-
1
-
-
0029808466
-
Cell cycle checkpoints: Preventing an identity crisis
-
Elledge, S.J. 1996. Cell cycle checkpoints: preventing an identity crisis. Science. 274:1664-1672.
-
(1996)
Science
, vol.274
, pp. 1664-1672
-
-
Elledge, S.J.1
-
2
-
-
0037178748
-
Interfaces between the detection, signaling, and repair of DNA damage
-
Rouse, J., and S.P. Jackson. 2002. Interfaces between the detection, signaling, and repair of DNA damage. Science. 297:547-551.
-
(2002)
Science
, vol.297
, pp. 547-551
-
-
Rouse, J.1
Jackson, S.P.2
-
3
-
-
9244251125
-
Cell-cycle checkpoints and cancer
-
Kastan, M.B., and J. Bartek. 2004. Cell-cycle checkpoints and cancer. Nature. 432:316-323.
-
(2004)
Nature
, vol.432
, pp. 316-323
-
-
Kastan, M.B.1
Bartek, J.2
-
4
-
-
17244367849
-
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
-
Bartkova, J., Z. Horejsi, K. Koed, A. Kramer, F. Tort, K. Zieger, P. Guldberg, M. Sehested, J.M. Nesland, C. Lukas, et al. 2005. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature. 434:864-870.
-
(2005)
Nature
, vol.434
, pp. 864-870
-
-
Bartkova, J.1
Horejsi, Z.2
Koed, K.3
Kramer, A.4
Tort, F.5
Zieger, K.6
Guldberg, P.7
Sehested, M.8
Nesland, J.M.9
Lukas, C.10
-
5
-
-
17244366865
-
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
-
Gorgoulis, V.G., L.V. Vassiliou, P. Karakaidos, P. Zacharatos, A. Kotsinas, T. Liloglou, M. Venere, R.A. Ditullio Jr., N.G. Kastrinakis, B. Levy, et al. 2005. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature. 434:907-913.
-
(2005)
Nature
, vol.434
, pp. 907-913
-
-
Gorgoulis, V.G.1
Vassiliou, L.V.2
Karakaidos, P.3
Zacharatos, P.4
Kotsinas, A.5
Liloglou, T.6
Venere, M.7
Ditullio Jr., R.A.8
Kastrinakis, N.G.9
Levy, B.10
-
6
-
-
3242882820
-
PI 3-kinase related kinases: 'Big' players in stress-induced signaling pathways
-
Abraham, R.T. 2004. PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair (Amst.). 3:883-887.
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 883-887
-
-
Abraham, R.T.1
-
7
-
-
13944277701
-
The life and death of DNA-PK
-
Collis, S.J., T.L. DeWeese, P.A. Jeggo, and A.R. Parker. 2005. The life and death of DNA-PK. Oncogene. 24:949-961.
-
(2005)
Oncogene
, vol.24
, pp. 949-961
-
-
Collis, S.J.1
DeWeese, T.L.2
Jeggo, P.A.3
Parker, A.R.4
-
8
-
-
0035449355
-
Cell cycle checkpoint signaling through the ATM and ATR kinases
-
Abraham, R.T. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15:2177-2196.
-
(2001)
Genes Dev.
, vol.15
, pp. 2177-2196
-
-
Abraham, R.T.1
-
9
-
-
0036903037
-
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP 1
-
Fernandez-Capetillo, O., H.T. Chen, A. Celeste, I. Ward, P.J. Romanienko, J.C. Morales, K. Naka, Z. Xia, R.D. Camerini-Otero, N. Motoyama, et al. 2002. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP 1. Nat. Cell Biol. 4:993-997.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 993-997
-
-
Fernandez-Capetillo, O.1
Chen, H.T.2
Celeste, A.3
Ward, I.4
Romanienko, P.J.5
Morales, J.C.6
Naka, K.7
Xia, Z.8
Camerini-Otero, R.D.9
Motoyama, N.10
-
10
-
-
18644375649
-
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription
-
Takai, H., K. Naka, Y. Okada, M. Watanabe, N. Harada, S. Saito, C.W. Anderson, E. Appella, M. Nakanishi, H. Suzuki, et al. 2002. Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J. 21:5195-5205.
-
(2002)
EMBO J.
, vol.21
, pp. 5195-5205
-
-
Takai, H.1
Naka, K.2
Okada, Y.3
Watanabe, M.4
Harada, N.5
Saito, S.6
Anderson, C.W.7
Appella, E.8
Nakanishi, M.9
Suzuki, H.10
-
11
-
-
0037335861
-
Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
-
Brown, E.J., and D. Baltimore. 2003. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 17:615-628.
-
(2003)
Genes Dev.
, vol.17
, pp. 615-628
-
-
Brown, E.J.1
Baltimore, D.2
-
12
-
-
17644432403
-
Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint
-
Liu, Q., S. Guntuku, X.S. Cui, S. Matsuoka, D. Cortez, K. Tamai, G. Luo, S. Carattini-Rivera, F. DeMayo, A. Bradley, et al. 2000. Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint. Genes Dev. 14:1448-1459.
-
(2000)
Genes Dev.
, vol.14
, pp. 1448-1459
-
-
Liu, Q.1
Guntuku, S.2
Cui, X.S.3
Matsuoka, S.4
Cortez, D.5
Tamai, K.6
Luo, G.7
Carattini-Rivera, S.8
DeMayo, F.9
Bradley, A.10
-
13
-
-
0032189483
-
Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
-
Sarkaria, J.N., R.S. Tibbetts, E.C. Busby, A.P. Kennedy, D.E. Hill, and R.T. Abraham. 1998. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer Res. 58:4375-4382.
-
(1998)
Cancer Res.
, vol.58
, pp. 4375-4382
-
-
Sarkaria, J.N.1
Tibbetts, R.S.2
Busby, E.C.3
Kennedy, A.P.4
Hill, D.E.5
Abraham, R.T.6
-
14
-
-
0035930536
-
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks
-
Ward, I.M., X. Wu, and J. Chen. 2001. Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. J. Biol. Chem. 276:47755-47758.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47755-47758
-
-
Ward, I.M.1
Wu, X.2
Chen, J.3
-
15
-
-
0034306332
-
Threonine 68 is required for radiation-induced phosphorylation and activation of Cds 1
-
Melchionna, R., X.B. Chen, A. Blasina, and C.H. McGowan. 2000. Threonine 68 is required for radiation-induced phosphorylation and activation of Cds 1. Nat. Cell Biol. 2:762-765.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 762-765
-
-
Melchionna, R.1
Chen, X.B.2
Blasina, A.3
McGowan, C.H.4
-
16
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist, C.J., and M.B. Kastan. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421:499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
17
-
-
0345073699
-
A splicing mutation affecting expression of ataxia-telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome
-
O'Driscoll, M., V.L. Ruiz-Perez, C.G. Woods, P.A. Jeggo, and J.A. Goodship. 2003. A splicing mutation affecting expression of ataxia- telangiectasia and Rad3-related protein (ATR) results in Seckel syndrome. Nat. Genet. 33:497-501.
-
(2003)
Nat. Genet.
, vol.33
, pp. 497-501
-
-
O'Driscoll, M.1
Ruiz-Perez, V.L.2
Woods, C.G.3
Jeggo, P.A.4
Goodship, J.A.5
-
18
-
-
0035941021
-
ATR and ATRIP: Partners in checkpoint signaling
-
Cortez, D., S. Guntuku, J. Qin, and S.J. Elledge. 2001. ATR and ATRIP: partners in checkpoint signaling. Science. 294:1713-1716.
-
(2001)
Science
, vol.294
, pp. 1713-1716
-
-
Cortez, D.1
Guntuku, S.2
Qin, J.3
Elledge, S.J.4
-
19
-
-
0035851090
-
Nuclear retention of ATM at sites of DNA double strand breaks
-
Andegeko, Y., L. Moyal, L. Mittelman, I. Tsarfaty, Y. Shiloh, and G. Rotman. 2001. Nuclear retention of ATM at sites of DNA double strand breaks. J. Biol. Chem. 276:38224-38230.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38224-38230
-
-
Andegeko, Y.1
Moyal, L.2
Mittelman, L.3
Tsarfaty, I.4
Shiloh, Y.5
Rotman, G.6
-
20
-
-
0034749425
-
DNA damage-dependent nuclear dynamics of the Mre11 complex
-
Mirzoeva, O.K., and J.H. Petrini. 2001. DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol. Cell. Biol. 21:281-288.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 281-288
-
-
Mirzoeva, O.K.1
Petrini, J.H.2
-
21
-
-
0038013782
-
Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation
-
Gatei, M., K. Sloper, C. Sorensen, R. Syljuasen, J. Falck, K. Hobson, K. Savage, J. Lukas, B.B. Zhou, J. Bartek, and K.K. Khanna. 2003. Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation. J. Biol. Chem. 278:14806-14811.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 14806-14811
-
-
Gatei, M.1
Sloper, K.2
Sorensen, C.3
Syljuasen, R.4
Falck, J.5
Hobson, K.6
Savage, K.7
Lukas, J.8
Zhou, B.B.9
Bartek, J.10
Khanna, K.K.11
-
22
-
-
3042573602
-
Flow cytometric analysis of kinase signaling cascades
-
Perez, O.D., P.O. Krutzik, and G.P. Nolan. 2004. Flow cytometric analysis of kinase signaling cascades. Methods Mol. Biol. 263:67-94.
-
(2004)
Methods Mol. Biol.
, vol.263
, pp. 67-94
-
-
Perez, O.D.1
Krutzik, P.O.2
Nolan, G.P.3
-
23
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri, A., J. Falck, C. Lukas, J. Bartek, G.C. Smith, J. Lukas, and S.P. Jackson. 2005. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 8:37-45.
-
(2005)
Nat. Cell Biol.
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.5
Lukas, J.6
Jackson, S.P.7
|