Calcitonin gene-related peptide, substance P, and tyrosine hydroxylase- immunoreactive innervation of rat bone marrows: An immunohistochemical and ultrastructural investigation on possible efferent and afferent mechanisms

Journal of Orthopaedic Research

Volumn 15, Issue 1, 1997, Pages 133-140

  Imai, S ^a   Tokunaga, Y ^a   Maeda, T ^a   Kikkawa, M ^a   Hukuda, S ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ENZYMES; JOINTS (ANATOMY); NEUROLOGY; ORTHOPEDICS;

AXONS; BONE MARROW; INTRAMEDULLARY SUBSTANCE P; NERVE FIBERS; PEPTIDE; SCHWANN CELL; TYROSINE HYDROXYLASE;

BONE;

CALCITONIN GENE RELATED PEPTIDE; SUBSTANCE P; TYROSINE 3 MONOOXYGENASE;

ADOLESCENT; ANIMAL TISSUE; ANKLE; ARTICLE; BONE MARROW; EFFERENT NERVE; IMMUNOHISTOCHEMISTRY; INNERVATION; KNEE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY NERVE; TARSAL JOINT; TIBIA; ULTRASTRUCTURE;

EID: 0031039838     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1002/jor.1100150120     Document Type: Article

References (39)

1. 1 Bjurholm A, Kreicbergs A, Brodin E, Schultzberg M: Substance P‐ and CGRP‐immunoreactive nerves in bone. Peptides 9: 165–171, 1988
2. 2 Bjurholm A, Kericbergs A, Terenius L, Goldstein M, Schultzberg M: Neuropeptide Y‐, tyrosine hydroxylase‐ and vasoactive intestinal polypeptide‐immunoreactive nerves in bone and surrounding tissues. J Auton Nerv Syst 25: 119–125, 1988
3. 3 Bjurholm A, Kreicbergs A, Schultzberg M: Fixation and demineralization of bone tissue for immunohistochemical staining of neuropeptides. Calcif Tissue Int 45: 227–231, 1989
4. 4 Bjurholm A, Kreicbergs A, Schultzberg M, Lerner UH: Neuroendocrine regulation of cyclic AMP formation in osteoblastic cell lines (UMR‐106–01, ROS 17/2.8, MC3T3‐E1, andSaos‐2) and primary bone cells. J Bone Miner Res 7: 1011–1019, 1992
5. 5 D'Souza M, MacIntyre I, Girgis SI, Mundy GR: Human synthetic calcitonin gene‐related peptide inhibits bone resorption in vitor. Endocrinology 119: 58–61, 1986
6. 6 Duncan CP, Shim SS: J Edouard Samson Address. The autonomic nerve supply of bone: an experimental study of the intraosseous adrenergic vasorum in the rabbit. J Bone Joint Surg [Br] 59: 323–330, 1977
7. 7 Helme RD, Eglezos A, Dandie GW, Andrews PV, Boyd RL: The effect of substance p on the regional lympg node antibody response to antigen stimulation in capsaicin‐pretreated rats. J Immunol 139: 3470–3473, 1987
8. 8 Hill EL, Elde R: Distribution ofCGRP‐, VIP‐, DβH‐, SP‐, and NPY ‐immunoreactive nerves in the periosteum of the rat. Cell Tissue Res 264: 469–480, 1991
9. 9 Hökfelt T, Kellerth JO Nilsson G, Pernow B: Substance P: localization in the cenrtal nervous system and in some primary sensory neurons, Science 190: 889–890, 1975
10. 10 Hökfelt T, Johansson O, Ljungdahl A, Lundberg JM, Schultaberg M: Peptidergic neurons. Nature 284: 515–521, 1980
11. 11 Holzer P: Local effector functions of capsaicin‐sensitive sensory nerve endings: inovlement of tachykinins, calcitonin gene‐related peptide and other neuropeptide. Neuroscience 24: 739–768, 1988
12. 12 Hukkanen M, Konttinen YT, Rees RG, Santavirta S, Terenghi G, Polak JM: Distribution of nerve endings and sensory neuropeptides in rat synovium, meniscus and bone. Int J Tissue React 14: 1–10, 1992
13. 13 Imai S, Hukuda S, Maeda T: Substance P‐immunoreactive and protein gene product 9.5‐immunoreactive nerve fibres in bone marrow of rat cocygeal vertebrace. J Orthop Res 12: 853–859, 1994
14. 14 Imai S, Hukuda S, Maeda T: Neonatal capsaicin pretreatment suppresses intramedullary inflammation in adjuvant‐induced spondylitis Clin Exp Immunol 95: 108–114, 1994
15. 15 Imai S, Hukuda S, Maeda T: Dually innervating nociceptive networks in the rat lumbar posterior longitudinal ligaments. Spine 19: 2086–2092, 1995
16. 16 Jancso G, Kiraly E, Jancso‐Gabor A: Pharmacologically in duced selective degeneration of chemosensitie primary sensory neurons. Nature 207: 741–743, 1977
17. 17 Ju G, Hökfelt T, Brodin E, Fahrenkrug J, Fischer JA, Frey P, Elde RP, Brown JC: Primary sensory neurons of the rat showing calcitonin gene‐related peptide immunoreactivity and their relation to substance P‐, somatostatin‐, galanin‐, Vasoactive intestinal polypeptide‐ and cholecystokining‐immunoreactive ganglinon cells. Cell Tissue Res 247: 417–431, 1987
18. 18 Konttinen YT, Kemppinen P, Segerberg M, Hukkanen M, Rees R, Santavirta S, Sorsa T, Pertovaara A, Polak JM: Peripheral and spinal neural mechanisms in arthritis, with particular reference to treatment of inflammation and pain. Arthritis Rheum 37: 965–982, 1994
19. 19 Kuntz A, Richings CA: Innervation of the bone marrow. J Comp Neurol 83: 213–222, 1945
20. 20 Lee Y, Takami K, Kawai Y, Girgis S, Hillyard CJ, MacIntyre I, Emson PC, Toyama M: Distribution of calcitonin generelated peptide in the rat peripheral nervous system with reference to its coexistence with substance P. Neuroscience 15: 1227–1237, 1985
21. 21 Linder BE, Nielsen LB, Jespersen SM, Bjurholm A, Bünger C, Hansen ES: Vasoconstrictive action of neuropeptide Y in bone: porcine tibia perfused in vivo. Acta Orthop Scand 65: 629–634, 1994
22. 22 Linder JE: A Simple and reliable method for the silver impergantion of nerves in paraffin sections of soft and mineralized tissues. J Anat 127: 543–551, 1978
23. 23 Lotz M, Vaughan JH, Carson DA: Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Science 241: 1218–1221, 1988
24. 24 Maggi CA, Meli A: The sensory ‐effernt function of capsaicin‐sensitive sensory neurons. Gen Pharmacol 19: 1–43, 1988
25. 25 Mapp PI: Innercation of the synovium. Ann Rheum Dis 54: 398–403, 1995
26. 26 Micevych PE, Kruger L: The status of calcitonin gene‐related Peptide as an effector peptide: the first decade of a novel pleiotropic neuropeptide. In: Calcitonin Gene‐Related Peptide, vol 657, pp 379–396. Ed by Y Tache, P Holzer, and MG Rosenfeld. New York, New York Academy of Science, 1992
27. 27 Milgram JW, Robinson RA: An electron microscopic demonstration of unmyelinated nerves in the Haversian canals of the adult dog. Bull Johns Hopkins Hops 117: 163–173, 1965
28. 28 Miller MR, Kasahara M: Observations on the innervation of human long bone. Anat Rec 145: 13–23, 1963
29. 29 Moore RN, Osmand AP, Dunn JA, Joshi JG, Rouse BT: Substance P augmentation of CSF‐1‐stimulated in vitro myelopoiesis: a Two‐signal progenitor restricted, tuftsin‐like effect. J Immunol 141: 2699–2703, 1988
30. 30 Moore TC: Modification of lymphocyte traffic by vasoactive neurotransmitter substances. Immunology 52: 511–518, 1993
31. 31 Mullins MW, Ciallella J, Rangnekar V, McGillis JP: Characterization of a calcitonin gene‐related peptide (CGRP) receptors on mouse bone marrow cells. Regul Pept 49: 65–72, 1993
32. 32 Nilssen J, Von Euler AM, Dalsgaard CJ: Stimulation of connective tissue cell growth by substane P and substance K. Nature 315: 61–63, 1985
33. 33 Nong YH, Titus RG, Ribeiro JM, Remold HG: Peptides encoded by the calcitonin gene inhibit macrophage function. J Immunol 143: 45–49, 1989
34. 34 Peters A, Palay SL, Webster HD: The Fine Structure of the Nervous System: Neurons and Their Supporting Cells, 3rd ed, pp 218. New York, Oxford University Press, 1991
35. 35 Rameshwar P, Ganes D, Gascon P: In vitro stimuloatory effect of substance p on hematopoiesis. Blood 81: 391–398, 1993
36. 36 Scicchitano R, Biennenstock J, Stanisz AM: In vivo immunomodulation by the neuropeptide substance P. Immunology 36: 733–735, 1988
37. 37 Thurston TJ: Distribution of nerves in long bones as shown by silver impregnation. J Anat 134: 719–728, 1982
38. 38 von Euler US, Gaddum JH: An unidentified depressor substance in certain tissue extracts. J Physiol 72: 74–87, 1931
39. 39 Zaidi M, Fuller K, Bevis PJR, Gaines Das RE, Chambers TJ, MacIntyre I: Calcitonin gene‐related peptide inhibits osteoclastic bone resorption: a comparative study, Calcif Tissue Int 40: 149–154, 1987