Experimental and Structural Evidence that Herpes 1 Kinase and Cellular DNA Polymerase(s) Discriminate on the Basis of Sugar Pucker

Journal of the American Chemical Society

Volumn 126, Issue 2, 2004, Pages 543-549

  Marquez, Victor E ^a   Ben Kasus, Tsipi ^b   Barchi Jr , Joseph J ^a   Green, Karen M ^a   Nicklaus, Marc C ^a   Agbaria, Riad ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CONFORMATIONS; DNA; ISOMERS; MOLECULAR STRUCTURE; SUGARS; TUMORS; VIRUSES;

CONFORMERS;

ENZYMES;

ANTIVIRUS AGENT; DNA POLYMERASE; METHANOCARBATHYMIDINE; METHANOL DERIVATIVE; PHOSPHOTRANSFERASE; SUGAR; THYMIDINE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANIMAL CELL; ARTICLE; CONFORMATION; CONTROLLED STUDY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GENETIC TRANSFECTION; HERPES SIMPLEX VIRUS 1; ISOMER; NONHUMAN; SOLID; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; DNA; DNA-DIRECTED DNA POLYMERASE; HERPESVIRUS 1, HUMAN; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THYMIDINE; THYMIDINE KINASE; TRANSFECTION; VERO CELLS;

EID: 0346456880     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja037929e     Document Type: Article

References (34)

1. Altona, C.; Sundaralingam, M. J. Am. Chem. Soc. 1972, 94, 8205-8212.
2. de Leeuw, H. P. M.; Haasnoot, C. A. G.; Altona, C. Isr. J. Chem. 1980. 20, 108-126.
3. Saenger, W. Principles in Nucleic Acid Structure; Springer-Verlag: New York, Berlin, Heilderberg, 1984. Chapter 9.
4. Neidle, S. Nucleic Acid Structure and Recognition; Oxford University Press: 2002. Chapter 5.
5. ref 3, Chapter 4.
6. Jayaram, B.; Sprous, D.; Young, M. A.; Beveridge, D. L. J. Am. Chem. Soc. 1998, 120, 10 629-10 633.
7. Rodriguez, J. B.; Marquez, V. E.; Nicklaus, M. C.; Barchi, Jr., J. J. Tetrahedron Lett. 1993, 34, 6233-6236.
8. Rodriguez, J. B.; Marquez, V. E.; Nicklaus, M. C.; Mitsuya, H.; Barchi Jr., J. J. J. Med. Chem. 1994, 37, 3389-3399.
9. Marquez, V. E.; Siddiqui, M. A.; Ezzitouni, A.; Russ, P.; Wang, J. Y.; Wagner, R. W.; Matteucci, M. D. J. Med. Chem. 1996, 39, 3739-3747.
10. Siddiqui, M. A.; Ford, Jr. H.; George, C.; Marquez, V. E. Nucleosides Nucleotides 1996, 15, 235-250.
11. Ezzitouni, A.; Barchi Jr., J. J.; Marquez, V. E. J. Chem. Soc., Chem. Commun. 1995, 1345-1346.
12. Ezzitouni, A.; Marquez, V. E. J. Chem. Soc., Perkin Trans 1 1997, 1073-1078.
13. Marquez, V. E.; Russ, P.; Alonso, R.; Siddiqui, M. A.; Hernandez, S.; George, C.; Nicklaus, M. C.; Dai, F.; Ford, Jr., H. Helv. Chim. Acta 1999, 82, 2119-2129.
14. Shin, K. J.; Moon, H. R.; George, C.; Marquez, V. E. J. Org. Chem. 2000, 65. 2172-2178.
15. Marquez, V. E.; Ezzitouni, A.; Russ, P.; Siddiqui, M. A.; Ford Jr., H.; Feldman, R. J.; Mitsuya, H.; George, C.; Barchi Jr., J. J. J. Am. Chem. Soc. 1998, 120, 2780-2789.
16. Wang, P.; Bransk, A. S.; Banavali, N. K.; Nicklaus, M. C.; Marquez, V. E.; Christman, J. K.; MacKerell, A. D. J. Am. Chem. Soc. 2000, 122, 12 422-12 434.
17. Jacobson, K. A.; Ji, X. D.; Li, A.; Melman, N.; Siddiqui, M. A.; Shin, K. J.; Marquez, V. E.; Ravi, R. G. J. Med. Chem. 2000, 43, 2196-2203.
18. Lee, K.; Ravi, R.; Ji, X. D.; Marquez, V. E. Bioorg. Med. Chem. Lett. 2001, 11, 1333-1337.
19. Ravi, G.; Lee, K.; Ji, X. D.; Kim, H. S.; Soltysiak, K. A.; Marquez, V. E.; Jacobson, K. A. Bioorg. Med. Chem. Lett. 2001, 11, 2295-2300.
20. Kim, H. S.; Ravi, R. G.; Marquez, V. E.; Maddileti, S.; Whilborg, A.-K.; Erlinge, D.; Malsmjo, M.; Boyer, J. L.; Harden, T. K.; Jacobson, K. A. J. Med. Chem. 2002, 45, 208-218.
21. Zalah, L.; Huleihel, M.; Manor, E.; Konson, A.; Ford Jr., H.; Marquez, V. E.; Johns, D. G.; Agbaria R. Antiviral Res. 2002, 55, 63-75.
22. ref 3, Chapter 2.
23. Altmann, K. H.; Kesselring, R.; Francotte, E.; Rihs, G. Tetrahedron Lett. 1994, 35, 2331-2334.
24. Altmann, K. H.; Imwinkelried, R.; Kesselring, R.; Rihs, G. Tetrahedron Lett. 1994, 35, 7625-7628.
25. Marquez, V. E.; Russ, P.; Alonso, R.; Siddiqui, M. A.; Shin, K. J.; George, C.; Nicklaus, M. C.; Dai, F.; Ford Jr., H. Nucleosides Nucleotides 1999, 18, 521-530.
26. Noy, R.; Ben-Zvi, Z.; Elezra, M.; Candoti, F.; Ford Jr., H.; Morris, J. C.; Marquez, V. E.; Johns, D. G.; Agbaria, R. Mol. Cancer Chemother. 2002, 1, 585-593.
27. Young, D. W.; Tollin, P.; Wilson, H. R. Acta Crystallogr., Sect. B, 1969, 25, 1423-1432.
28. Wild, K.; Bohner, T.; Folkers, G.; Schulz, G. E. Protein Sci. 1997, 6, 2097-2106.
29. Champness, J. N.; Bennett, M. S.; Wien, F.; Visse, R.; Summers, W. C.; Herdewijn, P.; De Clercq, E.; Ostrowski, T.; Jarvest, R. L.; Sanderson, M. R. Proteins 1998, 32, 350-361.
30. Prota, A.; Vogt, J.; Pilger, B.; Perozzo, R.; Wurth, C.; Marquez, V. E.; Russ, P.; Schultz, G. E.; Folkers, G.; Scapozza, L. Biochemistry 2000, 39, 9597-9603.
31. Timsit, Y. J. Biomol. Struct. Dvn. 2000, 169-176, Sp. Iss. SI.
32. Timsit, Y. J. Mol. Biol. 1999, 293, 835-853.
33. Mayer, C.; Timsit, Y. Cell Mol. Biol. 2001, 47, 815-522.
34. Stott, K.; Keeler, J.; Van, K.; Keelei, J.; Vziii, Q. N.; Shaka, A. J. J. Magn. Res. 1997, 125, 302-324.