer drug discovery: Let the cells do the talking
    • D'Alessandro A, Zolla L, Metabolomics and cancer drug discovery: let the cells do the talking. Drug Discov. Today 17(1-2), 3-9 (2012).
    • (2012) Drug Discov. Today , vol.17 , Issue.1-2 , pp. 3-9
    • D'Alessandro, A.1    Zolla, L.2
  • 70
    • 20044368617 scopus 로고    scopus 로고
    • GC-MS libraries for the rapid identification of metabolites in complex biological samples
    • Schauer N, Steinhauser D, Strelkov S et al. GC-MS libraries for the rapid identification of metabolites in complex biological samples. FEBS Lett. 579(6), 1332-1337 (2005).
    • (2005) FEBS Lett , vol.579 , Issue.6 , pp. 1332-1337
    • Schauer, N.1    Steinhauser, D.2    Strelkov, S.3
  • 71
    • 34548146614 scopus 로고    scopus 로고
    • Within-day reproducibility of an LC-MS-based method for metabonomic analysis: Application to human urine
    • Gika HG, Theodoridis GA, Wingate JE, Wilson ID. Within-day reproducibility of an LC-MS-based method for metabonomic analysis: application to human urine. J. Proteome Res. 6(8), 3291-3303 (2007).
    • (2007) J. Proteome Res , vol.6 , Issue.8 , pp. 3291-3303
    • Gika, H.G.1    Theodoridis, G.A.2    Wingate, J.E.3    Wilson, I.D.4
  • 73
    • 0142138236 scopus 로고    scopus 로고
    • Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterization of xenobiotic toxicity and disease diagnosis
    • Griffin JL. Metabonomics: NMR spectroscopy and pattern recognition analysis of body fluids and tissues for characterization of xenobiotic toxicity and disease diagnosis. Curr. Opin. Chem. Biol. 7(5), 648-654 (2003).
    • (2003) Curr. Opin. Chem. Biol , vol.7 , Issue.5 , pp. 648-654
    • Griffin, J.L.1
  • 74
    • 32444432587 scopus 로고    scopus 로고
    • METLIN: A metabolite mass spectral database
    • Smith C, O'Maille G, Want E et al. METLIN: a metabolite mass spectral database. Ther. Drug Monit. 27(6), 747-751 (2005).
    • (2005) Ther. Drug Monit , vol.27 , Issue.6 , pp. 747-751
    • Smith, C.1    O'Maille, G.2    Want, E.3
  • 76
    • 32444432587 scopus 로고    scopus 로고
    • METLIN: A metabolite mass spectral database
    • Smith CA, Maille GO, Want EJ et al. METLIN: a metabolite mass spectral database. Ther. Drug Monit. 27(6), 747-751 (2005).
    • (2005) Ther. Drug Monit , vol.27 , Issue.6 , pp. 747-751
    • Smith, C.A.1    Maille, G.O.2    Want, E.J.3
  • 77
    • 33644874819 scopus 로고    scopus 로고
    • From genomics to chemical genomics: New developments in KEGG
    • Kanehisa M, Goro S, Hattori M et al. From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res. 34, D354-D357 (2006).
    • (2006) Nucleic Acids Res , vol.34
    • Kanehisa, M.1    Goro, S.2    Hattori, M.3
  • 78
    • 0037163883 scopus 로고    scopus 로고
    • Potential artefacts in protein-interaction networks
    • Aloy P, Russell RB. Potential artefacts in protein-interaction networks. FEBS Lett. 530, 253-254 (2002).
    • (2002) FEBS Lett , vol.530 , pp. 253-254
    • Aloy, P.1    Russell, R.B.2
  • 79
    • 0037161731 scopus 로고    scopus 로고
    • Comparative assessment of large-scale data sets of protein-protein interactions
    • von Mering C, Krause R, Snel B et al. Comparative assessment of large-scale data sets of protein-protein interactions. Nature 417, 399-403 (2002).
    • (2002) Nature , vol.417 , pp. 399-403
    • Von Mering, C.1    Krause, R.2    Snel, B.3
  • 80
    • 84861575100 scopus 로고    scopus 로고
    • Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures
    • Sato T, Watanabe H, Tsuganezawa K et al. Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures. Bioorg. Med. Chem. 20, 3756-3767 (2012).
    • (2012) Bioorg. Med. Chem , vol.20 , pp. 3756-3767
    • Sato, T.1    Watanabe, H.2    Tsuganezawa, K.3
  • 81
    • 84855955467 scopus 로고    scopus 로고
    • Systems medicine and metabolic modeling
    • Mardinoglu A, Nielsen J. Systems medicine and metabolic modeling. J. Int. Med. 271, 142-154 (2012).
    • (2012) J. Int. Med , vol.271 , pp. 142-154
    • Mardinoglu, A.1    Nielsen, J.2
  • 82
    • 77953808473 scopus 로고    scopus 로고
    • Next-generation genomics: An integrative approach
    • Hawkins R, Hon G, Ren B. Next-generation genomics: an integrative approach. Nat. Rev. Genet. 11, 476-486 (2010).
    • (2010) Nat. Rev. Genet , vol.11 , pp. 476-486
    • Hawkins, R.1    Hon, G.2    Ren, B.3
  • 85
    • 80054072674 scopus 로고    scopus 로고
    • SiRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells
    • Qin XY, Wei F, Yoshinaga J, Yonemoto J, Tanokura M, Sone H. siRNA-mediated knockdown of aryl hydrocarbon receptor nuclear translocator 2 affects hypoxia-inducible factor-1 regulatory signaling and metabolism in human breast cancer cells. FEBS Lett. 585, 3310-3315 (2011).
    • (2011) FEBS Lett , vol.585 , pp. 3310-3315
    • Qin, X.Y.1    Wei, F.2    Yoshinaga, J.3    Yonemoto, J.4    Tanokura, M.5    Sone, H.6
  • 86
    • 50149097983 scopus 로고    scopus 로고
    • Hypoxia HIF1 and glucose metabolism in the solid tumor
    • Denko NC. Hypoxia, HIF1 and glucose metabolism in the solid tumor. Nat. Rev. Cancer 8, 705-713 (2008).
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 705-713
    • Denko, N.C.1
  • 87
    • 0036468251 scopus 로고    scopus 로고
    • Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild type tumors and tumors deficient in hypoxia-inducible factor-1 beta (HIF-1beta): Evidence of an anabolic role for the HIF-1 pathway
    • Griffiths JR, McSheehy PM, Robinson SP et al. Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild type tumors and tumors deficient in hypoxia-inducible factor-1 beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway. Cancer Res. 62, 688-695 (2002).
    • (2002) Cancer Res , vol.62 , pp. 688-695
    • Griffiths, J.R.1    McSheehy, P.M.2    Robinson, S.P.3
  • 88
    • 33846910173 scopus 로고    scopus 로고
    • Global reconstruction of the human metabolic network based on genomic and bibliomic data
    • Duarte NC, Becker SA, Jamshidi N et al. Global reconstruction of the human metabolic network based on genomic and bibliomic data. Proc. Natl Acad. Sci. USA 104, 1777-1782 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 1777-1782
    • Duarte, N.C.1    Becker, S.A.2    Jamshidi, N.3
  • 89
    • 77954791900 scopus 로고    scopus 로고
    • Compartmentalization of the Edinburgh human metabolic network
    • Hao T, Ma HW, Zhao XM, Goryanin I. Compartmentalization of the Edinburgh Human Metabolic Network. BMC Bioinformatics 11(393), 1-12 (2010).
    • (2010) BMC Bioinformatics , vol.11 , Issue.393 , pp. 1-12
    • Hao, T.1    Ma, H.W.2    Zhao, X.M.3    Goryanin, I.4
  • 90
    • 14844326483 scopus 로고    scopus 로고
    • Computational prediction of human metabolic pathways from the complete human genome
    • Romero P, Wagg J, Green ML et al. Computational prediction of human metabolic pathways from the complete human genome. Genome Biol. 6(1), R21-R217 (2005).
    • (2005) Genome Biol , vol.6 , Issue.1
    • Romero, P.1    Wagg, J.2    Green, M.L.3
  • 91
    • 84863662483 scopus 로고    scopus 로고
    • Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT
    • Agren R, Bordel S, Mardinoglu A, Pornputtapong N, Nookaew I, Nielsen J. Reconstruction of genome-scale active metabolic networks for 69 human cell types and 16 cancer types using INIT. PLoS Comput. Biol. 8(5), 1-9 (2012).
    • (2012) PLoS Comput. Biol , vol.8 , Issue.5 , pp. 1-9
    • Agren, R.1    Bordel, S.2    Mardinoglu, A.3    Pornputtapong, N.4    Nookaew, I.5    Nielsen, J.6
  • 92
    • 77956407882 scopus 로고    scopus 로고
    • HepatoNet1: A comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology
    • Gille C, Bolling C, Hoppe A et al. HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology. Mol. Syst. Biol. 6(441), 1-13 (2010).
    • (2010) Mol. Syst. Biol , vol.6 , Issue.441 , pp. 1-13
    • Gille, C.1    Bolling, C.2    Hoppe, A.3
  • 93
    • 77956417789 scopus 로고    scopus 로고
    • Computational reconstruction of tissue-specific metabolic models: Application to human liver metabolism
    • Jerby L, Shlomi T, Ruppin E. Computational reconstruction of tissue-specific metabolic models: application to human liver metabolism. Mol. Syst. Biol. 6(401), 1-9 (2010).
    • (2010) Mol. Syst. Biol , vol.6 , Issue.401 , pp. 1-9
    • Jerby, L.1    Shlomi, T.2    Ruppin, E.3
  • 94
    • 78049445175 scopus 로고    scopus 로고
    • Drug off-target effects predicted using structural analysis in the context of a metabolic network model
    • Chang RL, Xie L, Bourne PE, Palsson BO. Drug off-target effects predicted using structural analysis in the context of a metabolic network model. PLoS Comput Biol. 6(9), e1000938 (2010).
    • (2010) PLoS Comput Biol , vol.6 , Issue.9
    • Chang, R.L.1    Xie, L.2    Bourne, P.E.3    Palsson, B.O.4
  • 95
    • 78650002545 scopus 로고    scopus 로고
    • Large-scale in silico modeling of metabolic interactions between cell types in the human brain
    • Lewis NE, Schramm G, Bordbar A et al. Large-scale in silico modeling of metabolic interactions between cell types in the human brain. Nat Biotechnol. 28, 1279-1285 (2010).
    • (2010) Nat Biotechnol , vol.28 , pp. 1279-1285
    • Lewis, N.E.1    Schramm, G.2    Bordbar, A.3
  • 96
    • 79960169210 scopus 로고    scopus 로고
    • IAB-RBC-283: A proteomically derived knowledge-base of erythrocyte metabolism that can be used to simulate its physiological and patho-physiological states
    • Bordbar A, Jamshidi N, Palsson BO. iAB-RBC-283: a proteomically derived knowledge-base of erythrocyte metabolism that can be used to simulate its physiological and patho-physiological states. BMC Syst. Biol. 5(110), 1-12 (2011).
    • (2011) BMC Syst. Biol , vol.5 , Issue.110 , pp. 1-12
    • Bordbar, A.1    Jamshidi, N.2    Palsson, B.O.3
  • 97
    • 77958537509 scopus 로고    scopus 로고
    • Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions
    • Bordbar A, Lewis NE, Schellenberger J, Palsson BO, Jamshidi N. Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions. Mol. Syst. Biol. 6(422), 1-14 (2010).
    • (2010) Mol. Syst. Biol , vol.6 , Issue.422 , pp. 1-14
    • Bordbar, A.1    Lewis, N.E.2    Schellenberger, J.3    Palsson, B.O.4    Jamshidi, N.5


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