An efficient and diastereoselective synthesis of PSI-6130: A clinically efficacious inhibitor of HCV NS5B polymerase

Journal of Organic Chemistry

Volumn 74, Issue 17, 2009, Pages 6819-6824

  Wang, Peiyuan ^a   Chun, Byoung Kwon ^a   Rachakonda, Suguna ^a   Du, Jinfa ^a   Khan, Noshena ^a   Shi, Junxing ^b   Stec, Wojciech ^c   Cleary, Darryl ^a   Ross, Bruce S ^a   Sofia, Michael J ^a  

^a PHARMASSET INC   (United States)

^b RFS Pharma LLC   (United States)

^c POLISH ACADEMY OF SCIENCES   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL EQUATIONS; CHIRAL REAGENT; CHROMATOGRAPHIC PURIFICATION; CLINICAL DEVELOPMENT; CLINICAL TRIAL; CYCLIC SULFATES; DIASTEREOSELECTIVE; DIASTEREOSELECTIVE SYNTHESIS; NUCLEOPHILIC SUBSTITUTIONS; PRODRUGS; SCALABLE SYNTHESIS; SELECTIVE INHIBITORS; STEREOCENTERS; STEREOSELECTIVE MANNER; SYNTHETIC ROUTES;

BEAM PLASMA INTERACTIONS; CHEMICAL REACTIONS; FLUORINE;

STEREOSELECTIVITY;

FLUORINE; PRODRUG; PSI 6130; R 7128; TEZACITABINE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CHROMATOGRAPHY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATITIS C; STEREOCHEMISTRY;

ANTIVIRAL AGENTS; CARBON; CHEMISTRY, ORGANIC; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY; DEOXYCYTIDINE; DRUG DESIGN; FLUORINE; GLYCERALDEHYDE; GLYCOSYLATION; LACTONES; MODELS, CHEMICAL; PHOSPHORANES; STEREOISOMERISM; VIRAL NONSTRUCTURAL PROTEINS;

EID: 69549122650     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo901345j     Document Type: Article

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