Role of the nervous system in cancer metastasis (Review)

Oncology Letters

Volumn 5, Issue 4, 2013, Pages 1101-1111

  Li, Sha ^a   Sun, Yanlai ^b,c   Gao, Dongwei ^a  

^a LANZHOU GENERAL HOSPITAL   (China)

^b SHANDONG CANCER HOSPITAL AND INSTITUTE   (China)

^c SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

Author keywords

Cancer metastasis; Nervous system

Indexed keywords

4 AMINOBUTYRIC ACID; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ENDORPHIN; BOMBESIN; INTERLEUKIN 6; MATRIX METALLOPROTEINASE; NETRIN 1; NEU DIFFERENTIATION FACTOR; NEUROTRANSMITTER; NEUROTROPHIN; NORADRENALIN; PREPROTACHYKININ; SUBSTANCE P; TROPOMYOSIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; BONE MARROW; CANCER CELL; DISEASE ASSOCIATION; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNOMODULATION; INFLAMMATION; METASTASIS; NERVE CELL; NERVOUS SYSTEM; NONHUMAN; TUMOR MICROENVIRONMENT;

EID: 84874438110     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1168     Document Type: Article

References (251)

1. Willis RA: The Spread of Tumors in the Human Body. 3rd edition. Butterworths, London, 1973.
2. Reiche EM, Nunes SO and Morimoto HK: Stress, depression, the immune system, and cancer. Lancet Oncol 5: 617-625, 2004.
3. Lutgendorf SK and Sood AK: Biobehavioral factors and cancer progression: physiological pathways and mechanisms. Psychosom Med 73: 724-730, 2011.
4. Thaker PH and Sood AK: Neuroendocrine influences on cancer biology. Semin Cancer Biol 18: 164-170, 2008.
5. Armaiz-Pena GN, Lutgendorf SK, Cole SW and Sood AK: Neuroendocrine modulation of cancer progression. Brain Behav Immun 23: 10-15, 2009.
6. Williams JB, Pang D, Delgado B, Kocherginsky M, Tretiakova M, Krausz T, Pan D, He J, McClintock MK and Conzen SD: A model of gene-environment interaction reveals altered mammary gland gene expression and increased tumor growth following social isolation. Cancer Prev Res (Phila) 2: 850-861, 2009.
7. McEwen BS: Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 87: 873-904, 2007.
8. Toh YC: Inhibitory effect of hypothalamic lesions on liver tumor induction by N-2-fluorenylacetamide in male rats. Cancer Res 38: 42-51, 1978.
9. Karasek M and Pawlikowski M: Pineal gland, melatonin and cancer. NEL Review. Neuro Endocrinol Lett 20: 139-144, 1999.
10. Bruni JE and Montemurro DG: Effect of hypothalamic lesions on the genesis of spontaneous mammary gland tumors in the mouse. Cancer Res 31: 854-863, 1971.
11. Chelmicka-Szorc E and Arnason BG: Effect of 6-hydroxydopamine on tumor growth. Cancer Res 36: 2382-2384, 1976.
12. Chelmicka-Schorr E and Arnason BG: Modulatory effect of the sympathetic nervous system on neuroblastoma tumor growth. Cancer Res 38: 1374-1375, 1978.
13. Seifert P and Spitznas M: Tumours may be innervated. Virchows Arch 438: 228-231, 2001.
14. Seifert P, Benedic M and Effert P: Nerve fibers in tumors of the human urinary bladder. Virchows Arch 440: 291-297, 2002.
15. Lu SH, Zhou Y, Que HP and Liu SJ: Peptidergic innervation of human esophageal and cardiac carcinoma. World J Gastroenterol 9: 399-403, 2003.
16. Liang YJ, Zhou P, Wongba W, Guardiola J, Walker J and Yu J: Pulmonary innervation, inflammation and carcinogenesis. Sheng Li Xue Bao 62: 191-195, 2010.
17. Li JH, Ma QY, Shen SG and Hu HT: Stimulation of dorsal root ganglion neurons activity by pancreatic cancer cell lines. Cell Biol Int 32: 1530-1535, 2008.
18. Albo D, Akay CL, Marshall CL, Wilks JA, Verstovsek G, Liu H, Agarwal N, Berger DH and Ayala GE: Neurogenesis in colorectal cancer is a marker of aggressive tumor behavior and poor outcomes. Cancer 117: 4834-4845, 2011.
19. Ayala GE, Wheeler TM, Shine HD, Schmelz M, Frolov A, Chakraborty S and Rowley D: In vitro dorsal root ganglia and human prostate cell line interaction: redefining perineural invasion in prostate cancer. Prostate 49: 213-223, 2001.
20. Batkin S, Piette LH and Wildman E: Effect of muscle denervation on growth of transplanted tumor in mice. Proc Natl Acad Sci USA 67: 1521-1527, 1970.
21. Papageorgiou A, Trontzos C, Kallistratos H, Kokkas B, Grigoriadis N and Grammaticos P: Slowing growth and histology changes in Lewis lung carcinoma implanted in a partly denervated muscle. Cancer Invest 21: 869-872, 2003.
22. Romeo HE, Colombo LL, Esquifino AI, Rosenstein RE, Chuluyan HE and Cardinali DP: Slower growth of tumours in sympathetically denervated murine skin. J Auton Nerv Syst 32: 159-164, 1991.
23. Peng J, Sheng W, Huang D, Venook AP, Xu Y, Guan Z and Cai S: Perineural invasion in pT3N0 rectal cancer: the incidence and its prognostic effect. Cancer 117: 1415-1421, 2011.
24. Feng FY, Qian Y, Stenmark MH, Halverson S, Blas K, Vance S, Sandler HM and Hamstra DA: Perineural invasion predicts increased recurrence, metastasis, and death from prostate cancer following treatment with dose-escalated radiation therapy. Int J Radiat Oncol Biol Phys 81: e361-e367, 2011.
25. Poeschl EM, Pollheimer MJ, Kornprat P, Lindtner RA, Schlemmer A, Rehak P, Vieth M and Langner C: Perineural invasion: correlation with aggressive phenotype and independent prognostic variable in both colon and rectum cancer. J Clin Oncol 28: e358-e360, e361-e362, 2010.
26. Liebig C, Ayala G, Wilks JA, Berger DH and Albo D: Perineural invasion in cancer: a review of the literature. Cancer 115: 3379-3391, 2009.
27. Khasraw M and Posner JB: Neurological complications of systemic cancer. Lancet Neurol 9: 1214-1227, 2010.
28. Toothaker TB and Rubin M: Paraneoplastic neurological syndromes: a review. Neurologist 15: 21-33, 2009.
29. Mravec B, Gidron Y and Hulin I: Neurobiology of cancer: Interactions between nervous, endocrine and immune systems as a base for monitoring and modulating the tumorigenesis by the brain. Semin Cancer Biol 18: 150-163, 2008.
30. Entschladen F, Palm D, Niggemann B and Zaenker KS: The cancer's nervous tooth: Considering the neuronal crosstalk within tumors. Semin Cancer Biol 18: 171-175, 2008.
31. Ondicova K and Mravec B: Role of nervous system in cancer aetiopathogenesis. Lancet Oncol 11: 596-601, 2010.
32. Sloan EK, Priceman SJ, Cox BF, Yu S, Pimentel MA, Tangkanangnukul V, Arevalo JM, Morizono K, Karanikolas BD, Wu L, Sood AK and Cole SW: The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Res 70: 7042-7052, 2010.
33. Gupta GP and Massague J: Cancer metastasis: building a framework. Cell 127: 679-695, 2006.
34. de Visser KE, Eichten A and Coussens LM: Paradoxical roles of the immune system during cancer development. Nat Rev Cancer 6: 24-37, 2006.
35. DeNardo DG, Johansson M and Coussens LM: Immune cells as mediators of solid tumor metastasis. Cancer Metastasis Rev 27: 11-18, 2008.
36. Wu Y and Zhou BP: Inflammation: a driving force speeds cancer metastasis. Cell Cycle 8: 3267-3273, 2009.
37. Solinas G, Marchesi F, Garlanda C, Mantovani A and Allavena P: Inflammation-mediated promotion of invasion and metastasis. Cancer Metastasis Rev 29: 243-248, 2010.
38. Nguyen DX, Bos PD and Massague J: Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9: 274-284, 2009.
39. Sung SY, Hsieh CL, Wu D, Chung LW and Johnstone PA: Tumor microenvironment promotes cancer progression, metastasis, and therapeutic resistance. Curr Probl Cancer 31: 36-100, 2007.
40. Calorini L and Bianchini F: Environmental control of invasiveness and metastatic dissemination of tumor cells: the role of tumor cell-host cell interactions. Cell Commun Signal 8: 24, 2010.
41. Shapiro DM and Warren S: Cancer innervation. Cancer Res 9: 707-711, 1949.
42. Mitchell BS, Schumacher U, Stauber VV and Kaiserling E: Are breast tumours innervated? Immunohistological investigations using antibodies against the neuronal marker protein gene product 9.5 (PGP 9.5) in benign and malignant breast lesions. Eur J Cancer 30A: 1100-1103, 1994.
43. Seifert P and Spitznas M: Axons in human choroidal melanoma suggest the participation of nerves in the control of these tumors. Am J Ophthalmol 133: 711-713, 2002.
44. Feng F, Yang J, Tong L, Yuan S, Tian Y, Hong L, Wang W and Zhang H: Substance P immunoreactive nerve fibres are related to gastric cancer differentiation status and could promote proliferation and migration of gastric cancer cells. Cell Biol Int 35: 623-629, 2011.
45. Gidron Y, Perry H and Glennie M: Does the vagus nerve inform the brain about preclinical tumours and modulate them? Lancet Oncol 6: 245-248, 2005.
46. Erin N, Boyer PJ, Bonneau RH, Clawson GA and Welch DR: Capsaicin-mediated denervation of sensory neurons promotes mammary tumor metastasis to lung and heart. Anticancer Res 24: 1003-1009, 2004.
47. Erin N, Akdas BG, Harms JF and Clawson GA: Vagotomy enhances experimental metastases of 4THMpc breast cancer cells and alters substance P level. Regul Pept 151: 35-42, 2008.
48. Palm D and Entschladen F: Neoneurogenesis and the neuroneoplastic synapse. Prog Exp Tumor Res 39: 91-98, 2007.
49. Zanker KS: The neuro-neoplastic synapse: does it exist? Prog Exp Tumor Res 39: 154-161, 2007.
50. Varner JA: Stem cells and neurogenesis in tumors. Prog Exp Tumor Res 39: 122-129, 2007.
51. Ayala GE, Dai H, Powell M, Li R, Ding Y, Wheeler TM, Shine D, Kadmon D, Thompson T, Miles BJ, Ittmann MM and Rowley D: Cancer-related axonogenesis and neurogenesis in prostate cancer. Clin Cancer Res 14: 7593-7603, 2008.
52. Mitchell BS, Schumacher U and Kaiserling E: Are tumours innervated? Immunohistological investigations using anti-bodies against the neuronal marker protein gene product 9.5 (PGP 9.5) in benign, malignant and experimental tumours. Tumour Biol 15: 269-274, 1994.
53. Terada T and Matsunaga Y: S-100-positive nerve fibers in hepatocellular carcinoma and intrahepatic cholangiocarcinoma: an immunohistochemical study. Pathol Int 51: 89-93, 2001.
54. Pollak M, Sem AW, Richard M, Tetenes E and Bell R: Inhibition of metastatic behavior of murine osteosarcoma by hypophysectomy. J Natl Cancer Inst 84: 966-971, 1992.
55. Giraldi T, Perissin L, Zorzet S, Rapozzi V and Rodani MG: Metastasis and neuroendocrine system in stressed mice. Int J Neurosci 74: 265-278, 1994.
56. Marchetti B, Spinola PG, Pelletier G and Labrie F: A potential role for catecholamines in the development and progression of carcinogen-induced mammary tumors: hormonal control of beta-adrenergic receptors and correlation with tumor growth. J Steroid Biochem Mol Biol 38: 307-320, 1991.
57. Fava G, Marucci L, Glaser S, Francis H, De Morrow S, Benedetti A, Alvaro D, Venter J, Meininger C, Patel T, Taffetani S, Marzioni M, Summers R, Reichenbach R and Alpini G: Gamma-Aminobutyric acid inhibits cholangiocarcinoma growth by cyclic AMP-dependent regulation of the protein kinase A/extracellular signal-regulated kinase 1/2 pathway. Cancer Res 65: 11437-11446, 2005.
58. Al-Wadei HA, Plummer HK III and Schuller HM: Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter gamma-aminobutyric acid. Carcinogenesis 30: 506-511, 2009.
59. Yamanaka Y, Mammoto T, Kirita T, Mukai M, Mashimo T, Sugimura M, Kishi Y and Nakamura H: Epinephrine inhibits invasion of oral squamous carcinoma cells by modulating intra-cellular cAMP. Cancer Lett 176: 143-148, 2002.
60. Wang T, Huang W and Chen F: Baclofen, a GABAB receptor agonist, inhibits human hepatocellular carcinoma cell growth in vitro and in vivo. Life Sci 82: 536-541, 2008.
61. Ellis LM: The role of neuropilins in cancer. Mol Cancer Ther 5: 1099-1107, 2006.
62. Rizzolio S and Tamagnone L: Multifaceted role of neuropilins in cancer. Curr Med Chem 18: 3563-3575, 2011.
63. Kreuter M, Bielenberg D, Hida Y, Hida K and Klagsbrun M: Role of neuropilins and semaphorins in angiogenesis and cancer. Ann Hematol 81 (Suppl 2): S74, 2002.
64. Chedotal A, Kerjan G and Moreau-Fauvarque C: The brain within the tumor: new roles for axon guidance molecules In cancers. Cell Death Differ 12: 1044-1056, 2005.
65. Nakagawara A: Trk receptor tyrosine kinases: a bridge between cancer and neural development. Cancer Lett 169: 107-114, 2001.
66. Wong HP, Ho JW, Koo MW, Yu L, Wu WK, Lam EK, Tai EK, Ko JK, Shin VY, Chu KM and Cho CH: Effects of adrenaline in human colon adenocarcinoma HT-29 cells. Life Sci 88: 1108-1112, 2011.
67. Marin YE and Chen S: Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development. J Mol Med (Berl) 82: 735-749, 2004.
68. Castro-Rivera E, Ran S, Brekken RA and Minna JD: Semaphorin 3B inhibits the phosphatidylinositol 3-kinase/Akt pathway through neuropilin-1 in lung and breast cancer cells. Cancer Res 68: 8295-8303, 2008.
69. Kigel B, Varshavsky A, Kessler O and Neufeld G: Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells. PLoS One 3: e3287, 2008.
70. Pisick E, Jagadeesh S and Salgia R: Receptor tyrosine kinases and inhibitors in lung cancer. Scientific World Journal 4: 589-604, 2004.
71. Muller JM: Potential inhibition of the neuro-neoplastic inter-actions: the clue of a GPCR-targeted therapy. Prog Exp Tumor Res 39: 130-153, 2007.
72. Fitzgerald PJ: Is norepinephrine an etiological factor in some types of cancer? Int J Cancer 124: 257-263, 2009.
73. Cole SW and Sood AK: Molecular pathways: beta-adrenergic signaling pathways in cancer. Clin Cancer Res 18: 1201-1206, 2011.
74. Al-Wadei HA, Plummer HK III, Ullah MF, Unger B, Brody JR and Schuller HM: Social stress promotes and γ-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer. Cancer Prev Res (Phila) 5: 189-196, 2012.
75. Casazza A, Kigel B, Maione F, Capparuccia L, Kessler O, Giraudo E, Mazzone M, Neufeld G and Tamagnone L: Tumour growth inhibition and anti-metastatic activity of a mutated furin-resistant Semaphorin 3E isoform. EMBO Mol Med 4: 234-250, 2012.
76. Erin N, Zhao W, Bylander J, Chase G and Clawson G: Capsaicin-induced inactivation of sensory neurons promotes a more aggressive gene expression phenotype in breast cancer cells. Breast Cancer Res Treat 99: 351-364, 2006.
77. Nasarre P, Potiron V, Drabkin H and Roche J: Guidance molecules in lung cancer. Cell Adh Migr 4: 130-145, 2010.
78. Weick A and Augustin HG: Double attack on tumors by targeting with guidance molecules. Arterioscler Thromb Vasc Biol 31: 721-722, 2011.
79. Bernet A and Fitamant J: Netrin-1 and its receptors in tumour growth promotion. Expert Opin Ther Targets 12: 995-1007, 2008.
80. Schuller HM and Al-Wadei HA: Neurotransmitter receptors as central regulators of pancreatic cancer. Future Oncol 6: 221-228, 2010.
81. Novotny A, Ryberg K, Heiman UJ, Nilsson L, Khorram-Manesh A, Nordgren S, Delbro DS and Nylund G: Is acetylcholine a signaling molecule for human colon cancer progression? Scand J Gastroenterol 46: 446-455, 2011.
82. Al-Wadei HA, Al-Wadei MH and Schuller HM: Cooperative regulation of non-small cell lung carcinoma by nicotinic and beta-adrenergic receptors: a novel target for intervention. PLoS One 7: e29915, 2012.
83. Al-Wadei H A, Ullah M F and Al-Wadei M: GA BA (γ-aminobutyric acid), a non-protein amino acid counters the β-adrenergic cascade-activated oncogenic signaling in pancreatic cancer: a review of experimental evidence. Mol Nutr Food Res 55: 1745-1758, 2011.
84. Neufeld G, Shraga-Heled N, Lange T, Guttmann-Raviv N, Herzog Y and Kessler O: Semaphorins in cancer. Front Biosci 10: 751-760, 2005.
85. Rizzolio S and Tamagnone L: Semaphorin signals on the road to cancer invasion and metastasis. Cell Adh Migr 1: 62-68, 2007.
86. Chen C, Li M, Chai H, Yang H, Fisher WE and Yao Q: Roles of neuropilins in neuronal development, angiogenesis, and cancers. World J Surg 29: 271-275, 2005.
87. Baba T, Kariya M, Higuchi T, Mandai M, Matsumura N, Kondoh E, Miyanishi M, Fukuhara K, Takakura K and Fujii S: Neuropilin-1 promotes unlimited growth of ovarian cancer by evading contact inhibition. Gynecol Oncol 105: 703-711, 2007.
88. Warrington RJ and Lewis KE: Natural antibodies against nerve growth factor inhibit in vitro prostate cancer cell metastasis. Cancer Immunol Immunother 60: 187-195, 2011.
89. Arakawa H: Netrin-1 and its receptors in tumorigenesis. Nat Rev Cancer 4: 978-987, 2004.
90. Kalariti N, Pissimissis N and Koutsilieris M: The glutamatergic system outside the CNS and in cancer biology. Expert Opin Investig Drugs 14: 1487-1496, 2005.
91. Watanabe M, Maemura K, Oki K, Shiraishi N, Shibayama Y and Katsu K: Gamma-aminobutyric acid (GABA) and cell prolif-eration: focus on cancer cells. Histol Histopathol 21: 1135-1141, 2006.
92. Chang HJ, Yoo BC, Lim SB, Jeong SY, Kim WH and Park JG: Metabotropic glutamate receptor 4 expression in colorectal carcinoma and its prognostic significance. Clin Cancer Res 11: 3288-3295, 2005.
93. Park SY, Lee SA, Han IH, Yoo BC, Lee SH, Park JY, Cha IH, Kim J and Choi SW: Clinical significance of metabotropic glutamate receptor 5 expression in oral squamous cell carcinoma. Oncol Rep 17: 81-87, 2007.
94. Palma C: Tachykinins and their receptors in human malignancies. Curr Drug Targets 7: 1043-1052, 2006.
95. Ruscica M, Dozio E, Motta M and Magni P: Relevance of the neuropeptide Y system in the biology of cancer progression. Curr Top Med Chem 7: 1682-1691, 2007.
96. Chatikhine VA, Delpech B, Duval C, Chauzy C, D'Aniou J and Chevrier A: Expression of beta-endorphin in human breast cancer and adenofibromas. Ann NY Acad Sci 680: 473-475, 1993.
97. Sarkar DK, Zhang C, Murugan S, Dokur M, Boyadjieva NI, Ortiguela M, Reuhl KR and Mojtehedzadeh S: Transplantation of beta-endorphin neurons into the hypothalamus promotes immune function and restricts the growth and metastasis of mammary carcinoma. Cancer Res 71: 6282-6291, 2011.
98. Mancino M, Ametller E, Gascon P and Almendro V: The neuronal influence on tumor progression. Biochim Biophys Acta 1816: 105-118, 2011.
99. MacDougall JR and Matrisian LM: Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis. Cancer Metastasis Rev 14: 351-362, 1995.
100. Deryugina EI and Quigley JP: Matrix metalloproteinases and tumor metastasis. Cancer Metastasis Rev 25: 9-34, 2006.
101. Wu W, Yamaura T, Murakami K, Ogasawara M, Hayashi K, Murata J and Saiki I: Involvement of TNF-alpha in enhancement of invasion and metastasis of colon 26-L5 carcinoma cells in mice by social isolation stress. Oncol Res 11: 461-469, 1999.
102. Yang EV, Bane CM, MacCallum RC, Kiecolt-Glaser JK, Malarkey WB and Glaser R: Stress-related modulation of matrix metalloproteinase expression. J Neuroimmunol 133: 144-150, 2002.
103. Yao J, Xiong S, Klos K, Nguyen N, Grijalva R, Li P and Yu D: Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells. Oncogene 20: 8066-8074, 2001.
104. Okada Y, Eibl G, Guha S, Duffy JP, Reber HA and Hines OJ: Nerve growth factor stimulates MMP-2 expression and activity and increases invasion by human pancreatic cancer cells. Clin Exp Metastasis 21: 285-292, 2004.
105. Okada Y, Eibl G, Duffy JP, Reber HA and Hines OJ: Glial cell-derived neurotrophic factor upregulates the expression and activation of matrix metalloproteinase-9 in human pancreatic cancer. Surgery 134: 293-299, 2003.
106. Menter DG, Herrmann JL and Nicolson GL: The role of trophic factors and autocrine/paracrine growth factors in brain metastasis. Clin and Exp Metastasis 13: 67-88, 1995.
107. Yang EV, Sood AK, Chen M, Li Y, Eubank TD, Marsh CB, Jewell S, Flavahan NA, Morrison C, Yeh PE, Lemeshow S and Glaser R: Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res 66: 10357-10364, 2006.
108. Azuma H, Inamoto T, Sakamoto T, Kiyama S, Ubai T, Shinohara Y, Maemura K, Tsuji M, Segawa N, Masuda H, Takahara K, Katsuoka Y and Watanabe M: Gam maaminobutyric acid as a promoting factor of cancer metastasis; induction of matrix metalloproteinase production is potentially its underlying mechanism. Cancer Res 63: 8090-8096, 2003.
109. Simpson CD, Anyiwe K and Schimmer AD: Anoikis resistance and tumor metastasis. Cancer Lett 272: 177-185, 2008.
110. Douma S, Van Laar T, Zevenhoven J, Meuwissen R, Van Garderen E and Peeper DS: Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 430: 1034-1039, 2004.
111. Geiger TR and Peeper DS: The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective. Cancer Res 65: 7033-7036, 2005.
112. Geiger TR and Peeper DS: Critical role for TrkB kinase function in anoikis suppression, tumorigenesis, and metastasis. Cancer Res 67: 6221-6229, 2007.
113. Strizzi L, Bianco C, Raafat A, Abdallah W, Chang C, Raafat D, Hirota M, Hamada S, Sun Y, Normanno N, Callahan R, Hinck L and Salomon D: Netrin-1 regulates invasion and migration of mouse mammary epithelial cells overexpressing Cripto-1 in vitro and in vivo. J Cell Sci 118: 4633-4643, 2005.
114. Christensen C, Ambartsumian N, Gilestro G, Thomsen B, Comoglio P, Tamagnone L, Guldberg P and Lukanidin E: Proteolytic processing converts the repelling signal Sema3E into an inducer of invasive growth and lung metastasis. Cancer Res 65: 6167-6177, 2005.
115. Kruger RP, Aurandt J and Guan KL: Semaphorins command cells to move. Nat Rev Mol Cell Biol 6: 789-800, 2005.
116. Kim HK, Zhang H, Li H, Wu TT, Swisher S, He D, Wu L, Xu J, Elmets CA, Athar M, Xu XC and Xu H: Slit2 inhibits growth and metastasis of fibrosarcoma and squamous cell carcinoma. Neoplasia 10: 1411-1420, 2008.
117. Casazza A, Finisguerra V, Capparuccia L, Camperi A, Swiercz JM, Rizzolio S, Rolny C, Christensen C, Bertotti A, Sarotto I, Risio M, Trusolino L, Weitz J, Schneider M, Mazzone M, Comoglio PM and Tamagnone L: Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice. J Clin Invest 120: 2684-2698, 2010.
118. Entschladen F, Lang K, Drell TL, Joseph J and Zaenker KS: Neurotransmitters are regulators for the migration of tumor cells and leukocytes. Cancer Immunol Immunother 51: 467-482, 2002.
119. Masur K, Niggemann B, Zanker KS and Entschladen F: Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers. Cancer Res 61: 2866-2869, 2001.
120. Drell TT, Joseph J, Lang K, Niggemann B, Zaenker KS and Entschladen F: Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells. Breast Cancer Res Treat 80: 63-70, 2003.
121. Joseph J, Niggemann B, Zaenker KS and Entschladen F: The neurotransmitter gamma-aminobutyric acid is an inhibitory regulator for the migration of SW 480 colon carcinoma cells. Cancer Res 62: 6467-6469, 2002.
122. Watanabe M, Maemura K, Kanbara K, Tamayama T and Hayasaki H: GABA and GABA receptors in the central nervous system and other organs. Int Rev Cytol 213: 1-47, 2002.
123. Miller RJ, Rostene W, Apartis E, Banisadr G, Biber K, Milligan ED, White FA and Zhang J: Chemokine action in the nervous system. J Neurosci 28: 11792-11795, 2008.
124. Zhang N and Oppenheim JJ: Crosstalk between chemokines and neuronal receptors bridges immune and nervous systems. J Leukoc Biol 78: 1210-1214, 2005.
125. Muller A, Homey B, Soto H, Ge N, Catron D, Buchanan ME, McClanahan T, Murphy E, Yuan W, Wagner SN, Barrera JL, Mohar A, Verastegui E and Zlotnik A: Involvement of chemokine receptors in breast cancer metastasis. Nature 410: 50-56, 2001.
126. Balkwill F: Cancer and the chemokine network. Nat Rev Cancer 4: 540-550, 2004.
127. Singh S, Sadanandam A and Singh RK: Chemokines in tumor angiogenesis and metastasis. Cancer Metastasis Rev 26: 453-467, 2007.
128. Weiss L: Cancer cell traffic from the lungs to the liver: an example of metastatic inefficiency. Int J Cancer 25: 385-392, 1980.
129. Weiss L: Deformation-driven, lethal damage to cancer cells. Its contribution to metastatic inefficiency. Cell Biophys 18: 73-79, 1991.
130. Bacac M and Stamenkovic I: Metastatic cancer cell. Annu Rev Pathol 3:221-247, 2008.
131. Brain SD: Sensory neuropeptides: their role in inflammation and wound healing. Immunopharmacology 37: 133-152, 1997.
132. Ishihara K, Kamata M, Hayashi I, Yamashina S and Majima M: Roles of bradykinin in vascular permeability and angiogenesis in solid tumor. Int Immunopharmacol 2: 499-509, 2002.
133. O'Connor TM, O'Connell J, O'Brien DI, Goode T, Bredin CP and Shanahan F: The role of substance P in inflammatory disease. J Cell Physiol 201: 167-180, 2004.
134. Marchesi F, Piemonti L, Mantovani A and Allavena P: Molecular mechanisms of perineural invasion, a forgotten pathway of dissemination and metastasis. Cytokine Growth Factor Rev 21: 77-82, 2010.
135. Jhawer M, Coit D, Brennan M, Qin LX, Gonen M, Klimstra D, Tang L, Kelsen DP and Shah MA: Perineural invasion after preoperative chemotherapy predicts poor survival in patients with locally advanced gastric cancer: gene expression analysis with pathologic validation. Am J Clin Oncol 32: 356-362, 2009.
136. Bilici A, Seker M, Ustaalioglu BB, Kefeli U, Yildirim E, Yavuzer D, Aydin FM, Salepci T, Oncel M and Gumus M: Prognostic significance of perineural invasion in patients with gastric cancer who underwent curative resection. Ann Surg Oncol 17: 2037-2044, 2010.
137. Ceyhan GO, Liebl F, Maak M, Schuster T, Becker K, Langer R, Demir IE, Hartel M, Friess H and Rosenberg R: The severity of neural invasion is a crucial prognostic factor in rectal cancer independent of neoadjuvant radiochemotherapy. Ann Surg 252: 797-804, 2010.
138. Binmadi NO and Basile JR: Perineural invasion in oral squamous cell carcinoma: a discussion of significance and review of the literature. Oral Oncol 47: 1005-1010, 2011.
139. Tai SK, Li WY, Chu PY, Chang SY, Tsai TL, Wang YF and Huang JL: Risks and clinical implications of perineural invasion in T1-2 oral tongue squamous cell carcinoma. Head Neck 34: 994-1001, 2011.
140. Miller ME, Palla B, Chen Q, Elashoff DA, Abemayor E, St John JM and Lai CK: A novel classification system for perineural invasion in noncutaneous head and neck squamous cell carcinoma: histologic subcategories and patient outcomes. Am J Otolaryngol 33: 212-215, 2012.
141. Hibi T, Mori T, Fukuma M, Yamazaki K, Hashiguchi A, Yamada T, Tanabe M, Aiura K, Kawakami T, Ogiwara A, Kosuge T, Kitajima M, Kitagawa Y and Sakamoto M: Synuclein-gamma is closely involved in perineural invasion and distant metastasis in mouse models and is a novel prognostic factor in pancreatic cancer. Clin Cancer Res 15: 2864-2871, 2009.
142. Karak SG, Quatrano N, Buckley J and Ricci AJ: Prevalence and significance of perineural invasion in invasive breast carcinoma. Conn Med 74: 17-21, 2010.
143. Meinel A, Fischer U, Bilek K, Hentschel B and Horn LC: Morphological parameters associated with perineural invasion (PNI) in carcinoma of the cervix uteri. Int J Surg Pathol 19: 159-163, 2011.
144. Bixby JL and Harris WA: Molecular mechanisms of axon growth and guidance. Annu Rev Cell Biol 7: 117-159, 1991.
145. Goldberg JL: How does an axon grow? Genes Dev 17: 941-958, 2003.
146. Pasterkamp RJ, Peschon JJ, Spriggs MK and Kolodkin AL: Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature 424: 398-405, 2003.
147. Chilton JK: Molecular mechanisms of axon guidance. Dev Biol 292: 13-24, 2006.
148. Winckler B: BDNF instructs the kinase LKB1 to grow an axon. Cell 129: 459-460, 2007.
149. Artigiani S, Comoglio PM and Tamagnone L: Plexins, semaphorins, and scatter factor receptors: a common root for cell guidance signals? Iubmb Life 48: 477-482, 1999.
150. Iwahashi N, Nagasaka T, Tezel G, Iwashita T, Asai N, Murakumo Y, Kiuchi K, Sakata K, Nimura Y and Takahashi M: Expression of glial cell line-derived neurotrophic factor correlates with perineural invasion of bile duct carcinoma. Cancer 94: 167-174, 2002.
151. Tomaselli KJ, Reichardt LF and Bixby JL: Distinct molecular interactions mediate neuronal process outgrowth on non-neuronal cell surfaces and extracellular matrices. J Cell Biol 103: 2659-2672, 1986.
152. Folkman J: Role of angiogenesis in tumor growth and metastasis. Semin Oncol 29: 15-18, 2002.
153. Hillen F and Griffioen AW: Tumour vascularization: sprouting angiogenesis and beyond. Cancer Metastasis Rev 26: 489-502, 2007.
154. Weis SM and Cheresh DA: Tumor angiogenesis: molecular pathways and therapeutic targets. Nat Med 17: 1359-1370, 2011.
155. Lutgendorf SK, Cole S, Costanzo E, Bradley S, Coffin J, Jabbari S, Rainwater K, Ritchie JM, Yang M and Sood AK: Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin Cancer Res 9: 4514-4521, 2003.
156. Thaker PH, Han LY, Kamat AA, Arevalo JM, Takahashi R, Lu C, Jennings NB, Armaiz-Pena G, Bankson JA, Ravoori M, Merritt WM, Lin YG, Mangala LS, Kim TJ, Coleman RL, Landen CN, Li Y, Felix E, Sanguino AM, Newman RA, Lloyd M, Gershenson DM, Kundra V, Lopez-Berestein G, Lutgendorf SK, Cole SW and Sood AK: Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med 12: 939-944, 2006.
157. Tilan J and Kitlinska J: Sympathetic neurotransmitters and tumor angiogenesis-link between stress and cancer progression. J Oncol: 539706, 2010.
158. Park SY, Kang JH, Jeong KJ, Lee J, Han JW, Choi WS, Kim YK, Kang J, Park CG and Lee HY: Norepinephrine induces VEGF expression and angiogenesis by a hypoxia-inducible factor-1α protein-dependent mechanism. Int J Cancer 128: 2306-2316, 2011.
159. Chakroborty D, Sarkar C, Basu B, Dasgupta PS and Basu S: Catecholamines regulate tumor angiogenesis. Cancer Res 69: 3727-3730, 2009.
160. Chakroborty D, Sarkar C, Mitra RB, Banerjee S, Dasgupta PS and Basu S: Depleted dopamine in gastric cancer tissues: dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis. Clin Cancer Res 10: 4349-4356, 2004.
161. Basu S, Nagy JA, Pal S, Vasile E, Eckelhoefer IA, Bliss VS, Manseau EJ, Dasgupta PS, Dvorak HF and Mukhopadhyay D: The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med 7: 569-574, 2001.
162. Lutgendorf SK, DeGeest K, Dahmoush L, Farley D, Penedo F, Bender D, Goodheart M, Buekers TE, Mendez L, Krueger G, Clevenger L, Lubaroff DM, Sood AK and Cole SW: Social isolation is associated with elevated tumor norepinephrine in ovarian carcinoma patients. Brain Behav Immun 25: 250-255, 2011.
163. Basile JR, Castilho RM, Williams VP and Gutkind JS: Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis. Proc Natl Acad Sci USA 103: 9017-9022, 2006.
164. Kigel B, Rabinowicz N, Varshavsky A, Kessler O and Neufeld G: Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling. Blood 118: 4285-4296, 2011.
165. Casazza A, Fu X, Johansson I, Capparuccia L, Andersson F, Giustacchini A, Squadrito ML, Venneri MA, Mazzone M, Larsson E, Carmeliet P, De Palma M, Naldini L, Tamagnone L and Rolny C: Systemic and targeted delivery of semaphorin 3A inhibits tumor angiogenesis and progression in mouse tumor models. Arterioscler Thromb Vasc Biol 31: 741-749, 2011.
166. Sakurai A, Doci C and Gutkind JS: Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer. Cell Res 22: 23-32, 2012.
167. Toda M, Suzuki T, Hosono K, Hayashi I, Hashiba S, Onuma Y, Amano H, Kurihara Y, Kurihara H, Okamoto H, Hoka S and Majima M: Neuronal system-dependent facilitation of tumor angiogenesis and tumor growth by calcitonin gene-related peptide. Proc Natl Acad Sci USA 105: 13550-13555, 2008.
168. Lee EW, Michalkiewicz M, Kitlinska J, Kalezic I, Switalska H, Yoo P, Sangk ha rat A, Ji H, Li L, Michalkiewicz T, Ljubisavljevic M, Johansson H, Grant DS and Zukowska Z: Neuropeptide Y induces ischemic angiogenesis and restores function of ischemic skeletal muscles. J Clin Invest 111: 1853-1862, 2003.
169. Filipski E and Levi F: Circadian disruption in experimental cancer processes. Integr Cancer Ther 8: 298-302, 2009.
170. Goodwin AM and D'Amore PA: Wnt signaling in the vasculature. Angiogenesis 5: 1-9, 2002.
171. Masckauchan TN and Kitajewski J: Wnt/Frizzled signaling in the vasculature: new angiogenic factors in sight. Physiology (Bethesda) 21: 181-188, 2006.
172. Adams RH and Eichmann A: Axon guidance molecules in vascular patterning. Cold Spring Harb Perspect Biol 2: a1875, 2010.
173. Melani M and Weinstein BM: Common factors regulating patterning of the nervous and vascular systems. Annu Rev Cell Dev Biol 26: 639-665, 2010.
174. Carmeliet P and Tessier-Lavigne M: Common mechanisms of nerve and blood vessel wiring. Nature 436: 193-200, 2005.
175. Entschladen F, Palm D, Drell TT, Lang K and Zaenker KS: Connecting a tumor to the environment. Curr Pharm Des 13: 3440-3444, 2007.
176. Capparuccia L and Tamagnone L: Semaphorin signaling in cancer cells and in cells of the tumor microenvironment - two sides of a coin. J Cell Sci 122: 1723-1736, 2009.
177. Schirrmacher V, Fogel M, Russmann E, Bosslet K, Altevogt P and Beck L: Antigenic variation in cancer metastasis: immune escape versus immune control. Cancer Metastasis Rev 1: 241-274, 1982.
178. Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM and Karin M: Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature 470: 548-553, 2011
179. Rabin BS, Cohen S, Ganguli R, Lysle DT and Cunnick JE: Bidirectional interaction between the central nervous system and the immune system. Crit Rev Immunol 9: 279-312, 1989.
180. Steinman L: Connections between the immune system and the nervous system. Proc Natl Acad Sci USA 90: 7912-7914, 1993.
181. Grivennikov SI, Greten FR and Karin M: Immunity, inflammation, and cancer. Cell 140: 883-899, 2010.
182. Lin WW and Karin M: A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest 117: 1175-1183, 2007.
183. Karin M and Greten FR: NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 5: 749-759, 2005.
184. Ben-Eliyahu S, Yirmiya R, Liebeskind JC, Taylor AN and Gale RP: Stress increases metastatic spread of a mammary tumor in rats: evidence for mediation by the immune system. Brain Behav Immun 5: 193-205, 1991.
185. Ben-Eliyahu S, Page GG, Yirmiya R and Shakhar G: Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity. Int J Cancer 80: 880-888, 1999.
186. Levy SM, Herberman RB, Lippman M, D'Angelo T and Lee J: Immunological and psychosocial predictors of disease recurrence in patients with early-stage breast cancer. Behav Med 17: 67-75, 1991.
187. Logan RW and Sarkar DK: Circadian nature of immune function. Mol Cell Endocrinol 349: 82-90, 2012.
188. Rana S and Mahmood S: Circadian rhythm and its role in malignancy. J Circadian Rhythms 8: 3, 2010.
189. Kiecolt-Glaser JK and Glaser R: Psychoneuroimmunology and cancer: fact or fiction? Eur J Cancer 35: 1603-1607, 1999.
190. Tracey KJ: The inflammatory reflex. Nature 420: 853-859, 2002.
191. Libert C: Inflammation: A nervous connection. Nature 421: 328-329, 2003
192. Rosas-Ballina M and Tracey KJ: Cholinergic control of inflammation. J Intern Med 265: 663-679, 2009.
193. Rosenberger P, Schwab JM, Mirakaj V, Masekowsky E, Mager A, Morote-Garcia JC, Unertl K and Eltzschig HK: Hypoxia-inducible factor-dependent induction of netrin-1 dampens inflammation caused by hypoxia. Nat Immunol 10: 195-202, 2009.
194. Tracey KJ: Reflex control of immunity. Nat Rev Immunol 9: 418-428, 2009.
195. Van Der Zanden EP, Boeckxstaens GE and de Jonge WJ: The vagus nerve as a modulator of intestinal inflammation. Neurogastroenterol Motil 21: 6-17, 2009.
196. Ley S, Weigert A and Brune B: Neuromediators in inflammation-a macrophage/nerve connection. Immunobiology 215: 674-684, 2010.
197. Meregnani J, Clarencon D, Vivier M, Peinnequin A, Mouret C, Sinniger V, Picq C, Job A, Canini F, Jacquier-Sarlin M and Bonaz B: Anti-inflammatory effect of vagus nerve stimulation in a rat model of inflammatory bowel disease. Auton Neurosci 160: 82-89, 2011.
198. Pohanka M, Snopkova S, Havlickova K, Bostik P, Sinkorova Z, Fusek J, Kuca K and Pikula J: Macrophage-assisted inflammation and pharmacological regulation of the cholinergic anti-inflammatory pathway. Curr Med Chem 18: 539-551, 2011.
199. Cerejeira J, Nogueira V, Luis P, Vaz-Serra A and Mukaetova-Ladinska EB: The cholinergic system and inflammation: common pathways in delirium pathophysiology. J Am Geriatr Soc 60: 669-675, 2012.
200. Peterson CY, Krzyzaniak M, Coimbra R and Chang DC: Vagus nerve and postinjury inflammatory response. Arch Surg 147: 76-80, 2012.
201. Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, Atkinson C, Malarkey WB and Glaser R: Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci USA 100: 9090-9095, 2003.
202. Madden KS, Szpunar MJ and Brown EB: beta-Adrenergic receptors (beta-AR) regulate VEGF and IL-6 production by divergent pathways in high beta-AR-expressing breast cancer cell lines. Breast Cancer Res Treat 130: 747-758, 2011.
203. Yang EV, Kim SJ, Donovan EL, Chen M, Gross AC, Webster MJ, Barsky SH and Glaser R: Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression. Brain Behav Immun 23: 267-275, 2009.
204. Stathopoulos GT, Sherrill TP, Han W, Sadikot RT, Yull FE, Blackwell TS and Fingleton B: Host nuclear factor-kappaB activation potentiates lung cancer metastasis. Mol Cancer Res 6: 364-371, 2008.
205. Paradisi A and Mehlen P: Netrin-1, a missing link between chronic inflammation and tumor progression. Cell Cycle 9: 1253-1262, 2010.
206. Pantel K and Brakenhoff RH: Dissecting the metastatic cascade. Nat Rev Cancer 4: 448-456, 2004.
207. Rafii S, Lyden D, Benezra R, Hattori K and Heissig B: Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy? Nat Rev Cancer 2: 826-835, 2002.
208. Direkze NC, Hodivala-Dilke K, Jeffery R, Hunt T, Poulsom R, Oukrif D, Alison MR and Wright NA: Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res 64: 8492-8495, 2004.
209. Ishii G, Sangai T, Oda T, Aoyagi Y, Hasebe T, Kanomata N, Endoh Y, Okumura C, Okuhara Y, Magae J, Emura M, Ochiya T and Ochiai A: Bone-marrow-derived myofibroblasts contribute to the cancer-induced stromal reaction. Biochem Biophys Res Commun 309: 232-240, 2003.
210. Psaila B and Lyden D: The metastatic niche: adapting the foreign soil. Nat Rev Cancer 9: 285-293, 2009.
211. Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S and Lyden D: VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature 438: 820-827, 2005.
212. Miyan JA, Broome CS and Whetton AD: Neural regulation of bone marrow. Blood 92: 2971-2973, 1998.
213. Canaani J, Kollet O and Lapidot T: Neural regulation of bone, marrow, and the microenvironment. Front Biosci 3: 1021-1031, 2011.
214. Benestad HB, Strom-Gundersen I, Iversen PO, Haug E and Nja A: No neuronal regulation of murine bone marrow function. Blood 91: 1280-1287, 1998.
215. Artico M, Bosco S, Cavallotti C, Agostinelli E, Giuliani-Piccari G, Sciorio S, Cocco L and Vitale M: Noradrenergic and cholinergic innervation of the bone marrow. Int J Mol Med 10: 77-80, 2002.
216. Imai S, Tokunaga Y, Maeda T, Kikkawa M and Hukuda S: Calcitonin gene-related peptide, substance P, and tyrosine hydroxylase-immunoreactive innervation of rat bone marrows: an immunohistochemical and ultrastructural investigation on possible efferent and afferent mechanisms. J Orthop Res 15: 133-140, 1997.
217. Singh D, Joshi DD, Hameed M, Qian J, Gascon P, Maloof PB, Mosenthal A and Rameshwar P: Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis. Proc Natl Acad Sci USA 97: 388-393, 2000.
218. Castro TA, Cohen MC and Rameshwar P: The expression of neurokinin-1 and preprotachykinin-1 in breast cancer cells depends on the relative degree of invasive and metastatic potential. Clin Exp Metastasis 22: 621-628, 2005.
219. Lyden D, Hattori K, Dias S, Costa C, Blaikie P, Butros L, Chadburn A, Heissig B, Marks W, Witte L, Wu Y, Hicklin D, Zhu Z, Hackett NR, Crystal RG, Moore MA, Hajjar KA, Manova K, Benezra R and Rafii S: Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 7: 1194-1201, 2001.
220. Rajantie I, Ilmonen M, Alminaite A, Ozerdem U, Alitalo K and Salven P: Adult bone marrow-derived cells recruited during angiogenesis comprise precursors for periendothelial vascular mural cells. Blood 104: 2084-2086, 2004.
221. Chakroborty D, Chowdhury UR, Sarkar C, Baral R, Dasgupta PS and Basu S: Dopamine regulates endothelial progenitor cell mobilization from mouse bone marrow in tumor vascularization. J Clin Invest 118: 1380-1389, 2008.
222. Zhang W: Mesenchymal stem cells in cancer: friends or foes. Cancer Biol Ther 7: 252-254, 2008.
223. Pollard JW: Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer 4: 71-78, 2004.
224. Condeelis J and Pollard JW: Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124: 263-266, 2006.
225. Qian BZ and Pollard JW: Macrophage diversity enhances tumor progression and metastasis. Cell 141: 39-51, 2010.
226. Maestroni GJ: Catecholaminergic regulation of hematopoiesis in mice. Blood 92: 2971-2973, 1998.
227. Maestroni GJ: Dendritic cell migration controlled by alpha 1b-adrenergic receptors. J Immunol 165: 6743-6747, 2000.
228. Katayama Y, Battista M, Kao WM, Hidalgo A, Peired AJ, Thomas SA and Frenette PS: Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow. Cell 124: 407-421, 2006.
229. Mendez-Ferrer S, Lucas D, Battista M and Frenette PS: Haematopoietic stem cell release is regulated by circadian oscillations. Nature 452: 442-447, 2008.
230. Bissell MJ and Radisky D: Putting tumours in context. Nat Rev Cancer 1: 46-54, 2001.
231. Egeblad M, Nakasone ES and Werb Z: Tumors as organs: complex tissues that interface with the entire organism. Dev Cell 18: 884-901, 2010.
232. Mareel M, Oliveira MJ and Madani I: Cancer invasion and metastasis: interacting ecosystems. Virchows Arch 454: 599-622, 2009.
233. Ben-Eliyahu S, Shakhar G, Page GG, Stefanski V and Shakhar K: Suppression of NK cell activity and of resistance to metastasis by stress: a role for adrenal catecholamines and beta-adrenoceptors. Neuroimmunomodulat 8: 154-164, 2000.
234. Schuller HM, Al-Wadei HA, Ullah MF and Plummer HK III: Regulation of pancreatic cancer by neuropsychological stress responses: a novel target for intervention. Carcinogenesis 33: 191-196, 2012.
235. Yasuniwa Y, Izumi H, Wang KY, Shimajiri S, Sasaguri Y, Kawai K, Kasai H, Shimada T, Miyake K, Kashiwagi E, Hirano G, Kidani A, Akiyama M, Han B, Wu Y, Ieiri I, Higuchi S and Kohno K: Circadian disruption accelerates tumor growth and angio/stromagenesis through a Wnt signaling pathway. PLoS One 5: e15330, 2010.
236. Arjona A and Sarkar DK: Are circadian rhythms the code of hypothalamic-immune communication? Insights from natural killer cells. Neurochem Res 33: 708-718, 2010.
237. Filipski E, King VM, Li X, Granda TG, Mormont MC, Liu X, Claustrat B, Hastings MH and Levi F: Host circadian clock as a control point in tumor progression. J Natl Cancer Inst 94: 690-697, 2002.
238. Andersen BL, Kiecolt-Glaser JK and Glaser R: A biobehavioral model of cancer stress and disease course. Am Psychol 49: 389-404, 1994.
239. Spiegel D: Mind matters in cancer survival. Psychooncology 21: 588-593, 2012.
240. Ebos J M, Lee CR, Cruz-Munoz W, Bjarnason GA, Christensen JG and Kerbel RS: Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell 15: 232-239, 2009.
241. Rugo HS: Inhibiting angiogenesis in breast cancer: the beginning of the end or the end of the beginning? J Clin Oncol 30: 898-901, 2012.
242. Pàez-Ribes M, Allen E, Hudock J, Takeda T, Okuyama H and Viñals F: Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell 15: 220-231, 2009.
243. Powe DG and Entschladen F: Targeted therapies: Using beta-blockers to inhibit breast cancer progression. Nat Rev Clin Oncol 8: 511-512, 2011.
244. Barron TI, Connolly RM, Sharp L, Bennett K and Visvanathan K: Beta blockers and breast cancer mortality: a population-based study. J Clin Oncol 29: 2635-2644, 2011.
245. Syromiatnikov AV and Alistratov AV: Changes in the efferent impulsation in the vagus nerves during the metastasis of Lewis lung carcinoma in mice. Eksp Onkol 11: 47-50, 1989.
246. Li ZJ and Cho CH: Neurotransmitters, more than meets the eye--neurotransmitters and their perspectives in cancer development and therapy. Eur J Pharmacol 667: 17-22, 2011.
247. Schuller HM, Al-Wadei HA and Majidi M: GABA B receptor is a novel drug target for pancreatic cancer. Cancer 112: 767-778, 2008.
248. Yang ZF, Ho DW, Lam CT, Luk JM, Lum CT, Yu WC, Poon RT and Fan ST: Identification of brain-derived neurotrophic factor as a novel functional protein in hepatocellular carcinoma. Cancer Res 65: 219-225, 2005.
249. Harburg GC and Hinck L: Navigating breast cancer: axon guidance molecules as breast cancer tumor suppressors and oncogenes. J Mammary Gland Biol Neoplasia 16: 257-270, 2011.
250. Mehlen P, Delloye-Bourgeois C and Chedotal A: Novel roles for Slits and netrins: axon guidance cues as anticancer targets? Nat Rev Cancer 11: 188-197, 2011.
251. Welch DR, Cooper CR, Hurst DR, Lynch CC, Martin MD, Vaidya KS, VanSaun MN and Mastro AM: Metastasis Research Society-American Association For Cancer Research Joint Conference on Metastasis. Cancer Res 68: 9578-9582, 2008.