Metabolic pathways of N-methanocarbathymidine, a novel antiviral agent, in native and herpes simplex virus type 1 infected Vero cells

Antiviral Research

Volumn 55, Issue 1, 2002, Pages 63-75

  Zalah, Livnat ^a   Huleihel, Mahmoud ^a   Manor, Esther ^a   Konson, Alexander ^a   Ford Jr , Harry ^b   Marquez, Victor E ^b   Johns, David G ^b   Agbaria, Riad ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Ganciclovir; Herpes simplex thymidine kinase; Herpes simplex virus; N Methanocarbathymidine; Phosphorylation; Plaque forming unit

Indexed keywords

ANTIVIRUS AGENT; DRUG METABOLITE; GANCICLOVIR; N METHANOCARBATHYMIDINE; THYMIDINE DERIVATIVE; UNCLASSIFIED DRUG; DRUG DERIVATIVE; N-METHANOCARBATHYMIDINE; POLYPHOSPHATE; THYMIDINE; TRIPHOSPHORIC ACID;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; CELL METABOLISM; CERCOPITHECIDAE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENCY; HERPES SIMPLEX VIRUS 1; NONHUMAN; PRIORITY JOURNAL; VERO CELL; VIRUS INHIBITION; VIRUS PLAQUE; WILD TYPE; ANIMAL; CERCOPITHECUS; COMPARATIVE STUDY; CYTOPATHOGENIC EFFECT; DRUG EFFECT; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

ANIMAL; ANTIVIRAL AGENTS; CERCOPITHECUS AETHIOPS; COMPARATIVE STUDY; CYTOPATHOGENIC EFFECT, VIRAL; GANCICLOVIR; HERPESVIRUS 1, HUMAN; PHOSPHORYLATION; POLYPHOSPHATES; THYMIDINE; VERO CELLS; ANIMALS;

HERPESVIRIDAE; HUMAN HERPESVIRUS 1; SIMPLEXVIRUS;

EID: 0035997929     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(02)00010-4     Document Type: Article

References (36)

1. Effects of IMP dehydrogenase inhibitors on the phosphorylation of ganciclovir in MOLT-4 cells before and after herpes simplex virus thymidine kinase gene transduction
2. Comparative cytostatic activity of different antiherpetic drugs against herpes simplex virus thymidine kinase gene-transfected tumor cells
3. Thymidylate synthase is the principal target enzyme for the cytostatic activity of (E)-5-(2-bromovinyl)-2′-deoxyuridine against murine mammary carcinoma (FM3A) cells transformed with the herpes simplex virus type 1 or type 2 thymidine kinase gene
4. In vitro evidence that metabolic cooperation is responsible for the bystander effect observed with HSV tk retroviral gene therapy
5. Phosphorylation of the antiviral precursor 9-(1,3-dihydroxy-2-propoxymethyl)guanine monophosphate by guanylate kinase isozymes
6. Kinetic studies of herpes simplex virus type 1-encoded thymidine and thymidylate kinase, a multifunctional enzyme
7. Metabolism of 9-(1,3-dihydroxy-2-propoxymethyl)guanine, a new anti-herpes virus compound, in herpes simplex virus-infected cells
8. Comparative efficacy of antiherpes drugs against different strains of herpes simplex virus
9. Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. Effects on primer-template function
10. Selectivity of action of an antiherpetic agent, 9-(2-hydroxyethoxymethyl)guanine
11. 9-([2-Hydroxy-1-hydroxymethyl)ethoxy]methyl)guanine: A selective inhibitor of herpes group virus replication
12. Cellular pharmacology of cyclopentenyl cytosine in Molt-4 lymphoblasts
13. Interaction of herpes simplex virus-induced DNA polymerase with 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate
14. Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine
15. Viral thymidine kinases and their relatives
16. A comparison of the antiviral agents 2′-nor-2′-deoxyguanosine and acyclovir: Uptake and phosphorylation in tissue culture and kinetics of in vitro inhibition of viral and cellular DNA polymerases by their respective triphosphates
17. Intracellular accumulation of subgenomic noninfectious human cytomegalovirus DNA in infected cells in the presence of ganciclovir
18. Comparative in vivo genotoxicity of antiviral nucleoside analogues; Penciclovir, acyclovir, ganciclovir and xanthine analogue, caffeine, in mouse bone marrow micronucleus assay
19. Synthesis and antiviral activity of the carbocyclic analogues of (E)-5-(2-halovinyl)-2′-deoxyuridines and (E)-5-(2-halovinyl)-2′-deoxycytidines
20. Antiviral effect of red microalgal polysaccharides on Herpes simplex and Varicella zoster viruses
21. Acyclic guanosine analogs inhibit DNA polymerase α, β, and ε with very different potencies and have unique mechanism of action
22. Mechanism of 'bystander effect' killing in the herpes simples thymidine kinase gene therapy model of cancer treatment
23. Enzymatic phosphorylation of acyclic nucleoside analogs and correlation with antiherpetic activities
24. Nucleosides with a twist. Can fixed forms of sugar ring pucker influence biological activity in nucleosides and oligonucleotides?
25. The design, synthesis and properties of highly potent and selective inhibitors of herpes simplex virus types 1 and 2 thymidine kinase
26. Phosphorylation of acyclovir diphosphate by GMP kinase
27. Kinetic and crystal structure of the wild-type and engineered Y101F mutant of the herpes simplex virus type 1 thymidine kinase interacting with (North)-methanocarba-thymidine
28. Herpes simplex virus type 1 DNA polymerase inhibition by acyclovir triphosphate
29. Insertion and extension of acyclic, dideoxy, and ara nucleotides by herpesviridae, human alpha and human beta polymerases. A unique inhibition mechanism for 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate
30. Anti-herpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine
31. Antiviral therapy of herpes simplex
32. Inhibition by ganciclovir of cell growth and DNA synthesis of cells biochemically transformed with herpesvirus genetic information
33. Cytogenetic genotoxicity of the antiherpes virostatics in Chinese hamster V79-E cells. I. Purine nucleoside analogues
34. Inhibition of virus-encoded thymidine kinase suppresses herpes simplex virus replication in vitro and in vivo