O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 2, 2009, Pages 576-581

  Klapacz, Joanna ^a   Meira, Lisiane B ^a   Luchetti, David G ^a   Calvo, Jennifer A ^a   Bronson, Roderick T ^b   Edelmann, Winfried ^c   Samson, Leona D ^a,b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Alkylation resistance; Apoptosis; DNA alkylation; Mgmt; N methyl N nitrosourea (MNU)

Indexed keywords

6 O METHYLGUANINE; DNA; EXONUCLEASE; EXONUCLEASE 1; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLNITRONITROSOGUANIDINE; METHYLNITROSOUREA; MITOMYCIN C; PROTEIN MSH6; UNCLASSIFIED DRUG; DNA BINDING PROTEIN; DRUG DERIVATIVE; EXODEOXYRIBONUCLEASE; EXODEOXYRIBONUCLEASE I; GUANINE; MSH6 PROTEIN, MOUSE; O (6) METHYLGUANINE; O-(6)-METHYLGUANINE;

ALKYLATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BASE MISPAIRING; BONE MARROW; BONE MARROW CELL; CELL FUNCTION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; EMBRYO; EMBRYO CELL; EXPERIMENTAL MODEL; FIBROBLAST; IN VIVO STUDY; KNOCKOUT MOUSE; LOW DRUG DOSE; MISMATCH REPAIR; MOLECULAR RECOGNITION; MOUSE; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN FUNCTION; SINGLE DRUG DOSE; SPLEEN; THYMUS; WILD TYPE; ANIMAL; C57BL MOUSE; CYTOLOGY; GENETICS; MOUSE MUTANT; PHYSIOLOGY;

MUS;

ALKYLATION; ANIMALS; APOPTOSIS; BASE PAIR MISMATCH; BONE MARROW CELLS; CELL PROLIFERATION; DNA-BINDING PROTEINS; EXODEOXYRIBONUCLEASES; FIBROBLASTS; GUANINE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; SPLEEN; THYMUS GLAND;

EID: 58849124160     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0811991106     Document Type: Article

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