The cancer's nervous tooth: Considering the neuronal crosstalk within tumors

Seminars in Cancer Biology

Volumn 18, Issue 3, 2008, Pages 171-175

  Entschladen, Frank ^a   Palm, Daniel ^a   Niggemann, Bernd ^a   Zaenker, Kurt S ^a  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

Metastasis formation; Neoneurogenesis; Neuro neoplastic synapse; Neurotransmitters

Indexed keywords

3 [3,5 BIS(TRIFLUOROMETHYL)BENZYLOXY] 2 PHENYLPIPERIDINE; 3 ISOPROPYLAMINO 1 (7 METHYL 4 INDANYLOXY) 2 BUTANOL; ATENOLOL; BRAIN DERIVED GROWTH FACTOR; DOPAMINE; METOCLOPRAMIDE; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; NORADRENALIN; PROPRANOLOL DERIVATIVE; VASCULOTROPIN;

CANCER GROWTH; CARCINOGENESIS; CELL INTERACTION; HUMAN; IMMUNE SYSTEM; INNERVATION; METASTASIS; NEOPLASM; NERVE CELL; NERVOUS SYSTEM; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; REVIEW; SYNAPSE; TUMOR CELL; TUMOR GROWTH;

ANIMALS; CELL COMMUNICATION; CHEMOTAXIS; HUMANS; NEOPLASMS; NEURONS; SIGNAL TRANSDUCTION;

EID: 42649110948     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcancer.2007.12.004     Document Type: Review

References (32)

1. Vajdic C.M., McDonald S.P., McCredie M.R., van Leeuwen M.T., Stewart J.H., Law M., et al. Cancer incidence before and after kidney transplantation. JAMA 296 23 (2006) 2823-2831
2. Wimmer C.D., Rentsch M., Crispin A., Illner W.D., Arbogast H., Graeb C., et al. The janus face of immunosuppression - de novo malignancy after renal transplantation: the experience of the Transplantation Center Munich. Kidney Int (2007)
3. Lang K., Drell T.L., Niggemann B., Zanker K.S., and Entschladen F. Neurotransmitters regulate the migration and cytotoxicity in natural killer cells. Immunol Lett 90 2-3 (2003) 165-172
4. Jiang X.H., Guo S.Y., Xu S., Yin Q.Z., Ohshita Y., Naitoh M., et al. Sympathetic nervous system mediates cold stress-induced suppression of natural killer cytotoxicity in rats. Neurosci Lett 357 1 (2004) 1-4
5. Maestroni G.J. Adrenergic modulation of dendritic cells function: relevance for the immune homeostasis. Curr Neurovasc Res 2 2 (2005) 169-173
6. Bastian P., Posch B., Lang K., Niggemann B., Zaenker K.S., Hatt H., et al. Phosphatidylinositol 3-kinase in the G protein-coupled receptor-induced chemokinesis and chemotaxis of MDA-MB-468 breast carcinoma cells: a comparison with leukocytes. Mol Cancer Res 4 6 (2006) 411-421
7. Levite M. Nerve-driven immunity. The direct effects of neurotransmitters on T-cell function. Ann N Y Acad Sci 917 (2000) 307-321
8. Reiche E.M., Nunes S.O., and Morimoto H.K. Stress, depression, the immune system, and cancer. Lancet Oncol 5 10 (2004) 617-625
9. Carmeliet P. VEGF as a key mediator of angiogenesis in cancer. Oncology 69 Suppl. 3 (2005) 4-10
10. Strieter R.M., Burdick M.D., Gomperts B.N., Belperio J.A., and Keane M.P. CXC chemokines in angiogenesis. Cytokine Growth Factor Rev 16 6 (2005) 593-609
11. McColl B.K., Stacker S.A., and Achen M.G. Molecular regulation of the VEGF family-inducers of angiogenesis and lymphangiogenesis. APMIS 112 7-8 (2004) 463-480
12. Orellana C. Is lymphangiogenesis as important as angiogenesis?. Lancet Oncol 6 5 (2005) 265
13. Dolle L., El Yazidi-Belkoura I., Adriaenssens E., Nurcombe V., and Hondermarck H. Nerve growth factor overexpression and autocrine loop in breast cancer cells. Oncogene 22 36 (2003) 5592-5601
14. Geldof A.A., Van Haarst E.P., and Newling D.W. Neurotrophic factors in prostate and prostatic cancer. Prostate Cancer Prostatic Dis 1 5 (1998) 236-241
15. Ricci A., Greco S., Mariotta S., Felici L., Bronzetti E., Cavazzana A., et al. Neurotrophins and neurotrophin receptors in human lung cancer. Am J Respir Cell Mol Biol 25 4 (2001) 439-446
16. Chedotal A., Kerjan G., and Moreau-Fauvarque C. The brain within the tumor: new roles for axon guidance molecules in cancers. Cell Death Differ 12 8 (2005) 1044-1056
17. Lu S.H., Zhou Y., Que H.P., and Liu S.J. Peptidergic innervation of human esophageal and cardiac carcinoma. World J Gastroenterol 9 3 (2003) 399-403
18. Seifert P., and Spitznas M. Axons in human choroidal melanoma suggest the participation of nerves in the control of these tumors. Am J Ophthalmol 133 5 (2002) 711-713
19. Seifert P., Benedic M., and Effert P. Nerve fibers in tumors of the human urinary bladder. Virchows Arch 440 3 (2002) 291-297
20. Grabowski P., Maaser K., Hanski C., Stein H., Sturm I., Hopfenmuller W., et al. Prognostic value of multimarker analysis in stage III colorectal cancer: one step forward towards an individualized therapy decision. Onkologie 28 (2005) 399-403
21. Grabowski P., Schindler I., Anagnostopoulos I., Foss H.D., Riecken E.O., Mansmann U., et al. Neuroendocrine differentiation is a relevant prognostic factor in stage III-IV colorectal cancer. Eur J Gastroenterol Hepatol 13 4 (2001) 405-411
22. Entschladen F., Palm D., Lang K., Drell T.L., and Zaenker K.S. Neoneurogenesis: tumors may initiate their own innervation by the release of neurotrophic factors in analogy to lymphangiogenesis and neoangiogenesis. Med Hypotheses 67 (2006) 33-35
23. Montano X., and Djamgoz M.B. Epidermal growth factor, neurotrophins and the metastatic cascade in prostate cancer. FEBS Lett 571 1-3 (2004) 1-8
24. Dolle J.P., Rezvan A., Allen F.D., Lazarovici P., and Lelkes P.I. Nerve growth factor-induced migration of endothelial cells. J Pharmacol Exp Ther 315 3 (2005) 1220-1227
25. Park K.W., Crouse D., Lee M., Karnik S.K., Sorensen L.K., Murphy K.J., et al. The axonal attractant Netrin-1 is an angiogenic factor. Proc Natl Acad Sci USA 101 46 (2004) 16210-16215
26. Zhang H., Vutskits L., Pepper M.S., and Kiss J.Z. VEGF is a chemoattractant for FGF-2-stimulated neural progenitors. J Cell Biol 163 6 (2003) 1375-1384
27. Entschladen F., Palm D., Drell T.L., Lang K., and Zaenker K.S. Connecting a tumor to the environment. Curr Pharm Des 13 33 (2007) 3440-3444
28. Encinas M., Iglesias M., Liu Y., Wang H., Muhaisen A., Cena V., et al. Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J Neurochem 75 3 (2000) 991-1003
29. Masur K., Niggemann B., Zanker K.S., and Entschladen F. Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers. Cancer Res 61 7 (2001) 2866-2869
30. Drell T.L., Joseph J., Lang K., Niggemann B., Zaenker K.S., and Entschladen F. Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells. Breast Cancer Res Treat 80 1 (2003) 63-70
31. Lang K., Drell T.L., Lindecke A., Niggemann B., Kaltschmidt C., Zaenker K.S., et al. Induction of a metastatogenic tumor cell type by neurotransmitters and its pharmacological inhibition by established drugs. Int J Cancer 112 2 (2004) 231-238
32. Palm D., Lang K., Niggemann B., Drell T.L., Masur K., Zaenker K.S., et al. The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers. Int J Cancer 118 11 (2006) 2744-2749