O6-Methylguanine DNA lesions induce an intra-S-phase arrest from which cells exit into apoptosis governed by early and late multi-pathway signaling network activation

Integrative Biology (United Kingdom)

Volumn 4, Issue 10, 2012, Pages 1237-1255

  Noonan, Ericka M ^a   Shah, Dharini ^a   Yaffe, Michael B ^a   Lauffenburger, Douglas A ^a   Samson, Leona D ^a  

^a Massachusetts Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 O METHYLGUANINE; CASPASE 3; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DNA METHYLTRANSFERASE; HISTONE H2AX; METHYLNITRONITROSOGUANIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; ANTINEOPLASTIC AGENT; DNA; DRUG DERIVATIVE; GUANINE; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE;

APOPTOSIS; ARTICLE; CELL CYCLE PROGRESSION; CELL DEATH; CELL FUNCTION; CELL SURVIVAL; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; DNA REPLICATION; HUMAN; HUMAN CELL; MISMATCH REPAIR; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; S PHASE CELL CYCLE CHECKPOINT; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; BASE MISPAIRING; CELL CYCLE; CELL CYCLE S PHASE; CELL LINE; DNA REPAIR; DOSE RESPONSE; DRUG EFFECT; GENE EXPRESSION REGULATION; METABOLISM; NEOPLASM;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BASE PAIR MISMATCH; CELL CYCLE; CELL DEATH; CELL LINE; DNA; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANINE; HUMANS; NEOPLASMS; S PHASE; SIGNAL TRANSDUCTION;

EID: 84874405804     PISSN: 17579694     EISSN: 17579708     Source Type: Journal    
DOI: 10.1039/c2ib20091k     Document Type: Article

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