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Volumn 49, Issue 4, 2013, Pages 657-667

Activation of DSB Processing Requires Phosphorylation of CtIP by ATR

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; ATR PROTEIN; DEOXYRIBONUCLEOPROTEIN; DOUBLE STRANDED DNA; PROTEIN CTIP; THREONINE; UNCLASSIFIED DRUG;

EID: 84874243900     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2012.11.020     Document Type: Article
Times cited : (104)

References (72)
  • 1
    • 44349086462 scopus 로고    scopus 로고
    • Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex
    • Akamatsu Y., Murayama Y., Yamada T., Nakazaki T., Tsutsui Y., Ohta K., Iwasaki H. Molecular characterization of the role of the Schizosaccharomyces pombe nip1+/ctp1+ gene in DNA double-strand break repair in association with the Mre11-Rad50-Nbs1 complex. Mol. Cell. Biol. 2008, 28:3639-3651.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 3639-3651
    • Akamatsu, Y.1    Murayama, Y.2    Yamada, T.3    Nakazaki, T.4    Tsutsui, Y.5    Ohta, K.6    Iwasaki, H.7
  • 2
    • 11044234004 scopus 로고    scopus 로고
    • Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway
    • Alderton G.K., Joenje H., Varon R., Børglum A.D., Jeggo P.A., O'Driscoll M. Seckel syndrome exhibits cellular features demonstrating defects in the ATR-signalling pathway. Hum. Mol. Genet. 2004, 13:3127-3138.
    • (2004) Hum. Mol. Genet. , vol.13 , pp. 3127-3138
    • Alderton, G.K.1    Joenje, H.2    Varon, R.3    Børglum, A.D.4    Jeggo, P.A.5    O'Driscoll, M.6
  • 3
    • 26644437215 scopus 로고    scopus 로고
    • Identification of mammalian proteins cross-linked to DNA by ionizing radiation
    • Barker S., Weinfeld M., Zheng J., Li L., Murray D. Identification of mammalian proteins cross-linked to DNA by ionizing radiation. J. Biol. Chem. 2005, 280:33826-33838.
    • (2005) J. Biol. Chem. , vol.280 , pp. 33826-33838
    • Barker, S.1    Weinfeld, M.2    Zheng, J.3    Li, L.4    Murray, D.5
  • 4
    • 2942594756 scopus 로고    scopus 로고
    • The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation
    • Baroni E., Viscardi V., Cartagena-Lirola H., Lucchini G., Longhese M.P. The functions of budding yeast Sae2 in the DNA damage response require Mec1- and Tel1-dependent phosphorylation. Mol. Cell. Biol. 2004, 24:4151-4165.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 4151-4165
    • Baroni, E.1    Viscardi, V.2    Cartagena-Lirola, H.3    Lucchini, G.4    Longhese, M.P.5
  • 5
    • 0037665234 scopus 로고    scopus 로고
    • ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation
    • Barr S.M., Leung C.G., Chang E.E., Cimprich K.A. ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation. Curr. Biol. 2003, 13:1047-1051.
    • (2003) Curr. Biol. , vol.13 , pp. 1047-1051
    • Barr, S.M.1    Leung, C.G.2    Chang, E.E.3    Cimprich, K.A.4
  • 6
    • 59249107930 scopus 로고    scopus 로고
    • Interplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repair
    • Budd M.E., Campbell J.L. Interplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repair. PLoS ONE 2009, 4:e4267.
    • (2009) PLoS ONE , vol.4
    • Budd, M.E.1    Campbell, J.L.2
  • 8
    • 18244371925 scopus 로고    scopus 로고
    • Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
    • Byun T.S., Pacek M., Yee M.C., Walter J.C., Cimprich K.A. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev. 2005, 19:1040-1052.
    • (2005) Genes Dev. , vol.19 , pp. 1040-1052
    • Byun, T.S.1    Pacek, M.2    Yee, M.C.3    Walter, J.C.4    Cimprich, K.A.5
  • 10
    • 47749141560 scopus 로고    scopus 로고
    • ATR: an essential regulator of genome integrity
    • Cimprich K.A., Cortez D. ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 2008, 9:616-627.
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 616-627
    • Cimprich, K.A.1    Cortez, D.2
  • 11
    • 0037245862 scopus 로고    scopus 로고
    • An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
    • Costanzo V., Shechter D., Lupardus P.J., Cimprich K.A., Gottesman M., Gautier J. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol. Cell 2003, 11:203-213.
    • (2003) Mol. Cell , vol.11 , pp. 203-213
    • Costanzo, V.1    Shechter, D.2    Lupardus, P.J.3    Cimprich, K.A.4    Gottesman, M.5    Gautier, J.6
  • 13
    • 77955847245 scopus 로고    scopus 로고
    • Multiple roles of ATM in monitoring and maintaining DNA integrity
    • Derheimer F.A., Kastan M.B. Multiple roles of ATM in monitoring and maintaining DNA integrity. FEBS Lett. 2010, 584:3675-3681.
    • (2010) FEBS Lett. , vol.584 , pp. 3675-3681
    • Derheimer, F.A.1    Kastan, M.B.2
  • 15
    • 68249092083 scopus 로고    scopus 로고
    • Studying the DNA damage response using in vitro model systems
    • Garner E., Costanzo V. Studying the DNA damage response using in vitro model systems. DNA Repair (Amst.) 2009, 8:1025-1037.
    • (2009) DNA Repair (Amst.) , vol.8 , pp. 1025-1037
    • Garner, E.1    Costanzo, V.2
  • 16
    • 58149308077 scopus 로고    scopus 로고
    • Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions
    • Hartsuiker E., Mizuno K., Molnar M., Kohli J., Ohta K., Carr A.M. Ctp1CtIP and Rad32Mre11 nuclease activity are required for Rec12Spo11 removal, but Rec12Spo11 removal is dispensable for other MRN-dependent meiotic functions. Mol. Cell. Biol. 2009, 29:1671-1681.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 1671-1681
    • Hartsuiker, E.1    Mizuno, K.2    Molnar, M.3    Kohli, J.4    Ohta, K.5    Carr, A.M.6
  • 17
    • 58149289464 scopus 로고    scopus 로고
    • Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA
    • Hartsuiker E., Neale M.J., Carr A.M. Distinct requirements for the Rad32(Mre11) nuclease and Ctp1(CtIP) in the removal of covalently bound topoisomerase I and II from DNA. Mol. Cell 2009, 33:117-123.
    • (2009) Mol. Cell , vol.33 , pp. 117-123
    • Hartsuiker, E.1    Neale, M.J.2    Carr, A.M.3
  • 18
    • 0021111515 scopus 로고
    • Gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini
    • Henner W.D., Rodriguez L.O., Hecht S.M., Haseltine W.A. gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini. J. Biol. Chem. 1983, 258:711-713.
    • (1983) J. Biol. Chem. , vol.258 , pp. 711-713
    • Henner, W.D.1    Rodriguez, L.O.2    Hecht, S.M.3    Haseltine, W.A.4
  • 20
    • 70349859881 scopus 로고    scopus 로고
    • DNA damage, aging, and cancer
    • Hoeijmakers J.H. DNA damage, aging, and cancer. N. Engl. J. Med. 2009, 361:1475-1485.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 1475-1485
    • Hoeijmakers, J.H.1
  • 21
    • 66149114020 scopus 로고    scopus 로고
    • Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
    • Huertas P., Jackson S.P. Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J. Biol. Chem. 2009, 284:9558-9565.
    • (2009) J. Biol. Chem. , vol.284 , pp. 9558-9565
    • Huertas, P.1    Jackson, S.P.2
  • 23
    • 47949121598 scopus 로고    scopus 로고
    • Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
    • Jazayeri A., Balestrini A., Garner E., Haber J.E., Costanzo V. Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J. 2008, 27:1953-1962.
    • (2008) EMBO J. , vol.27 , pp. 1953-1962
    • Jazayeri, A.1    Balestrini, A.2    Garner, E.3    Haber, J.E.4    Costanzo, V.5
  • 24
    • 33747188326 scopus 로고    scopus 로고
    • Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation
    • Keeney S., Neale M.J. Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation. Biochem. Soc. Trans. 2006, 34:523-525.
    • (2006) Biochem. Soc. Trans. , vol.34 , pp. 523-525
    • Keeney, S.1    Neale, M.J.2
  • 25
    • 0033621392 scopus 로고    scopus 로고
    • Substrate specificities and identification of putative substrates of ATM kinase family members
    • Kim S.T., Lim D.S., Canman C.E., Kastan M.B. Substrate specificities and identification of putative substrates of ATM kinase family members. J. Biol. Chem. 1999, 274:37538-37543.
    • (1999) J. Biol. Chem. , vol.274 , pp. 37538-37543
    • Kim, S.T.1    Lim, D.S.2    Canman, C.E.3    Kastan, M.B.4
  • 26
    • 80053447704 scopus 로고    scopus 로고
    • Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks
    • Langerak P., Mejia-Ramirez E., Limbo O., Russell P. Release of Ku and MRN from DNA ends by Mre11 nuclease activity and Ctp1 is required for homologous recombination repair of double-strand breaks. PLoS Genet. 2011, 7:e1002271.
    • (2011) PLoS Genet. , vol.7
    • Langerak, P.1    Mejia-Ramirez, E.2    Limbo, O.3    Russell, P.4
  • 27
    • 0030591663 scopus 로고    scopus 로고
    • DNA adducts from chemotherapeutic agents
    • Lawley P.D., Phillips D.H. DNA adducts from chemotherapeutic agents. Mutat. Res. 1996, 355:13-40.
    • (1996) Mutat. Res. , vol.355 , pp. 13-40
    • Lawley, P.D.1    Phillips, D.H.2
  • 28
    • 8844254050 scopus 로고    scopus 로고
    • Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries
    • Leahy J.J., Golding B.T., Griffin R.J., Hardcastle I.R., Richardson C., Rigoreau L., Smith G.C. Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg. Med. Chem. Lett. 2004, 14:6083-6087.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 6083-6087
    • Leahy, J.J.1    Golding, B.T.2    Griffin, R.J.3    Hardcastle, I.R.4    Richardson, C.5    Rigoreau, L.6    Smith, G.C.7
  • 29
    • 36949026694 scopus 로고    scopus 로고
    • Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
    • Lee J.H., Paull T.T. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene 2007, 26:7741-7748.
    • (2007) Oncogene , vol.26 , pp. 7741-7748
    • Lee, J.H.1    Paull, T.T.2
  • 30
    • 0036163019 scopus 로고    scopus 로고
    • Differential suppression of DNA repair deficiencies of Yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase)
    • Lewis L.K., Karthikeyan G., Westmoreland J.W., Resnick M.A. Differential suppression of DNA repair deficiencies of Yeast rad50, mre11 and xrs2 mutants by EXO1 and TLC1 (the RNA component of telomerase). Genetics 2002, 160:49-62.
    • (2002) Genetics , vol.160 , pp. 49-62
    • Lewis, L.K.1    Karthikeyan, G.2    Westmoreland, J.W.3    Resnick, M.A.4
  • 31
    • 0034644220 scopus 로고    scopus 로고
    • Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response
    • Li S., Ting N.S., Zheng L., Chen P.L., Ziv Y., Shiloh Y., Lee E.Y., Lee W.H. Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response. Nature 2000, 406:210-215.
    • (2000) Nature , vol.406 , pp. 210-215
    • Li, S.1    Ting, N.S.2    Zheng, L.3    Chen, P.L.4    Ziv, Y.5    Shiloh, Y.6    Lee, E.Y.7    Lee, W.H.8
  • 32
    • 56049111594 scopus 로고    scopus 로고
    • Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends
    • Liao S., Toczylowski T., Yan H. Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends. Nucleic Acids Res. 2008, 36:6091-6100.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 6091-6100
    • Liao, S.1    Toczylowski, T.2    Yan, H.3
  • 33
    • 56049111594 scopus 로고    scopus 로고
    • Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends
    • Liao S., Toczylowski T., Yan H. Identification of the Xenopus DNA2 protein as a major nuclease for the 5'->3' strand-specific processing of DNA ends. Nucleic Acids Res. 2008, 36:6091-6100.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 6091-6100
    • Liao, S.1    Toczylowski, T.2    Yan, H.3
  • 34
    • 80051766855 scopus 로고    scopus 로고
    • Mechanistic analysis of Xenopus EXO1's function in 5'-strand resection at DNA double-strand breaks
    • Liao S., Toczylowski T., Yan H. Mechanistic analysis of Xenopus EXO1's function in 5'-strand resection at DNA double-strand breaks. Nucleic Acids Res. 2011, 39:5967-5977.
    • (2011) Nucleic Acids Res. , vol.39 , pp. 5967-5977
    • Liao, S.1    Toczylowski, T.2    Yan, H.3
  • 35
    • 84861566250 scopus 로고    scopus 로고
    • Analysis of MRE11's function in the 5'->3' processing of DNA double-strand breaks
    • Liao S., Guay C., Toczylowski T., Yan H. Analysis of MRE11's function in the 5'->3' processing of DNA double-strand breaks. Nucleic Acids Res. 2012, 40:4496-4506.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 4496-4506
    • Liao, S.1    Guay, C.2    Toczylowski, T.3    Yan, H.4
  • 36
    • 84861566250 scopus 로고    scopus 로고
    • Analysis of MRE11's function in the 5'->3' processing of DNA double-strand breaks
    • Liao S., Guay C., Toczylowski T., Yan H. Analysis of MRE11's function in the 5'->3' processing of DNA double-strand breaks. Nucleic Acids Res. 2012, 40:4496-4506.
    • (2012) Nucleic Acids Res. , vol.40 , pp. 4496-4506
    • Liao, S.1    Guay, C.2    Toczylowski, T.3    Yan, H.4
  • 37
    • 34948872046 scopus 로고    scopus 로고
    • Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination
    • Limbo O., Chahwan C., Yamada Y., de Bruin R.A., Wittenberg C., Russell P. Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol. Cell 2007, 28:134-146.
    • (2007) Mol. Cell , vol.28 , pp. 134-146
    • Limbo, O.1    Chahwan, C.2    Yamada, Y.3    de Bruin, R.A.4    Wittenberg, C.5    Russell, P.6
  • 41
    • 0030759699 scopus 로고    scopus 로고
    • A general method for identifying recessive diploid-specific mutations in Saccharomyces cerevisiae, its application to the isolation of mutants blocked at intermediate stages of meiotic prophase and characterization of a new gene SAE2
    • McKee A.H., Kleckner N. A general method for identifying recessive diploid-specific mutations in Saccharomyces cerevisiae, its application to the isolation of mutants blocked at intermediate stages of meiotic prophase and characterization of a new gene SAE2. Genetics 1997, 146:797-816.
    • (1997) Genetics , vol.146 , pp. 797-816
    • McKee, A.H.1    Kleckner, N.2
  • 42
    • 71949092988 scopus 로고    scopus 로고
    • Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes
    • Milman N., Higuchi E., Smith G.R. Meiotic DNA double-strand break repair requires two nucleases, MRN and Ctp1, to produce a single size class of Rec12 (Spo11)-oligonucleotide complexes. Mol. Cell. Biol. 2009, 29:5998-6005.
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 5998-6005
    • Milman, N.1    Higuchi, E.2    Smith, G.R.3
  • 43
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    • Mimitou E.P., Symington L.S. Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 2008, 455:770-774.
    • (2008) Nature , vol.455 , pp. 770-774
    • Mimitou, E.P.1    Symington, L.S.2
  • 44
    • 0035692142 scopus 로고    scopus 로고
    • Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism
    • Moreau S., Morgan E.A., Symington L.S. Overlapping functions of the Saccharomyces cerevisiae Mre11, Exo1 and Rad27 nucleases in DNA metabolism. Genetics 2001, 159:1423-1433.
    • (2001) Genetics , vol.159 , pp. 1423-1433
    • Moreau, S.1    Morgan, E.A.2    Symington, L.S.3
  • 45
    • 34547107878 scopus 로고    scopus 로고
    • A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints
    • Mu J.J., Wang Y., Luo H., Leng M., Zhang J., Yang T., Besusso D., Jung S.Y., Qin J. A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints. J. Biol. Chem. 2007, 282:17330-17334.
    • (2007) J. Biol. Chem. , vol.282 , pp. 17330-17334
    • Mu, J.J.1    Wang, Y.2    Luo, H.3    Leng, M.4    Zhang, J.5    Yang, T.6    Besusso, D.7    Jung, S.Y.8    Qin, J.9
  • 46
    • 33646777679 scopus 로고    scopus 로고
    • Rapid activation of ATR by ionizing radiation requires ATM and Mre11
    • Myers J.S., Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J. Biol. Chem. 2006, 281:9346-9350.
    • (2006) J. Biol. Chem. , vol.281 , pp. 9346-9350
    • Myers, J.S.1    Cortez, D.2
  • 48
    • 79957690359 scopus 로고    scopus 로고
    • ATR signalling: more than meeting at the fork
    • Nam E.A., Cortez D. ATR signalling: more than meeting at the fork. Biochem. J. 2011, 436:527-536.
    • (2011) Biochem. J. , vol.436 , pp. 527-536
    • Nam, E.A.1    Cortez, D.2
  • 49
    • 23944459784 scopus 로고    scopus 로고
    • Endonucleolytic processing of covalent protein-linked DNA double-strand breaks
    • Neale M.J., Pan J., Keeney S. Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. Nature 2005, 436:1053-1057.
    • (2005) Nature , vol.436 , pp. 1053-1057
    • Neale, M.J.1    Pan, J.2    Keeney, S.3
  • 50
    • 0345073699 scopus 로고    scopus 로고
    • A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
    • O'Driscoll M., Ruiz-Perez V.L., Woods C.G., Jeggo P.A., Goodship J.A. A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat. Genet. 2003, 33:497-501.
    • (2003) Nat. Genet. , vol.33 , pp. 497-501
    • O'Driscoll, M.1    Ruiz-Perez, V.L.2    Woods, C.G.3    Jeggo, P.A.4    Goodship, J.A.5
  • 51
    • 78649451417 scopus 로고    scopus 로고
    • Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection
    • Paull T.T. Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection. DNA Repair (Amst.) 2010, 9:1283-1291.
    • (2010) DNA Repair (Amst.) , vol.9 , pp. 1283-1291
    • Paull, T.T.1
  • 52
    • 80052609660 scopus 로고    scopus 로고
    • Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair
    • Peterson S.E., Li Y., Chait B.T., Gottesman M.E., Baer R., Gautier J. Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair. J. Cell Biol. 2011, 194:705-720.
    • (2011) J. Cell Biol. , vol.194 , pp. 705-720
    • Peterson, S.E.1    Li, Y.2    Chait, B.T.3    Gottesman, M.E.4    Baer, R.5    Gautier, J.6
  • 53
    • 0030811331 scopus 로고    scopus 로고
    • Isolation of COM1, a new gene required to complete meiotic double-strand break-induced recombination in Saccharomyces cerevisiae
    • Prinz S., Amon A., Klein F. Isolation of COM1, a new gene required to complete meiotic double-strand break-induced recombination in Saccharomyces cerevisiae. Genetics 1997, 146:781-795.
    • (1997) Genetics , vol.146 , pp. 781-795
    • Prinz, S.1    Amon, A.2    Klein, F.3
  • 55
    • 73649143128 scopus 로고    scopus 로고
    • Ctp1 and the MRN-complex are required for endonucleolytic Rec12 removal with release of a single class of oligonucleotides in fission yeast
    • Rothenberg M., Kohli J., Ludin K. Ctp1 and the MRN-complex are required for endonucleolytic Rec12 removal with release of a single class of oligonucleotides in fission yeast. PLoS Genet. 2009, 5:e1000722.
    • (2009) PLoS Genet. , vol.5
    • Rothenberg, M.1    Kohli, J.2    Ludin, K.3
  • 57
    • 77957786786 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks
    • Shim E.Y., Chung W.H., Nicolette M.L., Zhang Y., Davis M., Zhu Z., Paull T.T., Ira G., Lee S.E. Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks. EMBO J. 2010, 29:3370-3380.
    • (2010) EMBO J. , vol.29 , pp. 3370-3380
    • Shim, E.Y.1    Chung, W.H.2    Nicolette, M.L.3    Zhang, Y.4    Davis, M.5    Zhu, Z.6    Paull, T.T.7    Ira, G.8    Lee, S.E.9
  • 58
    • 61649093808 scopus 로고    scopus 로고
    • Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks
    • Shiotani B., Zou L. Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol. Cell 2009, 33:547-558.
    • (2009) Mol. Cell , vol.33 , pp. 547-558
    • Shiotani, B.1    Zou, L.2
  • 59
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of DNA double-strand break repair pathway choice
    • Shrivastav M., De Haro L.P., Nickoloff J.A. Regulation of DNA double-strand break repair pathway choice. Cell Res. 2008, 18:134-147.
    • (2008) Cell Res. , vol.18 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3
  • 60
    • 80054755084 scopus 로고    scopus 로고
    • Study of cell cycle checkpoints using Xenopus cell-free extracts
    • Srinivasan S.V., Gautier J. Study of cell cycle checkpoints using Xenopus cell-free extracts. Methods Mol. Biol. 2011, 782:119-158.
    • (2011) Methods Mol. Biol. , vol.782 , pp. 119-158
    • Srinivasan, S.V.1    Gautier, J.2
  • 61
    • 84863152463 scopus 로고    scopus 로고
    • Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex
    • Sun J., Lee K.J., Davis A.J., Chen D.J. Human Ku70/80 protein blocks exonuclease 1-mediated DNA resection in the presence of human Mre11 or Mre11/Rad50 protein complex. J. Biol. Chem. 2012, 287:4936-4945.
    • (2012) J. Biol. Chem. , vol.287 , pp. 4936-4945
    • Sun, J.1    Lee, K.J.2    Davis, A.J.3    Chen, D.J.4
  • 62
    • 80755187806 scopus 로고    scopus 로고
    • Double-strand break end resection and repair pathway choice
    • Symington L.S., Gautier J. Double-strand break end resection and repair pathway choice. Annu. Rev. Genet. 2011, 45:247-271.
    • (2011) Annu. Rev. Genet. , vol.45 , pp. 247-271
    • Symington, L.S.1    Gautier, J.2
  • 65
    • 84859004905 scopus 로고    scopus 로고
    • S. Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions
    • Tomimatsu N., Mukherjee B., Deland K., Bolderson E., Khanna K.K., Burma S. S. Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions. DNA Repair (Amst.) 2012, 11:441-448.
    • (2012) DNA Repair (Amst.) , vol.11 , pp. 441-448
    • Tomimatsu, N.1    Mukherjee, B.2    Deland, K.3    Bolderson, E.4    Khanna, K.K.5    Burma, S.6
  • 68
    • 0035515249 scopus 로고    scopus 로고
    • Effect of DNA damage on a BRCA1 complex
    • Wu-Baer F., Baer R. Effect of DNA damage on a BRCA1 complex. Nature 2001, 414:36.
    • (2001) Nature , vol.414 , pp. 36
    • Wu-Baer, F.1    Baer, R.2
  • 69
    • 78951472460 scopus 로고    scopus 로고
    • Replication protein A promotes 5'->3' end processing during homology-dependent DNA double-strand break repair
    • Yan H., Toczylowski T., McCane J., Chen C., Liao S. Replication protein A promotes 5'->3' end processing during homology-dependent DNA double-strand break repair. J. Cell Biol. 2011, 192:251-261.
    • (2011) J. Cell Biol. , vol.192 , pp. 251-261
    • Yan, H.1    Toczylowski, T.2    McCane, J.3    Chen, C.4    Liao, S.5
  • 71
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu Z., Chung W.H., Shim E.Y., Lee S.E., Ira G. Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 2008, 134:981-994.
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5
  • 72
    • 0037567268 scopus 로고    scopus 로고
    • Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
    • Zou L., Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 2003, 300:1542-1548.
    • (2003) Science , vol.300 , pp. 1542-1548
    • Zou, L.1    Elledge, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.