Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: Comparison with mRNA levels and activities

Drug Metabolism and Disposition

Volumn 40, Issue 1, 2012, Pages 83-92

  Ohtsuki, Sumio ^a   Schaefer, Olaf ^b   Kawakami, Hirotaka ^a   Inoue, Tae ^a   Liehner, Stephanie ^c   Saito, Asami ^b   Ishiguro, Naoki ^b   Kishimoto, Wataru ^b   Ludwig Schwellinger, Eva ^c   Ebner, Thomas ^c   Terasaki, Tetsuya ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b NIPPON BOEHRINGER INGELHEIM CO LTD   (Japan)

^c BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMFEBUTAMONE; AMODIAQUINE; CARRIER PROTEIN; CYTOCHROME P450; CYTOCHROME P450 2A6; CYTOCHROME P450 2B6; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; DICLOFENAC; GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A6; GLUCURONOSYLTRANSFERASE 2B15; GLUCURONOSYLTRANSFERASE 2B7; LAURIC ACID; MEPHENYTOIN; MESSENGER RNA; MIDAZOLAM; NIFEDIPINE; ORGANIC ANION TRANSPORTER 2; PHENACETIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE FERRIHEMOPROTEIN REDUCTASE; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL MEMBRANE; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; LIVER; LIVER METABOLISM; LIVER MICROSOME; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TANDEM MASS SPECTROMETRY;

ADULT; AGE FACTORS; AGED; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCURONOSYLTRANSFERASE; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; MICROSOMES, LIVER; MIDDLE AGED; RNA, MESSENGER; YOUNG ADULT;

EID: 84455194082     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.111.042259     Document Type: Article

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