메뉴 건너뛰기




Volumn 782, Issue , 2011, Pages 119-158

Study of Cell Cycle Checkpoints Using Xenopus Cell-Free Extracts

Author keywords

ATM ATR kinases; cell cycle checkpoint; cell free extracts; chromatin binding; DNA damage; DNA replication; phosphorylation; Xenopus

Indexed keywords

ANIMAL; ARTICLE; CELL CYCLE CHECKPOINT; CELL FREE SYSTEM; DNA DAMAGE; DNA REPLICATION; GENETICS; PHOSPHORYLATION; PHYSIOLOGY; XENOPUS;

EID: 80054755084     PISSN: 10643745     EISSN: 19406029     Source Type: Book Series    
DOI: 10.1007/978-1-61779-273-1_10     Document Type: Chapter
Times cited : (8)

References (64)
  • 1
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • Jackson, S. P. and Bartek, J. (2009) The DNA-damage response in human biology and disease. Nature 461, 1071–1078.
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 2
    • 61749102378 scopus 로고    scopus 로고
    • Cell-cycle control in the face of damage – a matter of life or death
    • Clarke, P. R. and Allan, L. A. (2009) Cell-cycle control in the face of damage – a matter of life or death. Trends Cell Biol 19, 89–98.
    • (2009) Trends Cell Biol , vol.19 , pp. 89-98
    • Clarke, P.R.1    Allan, L.A.2
  • 3
    • 0029417833 scopus 로고
    • Regulation of cell cycle progression following DNA damage
    • Hensey, C. and Gautier, J. (1995) Regulation of cell cycle progression following DNA damage. Prog Cell Cycle Res 1, 149–162.
    • (1995) Prog Cell Cycle Res , vol.1 , pp. 149-162
    • Hensey, C.1    Gautier, J.2
  • 4
    • 0028962292 scopus 로고
    • The genetics of cell cycle checkpoints
    • Murray, A. W. (1995) The genetics of cell cycle checkpoints. Curr Opin Genet Dev 5, 5–11.
    • (1995) Curr Opin Genet Dev , vol.5 , pp. 5-11
    • Murray, A.W.1
  • 6
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou, B. B. and Elledge, S. J. (2000) The DNA damage response: putting checkpoints in perspective. Nature 408, 433–439.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 7
    • 1542608652 scopus 로고    scopus 로고
    • Xenopus cell-free extracts to study DNA damage checkpoints
    • Costanzo, V. and Gautier, J. (2004) Xenopus cell-free extracts to study DNA damage checkpoints. Methods Mol Biol 241, 255–267.
    • (2004) Methods Mol Biol , vol.241 , pp. 255-267
    • Costanzo, V.1    Gautier, J.2
  • 8
    • 0022981734 scopus 로고
    • Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs
    • Blow, J. J. and Laskey, R. A. (1986) Initiation of DNA replication in nuclei and purified DNA by a cell-free extract of Xenopus eggs. Cell 47, 577–587.
    • (1986) Cell , vol.47 , pp. 577-587
    • Blow, J.J.1    Laskey, R.A.2
  • 9
    • 0026263951 scopus 로고
    • Systems for the study of nuclear assembly, DNA replication, and nuclear breakdown in Xenopus laevis egg extracts
    • Smythe, C. and Newport, J. W. (1991) Systems for the study of nuclear assembly, DNA replication, and nuclear breakdown in Xenopus laevis egg extracts. Methods Cell Biol 35, 449–468.
    • (1991) Methods Cell Biol , vol.35 , pp. 449-468
    • Smythe, C.1    Newport, J.W.2
  • 10
    • 33745513871 scopus 로고    scopus 로고
    • Chromosomal DNA replication in a soluble cell-free system derived from Xenopus eggs
    • Tutter, A. V. and Walter, J. C. (2006) Chromosomal DNA replication in a soluble cell-free system derived from Xenopus eggs. Methods Mol Biol 322, 121–137.
    • (2006) Methods Mol Biol , vol.322 , pp. 121-137
    • Tutter, A.V.1    Walter, J.C.2
  • 13
    • 0032015702 scopus 로고    scopus 로고
    • Regulated chromosomal DNA replication in the absence of a nucleus
    • Walter, J., Sun, L. and Newport, J. (1998) Regulated chromosomal DNA replication in the absence of a nucleus. Mol Cell 1, 519–529.
    • (1998) Mol Cell , vol.1 , pp. 519-529
    • Walter, J.1    Sun, L.2    Newport, J.3
  • 14
    • 26244431903 scopus 로고    scopus 로고
    • Right place, right time, and only once: replication initiation in metazoans
    • Machida, Y. J., Hamlin, J. L. and Dutta, A. (2005) Right place, right time, and only once: replication initiation in metazoans. Cell 123, 13–24.
    • (2005) Cell , vol.123 , pp. 13-24
    • Machida, Y.J.1    Hamlin, J.L.2    Dutta, A.3
  • 15
    • 0025012866 scopus 로고
    • Cyclin is a component of maturation-promoting factor from Xenopus
    • Gautier, J., Minshull, J., Lohka, M., Glotzer, M., Hunt, T. and Maller, J. L. (1990) Cyclin is a component of maturation-promoting factor from Xenopus. Cell 60, 487–494.
    • (1990) Cell , vol.60 , pp. 487-494
    • Gautier, J.1    Minshull, J.2    Lohka, M.3    Glotzer, M.4    Hunt, T.5    Maller, J.L.6
  • 16
    • 0024299475 scopus 로고
    • Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+
    • Gautier, J., Norbury, C., Lohka, M., Nurse, P. and Maller, J. (1988) Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+. Cell 54, 433–439.
    • (1988) Cell , vol.54 , pp. 433-439
    • Gautier, J.1    Norbury, C.2    Lohka, M.3    Nurse, P.4    Maller, J.5
  • 17
    • 0025936510 scopus 로고
    • cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
    • Gautier, J., Solomon, M. J., Booher, R. N., Bazan, J. F. and Kirschner, M. W. (1991) cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell 67, 197–211.
    • (1991) Cell , vol.67 , pp. 197-211
    • Gautier, J.1    Solomon, M.J.2    Booher, R.N.3    Bazan, J.F.4    Kirschner, M.W.5
  • 18
    • 0020622592 scopus 로고
    • Formation in vitro of sperm pronuclei and mitotic chromosomes induced by amphibian ooplas-mic components
    • Lohka, M. J. and Masui, Y. (1983) Formation in vitro of sperm pronuclei and mitotic chromosomes induced by amphibian ooplas-mic components. Science 220, 719–721.
    • (1983) Science , vol.220 , pp. 719-721
    • Lohka, M.J.1    Masui, Y.2
  • 19
    • 0024978338 scopus 로고
    • Cyclin synthesis drives the early embryonic cell cycle
    • Murray, A. W. and Kirschner, M. W. (1989) Cyclin synthesis drives the early embryonic cell cycle. Nature 339, 275–280.
    • (1989) Nature , vol.339 , pp. 275-280
    • Murray, A.W.1    Kirschner, M.W.2
  • 20
    • 0024978344 scopus 로고
    • The role of cyclin synthesis and degradation in the control of maturation promoting factor activity
    • Murray, A. W., Solomon, M. J. and Kirschner, M. W. (1989) The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature 339, 280–286.
    • (1989) Nature , vol.339 , pp. 280-286
    • Murray, A.W.1    Solomon, M.J.2    Kirschner, M.W.3
  • 21
    • 68349151239 scopus 로고    scopus 로고
    • DNA replication in nucleus-free Xenopus egg extracts
    • Lebofsky, R., Takahashi, T. and Walter, J. C. (2009) DNA replication in nucleus-free Xenopus egg extracts. Methods Mol Biol 521, 229–252.
    • (2009) Methods Mol Biol , vol.521 , pp. 229-252
    • Lebofsky, R.1    Takahashi, T.2    Walter, J.C.3
  • 22
    • 33845634848 scopus 로고    scopus 로고
    • Analyzing the ATR-mediated checkpoint using Xenopus egg extracts
    • Lupardus, P. J., Van, C. and Cimprich, K. A. (2007) Analyzing the ATR-mediated checkpoint using Xenopus egg extracts. Methods 41, 222–231.
    • (2007) Methods , vol.41 , pp. 222-231
    • Lupardus, P.J.1    Van, C.2    Cimprich, K.A.3
  • 23
    • 4344685882 scopus 로고    scopus 로고
    • Xenopus cell-free extracts to study the DNA damage response
    • Costanzo, V., Robertson, K. and Gautier, J. (2004) Xenopus cell-free extracts to study the DNA damage response. Methods Mol Biol 280, 213–227.
    • (2004) Methods Mol Biol , vol.280 , pp. 213-227
    • Costanzo, V.1    Robertson, K.2    Gautier, J.3
  • 24
    • 40949133430 scopus 로고    scopus 로고
    • Plx1 is required for chromosomal DNA replication under stressful conditions
    • Trenz, K., Errico, A. and Costanzo, V. (2008) Plx1 is required for chromosomal DNA replication under stressful conditions. Embo J 27, 876–885.
    • (2008) Embo J , vol.27 , pp. 876-885
    • Trenz, K.1    Errico, A.2    Costanzo, V.3
  • 25
    • 0033636737 scopus 로고    scopus 로고
    • Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage
    • Costanzo, V., Robertson, K., Ying, C. Y., Kim, E., Avvedimento, E., Gottesman, M., Grieco, D. and Gautier, J. (2000) Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol Cell 6, 649–659.
    • (2000) Mol Cell , vol.6 , pp. 649-659
    • Costanzo, V.1    Robertson, K.2    Ying, C.Y.3    Kim, E.4    Avvedimento, E.5    Gottesman, M.6    Grieco, D.7    Gautier, J.8
  • 26
    • 0033637837 scopus 로고    scopus 로고
    • Initiation of eukaryotic DNA replication: Origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha
    • Walter, J. and Newport, J. (2000) Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. Mol Cell 5, 617–627.
    • (2000) Mol Cell , vol.5 , pp. 617-627
    • Walter, J.1    Newport, J.2
  • 29
    • 19344371406 scopus 로고    scopus 로고
    • Mre11 assembles linear DNA fragments into DNA damage signaling complexes
    • Costanzo, V., Paull, T., Gottesman, M. and Gautier, J. (2004) Mre11 assembles linear DNA fragments into DNA damage signaling complexes. PLoS Biol 2, E110.
    • (2004) Plos Biol , vol.2 , pp. E110
    • Costanzo, V.1    Paull, T.2    Gottesman, M.3    Gautier, J.4
  • 31
    • 77449088945 scopus 로고    scopus 로고
    • Origin-dependent initiation of DNA replication within telomeric sequences
    • Kurth, I. and Gautier, J. (2010) Origin-dependent initiation of DNA replication within telomeric sequences. Nucleic Acids Res 38, 467–476.
    • (2010) Nucleic Acids Res , vol.38 , pp. 467-476
    • Kurth, I.1    Gautier, J.2
  • 32
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • Kastan, M. B. and Bartek, J. (2004) Cell-cycle checkpoints and cancer. Nature 432, 316–323.
    • (2004) Nature , vol.432 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 33
    • 0042197119 scopus 로고    scopus 로고
    • Single-strand DNA gaps trigger an ATR-and Cdc7-dependent checkpoint
    • Costanzo, V. and Gautier, J. (2003) Single-strand DNA gaps trigger an ATR-and Cdc7-dependent checkpoint. Cell Cycle 2, 17.
    • (2003) Cell Cycle , vol.2 , pp. 17
    • Costanzo, V.1    Gautier, J.2
  • 34
    • 0344845197 scopus 로고    scopus 로고
    • Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development
    • Kim, J. M., Yamada, M. and Masai, H. (2003) Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development. Mutat Res 532, 29–40.
    • (2003) Mutat Res , vol.532 , pp. 29-40
    • Kim, J.M.1    Yamada, M.2    Masai, H.3
  • 36
    • 1842486794 scopus 로고    scopus 로고
    • Cdc25A phosphatase: Combinatorial phosphorylation, ubiqui-tylation and proteolysis
    • Busino, L., Chiesa, M., Draetta, G. F. and Donzelli, M. (2004) Cdc25A phosphatase: combinatorial phosphorylation, ubiqui-tylation and proteolysis. Oncogene 23, 2050–2056.
    • (2004) Oncogene , vol.23 , pp. 2050-2056
    • Busino, L.1    Chiesa, M.2    Draetta, G.F.3    Donzelli, M.4
  • 39
    • 0036510163 scopus 로고    scopus 로고
    • BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
    • Yarden, R. I., Pardo-Reoyo, S., Sgagias, M., Cowan, K. H. and Brody, L. C. (2002) BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet 30, 285–289.
    • (2002) Nat Genet , vol.30 , pp. 285-289
    • Yarden, R.I.1    Pardo-Reoyo, S.2    Sgagias, M.3    Cowan, K.H.4    Brody, L.C.5
  • 41
    • 68249092083 scopus 로고    scopus 로고
    • Studying the DNA damage response using in vitro model systems
    • Garner, E. and Costanzo, V. (2009) Studying the DNA damage response using in vitro model systems. DNA Repair (Amst) 8, 1025–1037.
    • (2009) DNA Repair (Amst) , vol.8 , pp. 1025-1037
    • Garner, E.1    Costanzo, V.2
  • 42
    • 68249154883 scopus 로고    scopus 로고
    • Responding to chromosomal breakage during M-phase: Insights from a cell-free system
    • Smith, E. and Costanzo, V. (2009) Responding to chromosomal breakage during M-phase: insights from a cell-free system. Cell Div 4, 15.
    • (2009) Cell Div , vol.4 , pp. 15
    • Smith, E.1    Costanzo, V.2
  • 43
    • 0037452872 scopus 로고    scopus 로고
    • Fragile sites: Breaking up over a slowdown
    • Cimprich, K. A. (2003) Fragile sites: breaking up over a slowdown. Curr Biol 13, R231-R233.
    • (2003) Curr Biol , vol.13 , pp. R231-R233
    • Cimprich, K.A.1
  • 44
    • 0037245862 scopus 로고    scopus 로고
    • An ATR-and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication
    • Costanzo, V., Shechter, D., Lupardus, P. J., Cimprich, K. A., Gottesman, M. and Gautier, J. (2003) An ATR-and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell 11, 203–213.
    • (2003) Mol Cell , vol.11 , pp. 203-213
    • Costanzo, V.1    Shechter, D.2    Lupardus, P.J.3    Cimprich, K.A.4    Gottesman, M.5    Gautier, J.6
  • 46
    • 0032190561 scopus 로고    scopus 로고
    • Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme
    • Burden, D. A. and Osheroff, N. (1998) Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme. Biochim Biophys Acta 1400, 139–154.
    • (1998) Biochim Biophys Acta , vol.1400 , pp. 139-154
    • Burden, D.A.1    Osheroff, N.2
  • 48
    • 0028989339 scopus 로고
    • Purification of an MCM-containing complex as a component of the DNA replication licensing system
    • Chong, J. P., Mahbubani, H. M., Khoo, C. Y. and Blow, J. J. (1995) Purification of an MCM-containing complex as a component of the DNA replication licensing system. Nature 375, 418–421.
    • (1995) Nature , vol.375 , pp. 418-421
    • Chong, J.P.1    Mahbubani, H.M.2    Khoo, C.Y.3    Blow, J.J.4
  • 49
    • 13244298119 scopus 로고    scopus 로고
    • Fanconi anemia proteins and the s phase checkpoint
    • Pichierri, P. and Rosselli, F. (2004) Fanconi anemia proteins and the s phase checkpoint. Cell Cycle 3, 698–700.
    • (2004) Cell Cycle , vol.3 , pp. 698-700
    • Pichierri, P.1    Rosselli, F.2
  • 50
    • 1842576658 scopus 로고    scopus 로고
    • The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways
    • Pichierri, P. and Rosselli, F. (2004) The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways. Embo J 23, 1178–1187.
    • (2004) Embo J , vol.23 , pp. 1178-1187
    • Pichierri, P.1    Rosselli, F.2
  • 51
    • 69149086829 scopus 로고    scopus 로고
    • Replication licensing and the DNA damage checkpoint
    • Cook, J. G. (2009) Replication licensing and the DNA damage checkpoint. Front Biosci 14, 5013–5030.
    • (2009) Front Biosci , vol.14 , pp. 5013-5030
    • Cook, J.G.1
  • 52
    • 0036531901 scopus 로고    scopus 로고
    • A unified view of the DNA-damage checkpoint
    • Melo, J. and Toczyski, D. (2002) A unified view of the DNA-damage checkpoint. Curr Opin Cell Biol 14, 237–245.
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 237-245
    • Melo, J.1    Toczyski, D.2
  • 53
    • 0032555924 scopus 로고    scopus 로고
    • The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts
    • Kumagai, A., Guo, Z., Emami, K. H., Wang, S. X. and Dunphy, W. G. (1998) The Xenopus Chk1 protein kinase mediates a caffeine-sensitive pathway of checkpoint control in cell-free extracts. J Cell Biol 142, 1559–1569.
    • (1998) J Cell Biol , vol.142 , pp. 1559-1569
    • Kumagai, A.1    Guo, Z.2    Emami, K.H.3    Wang, S.X.4    Dunphy, W.G.5
  • 54
    • 0037106186 scopus 로고    scopus 로고
    • A requirement for replication in activation of the ATR-dependent DNA damage checkpoint
    • Lupardus, P. J., Byun, T., Yee, M. C., Hekmat-Nejad, M. and Cimprich, K. A. (2002) A requirement for replication in activation of the ATR-dependent DNA damage checkpoint. Genes Dev 16, 2327–2332.
    • (2002) Genes Dev , vol.16 , pp. 2327-2332
    • Lupardus, P.J.1    Byun, T.2    Yee, M.C.3    Hekmat-Nejad, M.4    Cimprich, K.A.5
  • 55
    • 0141740426 scopus 로고    scopus 로고
    • Focusing on foci: H2AX and the recruitment of DNA-damage response factors
    • Fernandez-Capetillo, O., Celeste, A. and Nussenzweig, A. (2003) Focusing on foci: H2AX and the recruitment of DNA-damage response factors. Cell Cycle 2, 426–427.
    • (2003) Cell Cycle , vol.2 , pp. 426-427
    • Fernandez-Capetillo, O.1    Celeste, A.2    Nussenzweig, A.3
  • 56
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull, T. T., Rogakou, E. P., Yamazaki, V., Kirchgessner, C. U., Gellert, M. and Bonner, W. M. (2000) A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol 10, 886–895.
    • (2000) Curr Biol , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 57
    • 0035834693 scopus 로고    scopus 로고
    • ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    • Burma, S., Chen, B. P., Murphy, M., Kuri-masa, A. and Chen, D. J. (2001) ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 276, 42462–42467.
    • (2001) J Biol Chem , vol.276 , pp. 42462-42467
    • Burma, S.1    Chen, B.P.2    Murphy, M.3    Kuri-Masa, A.4    Chen, D.J.5
  • 58
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. and Bonner, W. M. (1998) DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 273, 5858–5868.
    • (1998) J Biol Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 60
  • 61
    • 33745058037 scopus 로고    scopus 로고
    • Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex
    • Dupre, A., Boyer-Chatenet, L. and Gautier, J. (2006) Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat Struct Mol Biol 13, 451–457.
    • (2006) Nat Struct Mol Biol , vol.13 , pp. 451-457
    • Dupre, A.1    Boyer-Chatenet, L.2    Gautier, J.3
  • 62
    • 0028943378 scopus 로고
    • Functions of the yeast meiotic recombination genes, MRE11 and MRE2
    • Ogawa, H., Johzuka, K., Nakagawa, T., Leem, S. H. and Hagihara, A. H. (1995) Functions of the yeast meiotic recombination genes, MRE11 and MRE2. Adv Biophys 31, 67–76.
    • (1995) Adv Biophys , vol.31 , pp. 67-76
    • Ogawa, H.1    Johzuka, K.2    Nakagawa, T.3    Leem, S.H.4    Hagihara, A.H.5
  • 63
    • 0032567041 scopus 로고    scopus 로고
    • The many interfaces of Mre11
    • Haber, J. E. (1998) The many interfaces of Mre11. Cell 95, 583–586.
    • (1998) Cell , vol.95 , pp. 583-586
    • Haber, J.E.1
  • 64
    • 3242670803 scopus 로고    scopus 로고
    • ATR and ATM regulate the timing of DNA replication origin firing
    • Shechter, D., Costanzo, V. and Gautier, J. (2004) ATR and ATM regulate the timing of DNA replication origin firing. Nat Cell Biol 6, 648–655.
    • (2004) Nat Cell Biol , vol.6 , pp. 648-655
    • Shechter, D.1    Costanzo, V.2    Gautier, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.