-
1
-
-
0025056930
-
Identification of a chromosome 18q gene that is altered in colorectal cancers
-
Fearon, E. R. et al. Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247, 49-56 (1990). An Important paper that reported cloning of DCC as a tumour-suppressor gene at chromosome 18q, where frequent deletions are observed in colorectal cancer.
-
(1990)
Science
, vol.247
, pp. 49-56
-
-
Fearon, E.R.1
-
2
-
-
0030995125
-
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene
-
Fazeli, A. et al. Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) gene. Nature 386, 796-804 (1997). This was the first paper to report the knockout of DCC, DCC-knockout mice did not show increased tumour susceptibility.
-
(1997)
Nature
, vol.386
, pp. 796-804
-
-
Fazeli, A.1
-
3
-
-
0030592522
-
Deleted in Colorectal Cancer (DCC) encodes a netrin receptor
-
Keino-Masu, K. et al. Deleted In Colorectal Cancer (DCC) encodes a netrin receptor. Cell 87, 175-185 (1996). The first report that demonstrated the function of DCC as a netrin-1 receptor.
-
(1996)
Cell
, vol.87
, pp. 175-185
-
-
Keino-Masu, K.1
-
4
-
-
0029959555
-
The molecular biology of axon guidance
-
Tessier-Lavigne, M. & Goodman, C. S. The molecular biology of axon guidance. Science 274, 1123-1133 (1996).
-
(1996)
Science
, vol.274
, pp. 1123-1133
-
-
Tessier-Lavigne, M.1
Goodman, C.S.2
-
5
-
-
0035514195
-
Dynamic regulation of axon guidance
-
Yu, T. W. & Bargmann, C. I. Dynamic regulation of axon guidance. Nature Neurosci. 4, 1169-1176 (2001).
-
(2001)
Nature Neurosci.
, vol.4
, pp. 1169-1176
-
-
Yu, T.W.1
Bargmann, C.I.2
-
6
-
-
0030577117
-
DCC is there a connection between tumorigenesis and cell guidance molecules?
-
Fearon, E. R. DCC; is there a connection between tumorigenesis and cell guidance molecules? Biochim. Biophys. Acta 1288, M17-M23 (1996).
-
(1996)
Biochim. Biophys. Acta
, vol.1288
-
-
Fearon, E.R.1
-
7
-
-
0030943272
-
Putative cancer gene shows up in development instead
-
Roush, W. Putative cancer gene shows up in development instead. Science 276, 534-535 (1997).
-
(1997)
Science
, vol.276
, pp. 534-535
-
-
Roush, W.1
-
8
-
-
0032558787
-
The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis
-
Mehlen, P. et al. The DCC gene product induces apoptosis by a mechanism requiring receptor proteolysis. Nature 395, 801-804 (1998). This important paper provided clear evidence for the first time that DCC regulates apoptosis as a dependence receptor.
-
(1998)
Nature
, vol.395
, pp. 801-804
-
-
Mehlen, P.1
-
9
-
-
0028138219
-
The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
-
Serafini, T. et al. The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6. Cell 78, 409-424 (1994).
-
(1994)
Cell
, vol.78
, pp. 409-424
-
-
Serafini, T.1
-
10
-
-
0025332245
-
The unc-5, unc-6 and unc-40 genes guide circumferential migration of pioneer axons and mesodermal cells on the epidermis of C. elegans
-
Hedgecook, E. M., Culotti, J. G. & Hall, D. H. The unc-5, unc-6 and unc-40 genes guide circumferential migration of pioneer axons and mesodermal cells on the epidermis of C. elegans. Neuron 2, 61-85 (1990).
-
(1990)
Neuron
, vol.2
, pp. 61-85
-
-
Hedgecook, E.M.1
Culotti, J.G.2
Hall, D.H.3
-
11
-
-
0026481173
-
UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans
-
Ishii, N., Wadsworth, W. G., Stern, B. D., Culotti, J. G. & Hedgecook, E. M. UNC-6, a laminin-related protein, guides cell and pioneer axon migrations in C. elegans. Neuron 9, 873-881 (1992).
-
(1992)
Neuron
, vol.9
, pp. 873-881
-
-
Ishii, N.1
Wadsworth, W.G.2
Stern, B.D.3
Culotti, J.G.4
Hedgecook, E.M.5
-
12
-
-
0028061313
-
Netrins are diffusible chemotropic factors for commissural axons in the embryonal spinal cord
-
Kennedy, T. E., Serafini, T., de la Torre, J. R. & Tessier-Lavigne, M. Netrins are diffusible chemotropic factors for commissural axons in the embryonal spinal cord. Cell 78, 425-435 (1994).
-
(1994)
Cell
, vol.78
, pp. 425-435
-
-
Kennedy, T.E.1
Serafini, T.2
De La Torre, J.R.3
Tessier-Lavigne, M.4
-
13
-
-
0030592485
-
UNC40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues
-
Chan, S. S. et al. UNC40, a C. elegans homolog of DCC (Deleted in Colorectal Cancer), is required in motile cells responding to UNC-6 netrin cues. Cell 87, 187-195 (1996).
-
(1996)
Cell
, vol.87
, pp. 187-195
-
-
Chan, S.S.1
-
14
-
-
0030582772
-
Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system
-
Serafini, T. et al. Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system. Cell 87, 1001-1014 (1996).
-
(1996)
Cell
, vol.87
, pp. 1001-1014
-
-
Serafini, T.1
-
15
-
-
0033020095
-
Netrin-1: Interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas
-
Meyerhardt, J. A. et al. Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas. Cell Growth Differ. 10, 35-42 (1999).
-
(1999)
Cell Growth Differ.
, vol.10
, pp. 35-42
-
-
Meyerhardt, J.A.1
-
16
-
-
0037454779
-
Quantification of expression of netrins, slits and their receptors in human prostate tumors
-
Latil, A. et al. Quantification of expression of netrins, slits and their receptors in human prostate tumors. Int. J. Cancer 103, 306-315 (2003).
-
(2003)
Int. J. Cancer
, vol.103
, pp. 306-315
-
-
Latil, A.1
-
17
-
-
0028228920
-
The DCC gene product in cellular differentiation and colorectal tumorigenesis
-
Hedrick, L. et al. The DCC gene product in cellular differentiation and colorectal tumorigenesis. Genes Dev. 8, 1174-1183 (1994).
-
(1994)
Genes Dev.
, vol.8
, pp. 1174-1183
-
-
Hedrick, L.1
-
18
-
-
0027934722
-
Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues
-
Reale, M. A. et al. Expression and alternative splicing of the deleted in colorectal cancer (DCC) gene in normal and malignant tissues. Cancer Res. 54, 4493-4501 (1994).
-
(1994)
Cancer Res.
, vol.54
, pp. 4493-4501
-
-
Reale, M.A.1
-
19
-
-
15844390729
-
Evaluation of candidate tumor suppressor genes on chromosome 18 in colorectal cancers
-
Thiagalingam, S. et al. Evaluation of candidate tumor suppressor genes on chromosome 18 in colorectal cancers. Nature Genet. 13, 343-346 (1996).
-
(1996)
Nature Genet.
, vol.13
, pp. 343-346
-
-
Thiagalingam, S.1
-
20
-
-
0027944119
-
Frequent allelic deletions and loss of expression characterize the DCC gene male germ cell tumors
-
Murty, V. V. et al. Frequent allelic deletions and loss of expression characterize the DCC gene male germ cell tumors. Oncogens 9, 3227-3231 (1994).
-
(1994)
Oncogens
, vol.9
, pp. 3227-3231
-
-
Murty, V.V.1
-
21
-
-
0034051009
-
Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers
-
Hilgers, W. et al. Homozygous deletions inactivate DCC, but not MADH4/DPC4/SMAD4, in a subset of pancreatic and biliary cancers. Genes Chromosomes Cancer 27, 353-357 (2000).
-
(2000)
Genes Chromosomes Cancer
, vol.27
, pp. 353-357
-
-
Hilgers, W.1
-
22
-
-
0029089259
-
Hereditary nonpolyposis colorectal cancer: The syndrome, the genes, and historical perspectives
-
Marra, G. & Boland, C. R. Hereditary nonpolyposis colorectal cancer: the syndrome, the genes, and historical perspectives. J. Natl Cancer Inst. 87, 1114-1125 (1995).
-
(1995)
J. Natl. Cancer Inst.
, vol.87
, pp. 1114-1125
-
-
Marra, G.1
Boland, C.R.2
-
23
-
-
0029560435
-
DCC expression is altered by multiple mechanisms in brain tumours
-
Ekstrand, B. C. et al. DCC expression is altered by multiple mechanisms in brain tumours. Oncogene 11, 2393-2402 (1995).
-
(1995)
Oncogene
, vol.11
, pp. 2393-2402
-
-
Ekstrand, B.C.1
-
24
-
-
0034935235
-
Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer
-
Sato, K. et al. Frequent loss of expression without sequence mutations of the DCC gene in primary gastric cancer. Br. J. Cancer 85, 199-203 (2001).
-
(2001)
Br. J. Cancer
, vol.85
, pp. 199-203
-
-
Sato, K.1
-
25
-
-
0026642513
-
Frequent loss of heterozygosity at the DCC locus in gastric cancer
-
Uchino, S. et al. Frequent loss of heterozygosity at the DCC locus in gastric cancer. Cancer Res. 52, 3099-3102 (1992).
-
(1992)
Cancer Res.
, vol.52
, pp. 3099-3102
-
-
Uchino, S.1
-
26
-
-
0026653164
-
Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma
-
Hohne, M. W., Halatsch, M. E., Kahl, G. F. & Weinel, R. J. Frequent loss of expression of the potential tumor suppressor gene DCC in ductal pancreatic adenocarcinoma. Cancer Res. 52, 2616-2619 (1992).
-
(1992)
Cancer Res.
, vol.52
, pp. 2616-2619
-
-
Hohne, M.W.1
Halatsch, M.E.2
Kahl, G.F.3
Weinel, R.J.4
-
27
-
-
0028225322
-
Allelotype of pancreatic adenocarcinoma
-
Seymour, A. B. et al. Allelotype of pancreatic adenocarcinoma. Cancer Res. 54, 2761-2764 (1994).
-
(1994)
Cancer Res.
, vol.54
, pp. 2761-2764
-
-
Seymour, A.B.1
-
28
-
-
0028875562
-
Allelotype of pancreatic adenocarcinoma using xenograft enrichment
-
Hahn, S. A. et al. Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res. 55, 4670-4675 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 4670-4675
-
-
Hahn, S.A.1
-
29
-
-
0028340088
-
Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis
-
Miyake, S. et al. Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis. Cancer Res. 54, 3007-3010 (1994).
-
(1994)
Cancer Res.
, vol.54
, pp. 3007-3010
-
-
Miyake, S.1
-
30
-
-
0027156230
-
Frequent loss of expression and loss of heterozygosity of the putative tumor suppressor gene DCC in prostatic tumors
-
Gao, X., Honn, K., Grignon, D., Sakr, W. & Chen, Y. Frequent loss of expression and loss of heterozygosity of the putative tumor suppressor gene DCC in prostatic tumors. Cancer Res. 53, 2723-2727 (1993).
-
(1993)
Cancer Res.
, vol.53
, pp. 2723-2727
-
-
Gao, X.1
Honn, K.2
Grignon, D.3
Sakr, W.4
Chen, Y.5
-
31
-
-
0028067606
-
Genetic alterations in localized prostate cancer: Identification of a common region of deletion on chromosome arm 18q
-
Latil, A. et al. Genetic alterations in localized prostate cancer: identification of a common region of deletion on chromosome arm 18q. Genes Chromosomes Cancer 11, 119-125 (1994).
-
(1994)
Genes Chromosomes Cancer
, vol.11
, pp. 119-125
-
-
Latil, A.1
-
32
-
-
0027968338
-
Loss of heterozygosity on chromosome 18q is associated with muscle-invasive transitional cell carcinoma of the bladder
-
Brewster, S. F., Gingell, J. C., Browne, S. & Brown, K. W. Loss of heterozygosity on chromosome 18q is associated with muscle-invasive transitional cell carcinoma of the bladder. Br. J. Cancer 70, 697-700 (1994).
-
(1994)
Br. J. Cancer
, vol.70
, pp. 697-700
-
-
Brewster, S.F.1
Gingell, J.C.2
Browne, S.3
Brown, K.W.4
-
33
-
-
0027280477
-
Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer
-
Thompson, A. M. et al. Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer. Br. J. Cancer 68, 64-68 (1993).
-
(1993)
Br. J. Cancer
, vol.68
, pp. 64-68
-
-
Thompson, A.M.1
-
34
-
-
0027944119
-
Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors
-
Murty, V. V. et al. Frequent allelic deletions and loss of expression characterize the DCC gene in male germ cell tumors. Oncogene 9, 3227-3231 (1994).
-
(1994)
Oncogene
, vol.9
, pp. 3227-3231
-
-
Murty, V.V.1
-
35
-
-
0030005452
-
Loss of DCC expression in neuroblastoma is associated with disease dissemination
-
Reale, M. A. et al. Loss of DCC expression in neuroblastoma is associated with disease dissemination. Clin. Cancer Res. 2, 1097-1102 (1996).
-
(1996)
Clin. Cancer Res.
, vol.2
, pp. 1097-1102
-
-
Reale, M.A.1
-
36
-
-
0029560435
-
DCC expression is altered by multiple mechanism in brain tumors
-
Ekstrand, B. C., Mansfield, T. A., Bigner, S. H. & Fearon, E. R. DCC expression is altered by multiple mechanism in brain tumors. Oncogene 11, 2393-2402 (1995).
-
(1995)
Oncogene
, vol.11
, pp. 2393-2402
-
-
Ekstrand, B.C.1
Mansfield, T.A.2
Bigner, S.H.3
Fearon, E.R.4
-
37
-
-
0027228509
-
Alterations in the deleted in colorectal carcinoma gene in human primary leukemias
-
Miyake, K., Inokuchi, K., Dan, K. & Nomura, T. Alterations in the deleted in colorectal carcinoma gene in human primary leukemias. Blood 82, 927-930 (1993).
-
(1993)
Blood
, vol.82
, pp. 927-930
-
-
Miyake, K.1
Inokuchi, K.2
Dan, K.3
Nomura, T.4
-
38
-
-
0027322884
-
DCC tumor suppressor gene is inactivated in hematologic malignancies showing monosomy 18
-
Porfiri, E., Seeker-Walker, L., Hoffbrand, A. & Hancock, J. DCC tumor suppressor gene is inactivated in hematologic malignancies showing monosomy 18. Blood 81, 2696-2701 (1993).
-
(1993)
Blood
, vol.81
, pp. 2696-2701
-
-
Porfiri, E.1
Seeker-Walker, L.2
Hoffbrand, A.3
Hancock, J.4
-
39
-
-
0027381076
-
Expression of the DCC gene in myelodysplastic syndromes and overt leukemia
-
Miyake, K., Inokuchi, K., Dan, K. & Nomura, T. Expression of the DCC gene in myelodysplastic syndromes and overt leukemia. Leukemia Res. 17, 785-788 (1993).
-
(1993)
Leukemia Res.
, vol.17
, pp. 785-788
-
-
Miyake, K.1
Inokuchi, K.2
Dan, K.3
Nomura, T.4
-
40
-
-
0030593038
-
DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
-
Hahn, S. A. et al. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1. Science 271, 350-353 (1996).
-
(1996)
Science
, vol.271
, pp. 350-353
-
-
Hahn, S.A.1
-
41
-
-
15844387270
-
Mad-related genes in the human
-
Riggins, G. J. et al. Mad-related genes in the human. Nature Genet. 13, 347-349 (1996).
-
(1996)
Nature Genet.
, vol.13
, pp. 347-349
-
-
Riggins, G.J.1
-
42
-
-
0025980976
-
Suppression of tumorigenicity in human colorectal carcinoma cells by introduction of normal chromosome 5 or 18
-
Tanaka, K. et al. Suppression of tumorigenicity in human colorectal carcinoma cells by introduction of normal chromosome 5 or 18. Nature 349, 340-342 (1991).
-
(1991)
Nature
, vol.349
, pp. 340-342
-
-
Tanaka, K.1
-
43
-
-
0026553850
-
Antisense RNA to the putative tumor suppressor gene DCC transforms Rat-1 fibroblasts
-
Narayanan, R. et al. Antisense RNA to the putative tumor suppressor gene DCC transforms Rat-1 fibroblasts. Oncogene 7, 553-561 (1992).
-
(1992)
Oncogene
, vol.7
, pp. 553-561
-
-
Narayanan, R.1
-
44
-
-
0029027344
-
The DCC gene suppresses the malignant phenotype of transformed human epithelial cells
-
Klingelhutz, A. J., Hedrick, L., Cho, K. R. & McDougall, J. K. The DCC gene suppresses the malignant phenotype of transformed human epithelial cells. Oncogene 10, 1581-1586 (1995).
-
(1995)
Oncogene
, vol.10
, pp. 1581-1586
-
-
Klingelhutz, A.J.1
Hedrick, L.2
Cho, K.R.3
McDougall, J.K.4
-
45
-
-
0030888324
-
Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors
-
Leonardo, E. D. et al. Vertebrate homologues of C. elegans UNC-5 are candidate netrin receptors. Nature 386, 833-838 (1997).
-
(1997)
Nature
, vol.386
, pp. 833-838
-
-
Leonardo, E.D.1
-
46
-
-
0037389629
-
The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment
-
Thiebault, K. et al. The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment. Proc. Natl Acad. Sci. USA 100, 4173-4178 (2003). The first paper to report the frequent alterations of the UNC5H family of proteins in human cancers and their roles as tumour suppressors.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 4173-4178
-
-
Thiebault, K.1
-
47
-
-
9344254898
-
Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns
-
Sekido, Y. et al. Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung cancer deletion region and demonstrate distinct expression patterns. Proc. Natl Acad. Sci. USA 93, 4120-4125 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 4120-4125
-
-
Sekido, Y.1
-
48
-
-
0038068926
-
Allelic loss on choromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer
-
Kuroki, T. et al. Allelic loss on choromosome 3p21.3 and promoter hypermethylation of semaphorin 3B in non-small cell lung cancer. Cancer Res. 63, 3352-3355 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 3352-3355
-
-
Kuroki, T.1
-
49
-
-
0035923529
-
Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B
-
Tomizawa, Y. et al. Inhibition of lung cancer cell growth and induction of apoptosis after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B. Proc. Natl Acad. Sci. USA 98, 13954-13959 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 13954-13959
-
-
Tomizawa, Y.1
-
50
-
-
0037081278
-
Human semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line
-
Tse, C., Xiang, R. H., Bracht, T. & Naylor, S. L. Human semaphorin 3B (SEMA3B) located at chromosome 3p21.3 suppresses tumor formation in an adenocarcinoma cell line. Cancer Res. 62, 542-546 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 542-546
-
-
Tse, C.1
Xiang, R.H.2
Bracht, T.3
Naylor, S.L.4
-
51
-
-
0036569936
-
Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice
-
Xiang, R. et al. Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice. Cancer Res. 62, 2637-2643 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 2637-2643
-
-
Xiang, R.1
-
52
-
-
0842304286
-
Semaphorin-3F is an inhibitor of tumor angiogenesis
-
Kessler, O. et al. Semaphorin-3F is an inhibitor of tumor angiogenesis. Cancer Res. 64, 1008-1015 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 1008-1015
-
-
Kessler, O.1
-
53
-
-
0033874073
-
Semaphorin SEMA3F localization in malignant human lung and cell lines: A suggested role in cell adhesion and cell migration
-
Brambilla, E., Constantin, B., Drabkin, H. & Roche, J. Semaphorin SEMA3F localization in malignant human lung and cell lines: a suggested role in cell adhesion and cell migration. Am. J. Pathol. 156, 939-950 (2000).
-
(2000)
Am. J. Pathol.
, vol.156
, pp. 939-950
-
-
Brambilla, E.1
Constantin, B.2
Drabkin, H.3
Roche, J.4
-
54
-
-
0038010147
-
Expression of VEGF, semaphoring SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumors, and cell lines
-
Lantuejoul, S. et al. Expression of VEGF, semaphoring SEMA3F, and their common receptors neuropilins NP1 and NP2 in preinvasive bronchial lesions, lung tumors, and cell lines. J. Pathol. 200, 336-347 (2003).
-
(2003)
J. Pathol.
, vol.200
, pp. 336-347
-
-
Lantuejoul, S.1
-
55
-
-
0037374598
-
SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells
-
Dallol, A., Morton, D., Maher, E. R. & Latif, F. SLIT2 axon guidance molecule is frequently inactivated in colorectal cancer and suppresses growth of colorectal carcinoma cells. Cancer Res. 63, 1054-1058 (2003).
-
(2003)
Cancer Res.
, vol.63
, pp. 1054-1058
-
-
Dallol, A.1
Morton, D.2
Maher, E.R.3
Latif, F.4
-
56
-
-
0037108922
-
SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers
-
Dallol, A. et al. SLIT2, a human homologue of the Drosophila Slit2 gene, has tumor suppressor activity and is frequently inactivated in lung and breast cancers. Cancer Res. 62, 5874-5880 (2002).
-
(2002)
Cancer Res.
, vol.62
, pp. 5874-5880
-
-
Dallol, A.1
-
57
-
-
0035910105
-
Tumor suppressors on 3p: A neoclassic quartet
-
Huebner, K. Tumor suppressors on 3p: a neoclassic quartet. Proc. Natl Acad. Sci. USA 98, 14763-14765 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 14763-14765
-
-
Huebner, K.1
-
58
-
-
85047696015
-
Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers
-
Dallol, A. et al. Tumour specific promoter region methylation of the human homologue of the Drosophila Roundabout gene DUTT1 (ROBO1) in human cancers. Oncogens 21, 3020-3038 (2002).
-
(2002)
Oncogens
, vol.21
, pp. 3020-3038
-
-
Dallol, A.1
-
59
-
-
7844226649
-
Homozygous deletions at 3p12 in breast and lung cancer
-
Sundaresan, V. Homozygous deletions at 3p12 in breast and lung cancer. Oncogene 17, 1723-1729 (1998).
-
(1998)
Oncogene
, vol.17
, pp. 1723-1729
-
-
Sundaresan, V.1
-
60
-
-
0028892812
-
Molecular characterization and chromosomal localization of DRT (EPHT3); a developmentally regulated human protein-tyrosine kinase gene of the EPH family
-
Ikegaki, N. et al. Molecular characterization and chromosomal localization of DRT (EPHT3); a developmentally regulated human protein-tyrosine kinase gene of the EPH family. Hum. Mol. Genet. 4, 2033-2045 (1995).
-
(1995)
Hum. Mol. Genet.
, vol.4
, pp. 2033-2045
-
-
Ikegaki, N.1
-
61
-
-
4444326581
-
Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer
-
Huusko, P. et al. Nonsense-mediated decay microarray analysis identifies mutations of EPHB2 in human prostate cancer. Nature Genet. 36, 979-983 (2004).
-
(2004)
Nature Genet.
, vol.36
, pp. 979-983
-
-
Huusko, P.1
-
62
-
-
0036551486
-
Scatter-factor and semaphoring receptors: Cell signaling for invasive growth
-
Trusolino, L. & Comoglio, P. M. Scatter-factor and semaphoring receptors: cell signaling for invasive growth. Nature Rev. Cancer 2, 289-299 (2002).
-
(2002)
Nature Rev. Cancer
, vol.2
, pp. 289-299
-
-
Trusolino, L.1
Comoglio, P.M.2
-
64
-
-
2342577589
-
The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells
-
Nakada, M. et al. The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells. Cancer Res. 64, 3179-3185 (2004).
-
(2004)
Cancer Res.
, vol.64
, pp. 3179-3185
-
-
Nakada, M.1
-
65
-
-
0032571426
-
Receptor links blood vessels, axons
-
Roush, W. Receptor links blood vessels, axons. Science 279, 2042 (1998).
-
(1998)
Science
, vol.279
, pp. 2042
-
-
Roush, W.1
-
66
-
-
0041848212
-
Slit-Robo: Neuronal guides signal in tumor angiogenesis
-
Liu, Z. J. & Herlyn, M. Slit-Robo: neuronal guides signal in tumor angiogenesis. Cancer Cell 4, 1-2 (2004).
-
(2004)
Cancer Cell
, vol.4
, pp. 1-2
-
-
Liu, Z.J.1
Herlyn, M.2
-
67
-
-
10744224816
-
Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity
-
Wang, B. et al. Induction of tumor angiogenesis by Slit-Robo signaling and inhibition of cancer growth by blocking Robo activity. Cancer Cell 4, 19-29 (2004).
-
(2004)
Cancer Cell
, vol.4
, pp. 19-29
-
-
Wang, B.1
-
68
-
-
1442295841
-
Apoptosis and dependence receptors: A molecular basis for cellular addiction
-
Bredesen, D. E., Mehlen, P. & Rabizaheh, S. Apoptosis and dependence receptors: a molecular basis for cellular addiction. Physiol. Rev. 84, 411-430 (2004).
-
(2004)
Physiol. Rev.
, vol.84
, pp. 411-430
-
-
Bredesen, D.E.1
Mehlen, P.2
Rabizaheh, S.3
-
69
-
-
1442301672
-
The dependence receptor hypothesis
-
Mehlen, P. & Bredesen, D. E. The dependence receptor hypothesis. Apoptosis 9, 37-49 (2004). References 68 and 69 are excellent and important reviews that introduce a new concept 'dependence receptor' to the field of cell death and provide the mechanistic data to support the new roles of 'dependence receptors' in apoptosis regulation.
-
(2004)
Apoptosis
, vol.9
, pp. 37-49
-
-
Mehlen, P.1
Bredesen, D.E.2
-
70
-
-
0035853158
-
The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation
-
Forcet, C. et al. The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation. Proc. Natl Acad. Sci. USA 98, 3415-3421 (2001) This paper clearly demonstrates that DCC-induced apoptosis is independent of both the mitochondrial apoptotic pathway and the death receptor/caspase-8 pathway.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 3415-3421
-
-
Forcet, C.1
-
71
-
-
0037135578
-
Mediation of the DCC apoptotic signal by DIP13α
-
Liu, J. et al. Mediation of the DCC apoptotic signal by DIP13α. J. Biol. Chem. 277, 26281-26285 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26281-26285
-
-
Liu, J.1
-
72
-
-
0035355209
-
Netrin-1 acts as a survival factor via its receptors UNC5H and DCC
-
Llambi, F. et al. Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. EMBO J. 20, 2715-2722 (2001). This was the first paper to report the role of the UNC5H family as dependence receptors and their involvement in apoptosis regulation.
-
(2001)
EMBO J.
, vol.20
, pp. 2715-2722
-
-
Llambi, F.1
-
73
-
-
1542569609
-
Meeting report: Cellular dependence - Old concept, new mechanisms
-
Mehlen, P. & Bredesen, D. E. Meeting report: cellular dependence - old concept, new mechanisms. Sci. STKE 2003, pe55 (2003).
-
(2003)
Sci. STKE
, vol.2003
-
-
Mehlen, P.1
Bredesen, D.E.2
-
74
-
-
0038608015
-
UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NARGE
-
Williams, M. E., Strickland, P., Watanabe, K. & Hinck, L. UNC5H1 induces apoptosis via its juxtamembrane region through an interaction with NARGE. J. Biol. Chem. 278, 17483-17490 (2003).
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 17483-17490
-
-
Williams, M.E.1
Strickland, P.2
Watanabe, K.3
Hinck, L.4
-
76
-
-
4143142328
-
Dependence receptors: Between life and death
-
Mehlen, P. & Thibert, C. Dependence receptors: between life and death. Cell. Mol. Life Sci. 61, 1854-1866 (2004).
-
(2004)
Cell. Mol. Life Sci.
, vol.61
, pp. 1854-1866
-
-
Mehlen, P.1
Thibert, C.2
-
77
-
-
0033603256
-
A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion
-
Hong, K. et al. A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsion. Cell 97, 927-941 (1999).
-
(1999)
Cell
, vol.97
, pp. 927-941
-
-
Hong, K.1
-
78
-
-
0034213950
-
Dimerization-dependent block of the proapoptotic effect of p75/NTR
-
Wang, J. J. et al. Dimerization-dependent block of the proapoptotic effect of p75/NTR. J. Neurosci. Res. 60, 587-593 (2000).
-
(2000)
J. Neurosci. Res.
, vol.60
, pp. 587-593
-
-
Wang, J.J.1
-
79
-
-
0033517348
-
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2
-
Mitsuuchi, Y. et al. Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/ threonine kinase AKT2. Oncogene 18, 4891-4898 (1999).
-
(1999)
Oncogene
, vol.18
, pp. 4891-4898
-
-
Mitsuuchi, Y.1
-
80
-
-
0031053586
-
Regulation of neuronal survival by the serine-threonine protein kinase Akt
-
Dudek, H. et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275, 661-665 (1997).
-
(1997)
Science
, vol.275
, pp. 661-665
-
-
Dudek, H.1
-
81
-
-
0031053360
-
Akt signaling: Linking membrane events to life and death decisions
-
Hemmings, B. A. Akt signaling: linking membrane events to life and death decisions. Science 275, 628-630 (1997).
-
(1997)
Science
, vol.275
, pp. 628-630
-
-
Hemmings, B.A.1
-
82
-
-
0037161667
-
Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MARK activation
-
Forcet, C. et al. Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MARK activation. Nature 417, 443-447 (2002).
-
(2002)
Nature
, vol.417
, pp. 443-447
-
-
Forcet, C.1
-
83
-
-
0032793067
-
B-raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway
-
Erhardt, P., Schremser, E. J. & Cooper, G. M. B-raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway. Mol. Cell. Biol. 19, 5308-5315 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5308-5315
-
-
Erhardt, P.1
Schremser, E.J.2
Cooper, G.M.3
-
84
-
-
0034703742
-
p53: Death star
-
Vousden, K. H. p53: death star. Cell 103, 691-694 (2000).
-
(2000)
Cell
, vol.103
, pp. 691-694
-
-
Vousden, K.H.1
-
85
-
-
0037339042
-
p53RDL1 regulates p53-dependent apoptosis
-
Tanikawa, C., Matsuda, K., Fukuda, S., Nakamura, Y. & Arakawa, H. p53RDL1 regulates p53-dependent apoptosis. Nature Cell Biol. 5, 216-223 (2003). Demonstrated the involvement of p53 in netrin-1 regulation and showed that UNC5B mediates p53-dependent apoptosis as a transcriptional target, but that UNC5B blocks p53-induced apoptosis in the presence of netrin-1.
-
(2003)
Nature Cell Biol.
, vol.5
, pp. 216-223
-
-
Tanikawa, C.1
Matsuda, K.2
Fukuda, S.3
Nakamura, Y.4
Arakawa, H.5
-
86
-
-
0036152522
-
The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1
-
Shekarabi, M. & Kennedy, T. E. The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1. Mol. Cell. Neurosci. 19, 1-17 (2002).
-
(2002)
Mol. Cell. Neurosci.
, vol.19
, pp. 1-17
-
-
Shekarabi, M.1
Kennedy, T.E.2
-
87
-
-
0023748414
-
Genetic alterations during colorectal-tumor development
-
Vogelstein, B. et al. Genetic alterations during colorectal-tumor development. N. Engl. J. Med. 319, 525-532 (1988).
-
(1988)
N. Engl. J. Med.
, vol.319
, pp. 525-532
-
-
Vogelstein, B.1
-
88
-
-
0025312728
-
A genetic model for colorectal tumorigenesis
-
Fearon, E. R. & Vogelstein, B. A genetic model for colorectal tumorigenesis. Cell 61, 759-767 (1990).
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.R.1
Vogelstein, B.2
-
89
-
-
0024959672
-
Clinical and pathological associations with allelic loss in colorectal carcinoma
-
Kern, S. E. et al. Clinical and pathological associations with allelic loss in colorectal carcinoma. JAMA 261, 3099-3103 (1989).
-
(1989)
JAMA
, vol.261
, pp. 3099-3103
-
-
Kern, S.E.1
-
90
-
-
4544283421
-
Netrin-1 controls colorectal tumorigenesis by regulating apoptosis
-
Mazelin, L. et al. Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431, 80-84 (2004).
-
(2004)
Nature
, vol.431
, pp. 80-84
-
-
Mazelin, L.1
-
91
-
-
0031936192
-
Apc1638N: A mouse model for familial adenomatous polyposis-associated desmold tumors and cutaneous cysts
-
Smits, R. et al. Apc1638N: a mouse model for familial adenomatous polyposis-associated desmold tumors and cutaneous cysts. Gastroenterology 114, 275-283 (1998).
-
(1998)
Gastroenterology
, vol.114
, pp. 275-283
-
-
Smits, R.1
-
92
-
-
0036149437
-
Identification of semaphorin 3B as a direct target of p53
-
Ochi, K., Mori, T., Toyama, Y., Nakamura, Y. & Arakawa, H. Identification of semaphorin3B as a direct target of p53. Neoplasia 4, 82-87 (2002).
-
(2002)
Neoplasia
, vol.4
, pp. 82-87
-
-
Ochi, K.1
Mori, T.2
Toyama, Y.3
Nakamura, Y.4
Arakawa, H.5
|