Inhibition of influenza virus-induced NF-kappaB and Raf/MEK/ERK activation can reduce both virus titers and cytokine expression simultaneously in vitro and in vivo

Antiviral Research

Volumn 92, Issue 1, 2011, Pages 45-56

  Pinto, Ruth ^a,c   Herold, Susanne ^a   Cakarova, Lidija ^a   Hoegner, Katrin ^a   Lohmeyer, Jürgen ^a   Planz, Oliver ^b   Pleschka, Stephan ^a  

^a JUSTUS LIEBIG UNIVERSITY   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c POLYTECHNIC INSTITUTE OF SANTARÉM   (Portugal)

Author keywords

Cytokines; IKK inhibition; Influenza virus; MEK inhibition; NF kappaB; Signal transduction

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; RAF PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ENZYME ACTIVATION; IN VITRO STUDY; IN VIVO STUDY; INFLUENZA VIRUS; LUNG ALVEOLUS EPITHELIUM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; VIRUS INHIBITION; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; CYTOKINES; DOWN-REGULATION; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; INFLUENZA, HUMAN; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-KAPPA B; NITRILES; ORTHOMYXOVIRIDAE; PROTO-ONCOGENE PROTEINS C-RAF; SULFONES; VIRAL LOAD; VIRUS REPLICATION;

MUS; ORTHOMYXOVIRIDAE;

EID: 80052696801     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2011.05.009     Document Type: Article

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