-
1
-
-
84856739946
-
Hypoxia-inducible factors in physiology and medicine
-
Semenza, G. L. 2012. Hypoxia-inducible factors in physiology and medicine Cell 148:399.
-
(2012)
Cell
, vol.148
, pp. 399
-
-
Semenza, G.L.1
-
2
-
-
77953268611
-
Alternative activation of macrophages: mechanism and functions
-
Gordon, S. and Martinez, F. O. 2010. Alternative activation of macrophages: mechanism and functions. Immunity 32:593.
-
(2010)
Immunity
, vol.32
, pp. 593
-
-
Gordon, S.1
Martinez, F.O.2
-
3
-
-
84857883847
-
Macrophage plasticity and polarization: in vivo veritas
-
Sica, A. and Mantovani, A. 2012. Macrophage plasticity and polarization: in vivo veritas. J. Clin. Invest. 122:787.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 787
-
-
Sica, A.1
Mantovani, A.2
-
4
-
-
79959963922
-
Hypoxia: a doubleedged sword of immunity
-
Sica, A., Melillo, G. and Varesio, L. 2011. Hypoxia: a doubleedged sword of immunity. J. Mol. Med. 89:657.
-
(2011)
J. Mol. Med.
, vol.89
, pp. 657
-
-
Sica, A.1
Melillo, G.2
Varesio, L.3
-
5
-
-
84855614902
-
Macrophages, metainflammation, and immuno-metabolism
-
Shapiro, H., Lutaty, A. and Ariel, A. 2011. Macrophages, metainflammation, and immuno-metabolism. Scientific World Journal. 11:2509.
-
(2011)
Scientific World Journal
, vol.11
, pp. 2509
-
-
Shapiro, H.1
Lutaty, A.2
Ariel, A.3
-
6
-
-
77950944395
-
Macrophages, innate immunity and cancer: balance, tolerance, and diversity
-
Mantovani, A. and Sica, A. 2010. Macrophages, innate immunity and cancer: balance, tolerance, and diversity. Curr. Opin. Immunol. 22:231.
-
(2010)
Curr. Opin. Immunol.
, vol.22
, pp. 231
-
-
Mantovani, A.1
Sica, A.2
-
7
-
-
0036187615
-
The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies
-
Bingle, L., Brown, N. J. and Lewis, C. E. 2002. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol. 196:254.
-
(2002)
J. Pathol.
, vol.196
, pp. 254
-
-
Bingle, L.1
Brown, N.J.2
Lewis, C.E.3
-
8
-
-
70350373671
-
The role of NF-kappaB in hypoxia-induced gene expression
-
Taylor, C. T. and Cummins, E. P. 2009. The role of NF-kappaB in hypoxia-induced gene expression. Ann. N. Y. Acad. Sci. 1177:178.
-
(2009)
Ann. N. Y. Acad. Sci.
, vol.1177
, pp. 178
-
-
Taylor, C.T.1
Cummins, E.P.2
-
9
-
-
84873864037
-
Molecular mechanisms regulating macrophage response to hypoxia
-
Rahat, M. A., Bitterman, H. and Lahat, N. 2011. Molecular mechanisms regulating macrophage response to hypoxia. Front. Immunol. 2:45.
-
(2011)
Front. Immunol.
, vol.2
, pp. 45
-
-
Rahat, M.A.1
Bitterman, H.2
Lahat, N.3
-
10
-
-
84859445000
-
Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
-
Semenza, G. L. 2012. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol. Sci. 33:207.
-
(2012)
Trends Pharmacol. Sci.
, vol.33
, pp. 207
-
-
Semenza, G.L.1
-
11
-
-
44849100198
-
NF- kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
-
Rius, J., Guma, M., Schachtrup, C. et al. 2008. NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature 453:807.
-
(2008)
Nature
, vol.453
, pp. 807
-
-
Rius, J.1
Guma, M.2
Schachtrup, C.3
-
12
-
-
84934442193
-
Mitochondrial reactive oxygen species are required for hypoxic HIF alpha stabilization
-
Simon, M. C. 2006. Mitochondrial reactive oxygen species are required for hypoxic HIF alpha stabilization. Adv. Exp. Med. Biol. 588:165.
-
(2006)
Adv. Exp. Med. Biol.
, vol.588
, pp. 165
-
-
Simon, M.C.1
-
13
-
-
1642581653
-
Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1α
-
Blouin, C. C., Pagé E. L., Soucy, G. M. and Richard, D. E. 2004. Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1α. Blood 103:11240.
-
(2004)
Blood
, vol.103
, pp. 11240
-
-
Blouin, C.C.1
Pagé, E.L.2
Soucy, G.M.3
Richard, D.E.4
-
14
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza, G. L. 2010. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 29:625.
-
(2010)
Oncogene
, vol.29
, pp. 625
-
-
Semenza, G.L.1
-
15
-
-
40949142209
-
The role of hypoxia-inducible factors in tumorigenesis
-
Rankin, E. B. and Giaccia, A. J. 2008. The role of hypoxia-inducible factors in tumorigenesis. Cell Death Differ. 15:678.
-
(2008)
Cell Death Differ
, vol.15
, pp. 678
-
-
Rankin, E.B.1
Giaccia, A.J.2
-
16
-
-
68249140395
-
Hypoxiainducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
-
Fang, H. Y., Hughes, R., Murdoch, C. et al. 2009. Hypoxiainducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood 114:844.
-
(2009)
Blood
, vol.114
, pp. 844
-
-
Fang, H.Y.1
Hughes, R.2
Murdoch, C.3
-
17
-
-
34250158361
-
Cutting edge: Essential role of hypoxia inducible factor-1α in development of lipopolysaccharide-induced sepsis
-
Peyssonnaux, C., Cejudo-Martin, P., Doedens, A., Zinkernagel, A. S., Johnson, R. S. and Nizet, V. 2007. Cutting edge: Essential role of hypoxia inducible factor-1α in development of lipopolysaccharide-induced sepsis. J. Immunol. 178:75169.
-
(2007)
J. Immunol.
, vol.178
, pp. 75169
-
-
Peyssonnaux, C.1
Cejudo-Martin, P.2
Doedens, A.3
Zinkernagel, A.S.4
Johnson, R.S.5
Nizet, V.6
-
18
-
-
22144492953
-
HIF-1α expression regulates the bactericidal capacity of phagocytes
-
Peyssonnaux, C., Datta, V., Cramer, T. et al. 2005. HIF-1α expression regulates the bactericidal capacity of phagocytes. J. Clin. Invest. 115:18065.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 18065
-
-
Peyssonnaux, C.1
Datta, V.2
Cramer, T.3
-
19
-
-
0037423948
-
HIF-1α is essential for myeloid cell-mediated inflammation
-
Cramer, T., Yamanishi, Y., Clausen, B. E. et al. 2003. HIF-1α is essential for myeloid cell-mediated inflammation. Cell 112:645.
-
(2003)
Cell
, vol.112
, pp. 645
-
-
Cramer, T.1
Yamanishi, Y.2
Clausen, B.E.3
-
20
-
-
0036493984
-
Relation of hypoxia-inducible factor-2 α (HIF-2 α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer
-
Leek, R. D., Talks, K. L., Pezzella, F. et al. 2002. Relation of hypoxia-inducible factor-2 α (HIF-2 α) expression in tumor-infiltrative macrophages to tumor angiogenesis and the oxidative thymidine phosphorylase pathway in Human breast cancer. Cancer Res. 62:1326.
-
(2002)
Cancer Res
, vol.62
, pp. 1326
-
-
Leek, R.D.1
Talks, K.L.2
Pezzella, F.3
-
21
-
-
78650985962
-
Opposing roles for HIF-1α and HIF-2α in the regulation of angiogenesis by mononuclear phagocytes
-
Eubank, T. D., Roda, J. M., Liu, H., O'Neil, T. and Marsh, C. B. 2011. Opposing roles for HIF-1α and HIF-2α in the regulation of angiogenesis by mononuclear phagocytes. Blood 117:323.
-
(2011)
Blood
, vol.117
, pp. 323
-
-
Eubank, T.D.1
Roda, J.M.2
Liu, H.3
O'Neil, T.4
Marsh, C.B.5
-
22
-
-
0034661990
-
Role of oxidants in NF-kappa B activation and TNFalpha gene transcription induced by hypoxia and endotoxin
-
Chandel, N. S., Trzyna, W. C., McClintock, D. S. and Schumacker, P. T. 2000. Role of oxidants in NF-kappa B activation and TNFalpha gene transcription induced by hypoxia and endotoxin. J. Immunol. 165:1013.
-
(2000)
J. Immunol.
, vol.165
, pp. 1013
-
-
Chandel, N.S.1
Trzyna, W.C.2
McClintock, D.S.3
Schumacker, P.T.4
-
23
-
-
73849101811
-
Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression
-
Takeda, K., Ichiki, T., Narabayashi, E. et al. 2009. Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression. Arterioscler. Thromb. Vasc. Biol. 29:2132.
-
(2009)
Arterioscler. Thromb. Vasc. Biol.
, vol.29
, pp. 2132
-
-
Takeda, K.1
Ichiki, T.2
Narabayashi, E.3
-
24
-
-
2342464085
-
The two NF-kappaB activation pathways and their role in innate and adaptive immunity
-
Bonizzi, G. and Karin, M. 2004. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol. 25:280.
-
(2004)
Trends Immunol
, vol.25
, pp. 280
-
-
Bonizzi, G.1
Karin, M.2
-
25
-
-
33845321931
-
Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NF-κB activity
-
Cummins, E. P., Berra, E., Comerford, K. M. et al. 2006. Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NF-κB activity. Proc. Natl. Acad. Sci. U.S.A. 103:18154.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 18154
-
-
Cummins, E.P.1
Berra, E.2
Comerford, K.M.3
-
26
-
-
40949088476
-
Biology of hypoxia-inducible factor-2alpha in development and disease
-
Patel, S. A. and Simon, M. C. 2008. Biology of hypoxia-inducible factor-2alpha in development and disease. Cell Death Differ. 15:628.
-
(2008)
Cell Death Differ
, vol.15
, pp. 628
-
-
Patel, S.A.1
Simon, M.C.2
-
27
-
-
84855387231
-
Upregulations of glucocorticoid-induced leucine zipper by hypoxia and glucocorticoid inhibit proinflammatory cytokines under hypoxic conditions in macrophages
-
Wang, Y., Ma, Y. Y., Song, X. L. et al. 2012. Upregulations of glucocorticoid-induced leucine zipper by hypoxia and glucocorticoid inhibit proinflammatory cytokines under hypoxic conditions in macrophages. J. Immunol. 188:222.
-
(2012)
J. Immunol.
, vol.188
, pp. 222
-
-
Wang, Y.1
Ma, Y.Y.2
Song, X.L.3
-
28
-
-
0034011611
-
Incubation of murine bone marrow cells in hypoxia ensures the maintenance of marrow-repopulating ability together with the expansion of committed progenitors
-
Ivanović, Z., Bartolozzi, B., Bernabei, P. A. et al. 2000. Incubation of murine bone marrow cells in hypoxia ensures the maintenance of marrow-repopulating ability together with the expansion of committed progenitors. Br. J. Haematol. 108:424.
-
(2000)
Br. J. Haematol.
, vol.108
, pp. 424
-
-
Ivanović, Z.1
Bartolozzi, B.2
Bernabei, P.A.3
-
29
-
-
0034465103
-
HIF-1 is essential for multilineage hematopoiesis in the embryo
-
Adelman, D. M., Maltepe, E. and Simon, M. C. 2000. HIF-1 is essential for multilineage hematopoiesis in the embryo. Adv. Exp. Med. Biol. 475:275.
-
(2000)
Adv. Exp. Med. Biol.
, vol.475
, pp. 275
-
-
Adelman, D.M.1
Maltepe, E.2
Simon, M.C.3
-
30
-
-
77956217067
-
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
-
Takubo, K., Goda, N., Yamada, W. et al. 2010. Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell 7:391.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 391
-
-
Takubo, K.1
Goda, N.2
Yamada, W.3
-
31
-
-
34547873919
-
Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow
-
Ĺesque, J. P., Winkler, I. G., Hendy, J. et al. 2007. Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow. Stem Cells 25:1954.
-
(2007)
Stem Cells
, vol.25
, pp. 1954
-
-
Lévesque, J.P.1
Winkler, I.G.2
Hendy, J.3
-
32
-
-
33745614886
-
Structural analogues of AMD3100 mobilise haematopoietic progenitor cells from bone marrow in vivo according to their ability to inhibit CXCL12 binding to CXCR4 in vitro
-
Martin, C., Bridger, G. J. and Rankin, S. M. 2006. Structural analogues of AMD3100 mobilise haematopoietic progenitor cells from bone marrow in vivo according to their ability to inhibit CXCL12 binding to CXCR4 in vitro. Br. J. Haematol. 134:326.
-
(2006)
Br. J. Haematol.
, vol.134
, pp. 326
-
-
Martin, C.1
Bridger, G.J.2
Rankin, S.M.3
-
33
-
-
4043184065
-
Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
-
Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J. et al. 2004. Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat. Med. 10:858.
-
(2004)
Nat. Med.
, vol.10
, pp. 858
-
-
Ceradini, D.J.1
Kulkarni, A.R.2
Callaghan, M.J.3
-
34
-
-
10744219598
-
Regulation of the chemokine receptor CXCR4 by hypoxia
-
Schioppa, T., Uranchimeg, B., Saccani, A. et al. 2003. Regulation of the chemokine receptor CXCR4 by hypoxia. J. Exp. Med. 198:1391.
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1391
-
-
Schioppa, T.1
Uranchimeg, B.2
Saccani, A.3
-
35
-
-
80355146868
-
Monocyte recruitment during infection and inflammation
-
Shi, C. and Pamer, E. G. 2011. Monocyte recruitment during infection and inflammation. Nat. Rev. Immunol. 11:762.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 762
-
-
Shi, C.1
Pamer, E.G.2
-
36
-
-
73149094288
-
CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis
-
Wang, Y., Cui, L., Gonsiorek, W. et al. 2009. CCR2 and CXCR4 regulate peripheral blood monocyte pharmacodynamics and link to efficacy in experimental autoimmune encephalomyelitis. J. Inflamm. (Lond). 6:32.
-
(2009)
J. Inflamm. (Lond).
, vol.6
, pp. 32
-
-
Wang, Y.1
Cui, L.2
Gonsiorek, W.3
-
37
-
-
0033040133
-
Hypoxia inhibits macrophage migration
-
Turner, L., Scotton, C., Negus, R. and Balkwill, F. 1999. Hypoxia inhibits macrophage migration. Eur. J. Immunol. 29:2280.
-
(1999)
Eur. J. Immunol.
, vol.29
, pp. 2280
-
-
Turner, L.1
Scotton, C.2
Negus, R.3
Balkwill, F.4
-
38
-
-
27744603002
-
Hypoxia regulates macrophage functions in inflammation
-
Murdoch, C., Muthana, M. and Lewis, C. E. 2005. Hypoxia regulates macrophage functions in inflammation. J. Immunol. 175:6257.
-
(2005)
J. Immunol.
, vol.175
, pp. 6257
-
-
Murdoch, C.1
Muthana, M.2
Lewis, C.E.3
-
39
-
-
34247631690
-
The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
-
Lum, J. J., Bui, T., Gruber, M. et al. 2007. The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis. Genes Dev. 21:1037.
-
(2007)
Genes Dev
, vol.21
, pp. 1037
-
-
Lum, J.J.1
Bui, T.2
Gruber, M.3
-
40
-
-
67649207249
-
Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions
-
Roiniotis, J., Dinh, H., Masendycz, P. et al. 2009. Hypoxia prolongs monocyte/macrophage survival and enhanced glycolysis is associated with their maturation under aerobic conditions. J. Immunol. 182:7974.
-
(2009)
J. Immunol.
, vol.182
, pp. 7974
-
-
Roiniotis, J.1
Dinh, H.2
Masendycz, P.3
-
41
-
-
0035194416
-
Hypoxia mediates increased neutrophil and macrophage adhesiveness to alveolar epithelial cells
-
Beck-Schimmer, B., Schimmer, R. C., Madjdpour, C., Bonvini, J. M., Pasch, T. and Ward, P. A. 2001. Hypoxia mediates increased neutrophil and macrophage adhesiveness to alveolar epithelial cells. Am. J. Respir. Cell Mol. Biol. 25:780.
-
(2001)
Am. J. Respir. Cell Mol. Biol.
, vol.25
, pp. 780
-
-
Beck-Schimmer, B.1
Schimmer, R.C.2
Madjdpour, C.3
Bonvini, J.M.4
Pasch, T.5
Ward, P.A.6
-
42
-
-
67149133742
-
The hypoxic synovial environment regulates expression of vascular endothelial growth factor and osteopontin in juvenile idiopathic arthritis
-
Bosco, M. C., Delfino, S., Ferlito, F. et al. 2009. The hypoxic synovial environment regulates expression of vascular endothelial growth factor and osteopontin in juvenile idiopathic arthritis. J. Rheumatol. 36:1318.
-
(2009)
J. Rheumatol.
, vol.36
, pp. 1318
-
-
Bosco, M.C.1
Delfino, S.2
Ferlito, F.3
-
43
-
-
0028786601
-
A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter
-
Melillo, G., Musso, T., Sica, A., Taylor, L. S., Cox, G. W. and Varesio, L. 1995. A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter. J. Exp. Med. 182:1683.
-
(1995)
J. Exp. Med.
, vol.182
, pp. 1683
-
-
Melillo, G.1
Musso, T.2
Sica, A.3
Taylor, L.S.4
Cox, G.W.5
Varesio, L.6
-
44
-
-
70249099576
-
Interdependence of hypoxic and innate immune responses
-
Nizet, V. and Johnson, R. S. 2009. Interdependence of hypoxic and innate immune responses. Nat. Rev. Immunol. 9:609.
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 609
-
-
Nizet, V.1
Johnson, R.S.2
-
45
-
-
36248996487
-
Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1α-dependent manner
-
Anand, R. J., Gribar, S. C., Li, J. et al. 2007. Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1α-dependent manner. J. Leukoc. Biol. 82:1257.
-
(2007)
J. Leukoc. Biol.
, vol.82
, pp. 1257
-
-
Anand, R.J.1
Gribar, S.C.2
Li, J.3
-
47
-
-
77949383238
-
Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor
-
Kim, S. Y., Choi, Y. J., Joung, S. M., Lee, B. H., Jung, Y. S. and Lee, J. Y. 2010. Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor. Immunology 129:516.
-
(2010)
Immunology
, vol.129
, pp. 516
-
-
Kim, S.Y.1
Choi, Y.J.2
Joung, S.M.3
Lee, B.H.4
Jung, Y.S.5
Lee, J.Y.6
-
48
-
-
64849087205
-
Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor
-
Acosta-Iborra, B., Elorza, A., Olazabal, I. M. et al. 2009. Macrophage oxygen sensing modulates antigen presentation and phagocytic functions involving IFN-gamma production through the HIF-1 alpha transcription factor. J. Immunol. 182:3155.
-
(2009)
J. Immunol.
, vol.182
, pp. 3155
-
-
Acosta-Iborra, B.1
Elorza, A.2
Olazabal, I.M.3
-
49
-
-
44449174536
-
Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia
-
Kuhlicke, J., Frick, J. S., Morote-Garcia, J. C., Rosenberger, P. and Eltzschig, H. K. 2007. Hypoxia inducible factor (HIF)-1 coordinates induction of Toll-like receptors TLR2 and TLR6 during hypoxia. PLoS ONE. 2:e1364.
-
(2007)
PLoS ONE
, vol.2
-
-
Kuhlicke, J.1
Frick, J.S.2
Morote-Garcia, J.C.3
Rosenberger, P.4
Eltzschig, H.K.5
-
50
-
-
4644318828
-
Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor
-
Appelhoff, R. J., Tian, Y. M., Raval, R. R. et al. 2004. Differential function of the prolyl hydroxylases PHD1, PHD2, and PHD3 in the regulation of hypoxia-inducible factor. J. Biol. Chem. 279:38458.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 38458
-
-
Appelhoff, R.J.1
Tian, Y.M.2
Raval, R.R.3
-
51
-
-
38649143118
-
Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism
-
Aragonés, J., Schneider, M., Van Geyte, K. et al. 2008. Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat. Genet. 40:170.
-
(2008)
Nat. Genet.
, vol.40
, pp. 170
-
-
Aragonés, J.1
Schneider, M.2
Van Geyte, K.3
-
52
-
-
77449090208
-
Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury
-
Schneider, M., Van Geyte, K., Fraisl, P. et al. 2010. Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury. Gastroenterology 138:1143-54.e1.
-
(2010)
Gastroenterology 138:1143-54
-
-
Schneider, M.1
Van Geyte, K.2
Fraisl, P.3
-
53
-
-
78649705245
-
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
-
Tambuwala, M. M., Cummins, E. P., Lenihan, C. R. et al. 2010. Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function. Gastroenterology 139:2093.
-
(2010)
Gastroenterology
, vol.139
, pp. 2093
-
-
Tambuwala, M.M.1
Cummins, E.P.2
Lenihan, C.R.3
-
54
-
-
42449163874
-
Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure
-
Minamishima, Y. A., Moslehi, J., Bardeesy, N., Cullen, D., Bronson, R. T. and Kaelin, W. G. Jr. 2008. Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure. Blood 111:3236.
-
(2008)
Blood
, vol.111
, pp. 3236
-
-
Minamishima, Y.A.1
Moslehi, J.2
Bardeesy, N.3
Cullen, D.4
Bronson, R.T.5
Kaelin Jr, W.G.6
-
55
-
-
33750976389
-
Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2
-
Takeda, K., Ho, V. C., Takeda, H., Duan, L. J., Nagy, A. and Fong, G. H. 2006. Placental but not heart defects are associated with elevated hypoxia-inducible factor alpha levels in mice lacking prolyl hydroxylase domain protein 2. Mol. Cell. Biol. 26:8336.
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 8336
-
-
Takeda, K.1
Ho, V.C.2
Takeda, H.3
Duan, L.J.4
Nagy, A.5
Fong, G.H.6
-
56
-
-
43249108443
-
Abnormal sympathoadrenal development and systemic hypotension in PHD3-/-mice
-
Bishop, T., Gallagher, D., Pascual, A. et al. 2008. Abnormal sympathoadrenal development and systemic hypotension in PHD3-/-mice. Mol. Cell. Biol. 28:3386.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 3386
-
-
Bishop, T.1
Gallagher, D.2
Pascual, A.3
-
57
-
-
59649117924
-
Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization
-
Mazzone, M., Dettori, D., Leite de Oliveira, R. et al. 2009. Heterozygous deficiency of PHD2 restores tumor oxygenation and inhibits metastasis via endothelial normalization. Cell 136:839.
-
(2009)
Cell
, vol.136
, pp. 839
-
-
Mazzone, M.1
Dettori, D.2
Leite de Oliveira, R.3
-
58
-
-
70350456693
-
A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo
-
Minamishima, Y. A., Moslehi, J., Padera, R. F., Bronson, R. T., Liao, R. and Kaelin, W. G. Jr. 2009. A feedback loop involving the Phd3 prolyl hydroxylase tunes the mammalian hypoxic response in vivo. Mol. Cell. Biol. 29:5729.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 5729
-
-
Minamishima, Y.A.1
Moslehi, J.2
Padera, R.F.3
Bronson, R.T.4
Liao, R.5
Kaelin Jr, W.G.6
-
59
-
-
84864823120
-
Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis
-
Kiss, J., Mollenhauer, M., Walmsley, S. R. et al. 2012. Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis. J. Immunol. 189:1955.
-
(2012)
J. Immunol.
, vol.189
, pp. 1955
-
-
Kiss, J.1
Mollenhauer, M.2
Walmsley, S.R.3
-
60
-
-
84864797376
-
The prolyl hydroxylase PHD3 identifies proinflammatory macrophages and its expression is regulated by activin A
-
Escribese, M. M., Sierra-Filardi, E., Nieto, C. et al. 2012. The prolyl hydroxylase PHD3 identifies proinflammatory macrophages and its expression is regulated by activin A. J. Immunol. 189:1946.
-
(2012)
J. Immunol.
, vol.189
, pp. 1946
-
-
Escribese, M.M.1
Sierra-Filardi, E.2
Nieto, C.3
-
61
-
-
80054121374
-
Macrophages in cancer and infectious diseases: the 'good' and the 'bad'
-
Porta, C., Riboldi, E., Totaro, M. G., Strauss, L., Sica, A. and Mantovani, A. 2011. Macrophages in cancer and infectious diseases: the 'good' and the 'bad'. Immunotherapy 3:1185.
-
(2011)
Immunotherapy
, vol.3
, pp. 1185
-
-
Porta, C.1
Riboldi, E.2
Totaro, M.G.3
Strauss, L.4
Sica, A.5
Mantovani, A.6
-
62
-
-
46249108568
-
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
-
Via, L. E., Lin, P. L., Ray, S. M. et al. 2008. Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infect. Immun. 76:2333.
-
(2008)
Infect. Immun.
, vol.76
, pp. 2333
-
-
Via, L.E.1
Lin, P.L.2
Ray, S.M.3
-
63
-
-
79959815079
-
Mycobacterium tuberculosis uses host triacylglycerol to accumulate lipid droplets and acquires a dormancylike phenotype in lipid-loaded macrophages
-
Daniel, J., Maamar, H., Deb, C., Sirakova, T. D. and Kolattukudy, P. E. 2011. Mycobacterium tuberculosis uses host triacylglycerol to accumulate lipid droplets and acquires a dormancylike phenotype in lipid-loaded macrophages. PLoS Pathog. 7:e1002093.
-
(2011)
PLoS Pathog
, vol.7
-
-
Daniel, J.1
Maamar, H.2
Deb, C.3
Sirakova, T.D.4
Kolattukudy, P.E.5
-
64
-
-
84860322767
-
Hypoxia triggers the expression of human β defensin 2 and antimicrobial activity against Mycobacterium tuberculosis in human macrophages
-
Nickel, D., Busch, M., Mayer, D., Hagemann, B., Knoll, V. and Stenger, S. 2012. Hypoxia triggers the expression of human β defensin 2 and antimicrobial activity against Mycobacterium tuberculosis in human macrophages. J. Immunol. 188:4001.
-
(2012)
J. Immunol.
, vol.188
, pp. 4001
-
-
Nickel, D.1
Busch, M.2
Mayer, D.3
Hagemann, B.4
Knoll, V.5
Stenger, S.6
-
65
-
-
34147122736
-
RNA interference for HIF-1alpha inhibits foam cells formation in vitro
-
Jiang, G., Li, T., Qiu, Y., Rui, Y., Chen, W. and Lou, Y. 2007. RNA interference for HIF-1alpha inhibits foam cells formation in vitro. Eur. J. Pharmacol. 562:183.
-
(2007)
Eur. J. Pharmacol.
, vol.562
, pp. 183
-
-
Jiang, G.1
Li, T.2
Qiu, Y.3
Rui, Y.4
Chen, W.5
Lou, Y.6
-
66
-
-
84857913810
-
Hypoxia-a key regulator of angiogenesis and inflammation in rheumatoid arthritis
-
Konisti, S., Kiriakidis, S. and Paleolog, E. M. 2012. Hypoxia-a key regulator of angiogenesis and inflammation in rheumatoid arthritis. Nat. Rev. Rheumatol. 8:153.
-
(2012)
Nat. Rev. Rheumatol.
, vol.8
, pp. 153
-
-
Konisti, S.1
Kiriakidis, S.2
Paleolog, E.M.3
-
67
-
-
79955772251
-
Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension
-
Vergadi, E., Chang, M. S., Lee, C. et al. 2011. Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension. Circulation 123:1986.
-
(2011)
Circulation
, vol.123
, pp. 1986
-
-
Vergadi, E.1
Chang, M.S.2
Lee, C.3
-
68
-
-
77956111527
-
Convergent pathways of macrophage polarization: The role of B cells
-
Sica, A., Porta, C., Riboldi, E. and Locati, M. 2010. Convergent pathways of macrophage polarization: The role of B cells. Eur. J. Immunol. 40:2131.
-
(2010)
Eur. J. Immunol.
, vol.40
, pp. 2131
-
-
Sica, A.1
Porta, C.2
Riboldi, E.3
Locati, M.4
-
69
-
-
39549087002
-
Pulmonary arterial remodeling induced by a Th2 immune response
-
Daley, E., Emson, C., Guignabert, C. et al. 2008. Pulmonary arterial remodeling induced by a Th2 immune response. J. Exp. Med. 205:361.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 361
-
-
Daley, E.1
Emson, C.2
Guignabert, C.3
-
70
-
-
0038390235
-
FIZZ1/ RELMalpha, a novel hypoxia-induced mitogenic factor in lung with vasoconstrictive and angiogenic properties
-
Teng, X., Li, D., Champion, H. C. and Johns, R. A. 2003. FIZZ1/ RELMalpha, a novel hypoxia-induced mitogenic factor in lung with vasoconstrictive and angiogenic properties. Circ. Res. 92:1065.
-
(2003)
Circ. Res.
, vol.92
, pp. 1065
-
-
Teng, X.1
Li, D.2
Champion, H.C.3
Johns, R.A.4
-
72
-
-
9444247541
-
Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium
-
Jürgensen, J. S., Rosenberger, C., Wiesener, M. S. et al. 2004. Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium. FASEB J. 18:1415.
-
(2004)
FASEB J
, vol.18
, pp. 1415
-
-
Jürgensen, J.S.1
Rosenberger, C.2
Wiesener, M.S.3
-
74
-
-
0036847816
-
Microglia as neuroprotective, immunocompetent cells of the CNS
-
Streit, W. J. 2002. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40:133.
-
(2002)
Glia
, vol.40
, pp. 133
-
-
Streit, W.J.1
-
75
-
-
33847785649
-
Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain
-
Lalancette-Hébert, M., Gowing, G., Simard, A., Weng, Y. C. and Kriz, J. 2007. Selective ablation of proliferating microglial cells exacerbates ischemic injury in the brain. J. Neurosci. 27:2596.
-
(2007)
J. Neurosci.
, vol.27
, pp. 2596
-
-
Lalancette-Hébert, M.1
Gowing, G.2
Simard, A.3
Weng, Y.C.4
Kriz, J.5
-
76
-
-
80455122752
-
Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis
-
Takeda, Y., Costa, S., Delamarre, E. et al. 2011. Macrophage skewing by Phd2 haplodeficiency prevents ischaemia by inducing arteriogenesis. Nature 479:122.
-
(2011)
Nature
, vol.479
, pp. 122
-
-
Takeda, Y.1
Costa, S.2
Delamarre, E.3
-
77
-
-
84862016400
-
The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism
-
Haschemi, A., Kosma, P., Gille, L. et al. 2012. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab. 15:813.
-
(2012)
Cell Metab
, vol.15
, pp. 813
-
-
Haschemi, A.1
Kosma, P.2
Gille, L.3
-
78
-
-
66849128258
-
A(2B) adenosine receptors in immunity and inflammation
-
Haskó G., Csóka, B., Németh, Z. H., Vizi, E. S. and Pacher, P. 2009. A(2B) adenosine receptors in immunity and inflammation. Trends Immunol. 30:263.
-
(2009)
Trends Immunol
, vol.30
, pp. 263
-
-
Haskó, G.1
Csóka, B.2
Németh, Z.H.3
Vizi, E.S.4
Pacher, P.5
-
79
-
-
0033820684
-
Adenosine inhibits IL-12 and TNF-α production via adenosine A2a receptordependent and independent mechanisms
-
Haskó G., Kuhel, D. G., Chen, J. F. et al. 2000. Adenosine inhibits IL-12 and TNF-α production via adenosine A2a receptordependent and independent mechanisms. FASEB J. 14:2065.
-
(2000)
FASEB J
, vol.14
, pp. 2065
-
-
Haskó, G.1
Kuhel, D.G.2
Chen, J.F.3
-
80
-
-
29144501467
-
Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism
-
Németh, Z. H., Lutz, C. S., Csóka, B. et al. 2005. Adenosine augments IL-10 production by macrophages through an A2B receptor-mediated posttranscriptional mechanism. J. Immunol. 175:8260.
-
(2005)
J. Immunol.
, vol.175
, pp. 8260
-
-
Németh, Z.H.1
Lutz, C.S.2
Csóka, B.3
-
81
-
-
0033559904
-
IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation
-
Xaus, J., Mirabet, M., Lloberas, J. et al. 1999. IFN-gamma up-regulates the A2B adenosine receptor expression in macrophages: a mechanism of macrophage deactivation. J. Immunol. 162:3607.
-
(1999)
J. Immunol.
, vol.162
, pp. 3607
-
-
Xaus, J.1
Mirabet, M.2
Lloberas, J.3
-
82
-
-
0032853298
-
Adenosine inhibits macrophage colony-stimulating factor-dependent proliferation of macrophages through the induction of p27kip-1 expression
-
Xaus, J., Valledor, A. F., Cardó M. et al. 1999. Adenosine inhibits macrophage colony-stimulating factor-dependent proliferation of macrophages through the induction of p27kip-1 expression. J. Immunol. 163:4140.
-
(1999)
J. Immunol.
, vol.163
, pp. 4140
-
-
Xaus, J.1
Valledor, A.F.2
Cardó, M.3
-
83
-
-
3042625540
-
Potential role of macrophages as immunoregulators of pregnancy
-
Mor, G. and Abrahams, V. M. 2003. Potential role of macrophages as immunoregulators of pregnancy. Reprod. Biol. Endocrinol. 1:119.
-
(2003)
Reprod. Biol. Endocrinol.
, vol.1
, pp. 119
-
-
Mor, G.1
Abrahams, V.M.2
-
84
-
-
0036984640
-
Role of angiogenesis in tumor growth and metastasis
-
Folkman, J. 2002. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 29(6 Suppl 16):15.
-
(2002)
Semin. Oncol.
, vol.29
, Issue.6 SUPPL 16
, pp. 15
-
-
Folkman, J.1
-
85
-
-
34547121206
-
Hypoxia in cancer: significance and impact on clinical outcome
-
Vaupel, P. and Mayer, A. 2007. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev. 26:225.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 225
-
-
Vaupel, P.1
Mayer, A.2
-
86
-
-
34547107592
-
Hypoxia-driven selection of the metastatic phenotype
-
Sullivan, R. and Graham, C. H. 2007. Hypoxia-driven selection of the metastatic phenotype. Cancer Metastasis Rev. 26:319.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 319
-
-
Sullivan, R.1
Graham, C.H.2
-
87
-
-
0001221508
-
On respiratory impairment in cancer cells
-
Warburg, O. 1956. On respiratory impairment in cancer cells. Science 124:269.
-
(1956)
Science
, vol.124
, pp. 269
-
-
Warburg, O.1
-
88
-
-
23044500915
-
Pyruvate kinase type M2 and its role in tumor growth and spreading
-
Mazurek, S., Boschek, C. B., Hugo, F. and Eigenbrodt, E. 2005. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin. Cancer Biol. 15:300.
-
(2005)
Semin. Cancer Biol.
, vol.15
, pp. 300
-
-
Mazurek, S.1
Boschek, C.B.2
Hugo, F.3
Eigenbrodt, E.4
-
89
-
-
39849102836
-
HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
-
Du, R., Lu, K. V., Petritsch, C. et al. 2008. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell 13:206.
-
(2008)
Cancer Cell
, vol.13
, pp. 206
-
-
Du, R.1
Lu, K.V.2
Petritsch, C.3
-
90
-
-
0035282432
-
Involvement of chemokine receptors in breast cancer metastasis
-
Müller, A., Homey, B., Soto, H. et al. 2001. Involvement of chemokine receptors in breast cancer metastasis. Nature 410:50.
-
(2001)
Nature
, vol.410
, pp. 50
-
-
Müller, A.1
Homey, B.2
Soto, H.3
-
91
-
-
24044461733
-
Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies
-
Lewis, C. and Murdoch, C. 2005. Macrophage responses to hypoxia: implications for tumor progression and anti-cancer therapies. Am. J. Pathol. 167:627.
-
(2005)
Am. J. Pathol.
, vol.167
, pp. 627
-
-
Lewis, C.1
Murdoch, C.2
-
92
-
-
24944587964
-
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
-
De Palma, M., Venneri, M. A., Galli, R. et al. 2005. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8:211.
-
(2005)
Cancer Cell
, vol.8
, pp. 211
-
-
De Palma, M.1
Venneri, M.A.2
Galli, R.3
-
94
-
-
79955517032
-
TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice
-
Welford, A. F., Biziato, D., Coffelt, S. B. et al. 2011. TIE2-expressing macrophages limit the therapeutic efficacy of the vascular-disrupting agent combretastatin A4 phosphate in mice. J. Clin. Invest. 121:1969.
-
(2011)
J. Clin. Invest.
, vol.121
, pp. 1969
-
-
Welford, A.F.1
Biziato, D.2
Coffelt, S.B.3
-
95
-
-
78149330949
-
HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
-
Corzo, C. A., Condamine, T., Lu, L. et al. 2010. HIF-1α regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J. Exp. Med. 207:2439.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2439
-
-
Corzo, C.A.1
Condamine, T.2
Lu, L.3
-
96
-
-
13544250819
-
Macrophage arginase regulation by CCAAT/enhancer-binding protein beta
-
Albina, J. E., Mahoney, E. J., Daley, J. M., Wesche, D. E., Morris, S. M. Jr and Reichner, J. S. 2005. Macrophage arginase regulation by CCAAT/enhancer-binding protein beta. Shock 23:168.
-
(2005)
Shock
, vol.23
, pp. 168
-
-
Albina, J.E.1
Mahoney, E.J.2
Daley, J.M.3
Wesche, D.E.4
Morris Jr, S.M.5
Reichner, J.S.6
-
97
-
-
34248172324
-
Altered macrophage differentiation and immune dysfunction in tumor development
-
Sica, A. and Bronte, V. 2007. Altered macrophage differentiation and immune dysfunction in tumor development. J. Clin. Invest. 117:1155.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1155
-
-
Sica, A.1
Bronte, V.2
-
98
-
-
34547098129
-
Targeting hypoxia cell signaling for cancer therapy
-
Melillo, G. 2007. Targeting hypoxia cell signaling for cancer therapy. Cancer Metastasis Rev. 26:341.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 341
-
-
Melillo, G.1
-
99
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G. L. 2003. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer. 3:721.
-
(2003)
Nat. Rev. Cancer.
, vol.3
, pp. 721
-
-
Semenza, G.L.1
-
100
-
-
79952233838
-
Use of macrophages to target therapeutic adenovirus to human prostate tumors
-
Muthana, M., Giannoudis, A., Scott, S. D. et al. 2011. Use of macrophages to target therapeutic adenovirus to human prostate tumors. Cancer Res. 71:1805.
-
(2011)
Cancer Res
, vol.71
, pp. 1805
-
-
Muthana, M.1
Giannoudis, A.2
Scott, S.D.3
-
101
-
-
79953750307
-
Targeting the ANG2/ TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells
-
Mazzieri, R., Pucci, F., Moi, D. et al. 2011. Targeting the ANG2/ TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells. Cancer Cell 19:512.
-
(2011)
Cancer Cell
, vol.19
, pp. 512
-
-
Mazzieri, R.1
Pucci, F.2
Moi, D.3
-
102
-
-
84866387976
-
The tumor-promoting flow of cells into, within and out of the tumor site: Regulation by the inflammatory axis of TNFα and chemokines
-
Ben-Baruch, A. 2012. The tumor-promoting flow of cells into, within and out of the tumor site: Regulation by the inflammatory axis of TNFα and chemokines. Cancer Microenviron. 5:151.
-
(2012)
Cancer Microenviron
, vol.5
, pp. 151
-
-
Ben-Baruch, A.1
-
103
-
-
47049126742
-
Chemokinemediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice
-
Sawanobori, Y., Ueha, S., Kurachi, M. et al. 2008. Chemokinemediated rapid turnover of myeloid-derived suppressor cells in tumor-bearing mice. Blood 111:5457.
-
(2008)
Blood
, vol.111
, pp. 5457
-
-
Sawanobori, Y.1
Ueha, S.2
Kurachi, M.3
|