Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977

Journal of Biological Chemistry

Volumn 285, Issue 45, 2010, Pages 34337-34347

  Murakami, Eisuke ^a   Tolstykh, Tatiana ^a   Bao, Haiying ^a   Niu, Congrong ^a   Micolochick Steuer, Holly M ^a   Bao, Donghui ^a   Chang, Wonsuk ^a   Espiritu, Christine ^a   Bansal, Shalini ^a   Lam, Angela M ^a   Otto, Michael J ^a   Sofia, Michael J ^a   Furman, Phillip A ^a  

^a PHARMASSET INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID MOIETY; CARBOXYL GROUPS; CARBOXYLESTERASES; DIASTEREOISOMERS; DIPHOSPHATES; HCV RNA; HEPATITIS C VIRUS; HUMAN HEPATOCYTES; IN-VITRO; MONOPHOSPHATES; NUCLEOPHILIC ATTACK; NUCLEOSIDE-DIPHOSPHATE KINASE; NUCLEOTIDE-BINDING PROTEINS; PHOSPHORAMIDATES; PRODRUGS; RNA-DEPENDENT RNA POLYMERASE; STEREOSPECIFIC REACTION; TRIPHOSPHATE; WESTERN-BLOT ANALYSIS;

AMINO ACIDS; CLONING; ESTERS; HYDROLYSIS; ISOMERS; METABOLISM; METABOLITES; PHENOLS; PHOSPHORUS; PHOSPHORYLATION; RNA; VIRUSES;

CLONE CELLS;

2' DEOXY 2' ALPHA FLUORO BETA C METHYLURIDINE 5' MONOPHOSPHATE; CARBOXYLESTERASE; CARBOXYPEPTIDASE C; CYTIDINE PHOSPHATE; HISTIDINE NUCLEOTIDE BINDING PROTEIN 1; HISTIDINE NUCLEOTIDE BINDING PROTEIN 3; LEUKOCYTE ELASTASE; NONSTRUCTURAL PROTEIN 5B; NUCLEOSIDE DERIVATIVE; NUCLEOSIDE DIPHOSPHATE KINASE; NUCLEOTIDE BINDING PROTEIN; PHOSPHORAMIDIC ACID DERIVATIVE; PSI 352707; PSI 7409; PSI 7410; PSI 7411; PSI 7581; PSI 7851; PSI 7976; PSI 7977; RNA POLYMERASE; SMALL INTERFERING RNA; TELAPREVIR; UNCLASSIFIED DRUG; URIDINE PHOSPHATE;

ARTICLE; CATALYSIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME METABOLISM; FETUS; GENE SILENCING; HEPATITIS C; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HYDROLYSIS; LIVER CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPLICON; STEADY STATE; STEREOCHEMISTRY; WESTERN BLOTTING;

ANTIVIRAL AGENTS; CARBOXYLIC ESTER HYDROLASES; CATHEPSIN A; CELL LINE; HEPACIVIRUS; HEPATOCYTES; HUMANS; HYDROLYSIS; NUCLEOSIDE-PHOSPHATE KINASE; PRODRUGS; RNA, VIRAL; STEREOISOMERISM; URIDINE MONOPHOSPHATE; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 78049375232     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.161802     Document Type: Article

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