Metabolomics and cancer drug discovery: Let the cells do the talking

Drug Discovery Today

Volumn 17, Issue 1-2, 2012, Pages 3-9

  D'Alessandro, Angelo ^a   Zolla, Lello ^a  

^a UNIVERSITY OF TUSCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT;

CANCER CELL; CANCER RESEARCH; CANCER THERAPY; CARCINOGENESIS; CELL PROLIFERATION; DRUG DEVELOPMENT; GLYCOLYSIS; HUMAN; METABOLOMICS; OXIDATIVE STRESS; REVIEW;

EID: 84855845466     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2011.09.017     Document Type: Short Survey

References (33)

1. C.J. Lord, and A. Ashworth Biology-driven cancer drug development: back to the future BMC Biol. 8 2010 38
2. A. D'Alessandro, and L. Zolla Pharmacoproteomics: a chess game on a protein field Drug Discov. Today 15 2010 1015 1023
3. D.S. Wishart Applications of metabolomics in drug discovery and development Drugs R. D. 9 2008 307 322
4. W.B. Dunn, and D.I. Ellis Metabolomics: current analytical platforms and methodologies Trends Anal. Chem. 24 2005 285 294 (Pubitemid 40461029)
5. A. D'Alessandro A robust high resolution reversed-phase HPLC strategy to investigate various metabolic species in different biological models Mol. Biosyst. 7 2011 1024 1032
6. D.B. Kell Systems biology, metabolic modelling and metabolomics in drug discovery and development Drug Discov. Today 11 2006 1085 1092 (Pubitemid 44810914)
7. M. Morris, and S.M. Watkins Focused metabolomic profiling in the drug development process: advances from lipid profiling Curr. Opin. Chem. Biol. 9 2005 407 412 (Pubitemid 41019688)
8. L. Zolla Proteomics studies reveal important information on small molecule therapeutics: a case study on plasma proteins Drug Discov. Today 13 2008 1042 1051
9. R.J. Williams Individual metabolic patterns and human disease: an exploratory study utilizing predominantly paper chromatographic methods Biochemical Institute Studies IV 1951 Univ. of Texas p. 204, Publication No. 5109
10. E.G. Bligh, and W.J. Dyer A rapid method of total lipid extraction and purification Can. J. Biochem. Physiol. 37 1959 911 917
11. J.K. Nicholson 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data Xenobiotica 29 1999 1181 1189
12. W.J. Griffiths Targeted metabolomics for biomarker discovery Angew. Chem. Int. Ed. Engl. 49 2010 5426 5445
13. J.M. Buscher Cross-platform comparison of methods for quantitative metabolomics of primary metabolism Anal. Chem. 81 2009 2135 2143
14. C.A. Smith METLIN: a metabolite mass spectral database Ther. Drug Monit. 27 2005 747 751 (Pubitemid 44391729)
15. M. Kanehisa From genomics to chemical genomics: new developments in KEGG Nucleic Acids Res. 34 2006 354 357
16. J.L. Griffin The Cinderella story of metabolic profiling: does metabolomics get to go to the functional genomics ball? Philos. Trans. R. Soc. Lond. B: Biol. Sci. 361 2006 147 161 (Pubitemid 44858949)
17. P. Mendes Why and when channeling can decrease pool size at constant net flux in a simple dynamic channel Biochim. Biophys. Acta 1289 1996 175 186
18. E. Urbanczyk-Wochniak Parallel analysis of transcript and metabolic profiles: a new approach in systems biology EMBO Rep. 4 2003 989 993 (Pubitemid 37407468)
19. G.G. Harrigan, and R. Goodacre Metabolic Profiling: Its Role in Biomarker Discovery and Gene Function Analysis 2003 Kluwer Academic Publishers
20. O. Warburg On the origin of cancer cells Science 123 1956 309 314
21. J.S. Bertram The molecular biology of cancer Mol. Aspects Med. 21 2000 167 223 (Pubitemid 32118230)
22. A. Vazquez Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited BMC Syst. Biol. 4 2010 58
23. A. Boiteux, and B. Hess Design of glycolysis Philos. Trans. R. Soc. Lond. B: Biol. Sci. 293 1981 5 22
24. M.M. Chi Metabolic changes in the glucose-induced apoptotic blastocyst suggest alterations in mitochondrial physiology Am. J. Physiol. Endocrinol. Metab. 283 2002 226 232
25. A. D'Alessandro Docosohaexanoic acid-supplemented PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomic, metabolomic and interactomic overview J. Proteomics 74 2011 2138 2158
26. W. Hu Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function Proc. Natl. Acad. Sci. U. S. A. 107 2010 7455 7460
27. G. Melino Functional regulation of p73 and p63: development and cancer Trends Biochem. Sci. 28 2003 663 670 (Pubitemid 37500901)
28. B. Mayer, and R. Oberbauer Mitochondrial regulation of apoptosis News Physiol. Sci. 18 2003 89 94 (Pubitemid 36782796)
29. T. Finkel, and P.M. Hwang The Krebs cycle meets the cell cycle: mitochondria and the G1-S transition Proc. Natl. Acad. Sci. U. S. A. 106 2009 11825 11826
30. D. Hanahan, and R.A. Weinberg The hallmarks of cancer Cell 100 2000 57 70 (Pubitemid 30046295)
31. D'Alessandro, A. et al. Redox proteomics and drug development. J. Proteomics, doi:10.1016/j.jprot.2011.01.001.
32. Z. Cai A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism Mol. Cell. Proteomics 9 2010 2617 2628
33. R.H. Xu Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia Cancer Res. 65 2005 613 621