ATR kinase activity regulates the intranuclear translocation of ATR and RPA following ionizing radiation

Current Biology

Volumn 13, Issue 12, 2003, Pages 1047-1051

  Barr, Sharon M ^a   Leung, Cindy G ^a   Chang, Elbert E ^a   Cimprich, Karlene A ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EUKARYOTA;

EID: 0037665234     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(03)00376-2     Document Type: Article

References (20)

1. Tibbetts, R.S., Cortez, D., Brumbaugh, K.M., Scully, R., Livingston, D., Elledge, S.J., and Abraham, R.T. (2000). Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress. Genes Dev. 14, 2989-3002.
2. Golub, E.I., Gupta, R.C., Haaf, T., Wold, M.S., and Radding, C.M. (1998). Interaction of human Rad51 recombination protein with single-stranded DNA binding protein, RPA. Nucleic Acids Res. 26, 5388-5393.
3. Nghiem, P., Park, P.K., Kim, Y., Vaziri, C., and Schreiber, S.L. (2001). ATR inhibition selectively sensitizes G1 checkpoint-deficient cells to lethal premature chromatin condensation. Proc. Natl. Acad. Sci. USA 98, 9092-9097.
4. Nghiem, P., Park, P.K., Kim Ys, Y.S., Desai, B.N., and Schreiber, S.L. (2002). ATR is not required for p53 activation but synergizes with p53 in the replication checkpoint. J. Biol. Chem. 277, 4428-4434.
5. Cliby, W.A., Roberts, C.J., Cimprich, K.A., Stringer, C.M., Lamb, J.R., Schreiber, S.L., and Friend, S.H. (1998). Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J. 17, 159-169.
6. Zou, L., Cortez, D., and Elledge, S.J. (2002). Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin. Genes Dev. 16, 198-208.
7. Negorev, D., and Maul, G.G. (2001). Cellular proteins localized at and interacting within ND10/PML nuclear bodies/PODs suggest functions of a nuclear depot. Oncogene 20, 7234-7242.
8. Lombard, D.B., and Guarente, L. (2000). Nijmegen breakage syndrome disease protein and MRE11 at PML nuclear bodies and meiotic telomeres. Cancer Res. 60, 2331-2334.
9. Mirzoeva, O.K., and Petrini, J.H. (2001). DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol. Cell. Biol. 21, 281-288.
10. Bischof, O., Kim, S.H., Irving, J., Beresten, S., Ellis, N.A., and Campisi, J. (2001). Regulation and localization of the Bloom syndrome protein in response to DNA damage. J. Cell Biol. 153, 367-380.
11. Sarkaria, J.N., Busby, E.C., Tibbetts, R.S., Roos, P., Taya, Y., Karnitz, L.M., and Abraham, R.T. (1999). Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res. 59, 4375-4382.
12. Paull, T.T., Rogakou, E.P., Yamazaki, V., Kirchgessner, C.U., Gellert, M., and Bonner, W.M. (2000). A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10, 886-895.
13. Ward, J.F. (1988). DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and repairability. Prog. Nucleic Acid Res. Mol. Biol. 35, 95-125.
14. Sutherland, B.M., Bennett, P.V., Sutherland, J.C., and Laval, J. (2002). Clustered DNA damages induced by x rays in human cells. Radiat. Res. 157, 611-616.
15. Lupardus, P.J., Byun, T., Yee, M.C., Hekmat-Nejad, M., and Cimprich, K.A. (2002). A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes Dev. 18, 2327-2332.
16. Stokes, M.P., Van Hatten, R., Lindsay, H.D., and Michael, W.M. (2002). DNA replication is required for the checkpoint response to damaged DNA in Xenopus egg extracts. J. Cell Biol. 158, 863-872.
17. Boisvert, F.M., Kruhlak, M.J., Box, A.K., Hendzel, M.J., and Bazett-Jones, D.P. (2001). The transcription coactivator CBP is a dynamic component of the promyelocytic leukemia nuclear body. J. Cell Biol. 152, 1099-1106.
18. Muratani, M., Gerlich, D., Janicki, S.M., Gebhard, M., Eils, R., and Spector, D.L. (2002). Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus. Nat. Cell Biol. 4, 106-110.
19. Matsuoka, S., Huang, M.X., and Elledge, S.J. (1998). Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282, 1893-1897.
20. Yang, S., Kuo, C., Bisi, J.E., and Kim, M.K. (2002). PML-dependent apoptosis after DNA damage is regulated by the checkpoint kinase hCds1/Chk2. Nat. Cell Biol. 4, 865-870.