The mechanism of action of β-D-2′-deoxy-2′-fluoro- 2′-C-methylcytidine involves a second metabolic pathway leading to β-D-2′-deoxy-2′-fluoro-2′-C-methyluridine 5′-triphosphate, a potent inhibitor of the hepatitis C virus RNA-dependent RNA polymerase

Antimicrobial Agents and Chemotherapy

Volumn 52, Issue 2, 2008, Pages 458-464

  Murakami, Eisuke ^a   Niu, Congrong ^a   Bao, Haiying ^a   Micolochick Steuer, Holly M ^a   Whitaker, Tony ^a,b   Nachman, Tammy ^a   Sofia, Michael A ^a   Wang, Peiyuan ^a   Otto, Michael J ^a   Furman, Phillip A ^a  

^a PHARMASSET INC   (United States)

^b RFS Pharma LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEXTRO 2' DEOXY 2' FLUORO 2' C METHYLCYTIDINE; BETA DEXTRO 2' DEOXY 2' FLUORO 2' C METHYLURIDINE 5' TRIPHOSPHATE; CYTIDINE PHOSPHATE; NUCLEOTIDE DIPHOSPHATE KINASE; PHOSPHOTRANSFERASE; PSI 6130; PSI 6206; RNA DIRECTED DNA POLYMERASE INHIBITOR; RNA DIRECTED RNA POLYMERASE; RO 2433; UNCLASSIFIED DRUG; URIDINE; URIDINE PHOSPHATE; ZEBULARINE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG METABOLISM; DRUG POTENCY; HEPATITIS C VIRUS; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; REPLICON; RNA REPLICATION;

ANTIVIRAL AGENTS; CELL LINE; CYTIDINE; DEOXYCYTIDINE; HEPACIVIRUS; HUMANS; MICROBIAL SENSITIVITY TESTS; PHOSPHORYLATION; REPLICON; RNA REPLICASE; STRUCTURE-ACTIVITY RELATIONSHIP; URIDINE TRIPHOSPHATE;

EID: 38649112300     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.01184-07     Document Type: Article

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