A specific interaction of small molecule entry inhibitors with the envelope glycoprotein complex of the Junín hemorrhagic fever arenavirus

Journal of Biological Chemistry

Volumn 286, Issue 8, 2011, Pages 6192-6200

  Thomas, Celestine J ^a   Casquilho Gray, Hedi E ^a   York, Joanne ^a   DeCamp, Dianne L ^a   Dai, Dongcheng ^b   Petrilli, Erin B ^c   Boger, Dale L ^d   Slayden, Richard A ^c   Amberg, Sean M ^b   Sprang, Stephen R ^a   Nunberg, Jack H ^a  

^a UNIVERSITY OF MONTANA   (United States)

^b SIGA Technologies Incorporated   (United States)

^c Veterinary Dentistry and Oral Surgery   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; BINDING POCKETS; BIODEFENSE; CELL SURFACE RECEPTORS; COMPETITIVE BINDING; DISSOCIATION CONSTANT; ENDOSOMES; ENVELOPE GLYCOPROTEINS; GENETIC STUDIES; MEMBRANE FUSION; NATIVE PROTEINS; OLD WORLDS; PUBLIC HEALTH; SIGNAL PEPTIDE; SMALL MOLECULES; SPECIFIC INTERACTION; TRANSFERRIN RECEPTORS; TRANSMEMBRANES;

CELL MEMBRANES; DISSOCIATION; GLYCOPROTEINS; HEALTH RISKS; LIPID BILAYERS; OLIGOMERS;

MOLECULES;

ANTIVIRUS AGENT; CD71 ANTIGEN; PIBENZIMOL; PROTEIN GPC; ST 161; ST 193; ST 294; ST 545; ST 761; TOLONIDINE; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG PROTEIN BINDING; JUNIN VIRUS; LIPID BILAYER; MEMBRANE FUSION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; SPECIES DIFFERENCE;

ANIMALS; ANTIGENS, CD; ANTIVIRAL AGENTS; ARENAVIRIDAE INFECTIONS; CERCOPITHECUS AETHIOPS; HUMANS; JUNIN VIRUS; RECEPTORS, TRANSFERRIN; VERO CELLS; VIRAL ENVELOPE PROTEINS; VIRUS INTERNALIZATION;

ANIMALIA; ARENAVIRUS; JUNIN VIRUS; OLD WORLD ARENAVIRUSES;

EID: 79953212241     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.196428     Document Type: Article

References (52)

1. Buchmeier, M. J., de la Torre, J. C., and Peters, C. J. (2007) in Fields Virology (Knipe, D. M., and Howley, P. M., eds) 5th Ed., pp. 1791-1828, Lippincott Williams & Wilkins, Philadelphia
2. Peters, C. J. (2002) Curr. Top. Microbiol. Immunol. 262, 65-74
3. Delgado, S., Erickson, B. R., Agudo, R., Blair, P. J., Vallejo, E., Albariño, C. G., Vargas, J., Comer, J. A., Rollin, P. E., Ksiazek, T. G., Olson, J. G., and Nichol, S. T. (2008) PLoS Pathog. 4, e1000047
4. McCormick, J. B., Webb, P. A., Krebs, J. W., Johnson, K. M., and Smith, E. S. (1987) J. Infect. Dis. 155, 437-444
5. Haas, W. H., Breuer, T., Pfaff, G., Schmitz, H., Köhler, P., Asper, M., Emmerich, P., Drosten, C., Gölnitz, U., Fleischer, K., and Günther, S. (2003) Clin. Infect. Dis. 36, 1254-1258
6. Amorosa, V., MacNeil, A., McConnell, R., Patel, A., Dillon, K. E., Hamilton, K., Erickson, B. R., Campbell, S., Knust, B., Cannon, D., Miller, D., Manning, C., Rollin, P. E., and Nichol, S. T. (2010) Emerg. Infect. Dis. 16, 1598-1600
7. Palacios, G., Savji, N., Hui, J., Travassos da Rosa, A., Popov, V., Briese, T., Tesh, R., and Lipkin, W. I. (2010) J. Gen. Virol. 91, 1315-1324
8. Department of Health and Human Services (2007) Federal Register 72, 20117-20128
9. NIAID (2011) NIAID Category A, B, and C Priority Pathogens, http://www.niaid.nih.gov/topics/BiodefenseRelated/Biodefense/research/Pages/ CatA.aspx
10. Eschli, B., Quirin, K., Wepf, A., Weber, J., Zinkernagel, R., and Hengartner, H. (2006) J. Virol. 80, 5897-5907
11. York, J., Berry, J. D., Ströher, U., Li, Q., Feldmann, H., Lu, M., Trahey, M., and Nunberg, J. H. (2010) J. Virol. 84, 6119-6129
12. York, J., Romanowski, V., Lu, M., and Nunberg, J. H. (2004) J. Virol. 78, 10783-10792
13. York, J., and Nunberg, J. H. (2006) J. Virol. 80, 7775-7780
14. Bolken, T. C., Laquerre, S., Zhang, Y., Bailey, T. R., Pevear, D. C., Kickner, S. S., Sperzel, L. E., Jones, K. F., Warren, T. K., Amanda Lund, S., Kirkwood-Watts, D. L., King, D. S., Shurtleff, A. C., Guttieri, M. C., Deng, Y., Bleam, M., and Hruby, D. E. (2006) Antiviral Res. 69, 86-97
15. Lee, A. M., Rojek, J. M., Spiropoulou, C. F., Gundersen, A. T., Jin, W., Shaginian, A., York, J., Nunberg, J. H., Boger, D. L., Oldstone, M. B., and Kunz, S. (2008) J. Biol. Chem. 283, 18734-18742
16. Larson, R. A., Dai, D., Hosack, V. T., Tan, Y., Bolken, T. C., Hruby, D. E., and Amberg, S. M. (2008) J. Virol. 82, 10768-10775
17. York, J., Dai, D., Amberg, S. M., and Nunberg, J. H. (2008) J. Virol. 82, 10932-10939
18. Sanchez, A., Pifat, D. Y., Kenyon, R. H., Peters, C. J., McCormick, J. B., and Kiley, M. P. (1989) J. Gen. Virol. 70, 1125-1132
19. York, J., and Nunberg, J. H. (2009) J. Virol. 83, 4121-4126
20. Eichler, R., Lenz, O., Strecker, T., Eickmann, M., Klenk, H. D., and Garten, W. (2003) EMBO Rep. 4, 1084-1088
21. Agnihothram, S. S., York, J., and Nunberg, J. H. (2006) J. Virol. 80, 5189-5198
22. Lenz, O., ter Meulen, J., Klenk, H. D., Seidah, N. G., and Garten, W. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 12701-12705
23. Beyer, W. R., Pöpplau, D., Garten, W., von Laer, D., and Lenz, O. (2003) J. Virol. 77, 2866-2872
24. Rojek, J. M., Lee, A. M., Nguyen, N., Spiropoulou, C. F., and Kunz, S. (2008) J. Virol. 82, 6045-6051
25. Beyer, W. R., Miletic, H., Ostertag, W., and von Laer, D. (2001) J. Virol. 75, 1061-1064
26. Capul, A. A., Perez, M., Burke, E., Kunz, S., Buchmeier, M. J., and de la Torre, J. C. (2007) J. Virol. 81, 9451-9460
27. Briknarová, K., Thomas, C. J., York, J., and Nunberg, J. H. (2010) J. Biol. Chem. 286, 1528-1536
28. Stenlund, P., Babcock, G. J., Sodroski, J., and Myszka, D. G. (2003) Anal. Biochem. 316, 243-250
29. Fuerst, T. R., Niles, E. G., Studier, F. W., and Moss, B. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 8122-8126
30. Nussbaum, O., Broder, C. C., and Berger, E. A. (1994) J. Virol. 68, 5411-5422
31. Matsuura, Y., Possee, R. D., Overton, H. A., and Bishop, D. H. (1987) J. Gen. Virol. 68, 1233-1250
32. Froeschke, M., Basler, M., Groettrup, M., and Dobberstein, B. (2003) J. Biol. Chem. 278, 41914-41920
33. York, J., Agnihothram, S. S., Romanowski, V., and Nunberg, J. H. (2005) Virology 343, 267-274
34. Earl, P. L., Doms, R. W., and Moss, B. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 648-652
35. Skehel, J. J., and Wiley, D. C. (2000) Annu. Rev. Biochem. 69, 531-569
36. White, J. M., Delos, S. E., Brecher, M., and Schornberg, K. (2008) Crit. Rev. Biochem. Mol. Biol. 43, 189-219
37. Harrison, S. C. (2008) Nat. Struct. Mol. Biol. 15, 690-698
38. Radoshitzky, S. R., Kuhn, J. H., Spiropoulou, C. F., Albariño, C. G., Nguyen, D. P., Salazar-Bravo, J., Dorfman, T., Lee, A. S., Wang, E., Ross, S. R., Choe, H., and Farzan, M. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 2664-2669
39. Agnihothram, S. S., York, J., Trahey, M., and Nunberg, J. H. (2007) J. Virol. 81, 4331-4337
40. Abraham, J., Corbett, K. D., Farzan, M., Choe, H., and Harrison, S. C. (2010) Nat. Struct. Mol. Biol. 17, 438-444
41. Chen, J., Lee, K. H., Steinhauer, D. A., Stevens, D. J., Skehel, J. J., and Wiley, D. C. (1998) Cell 95, 409-417
42. Thomas, C. J., Gangadhar, B. P., Namitha, S., and Surolia, A. (1998) J. Am. Chem. Soc. 120, 12428-12434
43. Pantophlet, R., and Burton, D. R. (2006) Annu. Rev. Immunol. 24, 739-769
44. Thoennes, S., Li, Z. N., Lee, B. J., Langley, W. A., Skehel, J. J., Russell, R. J., and Steinhauer, D. A. (2008) Virology 370, 403-414
45. Reed, M. L., Yen, H. L., DuBois, R. M., Bridges, O. A., Salomon, R., Webster, R. G., and Russell, C. J. (2009) J. Virol. 83, 3568-3580
46. Hoffman, L. R., Kuntz, I. D., and White, J. M. (1997) J. Virol. 71, 8808-8820
47. Russell, R. J., Kerry, P. S., Stevens, D. J., Steinhauer, D. A., Martin, S. R., Gamblin, S. J., and Skehel, J. J. (2008) Proc. Natl. Acad. Sci. U.S.A. 105, 17736-17741
48. Vanderlinden, E., Göktas, F., Cesur, Z., Froeyen, M., Reed, M. L., Russell, C. J., Cesur, N., and Naesens, L. (2010) J. Virol. 84, 4277-4288
49. Esnouf, R., Ren, J., Ross, C., Jones, Y., Stammers, D., and Stuart, D. (1995) Nat. Struct. Biol. 2, 303-308
50. De Clercq, E. (2004) Chem. Biodivers. 1, 44-64
51. Jorgensen, W. L., Ruiz-Caro, J., Tirado-Rives, J., Basavapathruni, A., Anderson, K. S., and Hamilton, A. D. (2006) Bioorg. Med. Chem. Lett. 16, 663-667
52. Martin, Y. C. (1998) in Designing Bioactive Molecules, Three-dimensional Techniques and Applications (Martin, Y. C., and Willett, A., eds) pp. 121-148, American Chemical Society, Washington, D.C.