Social stress promotes and γ-aminobutyric acid inhibits tumor growth in mouse models of non-small cell lung cancer

Cancer Prevention Research

Volumn 5, Issue 2, 2012, Pages 189-196

  Al Wadei, Hussein A N ^a,b   Plummer III, Howard K ^a   Ullah, Mohammad F ^a   Unger, Benjamin ^a   Brody, Joel R ^a   Schuller, Hildegard M ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b SANA A UNIVERSITY   (Yemen)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ADRENALIN; BUNGAROTOXIN RECEPTOR; CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTAMATE DECARBOXYLASE 65; GLUTAMATE DECARBOXYLASE 67; HYDROCORTISONE; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3; NICOTINIC RECEPTOR ALPHA4; NICOTINIC RECEPTOR ALPHA5; NORADRENALIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CANCER INHIBITION; CANCER PREVENTION; HUMAN; HUMAN CELL; IN VIVO STUDY; INTRACELLULAR SIGNALING; LUNG NON SMALL CELL CANCER; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SOCIAL STRESS; TUMOR XENOGRAFT;

ANIMALS; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; EPINEPHRINE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GABA AGENTS; GAMMA-AMINOBUTYRIC ACID; HUMANS; HYDROCORTISONE; LUNG NEOPLASMS; MALE; MICE; MICE, NUDE; MITOGEN-ACTIVATED PROTEIN KINASES; NOREPINEPHRINE; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, NICOTINIC; RNA, MESSENGER; SIGNAL TRANSDUCTION; SOCIAL SUPPORT; STRESS, PSYCHOLOGICAL;

EID: 84857667674     PISSN: 19406207     EISSN: 19406215     Source Type: Journal    
DOI: 10.1158/1940-6207.CAPR-11-0177     Document Type: Article

References (43)

1. ACS. Cancer facts and figures. Atlanta (GA): American Cancer Society; 2009.
2. Haiman CA, Stram DO, Wilkens LR, Pike MC, Kolonel LN, Henderson BE, et al. Ethnic and racial differences in the smoking-related risk of lung cancer. N Engl J Med 2006;354:333-42 (Pubitemid 43145058)
3. Bunn PAJ, Thatcher N. Systemic treatment for advanced (stage IIIb/IV) non-small cell lung cancer: more treatment options; more things to consider. Conclusions. Oncologist 2008;13:37-46.
4. Mackenbach JP, Huisman M, Anderson O, Bopp M, Borgan JK, Costa G, et al. Inequalities in lung cancer mortality by the educational level in 10 European populations. Eur J Cancer 2004;40: 126-35. (Pubitemid 37542324)
5. Hamer M, Chida Y, Molloy GJ. Psychological distress and cancer mortality. J Psychosom Res 2009;66:255-8.
6. Zabora J, BrintzenhofeSzoc K, Curbow B, Hooker C, Piantadosi S. The prevalence of psychological distress by cancer site. Psychooncology 2001;10:19-28. (Pubitemid 32106774)
7. Park PG, Merryman J, Orloff M, Schuller HM. Beta-adrenergic mitogenic signal transduction in peripheral lung adenocarcinoma: implications for individuals with preexisting chronic lung disease. Cancer Res 1995;55:3504-8.
8. Schuller HM, Tithof PK, Williams M, Plummer H III. The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid. Cancer Res 1999;59:4510-5. (Pubitemid 29428948)
9. Laag E, Majidi M, Cekanova C, Masi T, Takahashi T, Schuller HM. NNK activates ERK1/2 and CREB/ATF-1 via beta-1-AR and EGFR signaling in human lung adenocarcinoma and small airway epithelial cells. Int J Cancer 2006;119:1547-52. (Pubitemid 44258759)
10. Majidi M, Al-Wadei HA, Takahashi T, Schuller HM. Nongenomic beta estrogen receptors enhance beta1 adrenergic signaling induced by the nicotine-derived carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human small airway epithelial cells. Cancer Res 2007;67: 6863-71. (Pubitemid 47105533)
11. Schuller HM, Al-Wadei HA, Majidi M. Gamma-aminobutyric acid, a potential tumor suppressor for small airway-derived lung adenocarcinoma. Carcinogenesis 2008;29:1979-85.
12. Sterlemann V, Ganea K, Liebl C, Harbich D, Alaam S, Holsboer F, et al. Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: Implications for stress-related disorders. Horm Behav 2008;53:386-94.
13. Al-Wadei HA, Al-Wadei MH, Masi T, SchullerHM. Chronic exposure to estrogen and the tobacco carcinogen NNK cooperatively modulates nicotinic receptors in small airway epithelial cells. Lung Cancer 2010; 69:33-9.
14. Plummer HK III, Dhar MS, Cekanova M, Schuller HM. Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines. BMC Cancer 2005;5:104.
15. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-8. (Pubitemid 34164012)
16. Al-Wadei HA, Takahasi T, Schuller HM. PKA-dependent growth stimulation of cells derived from human pulmonary adenocarcinoma and small airway epithelium by dexamethasone. Eur J Cancer 2005;41: 2745-53. (Pubitemid 41607568)
17. McEwen BS. The neurobiology of stress: from serendipity to clinical relevance. Brain Res 2000;886:172-89.
18. Yokotani K, Okada S, Nakamura K. Characterization of functional nicotinic acetylcholine receptors involved in catecholamine release from isolated rat adrenal gland. Eur J Pharmacol 2002;446:83-7. (Pubitemid 34722560)
19. Wonnacott S. Presynaptic nicotinic ACh receptors. Trends Neurosci 1997;20:92-8. (Pubitemid 27050704)
20. Al-Wadei HA, Al-Wadei MH, Schuller HM. Chronic nicotine stimulates lung adenocarcinoma in vivo and in vitro via modulation of nicotinic acetylcholine receptor regulated excitatory and inhibitory neurotransmission characteristic of nicotine addiction [abstract #3231]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; 2010.
21. Wessler I, Kirkpatrick CJ. Acetylcholine beyond neurons: the non-neuronal cholinergic system in humans. Br J Pharmacol 2008;154: 1558-71.
22. Wallukat G. The beta-adrenergic receptors. Herz 2002;27:683-90.
23. Chapman RW, Hey JA, Rizzo CA, Bolser DC. GABAB receptors in the lung. Trends Pharmacol Sci 1993;14:26-9.
24. Schuller HM, Al-Wadei HA, Majidi M. GABA(B) receptor is a novel drug target for pancreatic cancer. Cancer 2008;112:767-78. (Pubitemid 351240570)
25. Schmidt MV, Scharf SH, Liebl C, Harbich D, Mayer B, Holsboer F, et al. A novel chronic social stress paradigm in female mice. Horm Behav 2010;57:415-20.
26. Moreno-Smith M, Lutgendorf SK, Sood AK. Impact of stress on cancer metastasis. Future Oncol 2010;6:1863-81.
27. Proskocil BJ, S. SH, Jia Y, Savchenko V, Blakely RD, Lindstrom J, et al. Acetylcholine is an autocrine or paracrine hormone synthesized and secreted by airway broncial epithelial cells. Endocrinology 2004;145: 2498-506.
28. Lindstrom J, Anand R, Gerzanich V, Peng X,WangF, Wells G. Structure and function of neuronal nicotinic acetylcholine receptors. Prog Brain Res 1996;109:125-37. (Pubitemid 27047080)
29. Hu W, Zhang M, Czéh B, Flügge G, Zhang W. Stress impairs GABAergic network function in the hippocampus by activating nongenomic glucocorticoid receptors and affecting the integrity of the parvalbumin- expressing neuronal network. Neuropsychopharmacology 2010;35: 1693-707.
30. Elizalde N, Garcia-Garcia AL, Totterdell S, Gendive N, Venzala E, Ramirez MJ, et al. Sustained stress-induced changes in mice as a model for chronic depression. Psychopharmacology 2010;210:393-406.
31. Al-Wadei HA, Plummer HK III, Schuller HM. Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter gammaaminobutyric acid. Carcinogenesis 2009;30:506-11.
32. Joseph J, Niggemann B, Zaenker KS, Entschladen F. The neurotransmitter gamma-aminobutyric acid is an inhibitory regulator for the migration of SW 480 colon carcinoma cells. Cancer Res 2002;62: 6467-9. (Pubitemid 35364108)
33. Drell TLt, Joseph J, Lang K, Niggemann B, Zaenker KS, Entschladen F. Effects of neurotransmitters on the chemokinesis and chemotaxis of MDA-MB-468 human breast carcinoma cells. Breast Cancer Res Treat 2003;80:63-70.
34. Padgett CL, SlesingerPA.GABABreceptor coupling to G-proteins and ion channels. Adv Pharmacol 2010;58:123-47.
35. Di Angelantonio S, Matteoni C, Fabbretti E, Nistri A. Molecular biology and electrophysiology of neuronal nicotinic receptors of rat chromaffin cells. Eur J Neurosci 2003;17:2313-22. (Pubitemid 36793740)
36. Tournier JM, Maouche K, Coraux C, Zahm JM, Cloëz-Tayarani I, Nawrocki-Raby B, et al. a3a5b2-Nicotinic acetylcholine receptor contributes to the wound repair of the respiratory epithelium by modulating intracellular calcium in migrating cells. Am J Pathol 2006;168:55-68. (Pubitemid 43062559)
37. Amos CI, Gorlov IP, Dong Q, Wu X, Zhang H, Lu EY, et al. Nicotinic acetylcholine receptor region on chromosome 15q25 and lung cancer risk among African Americans: a case-control study. J Natl Cancer Inst 2010;102:1199-205.
38. Sloan EK, Priceman SJ, Cox BF, Yu S, PimentelMA, Tangkanangnukul V, et al. The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Res 2010;70:7042-52.
39. Powe DG, Voss MJ, Zanker KS, Habashy HO, Green AR, Ellis IO, et al. Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival. Oncotarget 2010;1:628-38.
40. Masur K, Niggemann B, Zanker KS, Entschladen F. Norepinephrine-induced migration of SW 480 colon carcinoma cells is inhibited by beta-blockers. Cancer Res 2001;61:2866-9. (Pubitemid 32691927)
41. Wong HP, Yu L, Lam EK, Tai EK, Wu WK, Cho CH. Nicotine promotes cell proliferation via alpha7-nicotinic acetylcholine receptor and catecholamine- synthesizing enzymes-mediated pathway in human colon adenocarcinomaHT-29 cells. ToxicolAppl Pharmacol2007;221:261-7. (Pubitemid 46855813)
42. Palm D, Lang K, Niggemann B, Drell TLt, Masur K, Zaenker KS, et al. The norepinephrine-driven metastasis development of PC-3 human prostate cancer cells in BALB/c nude mice is inhibited by beta-blockers. Int J Cancer 2006;118:2744-9. (Pubitemid 43673352)
43. Sood AK, Bhatty R, Kamat AA, Landen CN, Han L, Thaker PH, et al. Stress hormone-mediated invasion of ovarian cancer cells. Clin Cancer Res 2006;12:369-75. (Pubitemid 43166123)