Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: Implications for stress-related enhancement of tumor progression

Brain, Behavior, and Immunity

Volumn 23, Issue 2, 2009, Pages 267-275

  Yang, Eric V ^a,b   Kim, Seung jae ^b   Donovan, Elise L ^b   Chen, Min ^b   Gross, Amy C ^b   Webster Marketon, Jeanette I ^a,b   Barsky, Sanford H ^a,c   Glaser, Ronald ^a,b,c  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Angiogenesis; Cytokines; IL 6; Interleukin (IL) 8; Melanoma; Norepinephrine; Psychological stress; Vascular endothelial growth factor

Indexed keywords

BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; NORADRENALIN; VASCULOTROPIN;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MELANOMA; MENTAL STRESS; METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR BIOPSY; TUMOR CELL LINE; TUMOR GROWTH; UPREGULATION;

CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-16; INTERLEUKIN-8; MELANOMA; NOREPINEPHRINE; POLYMERASE CHAIN REACTION; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; RNA, MESSENGER; STRESS, PHYSIOLOGICAL; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 58549084362     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2008.10.005     Document Type: Article

References (56)

1. In: Ader R. (Ed). Psychoneuroimmunology (2007), Elsevier Academic Press, Boston
2. Antoni M.H., Lutgendorf S.K., Cole S.W., Dhabhar F.S., Sephton S.E., McDonald P.G., Stefanek M., and Sood A.K. The influence of bio-behavioural factors on tumour biology: pathways and mechanisms. Nat. Rev. Cancer 6 (2006) 240-248
3. Balch C.M., Soong S.J., Gershenwald J.E., Thompson J.F., Reintgen D.S., Cascinelli N., Urist M., McMasters K.M., Ross M.I., Kirkwood J.M., Atkins M.B., Thompson J.A., Coit D.G., Byrd D., Desmond R., Zhang Y., Liu P.Y., Lyman G.H., and Morabito A. Prognostic factors analysis of 17, 600 melanoma patients: validation of the American Joint Committee on Cancer melanoma staging system. J. Clin. Oncol. 19 (2001) 3622-3634
4. Bar-Eli M. Role of interleukin-8 in tumor growth and metastasis of human melanoma. Pathobiology 67 (1999) 12-18
5. Barsky S.H., Sternlicht M.D., Safarians S., Nguyen M., Chin K., Stewart S.D., Hiti A.L., and Gray J.W. Evidence of a dominant transcriptional pathway which regulates an undifferentiated and complete metastatic phenotype. Oncogene 15 (1997) 2077-2091
6. Ben-Eliyahu S. The promotion of tumor metastasis by surgery and stress: immunological basis and implications for psychoneuroimmunology. Brain Behav. Immun. 17 Suppl. 1 (2003) S27-S36
7. Canada A.L., Fawzy N.W., and Fawzy F.I. Personality and disease outcome in malignant melanoma. J. Psychosom. Res. 58 (2005) 19-27
8. Chijiwa T., Mishima A., Hagiwara M., Sano M., Hayashi K., Inoue T., Naito K., Toshioka T., and Hidaka H. Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J. Biol. Chem. 265 (1990) 5267-5272
9. Drell T.L., Joseph J., Lang K., Niggemann B., Zaenker K.S., and Entschladen F. Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells. Breast Cancer Res. Treat. 80 (2003) 63-70
10. Entschladen F., Drell T.L., Lang K., Joseph J., and Zaenker K.S. Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters. Lancet Oncol. 5 (2004) 254-258
11. Fawzy F.I., Canada A.L., and Fawzy N.W. Malignant melanoma: effects of a brief, structured psychiatric intervention on survival and recurrence at 10-year follow-up. Arch. Gen. Psychiatry 60 (2003) 100-103
12. Fawzy F.I., Fawzy N.W., Hyun C.S., Elashoff R., Guthrie D., Fahey J.L., and Morton D.L. Malignant melanoma: effects of an early structured psychiatric intervention, coping, and affective state on recurrence and survival 6 years later. Arch. Gen. Psychiatry 50 (1993) 681-689
13. Gimbrone Jr. M.A., Leapman S.B., Cotran R.S., and Folkman J. Tumor dormancy in vivo by prevention of neovascularization. J. Exp. Med. 136 (1972) 261-276
14. Glaser R., and Kiecolt-Glaser J.K. Stress-induced immune dysfunction: implications for health. Nat. Rev. Immunol. 5 (2005) 243-251
15. Goldfarb Y., and Ben-Eliyahu S. Surgery as a risk factor for breast cancer recurrence and metastasis: mediating mechanisms and clinical prophylactic approaches. Breast Dis. 26 (2007) 99-114
16. Gomez-Merino D., Drogou C., Chennaoui M., Tiollier E., Mathieu J., and Guezennec C.Y. Effects of combined stress during intense training on cellular immunity, hormones and respiratory infections. Neuroimmunomodulation 12 (2005) 164-172
17. Haluska F., Pemberton T., Ibrahim N., and Kalinsky K. The RTK/RAS/BRAF/PI3K pathways in melanoma: biology, small molecule inhibitors, and potential applications. Semin. Oncol. 34 (2007) 546-554
18. Hasegawa H., and Saiki I. Psychosocial stress augments tumor development through beta-adrenergic activation in mice. Jpn. J. Cancer Res. 93 (2002) 729-735
19. Hicklin D.J., Wang Z., Arienti F., Rivoltini L., Parmiani G., and Ferrone S. Beta2-Microglobulin mutations, HLA class I antigen loss, and tumor progression in melanoma. J. Clin. Invest. 101 (1998) 2720-2729
20. Hidaka H., and Kobayashi R. Pharmacology of protein kinase inhibitors. Annu. Rev. Pharmacol. Toxicol. 32 (1992) 377-397
21. Johnson J.D., Campisi J., Sharkey C.M., Kennedy S.L., Nickerson M., Greenwood B.N., and Fleshner M. Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines. Neuroscience 135 (2005) 1295-1307
22. Kiecolt-Glaser J.K., Loving T.J., Stowell J.R., Malarkey W.B., Lemeshow S., Dickinson S.L., and Glaser R. Hostile marital interactions, proinflammatory cytokine production, and wound healing. Arch. Gen. Psychiatry 62 (2005) 1377-1384
23. Kiecolt-Glaser J.K., Marucha P.T., Malarkey W.B., Mercado A.M., and Glaser R. Slowing of wound healing by psychological stress. Lancet 346 (1995) 1194-1196
24. Kruk J., and Aboul-Enein H.Y. Psychological stress and the risk of breast cancer: a case-control study. Cancer Detect. Prev. 28 (2004) 399-408
25. Lamkin D.M., Lutgendorf S.K., McGinn S., Dao M., Maiseri H., DeGeest K., Sood A.K., and Lubaroff D.M. Positive psychosocial factors and NKT cells in ovarian cancer patients. Brain Behav. Immun. 22 (2008) 65-73
26. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25 (2001) 402-408
27. Löffek S., Zigrino P., Steiger J., Kurschat P., Smola H., and Mauch C. Melanoma cell-derived vascular endothelial growth factor induces endothelial tubulogenesis within fibrin gels by a metalloproteinase-mediated mechanism. Eur. J. Cell Biol. 85 (2006) 1167-1177
28. Lutgendorf S.K., Cole S., Costanzo E., Bradley S., Coffin J., Jabbari S., Rainwater K., Ritchie J.M., Yang M., and Sood A.K. Stress-related mediators stimulate vascular endothelial growth factor secretion by two ovarian cancer cell lines. Clin. Cancer Res. 9 (2003) 4514-4521
29. Mahabeleshwar G.H., and Byzova T.V. Angiogenesis in melanoma. Semin. Oncol. 34 (2007) 555-565
30. Masur K., Niggemann B., Zanker K.S., and Entschladen F. Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers. Cancer Res. 61 (2001) 2866-2869
31. Mercado A.M., Quan N., Padgett D.A., Sheridan J.F., and Marucha P.T. Restraint stress alters the expression of interleukin-1 and keratinocyte growth factor at the wound site: an in situ hybridization study. J. Neuroimmunol. 129 (2002) 74-83
32. Metcalfe C., Davey Smith G., Macleod J., and Hart C. The role of self-reported stress in the development of breast cancer and prostate cancer: a prospective cohort study of employed males and females with 30 years of follow-up. Eur. J. Cancer 43 (2007) 1060-1065
33. Nilsson M.B., Langley R.R., and Fidler I.J. Interleukin-6, secreted by human ovarian carcinoma cells, is a potent proangiogenic cytokine. Cancer Res. 65 (2005) 10794-10800
34. Osella-Abate S., Quaglino P., Savoia P., Leporati C., Comessatti A., and Bernengo M.G. VEGF-165 serum levels and tyrosinase expression in melanoma patients: correlation with the clinical course. Melanoma Res. 12 (2002) 325-334
35. Padgett D.A., and Glaser R. How stress influences the immune response. Trends Immunol. 24 (2003) 444-448
36. Palm D., Lang K., Niggemann B., Drell T.L.T., Masur K., Zaenker K.S., and Entschladen F. The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers. Int. J. Cancer 118 (2006) 2744-2749
37. Palmieri G., Casula M., Sini M.C., Ascierto P.A., and Cossu A. Issues affecting molecular staging in the management of patients with melanoma. J. Cell. Mol. Med. 11 (2007) 1052-1068
38. Payne A.S., and Cornelius L.A. The role of chemokines in melanoma tumor growth and metastasis. J. Invest. Dermatol. 118 (2002) 915-922
39. Rabin B.S. Stress, Immune Function, and Health: The Connection (1999), Wiley-Liss, New York
40. Reiche E.M.V., Nunes S.O.V., and Morimoto H.K. Stress, depression, the immune system, and cancer. Lancet Oncol. 5 (2004) 617-625
41. Restifo N.P., Marincola F.M., Kawakami Y., Taubenberger J., Yannelli J.R., and Rosenberg S.A. Loss of functional beta2-microglobulin in metastatic melanomas from five patients receiving immunotherapy. J. Natl. Cancer Inst. 88 (1996) 100-108
42. Riley V. Mouse mammary tumors: alteration of incidence as apparent function of stress. Science 189 (1975) 465-467
43. Safarians S., Sternlicht M.D., Freiman C.J., Huaman J.A., and Barsky S.H. The primary tumor is the primary source of metastasis in a human melanoma/SCID model. Implications for the direct autocrine and paracrine epigenetic regulation of the metastasis process. Int. J. Cancer 66 (1996) 151-158
44. Salahpour A., Bonin H., Bhalla S., Petaja-Repo U., and Bouvier M. Biochemical characterization of beta2-adrenergic receptor dimers and oligomers. Biol. Chem. 384 (2003) 117-123
45. Saul A.N., Oberyszyn T.M., Daugherty C., Kusewitt D., Jones S., Jewell S., Malarkey W.B., Lehman A., Lemeshow S., and Dhabhar F.S. Chronic stress and susceptibility to skin cancer. J. Natl. Cancer Inst. 97 (2005) 1760-1767
46. Segerstrom S.C., and Miller G.E. Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychol. Bull. 130 (2004) 601-630
47. Sood A.K., Bhatty R., Kamat A.A., Landen C.N., Han L., Thaker P.H., Li Y., Gershenson D.M., Lutgendorf S., and Cole S.W. Stress hormone-mediated invasion of ovarian cancer cells. Clin. Cancer Res. 12 (2006) 369-375
48. Tammela T., Enholm B., Alitalo K., and Paavonen K. The biology of vascular endothelial growth factors. Cardiovasc. Res. 65 (2005) 550-563
49. Temoshok L., Heller B.W., Sagebiel R.W., Blois M.S., Sweet D.M., DiClemente R.J., and Gold M.L. The relationship of psychosocial factors to prognostic indicators in cutaneous malignant melanoma. J. Psychosom. Res. 29 (1985) 139-153
50. Thaker P.H., Han L.Y., Kamat A.A., Arevalo J.M., Takahashi R., Lu C., Jennings N.B., Armaiz-Pena G., Bankson J.A., Ravoori M., Merritt W.M., Lin Y.G., Mangala L.S., Kim T.J., Coleman R.L., Landen C.N., Li Y., Felix E., Sanguino A.M., Newman R.A., Lloyd M., Gershenson D.M., Kundra V., Lopez-Berestein G., Lutgendorf S.K., Cole S.W., and Sood A.K. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat. Med. 12 (2006) 939
51. Thaker P.H., Lutgendorf S.K., and Sood A.K. The neuroendocrine impact of chronic stress on cancer. Cell Cycle 6 (2007) 430-433
52. Welch D.R., Bisi J.E., Miller B.E., Conaway D., Seftor E.A., Yohem K.H., Gilmore L.B., Seftor R.E., Nakajima M., and Hendrix M.J. Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line. Int. J. Cancer 47 (1991) 227-237
53. White V., English D., Coates H., Lagerlund M., Borland R., and Giles G. Is cancer risk associated with anger control and negative affect? Findings from a prospective cohort study. Psychosom. Med. 69 (2007) 667-674
54. Yang E.V., Donovan E.L., Benson D.M., and Glaser R. VEGF is differentially regulated in multiple myeloma-derived cell lines by norepinephrine. Brain Behav. Immun. 22 (2008) 318-323
55. Yang E.V., Sood A.K., Chen M., Li Y., Eubank T.D., Marsh C.B., Jewell S., Flavahan N.A., Morrison C., Yeh P.-E., Lemeshow S., and Glaser R. Norepinephrine Up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res. 66 (2006) 10357-10364
56. Yuan A., Chen J.J.W., Yao P.-L., and Yang P.-C. The role of interleukin-8 in cancer cells and microenvironment interaction. Front. Biosci. 10 (2005) 853-865