메뉴 건너뛰기




Volumn 33, Issue 6, 2013, Pages 1215-1248

Highlights in antiviral drug research: Antivirals at the horizon

Author keywords

Antiarenaviral; Antipicornaviral; CMX001; Cyclopropavir; DUY11; Favipiravir; LJ 001; N MCT; Natural products; PSI 352938; U0126

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 (2 CHLORO 4 IODOANILINO) N CYCLOPROPYLMETHOXY 3,4 DIFLUOROBENZAMIDE; 2' DEOXY 2' FLUORO 2' METHYLCYTIDINE; 4' AZIDOCYTIDINE; ACICLOVIR; AMANTADINE; ANTIVIRUS AGENT; CIDOFOVIR; CIDOFOVIR 3 HEXADECYLOXYPROPYL ESTER; FAVIPIRAVIR; FOSCARNET; GANCICLOVIR; HOMOISOFLAVONE DERIVATIVE; MERICITABINE; METHANOCARBATHYMIDINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; OSELTAMIVIR; PEGINTERFERON ALPHA; PLECONARIL; PSI 7411; RIBAVIRIN; RIMANTADINE; SOFOSBUVIR; SORAFENIB; TRITERPENOID; UNCLASSIFIED DRUG; VALGANCICLOVIR; VALOPICITABINE; VALTORCITABINE; VAPENDAVIR; ZANAMIVIR; BIOLOGICAL PRODUCT;

EID: 84874107763     PISSN: 01986325     EISSN: 10981128     Source Type: Journal    
DOI: 10.1002/med.21256     Document Type: Article
Times cited : (60)

References (205)
  • 1
    • 57349120749 scopus 로고    scopus 로고
    • The discovery of antiviral agents: Ten different compounds, ten different stories
    • De Clercq E. The discovery of antiviral agents: Ten different compounds, ten different stories. Med Res Rev 2008;28:929-953.
    • (2008) Med Res Rev , vol.28 , pp. 929-953
    • De Clercq, E.1
  • 2
    • 67649744221 scopus 로고    scopus 로고
    • Antiviral drug discovery: Ten more compounds, and ten more stories (part B)
    • De Clercq E. Antiviral drug discovery: Ten more compounds, and ten more stories (part B). Med Res Rev 2009;29:571-610.
    • (2009) Med Res Rev , vol.29 , pp. 571-610
    • De Clercq, E.1
  • 3
    • 67649744219 scopus 로고    scopus 로고
    • Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies and perspectives
    • De Clercq E. Another ten stories in antiviral drug discovery (part C): "Old" and "new" antivirals, strategies and perspectives. Med Res Rev 2009;29:611-645.
    • (2009) Med Res Rev , vol.29 , pp. 611-645
    • De Clercq, E.1
  • 4
    • 77953381888 scopus 로고    scopus 로고
    • Yet another ten stories on antiviral drug discovery (part D): Paradigms, paradoxes and paraductions
    • De Clercq E. Yet another ten stories on antiviral drug discovery (part D): Paradigms, paradoxes and paraductions. Med Res Rev 2010;30:667-707.
    • (2010) Med Res Rev , vol.30 , pp. 667-707
    • De Clercq, E.1
  • 5
    • 78650003024 scopus 로고    scopus 로고
    • The next ten stories on antiviral drug discovery (part E): Advents, advances and adventures
    • De Clercq E. The next ten stories on antiviral drug discovery (part E): Advents, advances and adventures. Med Res Rev 2011;31:118-160.
    • (2011) Med Res Rev , vol.31 , pp. 118-160
    • De Clercq, E.1
  • 6
    • 84884981291 scopus 로고    scopus 로고
    • In vitro selection of HCV replicons with reduced sensitivity to PSI-352938, a cyclicphosphate prodrug of β-d-2′-α-F-2′-β-C-methylguanosine
    • abstract no 10.
    • Lam AM, Espiritu C, Bansal S, Steuer HM, Zennou V, Otto MJ, Furman PA. In vitro selection of HCV replicons with reduced sensitivity to PSI-352938, a cyclicphosphate prodrug of β-d-2′-α-F-2′-β-C-methylguanosine. Antiviral Res 2011;90:A22, abstract no 10.
    • (2011) Antiviral Res , vol.90
    • Lam, A.M.1    Espiritu, C.2    Bansal, S.3    Steuer, H.M.4    Zennou, V.5    Otto, M.J.6    Furman, P.A.7
  • 7
    • 84884979554 scopus 로고    scopus 로고
    • Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase
    • abstract no 17.
    • Prichard M, Hartline C, Gill R, Bowlin T, James S. Cyclopropavir inhibits the normal function of the human cytomegalovirus UL97 kinase. Antiviral Res 2011;90:A24, abstract no 17.
    • (2011) Antiviral Res , vol.90
    • Prichard, M.1    Hartline, C.2    Gill, R.3    Bowlin, T.4    James, S.5
  • 8
    • 84863087239 scopus 로고    scopus 로고
    • In vivo efficacy of N-methanocarbathymidine (N-MCT) against herpes simplex virus type 2 in neonatal guinea pigs
    • abstract no 19.
    • Cardin R, Bravo F, Clark J, Earwood J, Glazer R, Rahman A, Bernstein D. In vivo efficacy of N-methanocarbathymidine (N-MCT) against herpes simplex virus type 2 in neonatal guinea pigs. Antiviral Res 2011;90:A24-25, abstract no 19.
    • (2011) Antiviral Res , vol.90
    • Cardin, R.1    Bravo, F.2    Clark, J.3    Earwood, J.4    Glazer, R.5    Rahman, A.6    Bernstein, D.7
  • 9
    • 84884975838 scopus 로고    scopus 로고
    • CMX001 (hexadecyloxypropyl cidofovir) antiviral activity against adenovirus in patients correlates with drug levels and viral sensitivity
    • abstract no 33.
    • Lanier ER, Painter W, Tippin TK, Anderson M, Lampert BM, Mommeja-Marin H, Trost LC. CMX001 (hexadecyloxypropyl cidofovir) antiviral activity against adenovirus in patients correlates with drug levels and viral sensitivity. Antiviral Res 2011;90:A27-28, abstract no 33.
    • (2011) Antiviral Res , vol.90
    • Lanier, E.R.1    Painter, W.2    Tippin, T.K.3    Anderson, M.4    Lampert, B.M.5    Mommeja-Marin, H.6    Trost, L.C.7
  • 10
    • 84884983058 scopus 로고    scopus 로고
    • Favipiravir (T-705) treatment of experimental arenaviral infection initiated after the onset of clinical disease
    • abstract no 107.
    • Gowen BB, Mendenhall M, Russell A, Smee DF, Furuta Y. Favipiravir (T-705) treatment of experimental arenaviral infection initiated after the onset of clinical disease. Antiviral Res 2011;90:A52, abstract no 107.
    • (2011) Antiviral Res , vol.90
    • Gowen, B.B.1    Mendenhall, M.2    Russell, A.3    Smee, D.F.4    Furuta, Y.5
  • 11
    • 84884984648 scopus 로고    scopus 로고
    • Combinatorial anti-arenaviral therapy with the small molecule SKI-1/S1P inhibitor PF-429242 and ribavirin
    • abstract no 136.
    • Pasquato A, Rochat C, de la Torre JC, Kunz S. Combinatorial anti-arenaviral therapy with the small molecule SKI-1/S1P inhibitor PF-429242 and ribavirin. Antiviral Res 2011;90:A62, abstract no 136.
    • (2011) Antiviral Res , vol.90
    • Pasquato, A.1    Rochat, C.2    de la Torre, J.C.3    Kunz, S.4
  • 12
    • 84884977160 scopus 로고    scopus 로고
    • OBR-5-340-A novel pyrazolo-pyrimidine derivative with strong antiviral activity against Coxsackievirus B3 in vitro and in vivo
    • abstract no 39.
    • Braun H, Makarov VA, Riabova OB, Komarova ES, Richter M, Wutzler P, Schmidtke M. OBR-5-340-A novel pyrazolo-pyrimidine derivative with strong antiviral activity against Coxsackievirus B3 in vitro and in vivo. Antiviral Res 2011;90:A29; abstract no 39.
    • (2011) Antiviral Res , vol.90
    • Braun, H.1    Makarov, V.A.2    Riabova, O.B.3    Komarova, E.S.4    Richter, M.5    Wutzler, P.6    Schmidtke, M.7
  • 13
    • 84884984141 scopus 로고    scopus 로고
    • Identification and characterization of OBR-5-340 - a novel broad-spectrum anti-human rhinovirus (HRV) inhibitor
    • abstract no 73.
    • Richter M, Makarov VA, Riabova OB, Wutzler P, Schmidtke M. Identification and characterization of OBR-5-340 - a novel broad-spectrum anti-human rhinovirus (HRV) inhibitor. Antiviral Res 2011;90:A40, abstract no 73.
    • (2011) Antiviral Res , vol.90
    • Richter, M.1    Makarov, V.A.2    Riabova, O.B.3    Wutzler, P.4    Schmidtke, M.5
  • 14
    • 84884983142 scopus 로고    scopus 로고
    • Mechanistic studies on a novel hydrophobic derivative of aglycoristocetin with potent and broad activity against influenza viruses
    • abstract 91.
    • Vanderlinden E, Vanstreels E, Vermeire K, Daelemans D, Herczegh P, Sztaricskai F, Naesens L. Mechanistic studies on a novel hydrophobic derivative of aglycoristocetin with potent and broad activity against influenza viruses. Antiviral Res 2011;90:A47, abstract 91.
    • (2011) Antiviral Res , vol.90
    • Vanderlinden, E.1    Vanstreels, E.2    Vermeire, K.3    Daelemans, D.4    Herczegh, P.5    Sztaricskai, F.6    Naesens, L.7
  • 15
    • 84884975302 scopus 로고    scopus 로고
    • Inhibition of human cytomegalovirus replication by tricin (4′,5,7-trihydroxy-3′,5′-dimethoxyflavone)
    • abstract no 131.
    • Murayama T, Li Y, Yamada R, Sadanari H, Matsubara K, Tuchida Y, Koketsu M, Watanabe K. Inhibition of human cytomegalovirus replication by tricin (4′, 5, 7-trihydroxy-3′, 5′-dimethoxyflavone). Antiviral Res 2011;90:A60, abstract no 131.
    • (2011) Antiviral Res , vol.90
    • Murayama, T.1    Li, Y.2    Yamada, R.3    Sadanari, H.4    Matsubara, K.5    Tuchida, Y.6    Koketsu, M.7    Watanabe, K.8
  • 16
    • 84884988495 scopus 로고    scopus 로고
    • Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo
    • abstract no 47.
    • Droebner K, Ludwig S, Pleschka S, Planz O. Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral Res 2011;90:A32, abstract no 47.
    • (2011) Antiviral Res , vol.90
    • Droebner, K.1    Ludwig, S.2    Pleschka, S.3    Planz, O.4
  • 17
    • 84884979022 scopus 로고    scopus 로고
    • Rigid amphipathic fusion inhibitors (RAFIs) inhibit infectivity of enveloped viruses by targeting envelope lipids to prevent fusion with cellular membranes
    • abstract no 43.
    • Colpitts CC, Ustinov AV, Korshun VA, Schang LM. Rigid amphipathic fusion inhibitors (RAFIs) inhibit infectivity of enveloped viruses by targeting envelope lipids to prevent fusion with cellular membranes. Antiviral Res 2011; A30, abstract no 43.
    • (2011) Antiviral Res
    • Colpitts, C.C.1    Ustinov, A.V.2    Korshun, V.A.3    Schang, L.M.4
  • 26
  • 28
    • 35648968189 scopus 로고    scopus 로고
    • Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) and identification of a novel active 5′-triphosphate species
    • Ma H, Jiang WR, Robledo N, Leveque V, Ali S, Lara-Jaime T, Masjedizadeh M, Smith DB, Cammack N, Klumpp K, Symons J. Characterization of the metabolic activation of hepatitis C virus nucleoside inhibitor beta-D-2′-Deoxy-2′-fluoro-2′-C-methylcytidine (PSI-6130) and identification of a novel active 5′-triphosphate species. J Biol Chem 2007;282:29812-29820.
    • (2007) J Biol Chem , vol.282 , pp. 29812-29820
    • Ma, H.1    Jiang, W.R.2    Robledo, N.3    Leveque, V.4    Ali, S.5    Lara-Jaime, T.6    Masjedizadeh, M.7    Smith, D.B.8    Cammack, N.9    Klumpp, K.10    Symons, J.11
  • 29
    • 38649112300 scopus 로고    scopus 로고
    • The mechanism of action of beta-D-2′-deoxy-2′-fluoro-2′-C-methylcytidine involves a second metabolic pathway leading to beta-D-2′-deoxy-2′-fluoro-2′-C-methyluridine 5′-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
    • Murakami E, Niu C, Bao H, Micolochick Steuer HM, Whitaker T, Nachman T, Sofia MA, Wang P, Otto MJ, Furman PA. The mechanism of action of beta-D-2′-deoxy-2′-fluoro-2′-C-methylcytidine involves a second metabolic pathway leading to beta-D-2′-deoxy-2′-fluoro-2′-C-methyluridine 5′-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase. Antimicrob Agents Chemother 2008;52:458-464.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 458-464
    • Murakami, E.1    Niu, C.2    Bao, H.3    Micolochick Steuer, H.M.4    Whitaker, T.5    Nachman, T.6    Sofia, M.A.7    Wang, P.8    Otto, M.J.9    Furman, P.A.10
  • 34
    • 79956069348 scopus 로고    scopus 로고
    • Stereoselective synthesis of PSI-352938: A β-D-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-3′,5′-cyclic phosphate nucleotide prodrug for the treatment of HCV
    • Reddy PG, Chun BK, Zhang HR, Rachakonda S, Ross BS, Sofia MJ. Stereoselective synthesis of PSI-352938: A β-D-2′-deoxy-2′-α-fluoro-2′-β-C-methyl-3′, 5′-cyclic phosphate nucleotide prodrug for the treatment of HCV. J Org Chem 2011;76:3782-3790.
    • (2011) J Org Chem , vol.76 , pp. 3782-3790
    • Reddy, P.G.1    Chun, B.K.2    Zhang, H.R.3    Rachakonda, S.4    Ross, B.S.5    Sofia, M.J.6
  • 38
    • 40749114495 scopus 로고    scopus 로고
    • Methylenecyclopropane analogues of nucleosides as anti-herpes agents
    • In: De Clercq E, Ed. Elsevier Science;
    • Zemlicka J. Methylenecyclopropane analogues of nucleosides as anti-herpes agents. In: De Clercq E, Ed. Advances in Antiviral Drug Design, Vol. 5. Elsevier Science; 2007. p 113-165.
    • (2007) Advances in Antiviral Drug Design, Vol. 5 , pp. 113-165
    • Zemlicka, J.1
  • 39
    • 1642458720 scopus 로고    scopus 로고
    • Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: Second-generation methylenecyclopropane analogues of nucleosides
    • Zhou S, Breitenbach JM, Borysko KZ, Drach JC, Kern ER, Gullen E, Cheng YC, Zemlicka J. Synthesis and antiviral activity of (Z)- and (E)-2, 2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: Second-generation methylenecyclopropane analogues of nucleosides. J Med Chem 2004;47:566-575.
    • (2004) J Med Chem , vol.47 , pp. 566-575
    • Zhou, S.1    Breitenbach, J.M.2    Borysko, K.Z.3    Drach, J.C.4    Kern, E.R.5    Gullen, E.6    Cheng, Y.C.7    Zemlicka, J.8
  • 42
    • 33747343175 scopus 로고    scopus 로고
    • Pivotal role of animal models in the development of new therapies for cytomegalovirus infections
    • Kern ER. Pivotal role of animal models in the development of new therapies for cytomegalovirus infections. Antiviral Res 2006;71:164-171.
    • (2006) Antiviral Res , vol.71 , pp. 164-171
    • Kern, E.R.1
  • 43
    • 34548031594 scopus 로고    scopus 로고
    • In search of effective anti-HHV-6 agents
    • De Clercq E, Naesens L. In search of effective anti-HHV-6 agents. J Clin Virol 2006;37(Suppl 1):S82-S86.
    • (2006) J Clin Virol , vol.37 , Issue.SUPPL 1
    • De Clercq, E.1    Naesens, L.2
  • 45
    • 78650664958 scopus 로고    scopus 로고
    • Cytomegalovirus UL97 mutations affecting cyclopropavir and ganciclovir susceptibility
    • Chou S, Bowlin TL. Cytomegalovirus UL97 mutations affecting cyclopropavir and ganciclovir susceptibility. Antimicrob Agents Chemother 2011;55:382-384.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 382-384
    • Chou, S.1    Bowlin, T.L.2
  • 46
    • 77955359554 scopus 로고    scopus 로고
    • Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir
    • Gentry BG, Kamil JP, Coen DM, Zemlicka J, Drach JC. Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir. Antimicrob Agents Chemother 2010;54:3093-3098.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 3093-3098
    • Gentry, B.G.1    Kamil, J.P.2    Coen, D.M.3    Zemlicka, J.4    Drach, J.C.5
  • 47
    • 78549278033 scopus 로고    scopus 로고
    • Phosphorylation of antiviral and endogenous nucleotides to di- and triphosphates by guanosine monophosphate kinase
    • Gentry BG, Gentry SN, Jackson TL, Zemlicka J, Drach JC. Phosphorylation of antiviral and endogenous nucleotides to di- and triphosphates by guanosine monophosphate kinase. Biochem Pharmacol 2011;81:43-49.
    • (2011) Biochem Pharmacol , vol.81 , pp. 43-49
    • Gentry, B.G.1    Gentry, S.N.2    Jackson, T.L.3    Zemlicka, J.4    Drach, J.C.5
  • 48
    • 65549158640 scopus 로고    scopus 로고
    • Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity
    • Mhaske SB, Ksebati B, Prichard MN, Drach JC, Zemlicka J. Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity. Bioorg Med Chem 2009;17:3892-3899.
    • (2009) Bioorg Med Chem , vol.17 , pp. 3892-3899
    • Mhaske, S.B.1    Ksebati, B.2    Prichard, M.N.3    Drach, J.C.4    Zemlicka, J.5
  • 49
    • 0029815436 scopus 로고    scopus 로고
    • Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides?
    • Marquez VE, Siddiqui MA, Ezzitouni A, Russ P, Wang J, Wagner RW, Matteucci MD. Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides? J Med Chem 1996;39:3739-3747.
    • (1996) J Med Chem , vol.39 , pp. 3739-3747
    • Marquez, V.E.1    Siddiqui, M.A.2    Ezzitouni, A.3    Russ, P.4    Wang, J.5    Wagner, R.W.6    Matteucci, M.D.7
  • 50
    • 0035997929 scopus 로고    scopus 로고
    • Metabolic pathways of N-methanocarbathymidine, a novel antiviral agent, in native and herpes simplex virus type 1 infected Vero cells
    • Zalah L, Huleihel M, Manor E, Konson A, Ford H, Jr, Marquez VE, Johns DG, Agbaria R. Metabolic pathways of N-methanocarbathymidine, a novel antiviral agent, in native and herpes simplex virus type 1 infected Vero cells. Antiviral Res 2002;55:63-75.
    • (2002) Antiviral Res , vol.55 , pp. 63-75
    • Zalah, L.1    Huleihel, M.2    Manor, E.3    Konson, A.4    Ford Jr, H.5    Marquez, V.E.6    Johns, D.G.7    Agbaria, R.8
  • 51
    • 0242299579 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine
    • Russ P, Schelling P, Scapozza L, Folkers G, De Clercq E, Marquez VE. Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine. J Med Chem 2003;46:5045-5054.
    • (2003) J Med Chem , vol.46 , pp. 5045-5054
    • Russ, P.1    Schelling, P.2    Scapozza, L.3    Folkers, G.4    De Clercq, E.5    Marquez, V.E.6
  • 53
    • 0346456880 scopus 로고    scopus 로고
    • Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker
    • Marquez VE, Ben-Kasus T, Barchi JJ, Jr, Green KM, Nicklaus MC, Agbaria R. Experimental and structural evidence that herpes 1 kinase and cellular DNA polymerase(s) discriminate on the basis of sugar pucker. J Am Chem Soc 2004;126:543-549.
    • (2004) J Am Chem Soc , vol.126 , pp. 543-549
    • Marquez, V.E.1    Ben-Kasus, T.2    Barchi Jr, J.J.3    Green, K.M.4    Nicklaus, M.C.5    Agbaria, R.6
  • 54
    • 0025271041 scopus 로고
    • Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2′-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R,5S)- and (-)-(1S,5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one
    • Béres J, Sági G, Tömösközi I, Gruber L, Baitz-Gács E, Otvös L, De Clercq E. Stereospecific synthesis and antiviral properties of different enantiomerically pure carbocyclic 2′-deoxyribonucleoside analogues derived from common chiral pools: (+)-(1R, 5S)- and (-)-(1S, 5R)-2-oxabicyclo[3.3.0]oct-6-en-3-one. J Med Chem 1990;33:1353-1360.
    • (1990) J Med Chem , vol.33 , pp. 1353-1360
    • Béres, J.1    Sági, G.2    Tömösközi, I.3    Gruber, L.4    Baitz-Gács, E.5    Otvös, L.6    De Clercq, E.7
  • 55
    • 33645773912 scopus 로고    scopus 로고
    • Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections
    • Prichard MN, Keith KA, Quenelle DC, Kern ER. Activity and mechanism of action of N-methanocarbathymidine against herpesvirus and orthopoxvirus infections. Antimicrob Agents Chemother 2006;50:1336-1341.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1336-1341
    • Prichard, M.N.1    Keith, K.A.2    Quenelle, D.C.3    Kern, E.R.4
  • 56
    • 33846137993 scopus 로고    scopus 로고
    • Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice
    • Smee DF, Wandersee MK, Bailey KW, Wong MH, Chu CK, Gadthula S, Sidwell RW. Cell line dependency for antiviral activity and in vivo efficacy of N-methanocarbathymidine against orthopoxvirus infections in mice. Antiviral Res 2007;73:69-77.
    • (2007) Antiviral Res , vol.73 , pp. 69-77
    • Smee, D.F.1    Wandersee, M.K.2    Bailey, K.W.3    Wong, M.H.4    Chu, C.K.5    Gadthula, S.6    Sidwell, R.W.7
  • 57
    • 34548609026 scopus 로고    scopus 로고
    • Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus
    • Smee DF, Hurst BL, Wong MH, Glazer RI, Rahman A, Sidwell RW. Efficacy of N-methanocarbathymidine in treating mice infected intranasally with the IHD and WR strains of vaccinia virus. Antiviral Res 2007;76:124-129.
    • (2007) Antiviral Res , vol.76 , pp. 124-129
    • Smee, D.F.1    Hurst, B.L.2    Wong, M.H.3    Glazer, R.I.4    Rahman, A.5    Sidwell, R.W.6
  • 58
    • 41549115919 scopus 로고    scopus 로고
    • Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine
    • Prichard MN, Kern ER, Quenelle DC, Keith KA, Moyer RW, Turner PC. Vaccinia virus lacking the deoxyuridine triphosphatase gene (F2L) replicates well in vitro and in vivo, but is hypersensitive to the antiviral drug (N)-methanocarbathymidine. Virol J 2008;5:39.
    • (2008) Virol J , vol.5 , pp. 39
    • Prichard, M.N.1    Kern, E.R.2    Quenelle, D.C.3    Keith, K.A.4    Moyer, R.W.5    Turner, P.C.6
  • 60
    • 69549129627 scopus 로고    scopus 로고
    • A greener enantioselective synthesis of the antiviral agent North-methanocarbathymidine (N-MCT) from 2-deoxy-d-ribose
    • Ludek OR, Marquez VE. A greener enantioselective synthesis of the antiviral agent North-methanocarbathymidine (N-MCT) from 2-deoxy-d-ribose. Tetrahedron 2009;65:8461-8467.
    • (2009) Tetrahedron , vol.65 , pp. 8461-8467
    • Ludek, O.R.1    Marquez, V.E.2
  • 61
    • 54849203900 scopus 로고    scopus 로고
    • D-(+)-iso-methanocarbathymidine: A high-affinity substrate for herpes simplex virus 1 thymidine kinase
    • Comin MJ, Vu BC, Boyer PL, Liao C, Hughes SH, Marquez VE. D-(+)-iso-methanocarbathymidine: A high-affinity substrate for herpes simplex virus 1 thymidine kinase. ChemMedChem 2008;3:1129-1134.
    • (2008) ChemMedChem , vol.3 , pp. 1129-1134
    • Comin, M.J.1    Vu, B.C.2    Boyer, P.L.3    Liao, C.4    Hughes, S.H.5    Marquez, V.E.6
  • 62
    • 33747108083 scopus 로고    scopus 로고
    • The history of N-methanocarbathymidine: The investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent
    • Marquez VE, Hughes SH, Sei S, Agbaria R. The history of N-methanocarbathymidine: The investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent. Antiviral Res 2006;71:268-275.
    • (2006) Antiviral Res , vol.71 , pp. 268-275
    • Marquez, V.E.1    Hughes, S.H.2    Sei, S.3    Agbaria, R.4
  • 63
    • 67349157073 scopus 로고    scopus 로고
    • Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: Current state of the art
    • Hostetler KY. Alkoxyalkyl prodrugs of acyclic nucleoside phosphonates enhance oral antiviral activity and reduce toxicity: Current state of the art. Antiviral Res 2009;82:A84-A98.
    • (2009) Antiviral Res , vol.82
    • Hostetler, K.Y.1
  • 64
    • 78349234678 scopus 로고    scopus 로고
    • Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies
    • Quenelle DC, Lampert B, Collins DJ, Rice TL, Painter GR, Kern ER. Efficacy of CMX001 against herpes simplex virus infections in mice and correlations with drug distribution studies. J Infect Dis 2010;202:1492-1499.
    • (2010) J Infect Dis , vol.202 , pp. 1492-1499
    • Quenelle, D.C.1    Lampert, B.2    Collins, D.J.3    Rice, T.L.4    Painter, G.R.5    Kern, E.R.6
  • 65
    • 2942574415 scopus 로고    scopus 로고
    • Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection
    • Bidanset DJ, Beadle JR, Wan WB, Hostetler KY, Kern ER. Oral activity of ether lipid ester prodrugs of cidofovir against experimental human cytomegalovirus infection. J Infect Dis 2004;190:499-503.
    • (2004) J Infect Dis , vol.190 , pp. 499-503
    • Bidanset, D.J.1    Beadle, J.R.2    Wan, W.B.3    Hostetler, K.Y.4    Kern, E.R.5
  • 66
    • 0035991718 scopus 로고    scopus 로고
    • Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro
    • Beadle JR, Hartline C, Aldern KA, Rodriguez N, Harden E, Kern ER, Hostetler KY. Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro. Antimicrob Agents Chemother 2002;46:2381-2386.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 2381-2386
    • Beadle, J.R.1    Hartline, C.2    Aldern, K.A.3    Rodriguez, N.4    Harden, E.5    Kern, E.R.6    Hostetler, K.Y.7
  • 68
    • 78650672358 scopus 로고    scopus 로고
    • Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection
    • Bravo FJ, Bernstein DI, Beadle JR, Hostetler KY, Cardin RD. Oral hexadecyloxypropyl-cidofovir therapy in pregnant guinea pigs improves outcome in the congenital model of cytomegalovirus infection. Antimicrob Agents Chemother 2011;55:35-41.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 35-41
    • Bravo, F.J.1    Bernstein, D.I.2    Beadle, J.R.3    Hostetler, K.Y.4    Cardin, R.D.5
  • 69
  • 70
    • 44449121495 scopus 로고    scopus 로고
    • Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model
    • Toth K, Spencer JF, Dhar D, Sagartz JE, Buller RM, Painter GR, Wold WS. Hexadecyloxypropyl-cidofovir, CMX001, prevents adenovirus-induced mortality in a permissive, immunosuppressed animal model. Proc Natl Acad Sci USA 2008;105:7293-7297.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7293-7297
    • Toth, K.1    Spencer, J.F.2    Dhar, D.3    Sagartz, J.E.4    Buller, R.M.5    Painter, G.R.6    Wold, W.S.7
  • 73
    • 47249149259 scopus 로고    scopus 로고
    • Cidofovir inhibits polyomavirus BK replication in human renal tubular cells downstream of viral early gene expression
    • Bernhoff E, Gutteberg TJ, Sandvik K, Hirsch HH, Rinaldo CH. Cidofovir inhibits polyomavirus BK replication in human renal tubular cells downstream of viral early gene expression. Am J Transplant 2008;8:1413-1422.
    • (2008) Am J Transplant , vol.8 , pp. 1413-1422
    • Bernhoff, E.1    Gutteberg, T.J.2    Sandvik, K.3    Hirsch, H.H.4    Rinaldo, C.H.5
  • 74
    • 33645785582 scopus 로고    scopus 로고
    • Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro
    • Randhawa P, Farasati NA, Shapiro R, Hostetler KY. Ether lipid ester derivatives of cidofovir inhibit polyomavirus BK replication in vitro. Antimicrob Agents Chemother 2006;50:1564-1566.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1564-1566
    • Randhawa, P.1    Farasati, N.A.2    Shapiro, R.3    Hostetler, K.Y.4
  • 75
    • 78049268991 scopus 로고    scopus 로고
    • 1-O-hexadecyloxypropyl cidofovir (CMX001) effectively inhibits polyomavirus BK replication in primary human renal tubular epithelial cells
    • Rinaldo CH, Gosert R, Bernhoff E, Finstad S, Hirsch HH. 1-O-hexadecyloxypropyl cidofovir (CMX001) effectively inhibits polyomavirus BK replication in primary human renal tubular epithelial cells. Antimicrob Agents Chemother 2010;54:4714-4722.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 4714-4722
    • Rinaldo, C.H.1    Gosert, R.2    Bernhoff, E.3    Finstad, S.4    Hirsch, H.H.5
  • 76
    • 78049256334 scopus 로고    scopus 로고
    • Hexadecyloxypropyl-cidofovir (CMX001) suppresses JC virus replication in human fetal brain SVG cell cultures
    • Jiang ZG, Cohen J, Marshall LJ, Major EO. Hexadecyloxypropyl-cidofovir (CMX001) suppresses JC virus replication in human fetal brain SVG cell cultures. Antimicrob Agents Chemother 2010;54:4723-4732.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 4723-4732
    • Jiang, Z.G.1    Cohen, J.2    Marshall, L.J.3    Major, E.O.4
  • 77
    • 79955549826 scopus 로고    scopus 로고
    • CMX001 (1-O-hexadecyloxypropyl-cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derived astrocytes
    • Gosert R, Rinaldo CH, Wernli M, Major EO, Hirsch HH. CMX001 (1-O-hexadecyloxypropyl-cidofovir) inhibits polyomavirus JC replication in human brain progenitor-derived astrocytes. Antimicrob Agents Chemother 2011;55:2129-2136.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 2129-2136
    • Gosert, R.1    Rinaldo, C.H.2    Wernli, M.3    Major, E.O.4    Hirsch, H.H.5
  • 78
    • 78149473837 scopus 로고    scopus 로고
    • Treatment of progressive multifocal leukoencephalopathy and idiopathic CD4+ lymphocytopenia
    • Patel A, Patel J, Ikwuagwu J. Treatment of progressive multifocal leukoencephalopathy and idiopathic CD4+ lymphocytopenia. J Antimicrob Chemother 2010;65:2489-2492.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 2489-2492
    • Patel, A.1    Patel, J.2    Ikwuagwu, J.3
  • 79
    • 3342879034 scopus 로고    scopus 로고
    • Design and development of oral drugs for the prophylaxis and treatment of smallpox infection
    • Painter GR, Hostetler KY. Design and development of oral drugs for the prophylaxis and treatment of smallpox infection. Trends Biotechnol 2004;22:423-427.
    • (2004) Trends Biotechnol , vol.22 , pp. 423-427
    • Painter, G.R.1    Hostetler, K.Y.2
  • 84
    • 79952169957 scopus 로고    scopus 로고
    • Ectromelia virus infections of mice as a model to support the licensure of anti-orthopoxvirus therapeutics
    • Parker S, Siddiqui AM, Painter G, Schriewer J, Buller RM. Ectromelia virus infections of mice as a model to support the licensure of anti-orthopoxvirus therapeutics. Viruses 2010;2:1918-1932.
    • (2010) Viruses , vol.2 , pp. 1918-1932
    • Parker, S.1    Siddiqui, A.M.2    Painter, G.3    Schriewer, J.4    Buller, R.M.5
  • 87
    • 77950482298 scopus 로고    scopus 로고
    • A mouse model of lethal infection for evaluating prophylactics and therapeutics against Monkeypox virus
    • Stabenow J, Buller RM, Schriewer J, West C, Sagartz JE, Parker S. A mouse model of lethal infection for evaluating prophylactics and therapeutics against Monkeypox virus. J Virol 2010;84:3909-3920.
    • (2010) J Virol , vol.84 , pp. 3909-3920
    • Stabenow, J.1    Buller, R.M.2    Schriewer, J.3    West, C.4    Sagartz, J.E.5    Parker, S.6
  • 88
    • 78650291480 scopus 로고    scopus 로고
    • Poxvirus interleukin-4 expression overcomes inherent resistance and vaccine-induced immunity: Pathogenesis, prophylaxis, and antiviral therapy
    • Chen N, Bellone CJ, Schriewer J, Owens G, Fredrickson T, Parker S, Buller RM. Poxvirus interleukin-4 expression overcomes inherent resistance and vaccine-induced immunity: Pathogenesis, prophylaxis, and antiviral therapy. Virology 2011;409:328-337.
    • (2011) Virology , vol.409 , pp. 328-337
    • Chen, N.1    Bellone, C.J.2    Schriewer, J.3    Owens, G.4    Fredrickson, T.5    Parker, S.6    Buller, R.M.7
  • 90
    • 79952152606 scopus 로고    scopus 로고
    • Efficacy of CMX001 as a prophylactic and presymptomatic antiviral agent in New Zealand white rabbits infected with rabbitpox virus, a model for orthopoxvirus infections of humans
    • Rice AD, Adams MM, Lampert B, Foster S, Lanier R, Robertson A, Painter G, Moyer RW. Efficacy of CMX001 as a prophylactic and presymptomatic antiviral agent in New Zealand white rabbits infected with rabbitpox virus, a model for orthopoxvirus infections of humans. Viruses 2001;3:63-82.
    • (2001) Viruses , vol.3 , pp. 63-82
    • Rice, A.D.1    Adams, M.M.2    Lampert, B.3    Foster, S.4    Lanier, R.5    Robertson, A.6    Painter, G.7    Moyer, R.W.8
  • 92
    • 12944317148 scopus 로고    scopus 로고
    • Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro
    • Wan WB, Beadle JR, Hartline C, Kern ER, Ciesla SL, Valiaeva N, Hostetler KY. Comparison of the antiviral activities of alkoxyalkyl and alkyl esters of cidofovir against human and murine cytomegalovirus replication in vitro. Antimicrob Agents Chemother 2005;49:656-662.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 656-662
    • Wan, W.B.1    Beadle, J.R.2    Hartline, C.3    Kern, E.R.4    Ciesla, S.L.5    Valiaeva, N.6    Hostetler, K.Y.7
  • 93
    • 79955484869 scopus 로고    scopus 로고
    • Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine
    • Ruiz J, Beadle JR, Buller RM, Schreiwer J, Prichard MN, Keith KA, Lewis KC, Hostetler KY. Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine. Bioorg Med Chem 2011;19:2950-2958.
    • (2011) Bioorg Med Chem , vol.19 , pp. 2950-2958
    • Ruiz, J.1    Beadle, J.R.2    Buller, R.M.3    Schreiwer, J.4    Prichard, M.N.5    Keith, K.A.6    Lewis, K.C.7    Hostetler, K.Y.8
  • 94
    • 80053329255 scopus 로고    scopus 로고
    • Maporal virus as a surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir
    • Buys KK, Jung KH, Smee DF, Furuta Y, Gowen BB. Maporal virus as a surrogate for pathogenic New World hantaviruses and its inhibition by favipiravir. Antivir Chem Chemother 2011;21:193-200.
    • (2011) Antivir Chem Chemother , vol.21 , pp. 193-200
    • Buys, K.K.1    Jung, K.H.2    Smee, D.F.3    Furuta, Y.4    Gowen, B.B.5
  • 97
    • 70349443188 scopus 로고    scopus 로고
    • Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells
    • Smee DF, Hurst BL, Egawa H, Takahashi K, Kadota T, Furuta Y. Intracellular metabolism of favipiravir (T-705) in uninfected and influenza A (H5N1) virus-infected cells. J Antimicrob Chemother 2009;64:741-746.
    • (2009) J Antimicrob Chemother , vol.64 , pp. 741-746
    • Smee, D.F.1    Hurst, B.L.2    Egawa, H.3    Takahashi, K.4    Kadota, T.5    Furuta, Y.6
  • 104
    • 59749106534 scopus 로고    scopus 로고
    • Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106
    • Julander JG, Shafer K, Smee DF, Morrey JD, Furuta Y. Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother 2009;53:202-209.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 202-209
    • Julander, J.G.1    Shafer, K.2    Smee, D.F.3    Morrey, J.D.4    Furuta, Y.5
  • 106
    • 64749095802 scopus 로고    scopus 로고
    • Effect of T-705 treatment on western equine encephalitis in a mouse model
    • Julander JG, Smee DF, Morrey JD, Furuta Y. Effect of T-705 treatment on western equine encephalitis in a mouse model. Antiviral Res 2009;82:169-171.
    • (2009) Antiviral Res , vol.82 , pp. 169-171
    • Julander, J.G.1    Smee, D.F.2    Morrey, J.D.3    Furuta, Y.4
  • 109
    • 56649102052 scopus 로고    scopus 로고
    • Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin
    • Gowen BB, Smee DF, Wong MH, Hall JO, Jung KH, Bailey KW, Stevens JR, Furuta Y, Morrey JD. Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin. PLoS One 2008;3:e3725.
    • (2008) PLoS One , vol.3
    • Gowen, B.B.1    Smee, D.F.2    Wong, M.H.3    Hall, J.O.4    Jung, K.H.5    Bailey, K.W.6    Stevens, J.R.7    Furuta, Y.8    Morrey, J.D.9
  • 110
    • 77951297749 scopus 로고    scopus 로고
    • Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models
    • Gowen BB, Wong MH, Jung KH, Smee DF, Morrey JD, Furuta Y. Efficacy of favipiravir (T-705) and T-1106 pyrazine derivatives in phlebovirus disease models. Antiviral Res 2010;86:121-127.
    • (2010) Antiviral Res , vol.86 , pp. 121-127
    • Gowen, B.B.1    Wong, M.H.2    Jung, K.H.3    Smee, D.F.4    Morrey, J.D.5    Furuta, Y.6
  • 113
    • 79952067922 scopus 로고    scopus 로고
    • Novel approaches in anti-arenaviral drug development
    • Lee AM, Pasquato A, Kunz S. Novel approaches in anti-arenaviral drug development. Virology 2011;411:163-169.
    • (2011) Virology , vol.411 , pp. 163-169
    • Lee, A.M.1    Pasquato, A.2    Kunz, S.3
  • 116
    • 78650517211 scopus 로고    scopus 로고
    • Imidazo[2,1-b]thiazole carbohydrate derivatives: Synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever
    • Barradas JS, Errea MI, DAccorso NB, Sepúlveda CS, Damonte EB. Imidazo[2, 1-b]thiazole carbohydrate derivatives: Synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever. Eur J Med Chem 2011;46:259-264.
    • (2011) Eur J Med Chem , vol.46 , pp. 259-264
    • Barradas, J.S.1    Errea, M.I.2    DAccorso, N.B.3    Sepúlveda, C.S.4    Damonte, E.B.5
  • 117
    • 34250196481 scopus 로고    scopus 로고
    • Broad-spectrum antiviral activity of small interfering RNA targeting the conserved RNA termini of Lassa virus
    • Müller S, Günther S. Broad-spectrum antiviral activity of small interfering RNA targeting the conserved RNA termini of Lassa virus. Antimicrob Agents Chemother 2007;51:2215-2218.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2215-2218
    • Müller, S.1    Günther, S.2
  • 118
    • 1542347736 scopus 로고    scopus 로고
    • Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus
    • Asper M, Sternsdorf T, Hass M, Drosten C, Rhode A, Schmitz H, Günther S. Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus. J Virol 2004;78:3162-3169.
    • (2004) J Virol , vol.78 , pp. 3162-3169
    • Asper, M.1    Sternsdorf, T.2    Hass, M.3    Drosten, C.4    Rhode, A.5    Schmitz, H.6    Günther, S.7
  • 119
    • 1842637875 scopus 로고    scopus 로고
    • Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus
    • Albiol Matanic VC, Castilla V. Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus. Int J Antimicrob Agents 2004;23:382-389.
    • (2004) Int J Antimicrob Agents , vol.23 , pp. 382-389
    • Albiol Matanic, V.C.1    Castilla, V.2
  • 122
    • 79952073408 scopus 로고    scopus 로고
    • Arenavirus reverse genetics: New approaches for the investigation of arenavirus biology and development of antiviral strategies
    • Emonet SE, Urata S, de la Torre JC. Arenavirus reverse genetics: New approaches for the investigation of arenavirus biology and development of antiviral strategies. Virology 2011;411:416-425.
    • (2011) Virology , vol.411 , pp. 416-425
    • Emonet, S.E.1    Urata, S.2    de la Torre, J.C.3
  • 125
    • 78650655132 scopus 로고    scopus 로고
    • Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease
    • Urata S, Yun N, Pasquato A, Paessler S, Kunz S, de la Torre JC. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J Virol 2011;85:795-803.
    • (2011) J Virol , vol.85 , pp. 795-803
    • Urata, S.1    Yun, N.2    Pasquato, A.3    Paessler, S.4    Kunz, S.5    de la Torre, J.C.6
  • 129
    • 55249103905 scopus 로고    scopus 로고
    • pH-induced activation of arenavirus membrane fusion is antagonized by small-molecule inhibitors
    • York J, Dai D, Amberg SM, Nunberg JH. pH-induced activation of arenavirus membrane fusion is antagonized by small-molecule inhibitors. J Virol 2008;82:10932-10939.
    • (2008) J Virol , vol.82 , pp. 10932-10939
    • York, J.1    Dai, D.2    Amberg, S.M.3    Nunberg, J.H.4
  • 131
    • 33744990410 scopus 로고    scopus 로고
    • Current status of anti-picornavirus therapies
    • Barnard DL. Current status of anti-picornavirus therapies. Curr Pharm Des 2006;12:1379-1390.
    • (2006) Curr Pharm Des , vol.12 , pp. 1379-1390
    • Barnard, D.L.1
  • 134
    • 0035245212 scopus 로고    scopus 로고
    • Treatment of potentially life-threatening enterovirus infections with pleconaril
    • Infect. Dis.
    • Rotbart HA, Webster AD. Treatment of potentially life-threatening enterovirus infections with pleconaril. Clin. Infect. Dis. 2001;32:228-235.
    • (2001) Clin. , vol.32 , pp. 228-235
    • Rotbart, H.A.1    Webster, A.D.2
  • 135
    • 0036580905 scopus 로고    scopus 로고
    • FDA panel rejects common cold treatment
    • Senior K. FDA panel rejects common cold treatment. Lancet Infect Dis 2002;2:264.
    • (2002) Lancet Infect Dis , vol.2 , pp. 264
    • Senior, K.1
  • 137
    • 0038548251 scopus 로고    scopus 로고
    • Pleconaril Respiratory Infection Study Group. Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: Results of 2 double-blind, randomized, placebo-controlled trials
    • Hayden FG, Herrington DT, Coats TL, Kim K, Cooper EC, Villano SA, Liu S, Hudson S, Pevear DC, Collett M, McKinlay M; Pleconaril Respiratory Infection Study Group. Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: Results of 2 double-blind, randomized, placebo-controlled trials. Clin Infect Dis 2003;36:1523-1532.
    • (2003) Clin Infect Dis , vol.36 , pp. 1523-1532
    • Hayden, F.G.1    Herrington, D.T.2    Coats, T.L.3    Kim, K.4    Cooper, E.C.5    Villano, S.A.6    Liu, S.7    Hudson, S.8    Pevear, D.C.9    Collett, M.10    McKinlay, M.11
  • 142
    • 57249089067 scopus 로고    scopus 로고
    • New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3
    • Schmidtke M, Wutzler P, Zieger R, Riabova OB, Makarov VA. New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3. Antiviral Res 2009;81:56-63.
    • (2009) Antiviral Res , vol.81 , pp. 56-63
    • Schmidtke, M.1    Wutzler, P.2    Zieger, R.3    Riabova, O.B.4    Makarov, V.A.5
  • 143
    • 10644297155 scopus 로고    scopus 로고
    • Synthesis and antiviral activity against Coxsackie virus B3 of some novel benzimidazole derivatives
    • Cheng J, Xie J, Luo X. Synthesis and antiviral activity against Coxsackie virus B3 of some novel benzimidazole derivatives. Bioorg Med Chem Lett 2005;15:267-269.
    • (2005) Bioorg Med Chem Lett , vol.15 , pp. 267-269
    • Cheng, J.1    Xie, J.2    Luo, X.3
  • 144
    • 20744436631 scopus 로고    scopus 로고
    • A small interfering RNA targeting coxsackievirus B3 protects permissive HeLa cells from viral challenge
    • Ahn J, Jun ES, Lee HS, Yoon SY, Kim D, Joo CH, Kim YK, Lee H. A small interfering RNA targeting coxsackievirus B3 protects permissive HeLa cells from viral challenge. J Virol 2005;79:8620-8624.
    • (2005) J Virol , vol.79 , pp. 8620-8624
    • Ahn, J.1    Jun, E.S.2    Lee, H.S.3    Yoon, S.Y.4    Kim, D.5    Joo, C.H.6    Kim, Y.K.7    Lee, H.8
  • 145
    • 68249114791 scopus 로고    scopus 로고
    • Combination of soluble coxsackievirus-adenovirus receptor and anti-coxsackievirus siRNAs exerts synergistic antiviral activity against coxsackievirus B3
    • Werk D, Pinkert S, Heim A, Zeichhardt H, Grunert HP, Poller W, Erdmann VA, Fechner H, Kurreck J. Combination of soluble coxsackievirus-adenovirus receptor and anti-coxsackievirus siRNAs exerts synergistic antiviral activity against coxsackievirus B3. Antiviral Res 2009;83:298-306.
    • (2009) Antiviral Res , vol.83 , pp. 298-306
    • Werk, D.1    Pinkert, S.2    Heim, A.3    Zeichhardt, H.4    Grunert, H.P.5    Poller, W.6    Erdmann, V.A.7    Fechner, H.8    Kurreck, J.9
  • 147
    • 3042572766 scopus 로고    scopus 로고
    • Mycophenolate mofetil inhibits the development of Coxsackie B3-virus-induced myocarditis in mice
    • Padalko E, Verbeken E, Matthys P, Aerts JL, De Clercq E, Neyts J. Mycophenolate mofetil inhibits the development of Coxsackie B3-virus-induced myocarditis in mice. BMC Microbiol 2003;3:25.
    • (2003) BMC Microbiol , vol.3 , pp. 25
    • Padalko, E.1    Verbeken, E.2    Matthys, P.3    Aerts, J.L.4    De Clercq, E.5    Neyts, J.6
  • 148
    • 0347064337 scopus 로고    scopus 로고
    • Inhibition of coxsackie B3 virus induced myocarditis in mice by 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile
    • Padalko E, Verbeken E, De Clercq E, Neyts J. Inhibition of coxsackie B3 virus induced myocarditis in mice by 2-(3, 4-dichlorophenoxy)-5-nitrobenzonitrile. J Med Virol 2004;72:263-267.
    • (2004) J Med Virol , vol.72 , pp. 263-267
    • Padalko, E.1    Verbeken, E.2    De Clercq, E.3    Neyts, J.4
  • 154
    • 33747268728 scopus 로고    scopus 로고
    • Antiviral activity and constituent of Ardisia chinensis benth against coxsackie B3 virus
    • Su M, Li Y, Leung KT, Cen Y, Li T, Chen R, Ooi VE. Antiviral activity and constituent of Ardisia chinensis benth against coxsackie B3 virus. Phytother Res 2006;20:634-639.
    • (2006) Phytother Res , vol.20 , pp. 634-639
    • Su, M.1    Li, Y.2    Leung, K.T.3    Cen, Y.4    Li, T.5    Chen, R.6    Ooi, V.E.7
  • 155
    • 25144443720 scopus 로고    scopus 로고
    • Antiviral activity and mode of action of caffeoylquinic acids from Schefflera heptaphylla (L.) Frodin
    • Li Y, But PP, Ooi VE. Antiviral activity and mode of action of caffeoylquinic acids from Schefflera heptaphylla (L.) Frodin. Antiviral Res 2005;68:1-9.
    • (2005) Antiviral Res , vol.68 , pp. 1-9
    • Li, Y.1    But, P.P.2    Ooi, V.E.3
  • 157
    • 34248229611 scopus 로고    scopus 로고
    • Antiviral triterpenoids from the medicinal plant Schefflera heptaphylla
    • Li Y, Jiang R, Ooi LS, But PP, Ooi VE. Antiviral triterpenoids from the medicinal plant Schefflera heptaphylla. Phytother Res 2007;21:466-470.
    • (2007) Phytother Res , vol.21 , pp. 466-470
    • Li, Y.1    Jiang, R.2    Ooi, L.S.3    But, P.P.4    Ooi, V.E.5
  • 158
    • 59949096966 scopus 로고    scopus 로고
    • In vivo and in vitro antiviral activities of calycosin-7-O-beta-D-glucopyranoside against coxsackie virus B3
    • Zhu H, Zhang Y, Ye G, Li Z, Zhou P, Huang C. In vivo and in vitro antiviral activities of calycosin-7-O-beta-D-glucopyranoside against coxsackie virus B3. Biol Pharm Bull 2009;32:68-73.
    • (2009) Biol Pharm Bull , vol.32 , pp. 68-73
    • Zhu, H.1    Zhang, Y.2    Ye, G.3    Li, Z.4    Zhou, P.5    Huang, C.6
  • 159
    • 33745771941 scopus 로고    scopus 로고
    • Antiviral flavans from the leaves of Pithecellobium clypearia
    • Li Y, Leung KT, Yao F, Ooi LS, Ooi VE. Antiviral flavans from the leaves of Pithecellobium clypearia. J Nat Prod 2006;69:833-835.
    • (2006) J Nat Prod , vol.69 , pp. 833-835
    • Li, Y.1    Leung, K.T.2    Yao, F.3    Ooi, L.S.4    Ooi, V.E.5
  • 160
    • 33750690473 scopus 로고    scopus 로고
    • Antiviral activity of substituted homoisoflavonoids on enteroviruses
    • Tait S, Salvati AL, Desideri N, Fiore L. Antiviral activity of substituted homoisoflavonoids on enteroviruses. Antiviral Res 2006;72:252-255.
    • (2006) Antiviral Res , vol.72 , pp. 252-255
    • Tait, S.1    Salvati, A.L.2    Desideri, N.3    Fiore, L.4
  • 162
    • 84884979342 scopus 로고    scopus 로고
    • Anti-influenza virus activity by tricin, isolated from Sasa Albo-marginata in Japan
    • San Francisco, CA, April. Antiviral Res 2010; 86:A49, abstract no 108.
    • Yazawa K, Tsuchida Y, Yamada R, Sadanari H, Murayama T. Anti-influenza virus activity by tricin, isolated from Sasa Albo-marginata in Japan. The Twenty-Third International Conference on Antiviral Research, San Francisco, CA, 25-28 April 2010. Antiviral Res 2010; 86:A49, abstract no 108.
    • (2010) The Twenty-Third International Conference on Antiviral Research , pp. 25-28
    • Yazawa, K.1    Tsuchida, Y.2    Yamada, R.3    Sadanari, H.4    Murayama, T.5
  • 163
    • 79952272904 scopus 로고    scopus 로고
    • Increased bioavailability of tricin-amino acid derivatives via a prodrug approach
    • Ninomiya M, Tanaka K, Tsuchida Y, Muto Y, Koketsu M, Watanabe K. Increased bioavailability of tricin-amino acid derivatives via a prodrug approach. J Med Chem 2011;54:1529-1536.
    • (2011) J Med Chem , vol.54 , pp. 1529-1536
    • Ninomiya, M.1    Tanaka, K.2    Tsuchida, Y.3    Muto, Y.4    Koketsu, M.5    Watanabe, K.6
  • 164
    • 0022636766 scopus 로고
    • A specific inhibitor for tyrosine protein kinase from Pseudomonas
    • Ogawara H, Akiyama T, Ishida J, Watanabe S, Suzuki K. A specific inhibitor for tyrosine protein kinase from Pseudomonas. J Antibiot 1986;39:606-608.
    • (1986) J Antibiot , vol.39 , pp. 606-608
    • Ogawara, H.1    Akiyama, T.2    Ishida, J.3    Watanabe, S.4    Suzuki, K.5
  • 166
  • 167
    • 35648989045 scopus 로고    scopus 로고
    • Arenavirus entry occurs through a cholesterol-dependent, non-caveolar, clathrin-mediated endocytic mechanism
    • Vela EM, Zhang L, Colpitts TM, Davey RA, Aronson JF. Arenavirus entry occurs through a cholesterol-dependent, non-caveolar, clathrin-mediated endocytic mechanism. Virology 2007;369:1-11.
    • (2007) Virology , vol.369 , pp. 1-11
    • Vela, E.M.1    Zhang, L.2    Colpitts, T.M.3    Davey, R.A.4    Aronson, J.F.5
  • 168
    • 77955843694 scopus 로고    scopus 로고
    • Genistein, a general kinase inhibitor, as a potential antiviral for arenaviral hemorrhagic fever as described in the Pirital virus-Syrian golden hamster model
    • Vela EM, Knostman KA, Mott JM, Warren RL, Garver JN, Vela LJ, Stammen RL. Genistein, a general kinase inhibitor, as a potential antiviral for arenaviral hemorrhagic fever as described in the Pirital virus-Syrian golden hamster model. Antiviral Res 2010;87:318-328.
    • (2010) Antiviral Res , vol.87 , pp. 318-328
    • Vela, E.M.1    Knostman, K.A.2    Mott, J.M.3    Warren, R.L.4    Garver, J.N.5    Vela, L.J.6    Stammen, R.L.7
  • 169
    • 58149344941 scopus 로고    scopus 로고
    • Antiviral activity of raoulic acid from Raoulia australis against Picornaviruses
    • Choi HJ, Lim CH, Song JH, Baek SH, Kwon DH. Antiviral activity of raoulic acid from Raoulia australis against Picornaviruses. Phytomedicine 2009;16:35-39.
    • (2009) Phytomedicine , vol.16 , pp. 35-39
    • Choi, H.J.1    Lim, C.H.2    Song, J.H.3    Baek, S.H.4    Kwon, D.H.5
  • 170
    • 78650254596 scopus 로고    scopus 로고
    • Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid
    • Pollara JJ, Laster SM, Petty IT. Inhibition of poxvirus growth by Terameprocol, a methylated derivative of nordihydroguaiaretic acid. Antiviral Res 2010;88:287-295.
    • (2010) Antiviral Res , vol.88 , pp. 287-295
    • Pollara, J.J.1    Laster, S.M.2    Petty, I.T.3
  • 171
    • 78650244224 scopus 로고    scopus 로고
    • Nigericin is a potent inhibitor of the early stage of vaccinia virus replication
    • Myskiw C, Piper J, Huzarewich R, Booth TF, Cao J, He R. Nigericin is a potent inhibitor of the early stage of vaccinia virus replication. Antiviral Res 2010;88:304-310.
    • (2010) Antiviral Res , vol.88 , pp. 304-310
    • Myskiw, C.1    Piper, J.2    Huzarewich, R.3    Booth, T.F.4    Cao, J.5    He, R.6
  • 172
    • 0020621659 scopus 로고
    • Modulation of glycosylation and transport of viral membrane glycoproteins by a sodium ionophore
    • Alonso-Caplen FV, Compans RW. Modulation of glycosylation and transport of viral membrane glycoproteins by a sodium ionophore. J Cell Biol 1983;97:659-668.
    • (1983) J Cell Biol , vol.97 , pp. 659-668
    • Alonso-Caplen, F.V.1    Compans, R.W.2
  • 173
    • 0028874823 scopus 로고
    • Monensin and nigericin prevent the inhibition of host translation by poliovirus, without affecting p220 cleavage
    • Irurzun A, Sánchez-Palomino S, Novoa I, Carrasco L. Monensin and nigericin prevent the inhibition of host translation by poliovirus, without affecting p220 cleavage. J Virol 1995;69:7453-7460.
    • (1995) J Virol , vol.69 , pp. 7453-7460
    • Irurzun, A.1    Sánchez-Palomino, S.2    Novoa, I.3    Carrasco, L.4
  • 178
    • 0036462250 scopus 로고    scopus 로고
    • Antiviral activity of brassinosteroids derivatives against measles virus in cell cultures
    • Wachsman MB, Ramirez JA, Galagovsky LR, Coto CE. Antiviral activity of brassinosteroids derivatives against measles virus in cell cultures. Antivir Chem Chemother 2002;13:61-66.
    • (2002) Antivir Chem Chemother , vol.13 , pp. 61-66
    • Wachsman, M.B.1    Ramirez, J.A.2    Galagovsky, L.R.3    Coto, C.E.4
  • 179
    • 27644532739 scopus 로고    scopus 로고
    • Antiviral mode of action of a synthetic brassinosteroid against Junin virus replication
    • Castilla V, Larzábal M, Sgalippa NA, Wachsman MB, Coto CE. Antiviral mode of action of a synthetic brassinosteroid against Junin virus replication. Antiviral Res 2005;68:88-95.
    • (2005) Antiviral Res , vol.68 , pp. 88-95
    • Castilla, V.1    Larzábal, M.2    Sgalippa, N.A.3    Wachsman, M.B.4    Coto, C.E.5
  • 182
    • 80052782091 scopus 로고    scopus 로고
    • Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo
    • Droebner K, Pleschka S, Ludwig S, Planz O. Antiviral activity of the MEK-inhibitor U0126 against pandemic H1N1v and highly pathogenic avian influenza virus in vitro and in vivo. Antiviral Res 2011;92:195-203.
    • (2011) Antiviral Res , vol.92 , pp. 195-203
    • Droebner, K.1    Pleschka, S.2    Ludwig, S.3    Planz, O.4
  • 185
    • 80052696801 scopus 로고    scopus 로고
    • Inhibition of influenza virus-induced NF-kappaB and Raf-MEK-ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo
    • Pinto R, Herold S, Cakarova L, Hoegner K, Lohmeyer J, Planz O, Pleschka S. Inhibition of influenza virus-induced NF-kappaB and Raf-MEK-ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo. Antiviral Res 2011, 92:45-56.
    • (2011) Antiviral Res , vol.92 , pp. 45-56
    • Pinto, R.1    Herold, S.2    Cakarova, L.3    Hoegner, K.4    Lohmeyer, J.5    Planz, O.6    Pleschka, S.7
  • 187
    • 0035815684 scopus 로고    scopus 로고
    • Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway
    • Ludwig S, Ehrhardt C, Neumeier ER, Kracht M, Rapp UR, Pleschka S. Influenza virus-induced AP-1-dependent gene expression requires activation of the JNK signaling pathway. J Biol Chem 2001;276:10990-10998.
    • (2001) J Biol Chem , vol.276 , pp. 10990-10998
    • Ludwig, S.1    Ehrhardt, C.2    Neumeier, E.R.3    Kracht, M.4    Rapp, U.R.5    Pleschka, S.6
  • 188
    • 0034653508 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells
    • Kujime K, Hashimoto S, Gon Y, Shimizu K, Horie T. p38 mitogen-activated protein kinase and c-jun-NH2-terminal kinase regulate RANTES production by influenza virus-infected human bronchial epithelial cells. J Immunol 2000;164:3222-3228.
    • (2000) J Immunol , vol.164 , pp. 3222-3228
    • Kujime, K.1    Hashimoto, S.2    Gon, Y.3    Shimizu, K.4    Horie, T.5
  • 189
  • 191
    • 0034005659 scopus 로고    scopus 로고
    • Inhibition of CD3/CD28-mediated activation of the MEK/ERK signaling pathway represses replication of X4 but not R5 human immunodeficiency virus type 1 in peripheral blood CD4(+) T lymphocytes
    • Popik W, Pitha PM. Inhibition of CD3/CD28-mediated activation of the MEK/ERK signaling pathway represses replication of X4 but not R5 human immunodeficiency virus type 1 in peripheral blood CD4(+) T lymphocytes. J Virol 2000;74:2558-2566.
    • (2000) J Virol , vol.74 , pp. 2558-2566
    • Popik, W.1    Pitha, P.M.2
  • 193
    • 33846085104 scopus 로고    scopus 로고
    • Suppression of coronavirus replication by inhibition of the MEK signaling pathway
    • Cai Y, Liu Y, Zhang X. Suppression of coronavirus replication by inhibition of the MEK signaling pathway. J Virol 2007;81:446-456.
    • (2007) J Virol , vol.81 , pp. 446-456
    • Cai, Y.1    Liu, Y.2    Zhang, X.3
  • 194
    • 77952239377 scopus 로고    scopus 로고
    • Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2
    • Zhang H, Feng H, Luo L, Zhou Q, Luo Z, Peng Y. Distinct effects of knocking down MEK1 and MEK2 on replication of herpes simplex virus type 2. Virus Res 2010;150:22-27.
    • (2010) Virus Res , vol.150 , pp. 22-27
    • Zhang, H.1    Feng, H.2    Luo, L.3    Zhou, Q.4    Luo, Z.5    Peng, Y.6
  • 195
    • 0035027950 scopus 로고    scopus 로고
    • MEK-specific inhibitor U0126 blocks spread of Borna disease virus in cultured cells
    • Planz O, Pleschka S, Ludwig S. MEK-specific inhibitor U0126 blocks spread of Borna disease virus in cultured cells. J Virol 2001;75:4871-4877.
    • (2001) J Virol , vol.75 , pp. 4871-4877
    • Planz, O.1    Pleschka, S.2    Ludwig, S.3
  • 197
    • 0028884033 scopus 로고
    • PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
    • Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 1995;270:27489-27494.
    • (1995) J Biol Chem , vol.270 , pp. 27489-27494
    • Alessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4    Saltiel, A.R.5
  • 199
    • 0036140260 scopus 로고    scopus 로고
    • Visna virus-induced activation of MAPK is required for virus replication and correlates with virus-induced neuropathology
    • Barber SA, Bruett L, Douglass BR, Herbst DS, Zink MC, Clements JE. Visna virus-induced activation of MAPK is required for virus replication and correlates with virus-induced neuropathology. J Virol 2002;76:817-828.
    • (2002) J Virol , vol.76 , pp. 817-828
    • Barber, S.A.1    Bruett, L.2    Douglass, B.R.3    Herbst, D.S.4    Zink, M.C.5    Clements, J.E.6
  • 201
    • 52149090536 scopus 로고    scopus 로고
    • Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection
    • Soroceanu L, Akhavan A, Cobbs CS. Platelet-derived growth factor-alpha receptor activation is required for human cytomegalovirus infection. Nature 2008;455:391-395.
    • (2008) Nature , vol.455 , pp. 391-395
    • Soroceanu, L.1    Akhavan, A.2    Cobbs, C.S.3
  • 203
    • 0031707104 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection
    • Rodems SM, Spector DH. Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection. J Virol 1998;72:9173-9180.
    • (1998) J Virol , vol.72 , pp. 9173-9180
    • Rodems, S.M.1    Spector, D.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.