SCOPUS 정보 검색 플랫폼

Volumn 20, Issue 12, 2012, Pages 3756-3767

Identification of novel drug-resistant EGFR mutant inhibitors by in silico screening using comprehensive assessments of protein structures

(17) Sato, Tomohiro a,b Watanabe, Hisami b Tsuganezawa, Keiko b Yuki, Hitomi b Mikuni, Junko b Yoshikawa, Seiko b Kukimoto Niino, Mutsuko b Fujimoto, Takako b Terazawa, Yumiko b Wakiyama, Motoaki b Kojima, Hirotatsu a Okabe, Takayoshi a Nagano, Tetsuo a Shirouzu, Mikako b Yokoyama, Shigeyuki a,b Tanaka, Akiko a,b Honma, Teruki b

a UNIVERSITY OF TOKYO (Japan)

b RIKEN (Japan)

Author keywords

Docking parameter optimization; Drug resistant mutant; Epidermal growth factor receptor; In silico screening

Indexed keywords

6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; GEFITINIB; LAPATINIB; QUERCETIN; QUERCETIN DERIVATIVE;

BINDING AFFINITY; COMPUTER MODEL; CONFERENCE PAPER; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG IDENTIFICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; IC 50; MOLECULAR DOCKING; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN STRUCTURE; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION;

DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, NEOPLASM; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; MUTATION; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861575100 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.04.042 Document Type: Conference Paper

Times cited : (11)

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