Synthesis, metabolic stability and antiviral evaluation of various alkoxyalkyl esters of cidofovir and 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl] adenine

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 9, 2011, Pages 2950-2958

  Ruiz, Jacqueline ^a,b   Beadle, James R ^a,b   Mark Buller, R ^c   Schreiwer, Jill ^c   Prichard, Mark N ^d   Keith, Kathy A ^d   Lewis, Kenneth C ^e   Hostetler, Karl Y ^a,b  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d University of Alabama at Birmingham   (United States)

^e OpAns LLC   (United States)

Author keywords

Acyclic nucleoside phosphonates; Antiviral evaluation; Cidofovir; CMX001; Cowpox virus; Ectromelia virus; HDP CDV; HPMPA; Omega oxidation; Prodrugs; Vaccinia virus

Indexed keywords

1 O OCTADECYL 2 O BENZYL GLYCERO 3 CIDOFOVIR; 12 METHYL TRIDECYLMETHANESULFONATE; 12 METHYL TRIDECYLOXYPROPANOL; 12 METHYL TRIDECYLOXYPROPYL CYCLIC CIDOFOVIR; 13 METHYL TETRADECYLMETHANESULFONATE; 13 METHYL TETRADECYLOXYPROPANOL; 13 METHYL TETRADECYLOXYPROPYL CYCLIC CIDOFOVIR; 14 CYCLOPROPYL TETRADECYLOXYPROPYL CYCLIC CIDOFOVIR; 14 CYCLOPROPYLTETRADECYL BROMIDE; 14 CYCLOPROPYLTETRADECYLOXYPROPANOL; 14 METHYL PENTADECYLMETHANESULFONATE; 14 METHYL PENTADECYLOXYPROPANOL; 15 METHYL HEXADECYLMETHANESULFONATE; 15 METHYL HEXADECYLOXYETHANOL; 15 METHYL HEXADECYLOXYETHYL 9 (3 HYDROXY 2 PHOSPHONOMETHOXYPROPYL)ADENINE; 15 METHYL HEXADECYLOXYPROPANOL; 15 METHYL HEXADECYLOXYPROPYL 9 (3 HYDROXY 2 PHOSPHONOMETHOXYPROPYL)ADENINE; 15 METHYL HEXADECYLOXYPROPYL CYCLIC CIDOFOVIR; 9 (3 HYDROXY 2 PHOSPHONOMETHOXYPROPYL)ADENINE; CIDOFOVIR; CIDOFOVIR 3 HEXADECYLOXYPROPYL ESTER; HEXADECENYLOXYETHYL 9 (3 HYDROXY 2 PHOSPHONOMETHOXYPROPYL)ADENINE; HEXADECYLOXYPROPYL 9 (3 HYDROXY 2 PHOSPHONOMETHOXYPROPYL)ADENINE; OMEGA HEXADECENYLOXYETHANOL; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; COWPOX VIRUS; DRUG CYTOTOXICITY; DRUG OXIDATION; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ECTROMELIA VIRUS; ESTERIFICATION; HUMAN; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS; VACCINIA VIRUS;

ADENINE; ANIMALS; ANTIVIRAL AGENTS; COWPOX VIRUS; CYTOSINE; ECTROMELIA VIRUS; ESTERS; GUINEA PIGS; HAPLORHINI; HUMANS; LIVER; PHOSPHONIC ACIDS; RATS; VACCINIA VIRUS;

ADENOVIRIDAE; CAVIA; COWPOX VIRUS; CYTOMEGALOVIRUS; DNA VIRUSES; ECTROMELIA VIRUS; POXVIRIDAE; RATTUS; SIMPLEXVIRUS; VACCINIA VIRUS; VARIOLA;

EID: 79955484869     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.03.034     Document Type: Article

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