The thiazolobenzimidazole TBZE-029 inhibits enterovirus replication by targeting a short region immediately downstream from motif C in the nonstructural protein 2C

Journal of Virology

Volumn 82, Issue 10, 2008, Pages 4720-4730

  De Palma, Armando M ^a   Heggermont, Ward ^a   Lanke, Kjerstin ^b   Coutard, Bruno ^c   Bergmann, Mirko ^f   Monforte, Anna Maria ^d   Canard, Bruno ^c   De Clercq, Erik ^a   Chimirri, Alba ^d   Pürstinger, Gerhard ^e   Rohayem, Jacques ^f   Van Kuppeveld, Frank ^b   Neyts, Johan ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c Centre National de la Recherche Scientifique   (France)

^d UNIVERSITY OF MESSINA   (Italy)

^e UNIVERSITY OF INNSBRUCK   (Austria)

^f The Calicilab   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; AMINO ACID; BENZIMIDAZOLE DERIVATIVE; GUANIDINE; HELICASE; NONSTRUCTURAL PROTEIN 2; NONSTRUCTURAL PROTEIN 2C; TBZE 029; 1 (2',6' DIFLUOROPHENYL) 1H,3H THIAZOLO(3,4 A)BENZIMIDAZOLE; 1-(2',6'-DIFLUOROPHENYL)-1H,3H-THIAZOLO(3,4-A)BENZIMIDAZOLE; 2C PROTEIN, VIRAL; ANTIVIRUS AGENT; CARRIER PROTEIN; HBBPC; MRL 1237; PYRIDINE DERIVATIVE; THIAZOLE DERIVATIVE; VIRUS PROTEIN; VIRUS RNA;

ANIMAL CELL; ARTICLE; CLONE; CONTROLLED STUDY; COXSACKIE VIRUS B3; DRUG INHIBITION; ENTEROVIRUS; ENZYME ACTIVITY; GENOTYPE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; VIRUS REPLICATION; AMINO ACID SUBSTITUTION; ANIMAL; ANTIVIRAL RESISTANCE; BIOSYNTHESIS; CERCOPITHECUS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; MISSENSE MUTATION; VERO CELL;

COXSACKIEVIRUS; ENTEROVIRUS;

ADENOSINE TRIPHOSPHATASES; AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; ANTIVIRAL AGENTS; BENZIMIDAZOLES; CARRIER PROTEINS; CERCOPITHECUS AETHIOPS; DRUG RESISTANCE, VIRAL; ENTEROVIRUS B, HUMAN; GUANIDINE; MOLECULAR STRUCTURE; MUTATION, MISSENSE; PYRIDINES; RNA, VIRAL; THIAZOLES; VERO CELLS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

EID: 43249108208     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01338-07     Document Type: Article

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