Suppression of NK cell activity and of resistance to metastasis by stress: A role for adrenal catecholamines and β-adrenoceptors

NeuroImmunoModulation

Volumn 8, Issue 3, 2000, Pages 154-164

  Ben Eliyahu, Shamgar ^a   Shakhar, Guy ^a   Page, Gayle G ^b   Stefanski, Volker ^c   Shakhar, Keren ^a  

^a TEL AVIV UNIVERSITY   (Israel)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

Immunomodulators; In vivo animal models; Neuroimmunology; NK cells; Rodent

Indexed keywords

3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ADRENALIN; ATENOLOL; BETA 1 ADRENERGIC RECEPTOR; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; BUTOXAMINE; CATECHOLAMINE; CHLORISONDAMINE; GANGLION BLOCKING AGENT; NADOLOL; ORCIPRENALINE;

ADRENAL MEDULLECTOMY; ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST ADENOCARCINOMA; CELL ACTIVITY; CONTROLLED STUDY; HOST RESISTANCE; IMMUNOMODULATION; IN VIVO STUDY; LUNG METASTASIS; LYMPHOCYTE COUNT; MALE; NATURAL KILLER CELL; NEUROIMMUNOLOGY; NONHUMAN; PRIORITY JOURNAL; RAT; STRESS; SWIMMING;

ADRENAL MEDULLA; ANIMALS; CATECHOLAMINES; DISEASE MODELS, ANIMAL; EPINEPHRINE; FEMALE; KILLER CELLS, NATURAL; LUNG NEOPLASMS; MALE; MAMMARY NEOPLASMS, EXPERIMENTAL; ORCIPRENALINE; RATS; RATS, INBRED F344; RECEPTORS, ADRENERGIC, BETA-1; RECEPTORS, ADRENERGIC, BETA-2; STRESS; SWIMMING; SYMPATHETIC NERVOUS SYSTEM; SYMPATHOMIMETICS; TUMOR CELLS, CULTURED;

EID: 0034532188     PISSN: 10217401     EISSN: None     Source Type: Journal    
DOI: 10.1159/000054276     Document Type: Article

References (76)

1. Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity
2. Stress-induced suppression of immunity in adrenalectomized rats
3. Stress increases metastatic spread of a mammary tumor in rats: Evidence for mediation by the immune system
4. A preliminary description of responses of free-ranging rhesus monkeys to brief capture experiences: Behavior, endocrine, immune, and health relationships
5. Stress and infectious disease in humans
6. Stress-related immune suppression: Health implications
7. Psychoneuroendocrine influences on immunocompetence and neoplasia
8. Stress and cancer
9. Social confrontation and tumor metastasis in rats: Defeat and beta-adrenergic mechanisms
10. Natural killer cells: Their roles in defenses against disease
11. Human NK cells: Their ligands, receptors and functions
12. The role of natural killer cells in human disease
13. Natural killer cells: Immunobiology and clinical prospects
14. Biology of natural killer cells
15. The role of natural killer cells in the control of tumor growth and metastasis
16. The role of natural killer cells in immune surveillance of cancer
17. In vivo role of natural killer cells: Involvement of large granular lymphocytes in the clearance of tumor cells in anti-asialo GM1-treated rats
18. Direct evidence for the role of LGL in the inhibition of experimental tumor metastases
19. Role of NK cells in the control of metastatic spread and growth of tumor cells in mice
20. Role of organ-associated NK cells in decreased formation of experimental metastases in lung and liver
21. In vivo assessment of natural killer cell activity in rats
22. The role of LGL/NK cells in surgery-induced promotion of metastasis and its attenuation by morphine
23. Evidence that stress and surgical interventions promote tumor development by suppressing natural killer cell activity
24. Expression and in-vivo modulation of alpha- and beta-adrenoceptors on human natural killer (CD16+) cells
25. Beta-adrenergic receptors in human leukocyte subpopulations
26. An immunopharmacological analysis of adrenaline-induced suppression of human natural killer cell cytotoxicity
27. Effects of beta-adrenergic receptor activation, cholera toxin and forskolin on human natural killer cell function
28. Norepinephrin inhibits human natural killer cell activity in vitro
29. Roles of sympathetic nervous system in the suppression of cytotoxicity of splenic natural killer cells in the rat
30. The effect of chemical sympathectomy on natural killer cells in mice
31. Immobilization increases norepinephrine release and reduces NK cytotoxicity in spleen of conscious rat
32. Hypothalamic modulation of splenic natural killer cell activity in rats
33. Evidence that shock-induced immune suppression is mediated by adrenal hormones and peripheral beta-adrenergic receptors
34. Central corticotropin-releasing factor mediates the suppressive effect of stress on natural killer cytotoxicity
35. Sympathetic nervous system mediates central corticotropin-releasing factor induced suppression of natural killer cytotoxicity
36. Brain IL-1-induced immunosuppression occurs through activation of both pituitary-adrenal axis and sympathetic nervous system by corticotropin-releasing factor
37. Depletion of catecholamines with alpha-methyl-p-tyrosine suppresses splenic NK cell activity
38. Sympathetic nervous system modulation of tumor metastases and host defense mechanisms
39. Adrenergic neuron blocking agents, psychological stress and tumor metastasis formation in mice
40. Intracerebral interleukin-1 beta impairs response to tumor invasion: Involvement of adrenal catecholamines
41. Signal transduction during human natural killer cell activation: Inositol phosphate generation and regulation by cyclic AMP
42. Evidence for a beta-adrenoceptor-mediated regulation of human natural killer cells
43. Natural killer cell activity during cortisol and adrenaline infusion in healthy volunteers
44. Natural killer cell activity and lymphocyte function during and after coronary artery bypass grafting in relation to the endocrine stress response
45. Modulation of natural killer cell activity in peripheral blood by physical exercise
46. Effect of eccentric exercise on natural killer cell activity
47. Adrenergic beta 1- and beta 1 + 2-receptor blockade suppress the natural killer cell response to head-up tilt in humans
48. Effects of elevated plasma noradrenaline concentration on the immune system in humans
49. Catecholamine-induced leukocytosis: Early observations, current research, and future directions
50. Evidence that the effect of physical exercise on NK cell activity is mediated by epinephrine
51. The effect of light, moderate and severe bicycle exercise on lymphocyte subsets, natural and lymphokine activated killer cells, lymphocyte proliferative response and interleukin 2 production
52. In vivo beta-adrenergic stimulation suppresses natural killer activity and compromises resistance to tumor metastasis in rats
53. dim subpopulations of rat natural killer cells
54. Monoclonal antibody to a triggering structure expressed on rat natural killer cells and adherent lymphokine-activated killer cells
55. Increased susceptibility to metastasis during pro-oestrus/oestrus in rats: Possible role of oestradiol and natural killer cells
56. Hypothermia in barbiturate-anesthetized rats suppresses natural killer cell activity and compromises resistance to tumor metastasis: A role for adrenergic mechanisms
57. Does surgery for the removal of cancer promote metastasis? Mediating mechanisms and prophylactic measures
58. Lowering of innate resistance of the lungs to the growth of blood-borne cancer cells in states of topical and systemic stress
59. The influence of stress and stress hormones on the transplantability of a non-immunogenic syngeneic murine tumor
60. Metastasis and neuroendocrine system in stressed mice
61. Blockers of adrenergic neurons and receptors, tumor progression and effects of rotational stress in mice
62. Evidence for involvement of B lymphocytes in the surveillance of lung metastasis in the rat
63. The natural killer cell response to exercise in spinal cord injured individuals
64. Exercise-induced immunomodulation - Possible roles of neuroendocrine and metabolic factors
65. Augmentation of cytotoxicity by natural killer (NK) cells after adrenaline administration in man
66. Stereological quantification of carboxyfluorescein-labeled rat lung metastasis: A new method for the assessment of natural killer cell activity and tumor adhesion in vivo and in situ
67. Acute alcohol intoxication suppresses natural killer cell activity and promotes tumor metastasis
68. A role for NK cells in greater susceptibility of young rats to metastatic formation
69. 2+-dependent pathways in the inhibition of human natural killer (NK) cell activity by cortisol
70. Mechanism of glucocorticoid action on murine natural killer cell activity
71. Stress-induced suppression of natural killer cell cytotoxicity in the rat: A naltrexone-insensitive paradigm
72. Pre-operative versus postoperative administration of morphine: Impact on the neuroendocrine, behavioural, and metastatic-enhancing effects of surgery
73. Effect of endogenous cortisol levels on natural killer cell activity in healthy humans
74. Natural killer cells and cancer